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1. 发明申请

WO02102278A2 DEVICE AND METHOD FOR DELIVERING MICRODOSES OF AGENT TO THE EAR 审中-公开
标题翻译：用于将药剂微粒体递送至耳朵的装置和方法
公开(公告)号：WO02102278A2
公开(公告)日：2002-12-27
申请号：PCT/US0219290
申请日：2002-06-17
申请人： DURECT CORP , ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
发明人： ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
IPC分类号： A61F11/00 , A61F
CPC分类号： A61F11/00
摘要： The present invention provides devices and methods for delivery of very low dosages to the inner ear. The device is a self-contained unit that reproducibly and consistently delivers a dose of therapeutic agent that is effective, yet below the ototoxic threshold for that agent. The invention further provides therapeutic methods using the device of the invention.
摘要翻译：本发明提供了用于将非常低剂量递送到内耳的装置和方法。该装置是一种独立的单元，其可重复地和一致地递送有效剂量的治疗剂，但低于该药剂的耳毒性阈值。本发明还提供了使用本发明的装置的治疗方法。

2. 发明申请

WO0243800A2 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于从药物递送装置进行控制的装置和方法
公开(公告)号：WO0243800A2
公开(公告)日：2002-06-06
申请号：PCT/US0143143
申请日：2001-11-21
申请人： DURECT CORP , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
发明人： BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00 , A61M39/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

3. 发明申请

WO0141858A3 CATHETER WITH STYLET LUMEN 审中-公开
标题翻译：带有白炽灯的导管
公开(公告)号：WO0141858A3
公开(公告)日：2002-01-31
申请号：PCT/US0033476
申请日：2000-12-07
申请人： DURECT CORP , GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
发明人： GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
IPC分类号： A61M25/00 , A61M25/01 , A61M25/14
CPC分类号： A61M25/0102 , A61M2025/0034 , A61M2025/0037 , A61M2025/0039
摘要： The present invention features a catheter suitable for drug delivery. The catheter comprises a catheter body comprising a proximal and a distal end, and defining a drug delivery lumen and a stylet lumen. The stylet lumen comprises a distal end configured to permit a stylet to abut the stylet lumen distal end, and a proximal aperture which is distal to the proximal end of the catheter, providing entry of the stylet into the side of the catheter. The stylet lumen is adapted for slidably receiving a stylet which can be used to guide the catheter to the intended site in the body of a subject and thus to facilitate implantation of the catheter.
摘要翻译：本发明的特征在于适于药物递送的导管。导管包括导管主体，其包括近端和远端，并且限定药物输送腔和探针管腔。探针管腔包括构造成允许探针邻接探针管腔远端的远端，以及远离导管近端的近端孔，提供探针进入导管侧。探针腔适于可滑动地容纳可用于将导管引导到受试者身体中预期部位的探针，并因此便于植入导管。

4. 发明申请

WO2008060317A3 DEVICES,SYSTEMS, AND METHODS USING MAGNETIC FORCE SYSTEMS IN OR ON TISSUE 审中-公开
标题翻译：使用磁力系统或组织的装置，系统和方法
公开(公告)号：WO2008060317A3
公开(公告)日：2008-10-23
申请号：PCT/US2007007052
申请日：2007-03-21
申请人： KONINKL PHILIPS ELECTRONICS NV , BOUCHER RYAN P , GILLIS EDWARD M , PARASCHAC JOE , RAMPERSAUD CHARLES R , PURDY CRAIG A
发明人： BOUCHER RYAN P , GILLIS EDWARD M , PARASCHAC JOE , RAMPERSAUD CHARLES R , PURDY CRAIG A
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Systems ( 10) and methods include magnetic structures for placement in or on tissues in an airway The magnetic structures ( 12, 14), carry sources of magnetism, which generate magnetic fields having directions The magnetic fields interact to provide magnetic forces that provide a desired therapeutic effect, e g, maintaining separation between the soft palate and/or the tongue and the posterior pharyngeal wall The systems ( 10), and methods size and configure the directions of the magnetic fields to provide stability, which makes possible the achievement of the desired therapeutic effect in a straightforward and elegant manner
摘要翻译：系统（10）和方法包括用于放置在气道中或组织中的磁性结构磁性结构（12,14）承载磁场，其产生具有方向的磁场。磁场相互作用以提供提供期望的磁力治疗效果，例如，保持软腭和/或舌和咽后壁之间的分离系统（10）和方法规模和配置磁场的方向以提供稳定性，这使得可能实现期望的治疗效果直观而优雅

5. 发明申请

WO2004050142A3 CATHETER LOOP MANAGER 审中-公开
公开(公告)号：WO2004050142A3
公开(公告)日：2007-05-03
申请号：PCT/US0338548
申请日：2003-12-04
申请人： DURECT CORP , POUTIATINE ANDREW I , GILLIS EDWARD M , PARIKH RITEN , FILICE JAMES A
发明人： POUTIATINE ANDREW I , GILLIS EDWARD M , PARIKH RITEN , FILICE JAMES A
IPC分类号： A61M5/32 , A61M20060101 , A61M5/142 , A61M25/00 , A61M25/01 , A61M39/12
CPC分类号： A61M5/14276 , A61M25/0097 , A61M25/0113 , A61M39/12
摘要： A catheter loop manager (10) which controls the slack portion of a catheter located adjacent to an implanted pump (12) and prevents fibrotic encapsulation of the slack catheter portion. The catheter loop manager comprises a retainer element (18) configured to associate with an implantable pump and to releasibly hold or retain a loop or section of catheter adjacent to the pump. A pull tool (20) is used to releasibly engage a catheter section and pull the catheter section into a loop within a retention channel in the retainer element.
摘要翻译：导管回路管理器（10），其控制位于植入泵（12）附近的导管的松弛部分并防止松弛导管部分的纤维化封装。导管回路管理器包括被配置为与可植入泵相关联并且可释放地保持或保持与泵相邻的导管的环或部分的保持器元件（18）。拉动工具（20）用于可释放地接合导管部分并将导管部分拉入保持器元件中的保持通道内的环中。

6. 发明申请

WO2004012794A8 IMPLANTABLE FLOW REGULATOR WITH FAILSAFE MODE AND RESERVE DRUG SUPPLY 审中-公开
标题翻译：具有故障安全模式和储备药物供应的植入式流量调节器
公开(公告)号：WO2004012794A8
公开(公告)日：2004-06-10
申请号：PCT/US0228575
申请日：2002-09-06
申请人： DURECT CORP , POUTIATINE ANDREW I , GILLIS EDWARD M , MAEUSLI PIERRE-ALAIN , GASS VOLKER
发明人： POUTIATINE ANDREW I , GILLIS EDWARD M , MAEUSLI PIERRE-ALAIN , GASS VOLKER
IPC分类号： A61M5/168 , A61M39/28 , A61M5/00
CPC分类号： A61M5/16877 , A61M5/16881 , A61M39/28
摘要： An implantable flow regulator (22) for regulating flow of a drug along a drug delivery pathway (14) form a drug source to a treatment site within a subject includes a movable diversion member (24) and an actuator. The movable diversion member (24) is operably coupled to a delivery pathway (14). The actuator is actuatable to move the diversion member (24) between at least a first mode position where the diversion member (24) restricts flow through the delivery pathway (14) (i.e., delivery pathway is "closed"), and a second mode position where the diversion member (24) is positioned to allow flow through the delivery pathway (14) (i.e., delivery pathway is "open"). Supplying power to actuate the actuator moves the diversion member (24) from its normally biased first mode or "closed" position, which is also a failsafe position, toward its second mode or "open" position. In the "open" position, drug is supplied to target sites, typically from a drug supply reserve within the regulator.
摘要翻译：用于调节药物沿着药物输送通道（14）的药物流动的可植入流量调节器（22）形成到对象内治疗部位的药物源，包括可移动转向构件（24）和致动器。可移动转向构件（24）可操作地联接到输送通道（14）。致动器可致动以在至少第一模式位置和第二模式之间移动分流构件24，在第一模式位置中分流构件24限制通过输送通路14的流动（即输送通路“关闭”），（24）定位成允许流过输送通道（14）（即输送通道“打开”）的位置。提供致动致动器的动力将分流构件24从其正常偏置的第一模式或“关闭”位置（其也是故障安全位置）朝向其第二模式或“打开”位置移动。在“开放”的位置，药物通常来自监管机构内的药物供应储备，供应给目标地点。

7. 发明申请

WO03002170A2 MINIMALLY INVASIVE DRUG DELIVERY CATHETER 审中-公开
标题翻译：微量进入药物输送导管
公开(公告)号：WO03002170A2
公开(公告)日：2003-01-09
申请号：PCT/US0221945
申请日：2002-06-27
申请人： DURECT CORP , GILLIS EDWARD M
发明人： GILLIS EDWARD M
IPC分类号： A61M25/00 , A61M25/16 , A61M
CPC分类号： A61M25/008 , A61M25/0054 , A61M25/0068 , A61M25/0069 , A61M2025/0042 , A61M2210/0693
摘要： The catheter of the invention is of a design adapted to be implanted, and fixed in place, without the use of a trocar or cannula, such that tissue damage is minimized both at the time of implantation, and later, over the period that the catheter remains implanted. In one embodiment, the catheter may be used to deliver a drug over a prolonged period of time, to a precise location, for instance to treat an inoperative tumor of the brain stem. In another embodiment, the catheter of the invention may be implanted, and maintained in place and used to deliver repeated doses of a drug to the same target over time without the necessity of repeatedly re-implanting a needle through tissue to access the target site.
摘要翻译：本发明的导管的设计适于在不使用套管针或套管的情况下植入并固定就位，使得在植入时和随后在导管仍然植入。在一个实施例中，导管可用于将药物在延长的时间段内递送至精确的位置，例如用于治疗脑干的无功能肿瘤。在另一个实施例中，本发明的导管可以被植入并保持在适当的位置并用于随着时间的推移将重复剂量的药物递送到相同的目标，而不需要重复地重新植入针头穿过组织以进入目标部位。

8. 发明申请

WO2012018545A3 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠呼吸暂停的系统和方法
公开(公告)号：WO2012018545A3
公开(公告)日：2012-05-03
申请号：PCT/US2011044880
申请日：2011-07-21
申请人： REVENT MEDICAL INC , GILLIS EDWARD M , SHADDUCK JOHN H , TRUCKAI CSABA , POUTIATINE ANDREW , BUSCEMI PAUL J
发明人： GILLIS EDWARD M , SHADDUCK JOHN H , TRUCKAI CSABA , POUTIATINE ANDREW , BUSCEMI PAUL J
IPC分类号： A61F5/56 , A61F2/02
CPC分类号： A61F5/566
摘要： A method of treating an airway disorder includes placing an implant in a patient's tongue, wherein the implant has first and second end portions that attach to tissue, and a tensioned medial portion between the first and second ends. The medial portion is configured to apply a pressure of less than a predetermined amount. Device systems associated with such methods are also provided.
摘要翻译：治疗气道疾病的方法包括将植入物放置在患者的舌中，其中植入物具有附接到组织的第一和第二端部以及第一和第二端之间的张紧的中间部分。内侧部分构造成施加小于预定量的压力。还提供了与这些方法相关的设备系统。

9. 发明申请

WO2011116384A3 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：WO2011116384A3
公开(公告)日：2012-01-19
申请号：PCT/US2011029218
申请日：2011-03-21
申请人： REVENT MEDICAL INC , GILLIS EDWARD M , POUTIATINE ANDREW , SHADDUCK JOHN H , TRUCKAI CSABA
发明人： GILLIS EDWARD M , POUTIATINE ANDREW , SHADDUCK JOHN H , TRUCKAI CSABA
IPC分类号： A61F5/56 , A61F2/00
CPC分类号： A61F5/566 , A61F2/00 , A61F5/56 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body includes an adjustment element configured to allow in-situ adjustment of the implant body between first and second tensioning forces applied to the site. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入物主体包括调整元件，其被配置为允许植入物本体在施加到部位的第一和第二张力之间进行原位调整。还提供了使用这种系统的方法。

10. 发明申请

WO2007120848A3 DEVICES, SYSTEMS AND METHODS USING MAGNETIC FORCE SYSTEMS IN THE TONGUE 审中-公开
标题翻译：使用磁力系统的设备，系统和方法
公开(公告)号：WO2007120848A3
公开(公告)日：2008-03-27
申请号：PCT/US2007009173
申请日：2007-04-12
申请人： APNEON INC , PARASCHAC JOE , BOUCHER RYAN P , GILLIS EDWARD M , DOELLING ERIC N , PURDY CRAIG A , LAX RONALD G
发明人： PARASCHAC JOE , BOUCHER RYAN P , GILLIS EDWARD M , DOELLING ERIC N , PURDY CRAIG A , LAX RONALD G
IPC分类号： A61F5/56
CPC分类号： A61F2/00 , A61F5/56 , A61F5/566 , A61F2210/009
摘要： Magnetic structured develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue.
摘要翻译：磁结构在舌头和咽后壁之间形成磁力，以稳定舌头的取向。

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