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1. 发明申请

WO2004039814A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2004039814A1
公开(公告)日：2004-05-13
申请号：PCT/JP2003/013684
申请日：2003-10-27
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , WAKUNAGA PHARMACEUTICAL CO., LTD. , OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OHGAKI, Masaru , TODA, Ayako , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATOH, Kenji
发明人： OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OHGAKI, Masaru , TODA, Ayako , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATOH, Kenji
IPC分类号： C07D501/46
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded together and form lower alkylene or lower alkenylene; R 3 is hydrogen or lower alkyl; R 4 is ; R 5 is carboxy or protected carboxy; and R 6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]化合物：其中R 1是低级烷基，羟基（低级）烷基或卤代（低级）烷基，R 2是氢或氨基保护基，或R“ 1 2键合在一起形成低级亚烷基或低级亚烯基; R 3是氢或低级烷基; R> 4

2. 发明申请

WO2002090364A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2002090364A1
公开(公告)日：2002-11-14
申请号：PCT/JP2002/004058
申请日：2002-04-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , WAKUNAGA PHARMACEUTICAL CO., LTD. , OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OGINO, Takashi , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , AKAMATSU, Hisashi , SATOH, Kenji
发明人： OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OGINO, Takashi , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , AKAMATSU, Hisashi , SATOH, Kenji
IPC分类号： C07D501/46
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R 1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded together and form lower alkylene; R 3 and R 5 are independently amino or protected amino; and R 4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]的化合物：其中A是低级亚烷基或低级亚烯基; R 1是低级烷基，羟基（低级）烷基，保护的羟基（低级）烷基，氨基（低级）烷基或保护的氨基（低级）烷基，R 2是氢或氨基保护基，或R 1 >和R 2结合在一起形成低级亚烷基; R 3和R 5独立地是氨基或保护的氨基; 和R 4是羧基或保护的羧基或其药学上可接受的盐，制备式[I]化合物的方法，以及药物组合物，其包含式[I]化合物与药学上可接受的载体。

3. 发明申请

WO2007119511A1 CEPHEM COMPOUNDS AND USE AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译： CEPHEM化合物和用作抗微生物剂
公开(公告)号：WO2007119511A1
公开(公告)日：2007-10-25
申请号：PCT/JP2007/056136
申请日：2007-03-16
申请人： Astellas Pharma Inc. , Wakunaga Pharmaceutical Co., Ltd. , YAMANAKA, Toshio , TODA, Ayako , OHKI, Hidenori , OKUDA, Shinya , KAWABATA, Kohji , MURANO, Kenji , HATANO, Kazuo , TAKEDA, Shinobu , NAKAI, Toru , OOGAKI, Masaru , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji
发明人： YAMANAKA, Toshio , TODA, Ayako , OHKI, Hidenori , OKUDA, Shinya , KAWABATA, Kohji , MURANO, Kenji , HATANO, Kazuo , TAKEDA, Shinobu , NAKAI, Toru , OOGAKI, Masaru , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji
IPC分类号： C07D501/46 , A61K31/546 , A61P31/00
CPC分类号： C07D501/46
摘要： The present invention provides a compound of the formula [I]: wherein R 1 is lower alkyl, etc. and R 2 is hydrogen, etc., or R 1 and R 2 are bonded together to form lower alkylene; R 3 is a group represented by wherein R 6 and R 7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R 8 and R 9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R 8 and R 9 , together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R 4 is lower alkyl, etc.; and R 5 is amino, etc., or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式[I]化合物：其中R 1是低级烷基等，R 2是氢等，或R 1， 1和R 2结合在一起形成低级亚烷基; R 3是由其中R 6和R 7独立地任选被保护的氨基等表示的基团; m和n分别为0〜6的整数。 R 8和R 9独立地是任选保护的氨基等，q和r独立地是0-6的整数，或R 8 O 和R 9与相邻的亚烷基和氮原子一起形成任选具有取代基的饱和含氮杂环; R 4是低级烷基等; 和R 5是氨基等，或其药学上可接受的盐。

4. 发明申请

WO2005019231A8 PHOSPHAZENE COMPOUND, PHOTOSENSITIVE RESIN COMPOSITION AND USE THEREOF 审中-公开
标题翻译：磷酸酯化合物，感光树脂组合物及其用途
公开(公告)号：WO2005019231A8
公开(公告)日：2005-10-20
申请号：PCT/JP2004007719
申请日：2004-06-03
申请人： KANEKA CORP , OKADA KOJI , YAMANAKA TOSHIO
发明人： OKADA KOJI , YAMANAKA TOSHIO
IPC分类号： C07F9/06 , C07F9/6581 , C08G79/02 , G03F7/027 , G03F7/032 , G03F7/037 , G03F7/038 , C07F9/24 , C08K5/5399 , C08L79/08 , G03F7/004
CPC分类号： C08G79/025 , C07F9/067 , C07F9/65812 , G03F7/027 , G03F7/032 , G03F7/037 , G03F7/0388
摘要： A phosphazene compound and photosensitive resin composition suitable for production of wiring boards, having such characteristics that no halogenated flame retardants are used; a water base development can be made; desirable pattern morphology can be realized; a balance can be struck between properties such as thermal stability, resistance to hydrolysis, processability and adherence on the one hand and photosensitivity, flame resistance and mechanical strength on the other hand; and they can meet the demand for miniaturization and weight reduction of electronic parts. There is provided a phosphazene compound that has in its molecule an unsaturated double bond resulting from reaction of phenoxyphosphazene compound having a phenolic hydroxyl and/or crosslinked phenoxyphosphazene compound obtained by crosslinking of the phenoxyphosphazene compound with epoxy compound having an unsaturated double bond and/or isocyanate compound. Furthermore, there is provided a photosensitive resin composition comprising the phenoxyphosphazene compound and at least carboxylated and/or hydroxylated soluble polyimide resin, and further comprising (meth)acrylic compound.
摘要翻译：适用于生产线路板的磷腈化合物和感光性树脂组合物，具有不使用卤化阻燃剂的特性; 可以进行水基开发; 可以实现理想的图案形态; 另一方面，热稳定性，耐水解性，加工性和粘附性等特性与光敏性，阻燃性和机械强度之间存在平衡。它们可以满足电子零件的小型化和减重的需求。提供了一种磷腈化合物，其在其分子中具有由具有酚氧基和/或交联的苯氧基磷腈化合物的苯氧基磷腈化合物与苯氧基磷腈化合物与具有不饱和双键的环氧化合物和/或异氰酸酯交联而得到的不饱和双键复合。此外，提供了包含苯氧基磷腈化合物和至少羧化和/或羟基化的可溶性聚酰亚胺树脂的光敏树脂组合物，并且还包含（甲基）丙烯酸化合物。

5. 发明申请

WO1995008536A1 N-(3-PIPERIDINYLCARBONYL)-BETA-ALANINE DERIVATIVES AS PAF ANTAGONISTS 审中-公开
标题翻译：作为PAF拮抗剂的N-（3-哌啶子基） - 苯胺衍生物
公开(公告)号：WO1995008536A1
公开(公告)日：1995-03-30
申请号：PCT/JP1994001550
申请日：1994-09-21
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OHKUBO, Mitsuru , TAKAHASHI, Fumie , YAMANAKA, Toshio , SAKAI, Hiroyoshi , KATO, Masayuki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/60
CPC分类号： C07D401/06 , C07D211/56 , C07D211/60 , C07D405/14 , C07D413/06 , Y02P20/55
摘要： This invention relates to beta -alanine derivatives represented by formula (I), wherein each symbol is as defined in the specification and pharmaceutically acceptable salt thereof which is glycoprotein IIb/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment of diseases indicated in the specification to a human being or an animal.
摘要翻译：本发明涉及由式（I）表示的β-丙氨酸衍生物，其中每个符号如说明书中所定义，其药学上可接受的盐是糖蛋白IIb / IIIa拮抗剂，血小板聚集抑制剂和纤维蛋白原结合抑制剂血小板，其制备方法，包含其的药物组合物以及用于预防和/或治疗本说明书中对人或动物指示的疾病的方法。

6. 发明申请

WO2008139986A1 NEW CYCLIC PEPTIDE COMPOUNDS 审中-公开
标题翻译：新型循环肽化合物
公开(公告)号：WO2008139986A1
公开(公告)日：2008-11-20
申请号：PCT/JP2008/058456
申请日：2008-04-25
申请人： Astellas Pharma Inc., , YAMANAKA, Toshio , OHKI, Hidenori , ISHIDA, Junya , TODA, Ayako , HARAYAMA, Yu , MAKINO, Takuya , KUNIKAWA, Shigeki , MIZUNO, Hiroaki , OHTAKE, Hiroaki
发明人： YAMANAKA, Toshio , OHKI, Hidenori , ISHIDA, Junya , TODA, Ayako , HARAYAMA, Yu , MAKINO, Takuya , KUNIKAWA, Shigeki , MIZUNO, Hiroaki , OHTAKE, Hiroaki
IPC分类号： A61K38/13 , C07K7/64
CPC分类号： C07K7/645 , A61K38/00
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
摘要翻译：本发明涉及一种基于对丙型肝炎病毒复制子的RNA复制的抑制活性的抗丙型肝炎病毒活性的新的环肽化合物或其盐，其制备方法，包含其的药物组合物，以及在人或动物中预防和/或治疗丙型肝炎的方法。

7. 发明申请

WO2005027909A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2005027909A1
公开(公告)日：2005-03-31
申请号：PCT/JP2004/014018
申请日：2004-09-17
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , Wakunaga Pharmaceutical Co., Ltd. , YAMANAKA, Toshio , MURANO, Kenji , TODA, Ayako , OHKI, Hidenori , OOGAKI, Masaru , OKUDA, Shinya , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATO, Kenji
发明人： YAMANAKA, Toshio , MURANO, Kenji , TODA, Ayako , OHKI, Hidenori , OOGAKI, Masaru , OKUDA, Shinya , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATO, Kenji
IPC分类号： A61K31/546
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl or hydroxy (lower) alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded together and form lower alkylene ; R 3 is -A-R 6 wherein A is bond, -NHCO-(CH 2 CO) n -, lower alkylene, -NH-CO-CO- or the like, and R 6 is (a) ou (b) wherein R 7 , R 8 , R 9 and R 10 are independently amino, guanidino, amidino or the like ; R 4 is carboxy or protected carboxy; and R 5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]化合物：其中R 1是低级烷基或羟基（低级）烷基，R 2是氢或氨基保护基，或R 1和R 2 >键合在一起形成低级亚烷基; R 3是-AR 6，其中A是键，-NHCO-（CH 2 CO）n - ，低级亚烷基，-NH-CO-CO-等，R 6是（a）ou ）其中R 7，R 8，R 9和R 10独立地是氨基，胍基，脒基等; R 4是羧基或被保护的羧基; 和R 5为氨基或被保护的氨基或其药学上可接受的盐，制备式[I]化合物的方法，以及药物组合物，其包含式[I]化合物与药学上可接受的载体。

8. 发明申请

WO1998024785A1 INDOLE-UREA DERIVATIVES WITH 5-HT ANTAGONIST PROPERTIES 审中-公开
标题翻译：具有5-HT拮抗剂性质的吲哚类衍生物
公开(公告)号：WO1998024785A1
公开(公告)日：1998-06-11
申请号：PCT/JP1997004390
申请日：1997-12-02
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , ITO, Kiyotaka , SPEARS, Glen, W. , YAMANAKA, Toshio , HARADA, Keiko , NODA, Yuka , SASAKI, Hiroshi , TAKAHASHI, Fumie , KATO, Masayuki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D403/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/04
摘要： A compound of formula (I) wherein R and R are each hydrogen or linked together to form ethylene, R is hydrogen or lower alkyl, R is heterocyclic group, R is hydrogen or nitro, and X is CH or N, and pharmaceutically acceptable salts thereof, which has pharmacological activities such as 5-hydroxytryptamine (5-HT) antagonism.
摘要翻译：式（I）化合物，其中R 1和R 2各自为氢或连接在一起形成乙烯，R 3为氢或低级烷基，R 4为杂环基，R 5为氢或硝基，X是CH或N，以及其药学上可接受的盐，其具有5-羟基色胺（5-HT）拮抗作用。

9. 发明申请

WO1997033869A1 N-[(R)-1-{3-(4-PIPERIDYL)PROPIONYL-3-PIPERIDYLCARBONYL]-2(S)-ACETYLAMINO-BETA-ALANINE AS FIBRINOGEN RECEPTOR ANTAGONIST 审中-公开
标题翻译： N - [（R）-1- {3-（4-哌啶基）丙炔-3-基哌嗪基] -2（S） - 乙酰氨基 - 阿魏酸作为纤维蛋白原受体拮抗剂
公开(公告)号：WO1997033869A1
公开(公告)日：1997-09-18
申请号：PCT/JP1997000769
申请日：1997-03-12
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OHKUBO, Mitsuru , TAKAHASHI, Fumie , YAMANAKA, Toshio , KATO, Masayuki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/42
CPC分类号： C07D211/60
摘要： This invention relates to beta -alanine derivative represented by formula (I), which is glycoprotein IIB/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment of diseases indicated in the specification to a human being or an animal.
摘要翻译：本发明涉及由式（I）表示的β-氨基酸衍生物，其为糖蛋白IIB / IIIa拮抗剂，血小板聚集抑制剂和纤维蛋白原与血小板结合的抑制剂，其制备方法，涉及药物组合物包括与本说明书中对人或动物预防和/或治疗疾病相关的方法和方法。

10. 发明申请

WO1996029309A1 N-ACYLPIPERIDINYLCARBONYLAMINOCARBOXYLIC ACIDS AND THEIR USE AS GLYCOPROTEIN IIB/IIa ANTAGONISTS AND FIBRINOGEN-BLOOD PLATELETS BINDING INHIBITORS 审中-公开
标题翻译： N-乙酰胆碱甲酰氨基羧酸及其作为糖蛋白IIB / IIa拮抗剂和纤维蛋白血小板结合抑制剂的用途
公开(公告)号：WO1996029309A1
公开(公告)日：1996-09-26
申请号：PCT/JP1996000643
申请日：1996-03-14
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OHKUBO, Mitsuru , TAKAHASHI, Fumie , YAMANAKA, Toshio , KATO, Masayuki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/36
CPC分类号： C07D217/26 , C07D211/36
摘要： This invention relates to beta -alanine derivatives represented by formula (Ia) wherein each symbol is as defined in the specification and pharmaceutically acceptable salt thereof which is glycoprotein IIB/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.
摘要翻译：本发明涉及由式（Ia）表示的β-丙氨酸衍生物，其中每个符号如说明书中所定义，其药学上可接受的盐是糖蛋白IIB / IIIa拮抗剂，血小板聚集抑制剂和纤维蛋白原与血液结合的抑制剂血小板，其制备方法，包含其的药物组合物以及用于预防和/或治疗本说明书中针对人或动物的疾病的方法。

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