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1. 发明申请

WO2006078320A3 METHODS FOR MANUFACTURING DELIVERY DEVICES AND DEVICES THEREOF 审中-公开
标题翻译：用于制造交付设备的方法及其设备
公开(公告)号：WO2006078320A3
公开(公告)日：2006-10-19
申请号：PCT/US2005027477
申请日：2005-08-03
申请人： BROOKWOOD PHARMACEUTICALS INC , STAAS JAY K , TICE THOMAS R , HUDSON BRUCE W , TIPTON ARTHUR J
发明人： STAAS JAY K , TICE THOMAS R , HUDSON BRUCE W , TIPTON ARTHUR J
IPC分类号： A61K9/00
CPC分类号： A61L31/06 , A61K9/0024 , A61K9/2027 , A61K9/204 , A61L27/34 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Described herein are methodes for reducing and achieving the desired release of an agent from a delivery system. The desired release kinetics are achieved by exposing the surface of the delivery system with a fluid for a desired period of time.
摘要翻译：这里描述的是用于减少和实现药剂从递送系统的期望释放的方法。所需的释放动力学通过用流体暴露输送系统的表面达所需的时间段来实现。

2. 发明申请

WO2010085608A1 POLYMER MIXTURES COMPRISING POLYMERS HAVING DIFFERENT NON-REPEATING UNITS AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：包含具有不同非重复单元的聚合物的聚合物混合物及其制备和使用方法
公开(公告)号：WO2010085608A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021743
申请日：2010-01-22
申请人： SURMODICS PHARMACEUTICALS, INC. , TIPTON, Arthur, J.
发明人： TIPTON, Arthur, J.
IPC分类号： C08L67/04 , C08L69/00 , C08L71/00 , C08G63/08 , C08G64/30 , C08G65/02
CPC分类号： C08G63/08 , C08G63/664 , C08G63/78 , C08G64/183 , C08G2261/126 , C08L67/04 , C08L69/00 , C08L71/00 , C08L2205/02 , C08L2666/02 , C08L2666/18
摘要： Described herein are polymer mixtures comprising polymers have at least one different non-repeating unit. Methods for making and using the polymer mixtures are also disclosed. Also disclosed are uses of the polymer mixtures, including methods for making microparticles from the polymer mixtures.
摘要翻译：本文描述的是包含聚合物的聚合物混合物，其具有至少一个不同的非重复单元。还公开了制备和使用聚合物混合物的方法。还公开了聚合物混合物的用途，包括从聚合物混合物制备微粒的方法。

3. 发明申请

WO2010075298A3 AN IMPLANTABLE COMPOSITE COMPRISING A TACKY BIOCOMPATIBLE POLYMER FILM AND A RELEASABLE BIOACTIVE AGENT 审中-公开
公开(公告)号：WO2010075298A3
公开(公告)日：2010-07-01
申请号：PCT/US2009/069024
申请日：2009-12-21
申请人： SURMODICS PHARMACEUTICALS, INC. , TIPTON, Arthur, J. , BURTON, Kevin, W. , TICE, Thomas, R. , BOWMAN, Howard , BIGGS, Danielle , MARKLAND, Peter
发明人： TIPTON, Arthur, J. , BURTON, Kevin, W. , TICE, Thomas, R. , BOWMAN, Howard , BIGGS, Danielle , MARKLAND, Peter
IPC分类号： A61K9/70 , A61K31/7036
摘要： Disclosed herein are implantable film-based composites, implantable elastic band composites, implantable flexible body composites, implantable suction cup composites, terpolymer compositions, spray coating compositions, methods for using the composites and compositions, and implant devices comprising the composites and compositions.

4. 发明申请

WO2004052336A3 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE 审中-公开
标题翻译：高粘度液体控制输送系统和医疗或手术装置
公开(公告)号：WO2004052336A3
公开(公告)日：2006-06-15
申请号：PCT/US0339311
申请日：2003-12-10
申请人： DURECT CORP , GIBSON JOHN W , MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J
发明人： GIBSON JOHN W , MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J
IPC分类号： A61K8/60 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K9/70 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00 , A61K9/10 , A61F6/06 , A61F9/02 , A61K9/20 , A61L27/00 , A61L25/00
CPC分类号： A61K47/10 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0073 , A61K9/1647 , A61K9/4858 , A61K9/7015 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/0015 , A61L24/0026 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/252 , A61L2300/402 , A61L2300/43 , A61L2300/602 , A61Q5/006
摘要： The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.
摘要翻译：本发明涉及形成液体，高粘度材料的新型非聚合物和组合物，其适于以受控的方式递送生物活性物质，并用作医疗或手术装置。该材料可以任选地用溶剂稀释以形成较低粘度的材料，使得材料易于施用。该溶剂可以是水不溶性或水溶性的，其中水溶性溶剂在体内快速扩散或迁移离开材料，留下较高粘度的液体材料。

5. 发明申请

WO2005089670A1 PHARMACEUTICAL COMPOSITIONS FOR ADMINISTRATION TO A SINUS 审中-公开
标题翻译：用于管理SINUS的药物组合物
公开(公告)号：WO2005089670A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/008743
申请日：2005-03-15
申请人： DURECT CORPORATION , THEEUWES, Felix , TIPTON, Arthur, J.
发明人： THEEUWES, Felix , TIPTON, Arthur, J.
IPC分类号： A61F2/00
CPC分类号： A61K9/0043
摘要： Pharmaceutical compositions for delivering a drug to a sinus in a subject are provided. The compositions are formed by the combination of a carrier material and a drug and are specially adapted for delivery to a sinus. The compositions have no fixed shape, and the carrier material serves to increase the viscosity or specific volume of the composition after introduction of the composition into the sinus. Also provided are methods for delivering a drug to a subject. The methods entail administering a pharmaceutical composition according to the present invention directly to a sinus. The drug is then released from the composition to the sinus. The pharmaceutical compositions can be administered to a sinus in liquid form, for example, as a suspension or solution using standard techniques. Also provided is the use of a carrier material in the manufacture of a drug delivery composition. The drug delivery composition is for delivering a drug to a sinus in a subject. The composition comprises the carrier material combined with the drug to be delivered, and has no fixed shape. After the composition is introduced into a sinus, the carrier material serves to increase the viscosity or specific volume of the composition.
摘要翻译：提供用于将药物递送至受试者中的窦的药物组合物。组合物通过载体材料和药物的组合形成，并且特别适于递送至窦。组合物没有固定的形状，并且载体材料用于在将组合物引入窦内后增加组合物的粘度或比体积。还提供了将药物递送到受试者的方法。所述方法需要将根据本发明的药物组合物直接给予鼻窦。然后将药物从组合物释放到窦。药物组合物可以以液体形式施用于窦，例如使用标准技术作为悬浮液或溶液施用。还提供了载体材料在制备药物递送组合物中的用途。药物递送组合物用于将药物递送至受试者的窦。该组合物包含与待输送药物结合的载体材料，并且没有固定的形状。在将组合物引入窦中之后，载体材料用于增加组合物的粘度或比体积。

6. 发明申请

WO2005067889A1 POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF ACTIVE AGENTS, PREFERABLY A GNRH 审中-公开
标题翻译：聚合物植入物，优选含有PEG和PLG的混合物，用于控制释放活性剂，优选A GNRH
公开(公告)号：WO2005067889A1
公开(公告)日：2005-07-28
申请号：PCT/US2004/043389
申请日：2004-12-23
申请人： DURECT CORPORATION , GIBSON, John, W. , TIPTON, Arthur, J.
发明人： GIBSON, John, W. , TIPTON, Arthur, J.
IPC分类号： A61K9/00
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/1635 , A61K9/1647 , A61K9/2031 , A61K38/09 , A61K38/24
摘要： Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject. Preferred hydrophobic component is a PLG. Preferred hydrophilic Components are a PEG or a methoxyPEG. Preferred peptides are LHRH, goserelin, leuprolide.
摘要翻译：提供了用于感兴趣的活性剂的控制释放的聚合装置。活性剂提供在可生物降解的聚合物体系内，以提供用于活性剂的受控释放的聚合物装置。聚合物体系是包含疏水组分和亲水组分的共聚物或聚合物共混物，并且聚合物体系当与例如当将该装置植入受试者中时与水系统接触或浸没在水系统中时不形成水凝胶。当将装置施用于受试者时，例如，当其被植入时，该装置以受控的方式释放活性剂，而没有滞后期或具有最小滞后期。还提供了生产聚合物装置的方法，以及使用聚合物装置来提供受试者中活性剂的受控释放的方法。优选的疏水组分是PLG。优选的亲水组分是PEG或甲氧基PEG。优选的肽是LHRH，戈舍瑞林，亮丙瑞林。

7. 发明申请

WO2004054542A3 ORAL DRUG DELIVERY SYSTEM COMPRISING HIGH VISCOSITY LIQUID CARRIER MATERIALS 审中-公开
标题翻译：包含高粘度液体载体材料的口服药物输送系统
公开(公告)号：WO2004054542A3
公开(公告)日：2004-08-26
申请号：PCT/US0340156
申请日：2003-12-15
申请人： DURECT CORP , YUM SU IL , SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C
发明人： YUM SU IL , SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
摘要翻译：适用于药物化合物和组合物施用的剂型和药物递送装置，包括化合物的口服药物施用。

8. 发明申请

WO2010075298A2 IMPLANTABLE COMPOSITES AND COMPOSITIONS COMPRISING RELEASABLE BIOACTIVE AGENTS 审中-公开
标题翻译：可植入的复合材料和包含可释放的生物剂的组合物
公开(公告)号：WO2010075298A2
公开(公告)日：2010-07-01
申请号：PCT/US2009069024
申请日：2009-12-21
申请人： SURMODICS PHARMACEUTICALS INC , TIPTON ARTHUR J , BURTON KEVIN W , TICE THOMAS R , BOWMAN HOWARD , BIGGS DANIELLE , MARKLAND PETER
发明人： TIPTON ARTHUR J , BURTON KEVIN W , TICE THOMAS R , BOWMAN HOWARD , BIGGS DANIELLE , MARKLAND PETER
IPC分类号： A61K9/70
CPC分类号： A61K9/0024 , A61K31/7036 , A61M5/14276 , A61M2205/04
摘要： Disclosed herein are implantable film-based composites, implantable elastic band composites, implantable flexible body composites, implantable suction cup composites, terpolymer compositions, spray coating compositions, methods for using the composites and compositions, and implant devices comprising the composites and compositions.
摘要翻译：本文公开了可植入膜基复合材料，可植入弹性带复合材料，可植入柔性体复合材料，可植入吸盘复合材料，三元共聚物组合物，喷涂组合物，使用复合材料和组合物的方法，以及包含该复合材料和组合物的植入装置。

9. 发明申请

WO0228366A9 DEVICES AND METHODS FOR MANAGEMENT OF INFLAMMATION 审中-公开
标题翻译：用于管理炎症的装置和方法
公开(公告)号：WO0228366A9
公开(公告)日：2003-02-13
申请号：PCT/US0131652
申请日：2001-10-09
申请人： DURECT CORP , CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
发明人： CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
IPC分类号： A61K9/00 , A61K9/22 , A61K31/352 , A61K31/37
CPC分类号： A61K9/0024 , A61K31/352
摘要： Devices and methods for the sustained release into a subject of an inhibitor of mast cell-mediated inflammation, specifically sustained-release of sodium cromoglycate as a prophylactic to prevent acute asthma attacks.
摘要翻译：用于持续释放到肥大细胞介导的炎症抑制剂的受试者的装置和方法，特别是缓释色甘酸钠作为预防性急性哮喘发作的预防剂。

10. 发明申请

WO0066087A8 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
公开(公告)号：WO0066087A8
公开(公告)日：2001-04-05
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.

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