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1. 发明申请

WO2007119511A1 CEPHEM COMPOUNDS AND USE AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译： CEPHEM化合物和用作抗微生物剂
公开(公告)号：WO2007119511A1
公开(公告)日：2007-10-25
申请号：PCT/JP2007/056136
申请日：2007-03-16
申请人： Astellas Pharma Inc. , Wakunaga Pharmaceutical Co., Ltd. , YAMANAKA, Toshio , TODA, Ayako , OHKI, Hidenori , OKUDA, Shinya , KAWABATA, Kohji , MURANO, Kenji , HATANO, Kazuo , TAKEDA, Shinobu , NAKAI, Toru , OOGAKI, Masaru , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji
发明人： YAMANAKA, Toshio , TODA, Ayako , OHKI, Hidenori , OKUDA, Shinya , KAWABATA, Kohji , MURANO, Kenji , HATANO, Kazuo , TAKEDA, Shinobu , NAKAI, Toru , OOGAKI, Masaru , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji
IPC分类号： C07D501/46 , A61K31/546 , A61P31/00
CPC分类号： C07D501/46
摘要： The present invention provides a compound of the formula [I]: wherein R 1 is lower alkyl, etc. and R 2 is hydrogen, etc., or R 1 and R 2 are bonded together to form lower alkylene; R 3 is a group represented by wherein R 6 and R 7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R 8 and R 9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R 8 and R 9 , together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R 4 is lower alkyl, etc.; and R 5 is amino, etc., or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式[I]化合物：其中R 1是低级烷基等，R 2是氢等，或R 1， 1和R 2结合在一起形成低级亚烷基; R 3是由其中R 6和R 7独立地任选被保护的氨基等表示的基团; m和n分别为0〜6的整数。 R 8和R 9独立地是任选保护的氨基等，q和r独立地是0-6的整数，或R 8 O 和R 9与相邻的亚烷基和氮原子一起形成任选具有取代基的饱和含氮杂环; R 4是低级烷基等; 和R 5是氨基等，或其药学上可接受的盐。

2. 发明申请

WO2005027909A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2005027909A1
公开(公告)日：2005-03-31
申请号：PCT/JP2004/014018
申请日：2004-09-17
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , Wakunaga Pharmaceutical Co., Ltd. , YAMANAKA, Toshio , MURANO, Kenji , TODA, Ayako , OHKI, Hidenori , OOGAKI, Masaru , OKUDA, Shinya , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATO, Kenji
发明人： YAMANAKA, Toshio , MURANO, Kenji , TODA, Ayako , OHKI, Hidenori , OOGAKI, Masaru , OKUDA, Shinya , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATO, Kenji
IPC分类号： A61K31/546
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl or hydroxy (lower) alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded together and form lower alkylene ; R 3 is -A-R 6 wherein A is bond, -NHCO-(CH 2 CO) n -, lower alkylene, -NH-CO-CO- or the like, and R 6 is (a) ou (b) wherein R 7 , R 8 , R 9 and R 10 are independently amino, guanidino, amidino or the like ; R 4 is carboxy or protected carboxy; and R 5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]化合物：其中R 1是低级烷基或羟基（低级）烷基，R 2是氢或氨基保护基，或R 1和R 2 >键合在一起形成低级亚烷基; R 3是-AR 6，其中A是键，-NHCO-（CH 2 CO）n - ，低级亚烷基，-NH-CO-CO-等，R 6是（a）ou ）其中R 7，R 8，R 9和R 10独立地是氨基，胍基，脒基等; R 4是羧基或被保护的羧基; 和R 5为氨基或被保护的氨基或其药学上可接受的盐，制备式[I]化合物的方法，以及药物组合物，其包含式[I]化合物与药学上可接受的载体。

3. 发明申请

WO2004039814A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2004039814A1
公开(公告)日：2004-05-13
申请号：PCT/JP2003/013684
申请日：2003-10-27
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , WAKUNAGA PHARMACEUTICAL CO., LTD. , OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OHGAKI, Masaru , TODA, Ayako , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATOH, Kenji
发明人： OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OHGAKI, Masaru , TODA, Ayako , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATOH, Kenji
IPC分类号： C07D501/46
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded together and form lower alkylene or lower alkenylene; R 3 is hydrogen or lower alkyl; R 4 is ; R 5 is carboxy or protected carboxy; and R 6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]化合物：其中R 1是低级烷基，羟基（低级）烷基或卤代（低级）烷基，R 2是氢或氨基保护基，或R“ 1 2键合在一起形成低级亚烷基或低级亚烯基; R 3是氢或低级烷基; R> 4

4. 发明申请

WO2002090364A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2002090364A1
公开(公告)日：2002-11-14
申请号：PCT/JP2002/004058
申请日：2002-04-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , WAKUNAGA PHARMACEUTICAL CO., LTD. , OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OGINO, Takashi , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , AKAMATSU, Hisashi , SATOH, Kenji
发明人： OHKI, Hidenori , OKUDA, Shinya , YAMANAKA, Toshio , OGINO, Takashi , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , AKAMATSU, Hisashi , SATOH, Kenji
IPC分类号： C07D501/46
CPC分类号： C07D501/00 , Y02P20/55
摘要： The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R 1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R 2 is hydrogen or amino protecting group, or R 1 and R 2 are bonded together and form lower alkylene; R 3 and R 5 are independently amino or protected amino; and R 4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]的化合物：其中A是低级亚烷基或低级亚烯基; R 1是低级烷基，羟基（低级）烷基，保护的羟基（低级）烷基，氨基（低级）烷基或保护的氨基（低级）烷基，R 2是氢或氨基保护基，或R 1 >和R 2结合在一起形成低级亚烷基; R 3和R 5独立地是氨基或保护的氨基; 和R 4是羧基或保护的羧基或其药学上可接受的盐，制备式[I]化合物的方法，以及药物组合物，其包含式[I]化合物与药学上可接受的载体。

5. 发明申请

WO2004101571A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2004101571A1
公开(公告)日：2004-11-25
申请号：PCT/JP2004/005630
申请日：2004-04-20
申请人： FUJISAWA PHARMACEUTICAL CO. LTD. , WAKUNAGA PHARMACEUTICAL CO. LTD. , YAMANAKA, Toshio , OHKI, Hidenori , OHGAKI, Masaru , OKUDA, Shinya , TODA, Ayako , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATOH, Kenji
发明人： YAMANAKA, Toshio , OHKI, Hidenori , OHGAKI, Masaru , OKUDA, Shinya , TODA, Ayako , KAWABATA, Kohji , INOUE, Satoshi , MISUMI, Keiji , ITOH, Kenji , SATOH, Kenji
IPC分类号： C07D501/46
CPC分类号： C07D501/00
摘要： The present invention relates to a compound of the formula [I]: wherein R 1 is lower alkyl which may have suitable substituent(s), R 2 is amino, protected amino or guanidino, R 3 is carboxy or protected carboxy, R 4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及式[I]化合物：其中R 1为可具有合适取代基的低级烷基，R 2为氨基，被保护的氨基或胍基，R 3为羧基或保护的羧基，R 4是氨基或被保护的氨基，A是低级亚烷基或其药学上可接受的盐，制备式[I]化合物的方法，以及药物组合物，其包含式[ I]与药学上可接受的载体混合。

6. 发明申请

WO2005105270A1 CATALYSTS AND METHOD FOR ELIMINATION OF ALDEHYDES 审中-公开
标题翻译：催化剂和消除ALDEHYDES的方法
公开(公告)号：WO2005105270A1
公开(公告)日：2005-11-10
申请号：PCT/EP2005/000572
申请日：2005-01-21
申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN , EGUCHI, Koichi , ITOH, Kenji
发明人： EGUCHI, Koichi , ITOH, Kenji
IPC分类号： B01D53/86
CPC分类号： B01D53/864 , B01J21/066 , B01J23/58 , B01J23/62 , B01J23/6562 , B01J23/8926 , B01J37/0009 , B01J37/0201
摘要： The present invention relates to a process for eliminating aldehydes by catalytic oxidation in the presence of at least one catalyst, wherein said catalyst is a three-component catalyst comprising a catalytic composition of the general formula: Ru/ZrO 2 - MO X wherein M is selected from the group consisting of calcium (Ca), manganese (Mn), copper (Cu) and/or indium (In). In said formula, x comprises values in the range of from 0.2 to 3, especially from 0.5 to 2, the respective upper and lower limiting values being included. The process of the present invention may be run at relatively moderate temperatures (e.g. ambient temperature) and since it renounces the use of the cost-intensive noble metal platinum as catalytic material, it is also economic. The process leads to a high conversion rate of said aldehydes, thus resulting in harmless degradation products, especially carbon dioxide and water.
摘要翻译：本发明涉及一种在至少一种催化剂存在下通过催化氧化除去醛的方法，其中所述催化剂是三组分催化剂，其包含通式为Ru / ZrO 2 -MXX的催化组合物，其中M选自由钙（Ca），锰（Mn），铜（Cu）和/或铟（In）组成的组。在所述公式中，x包括在0.2至3范围内的值，特别是0.5至2，包括相应的上限值和下限值。本发明的方法可以在相对温和的温度（例如环境温度）下运行，并且由于它放弃使用成本密集的贵金属铂作为催化材料，所以它也是经济的。该方法导致所述醛的高转化率，从而导致无害的降解产物，特别是二氧化碳和水。

7. 发明申请

WO2009110485A1 GAS-LIQUID DISPERSION DEVICE AND METHOD FOR PRODUCING GAS-LIQUID DISPERSION 审中-公开
标题翻译：气体液体分散装置及其制备气体分散体的方法
公开(公告)号：WO2009110485A1
公开(公告)日：2009-09-11
申请号：PCT/JP2009/054001
申请日：2009-02-25
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED , ITOH, Kenji , YAMASHITA, Mayuko , ISHIHARA, Shinjiro
发明人： ITOH, Kenji , YAMASHITA, Mayuko , ISHIHARA, Shinjiro
IPC分类号： B01F5/06 , B01F3/04 , B01F5/02 , B01J8/02 , B01J19/24 , C07C1/22 , C07C15/085
CPC分类号： B01J8/0453 , B01J8/008 , B01J21/06 , B01J21/063 , B01J29/89 , B01J2208/00725
摘要： The present invention relates to a gas-liquid dispersion device which is used in a column wherein a gas-liquid mixed fluid flows upward which comprises a liquid as a continuous phase and a gas as a dispersed phase, characterized in that the gas is dispersed effectively into the liquid, so that a sufficient contact between the gas and the liquid can be attained. The device is characterized in that (A) the plate has at least one hole through which the gas and the liquid pass, (B) one end of the conduit is connected to the hole at a lower surface of the plate so that the conduit extends downward from the plate, (C) at least one passage for the gas is provided through a side surface of the conduit, and (D) at least one passage for the liquid is provided in a lower part of the conduit.
摘要翻译：气液分散装置技术领域本发明涉及一种气液分散装置，其用于气液混合流体向上流动的塔中，该液体分散装置包括作为连续相的液体和作为分散相的气体，其特征在于，气体被有效地分散进入液体，从而可以获得气体和液体之间的充分接触。该装置的特征在于，（A）板具有至少一个孔，气体和液体通过该孔，（B）导管的一端连接到板的下表面处的孔，使得导管延伸（C）通过导管的侧表面提供至少一个用于气体的通道，（D）至少一个用于液体的通道设置在导管的下部。

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