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1. 发明申请

WO2008139986A1 NEW CYCLIC PEPTIDE COMPOUNDS 审中-公开
标题翻译：新型循环肽化合物
公开(公告)号：WO2008139986A1
公开(公告)日：2008-11-20
申请号：PCT/JP2008/058456
申请日：2008-04-25
申请人： Astellas Pharma Inc., , YAMANAKA, Toshio , OHKI, Hidenori , ISHIDA, Junya , TODA, Ayako , HARAYAMA, Yu , MAKINO, Takuya , KUNIKAWA, Shigeki , MIZUNO, Hiroaki , OHTAKE, Hiroaki
发明人： YAMANAKA, Toshio , OHKI, Hidenori , ISHIDA, Junya , TODA, Ayako , HARAYAMA, Yu , MAKINO, Takuya , KUNIKAWA, Shigeki , MIZUNO, Hiroaki , OHTAKE, Hiroaki
IPC分类号： A61K38/13 , C07K7/64
CPC分类号： C07K7/645 , A61K38/00
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
摘要翻译：本发明涉及一种基于对丙型肝炎病毒复制子的RNA复制的抑制活性的抗丙型肝炎病毒活性的新的环肽化合物或其盐，其制备方法，包含其的药物组合物，以及在人或动物中预防和/或治疗丙型肝炎的方法。

2. 发明申请

WO1996004241A2 BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS 审中-公开
标题翻译：苯甲酰胺衍生物作为药物
公开(公告)号：WO1996004241A2
公开(公告)日：1996-02-15
申请号：PCT/JP1995001479
申请日：1995-07-25
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KUNO, Atsushi , MIZUNO, Hiroaki , YAMASAKI, Kumi , INOUE, Yoshikazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C279/22
CPC分类号： C07D263/56 , C07C279/22 , C07C2601/10 , C07C2602/10 , C07C2602/12 , C07C2602/28 , C07D209/08 , C07D215/14 , C07D217/02 , C07D241/42 , C07D295/13 , C07D307/46 , C07D307/56 , C07D307/79 , C07D307/80 , C07D307/82 , C07D311/58 , C07D311/96 , C07D317/54 , C07D333/22 , C07D333/28 , C07D333/36 , C07D333/54 , C07D333/56 , C07D333/62 , C07D471/04
摘要： Guanidine derivatives of formula (I) wherein R is hydrogen, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, acyl(lower)alkoxy, acyl(lower)alkenyl, or acyl, and R is ar(lower)alkenyl; aryl substituted with two suitable substituents; indenyl, indanyl, dihydrobenzocycloheptenyl, di(or tetra or hexa or octa or deca)hydronaphthyl, cyclopentenyl, dihydrothienyl, dihydrofuryl or heterobicyclic group, each of which may have suitable substituent(s); lower alkylthienyl; mono(or di)halothienyl; mono(or di or tri)halo(lower)alkylthienyl; acylthienyl; halofuryl; or mono(or di or tri)halo(lower)alkylfuryl; and a pharmaceutically acceptable salt thereof, which is useful as a medicament.
摘要翻译：式（I）的胍衍生物，其中R 1是氢，羟基（低级）烷基，保护的羟基（低级）烷基，酰基（低级）烷氧基，酰基（低级）烯基或酰基，R 2是Ar （低级）链烯基; 被两个合适的取代基取代的芳基; 茚基，茚满基，二氢苯并环庚烯基，二（或四或六或八或十碳）氢萘基，环戊烯基，二氢噻吩基，二氢呋喃基或杂双环基团，各自可具有合适的取代基; 低级烷基噻吩基; 单（或二）卤代噻吩基; 单（或二或三）卤代（低级）烷基噻吩基; acylthienyl; halofuryl; 或单（或二或三）卤代（低级）烷基呋喃基; 和其药学上可接受的盐，其可用作药物。

3. 发明申请

WO2002072621A2 NEW COMPOUND 审中-公开
标题翻译：新化合物
公开(公告)号：WO2002072621A2
公开(公告)日：2002-09-19
申请号：PCT/JP2002/002109
申请日：2002-03-07
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TODA, Ayako , MIZUNO, Hiroaki , MATSUYA, Takahiro , MATSUDA, Hiroshi , MURANO, Kenji , BARRETT, David , OGINO, Takashi , MATSUDA, Keiji
发明人： TODA, Ayako , MIZUNO, Hiroaki , MATSUYA, Takahiro , MATSUDA, Hiroshi , MURANO, Kenji , BARRETT, David , OGINO, Takashi , MATSUDA, Keiji
IPC分类号： C07K7/56
CPC分类号： C07K7/56 , A61K38/00
摘要： This invention relates to new polypeptide compound represented by the following general formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1, 3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由以下通式（I）表示的新的多肽化合物：其中R 1，R 2，R 3，R 4，R 5和R 6如上所定义在具有抗微生物活性（特别是抗真菌活性）的描述中，其对β-1,3-葡聚糖合酶的抑制活性，其制备方法，包含其的药物组合物，以及预防性方法和/或治疗性治疗包括卡氏肺囊虫感染（例如卡氏肺囊虫肺炎）的感染性疾病或动物。

4. 发明申请

WO2003068807A2 NEW COMPOUND 审中-公开
标题翻译：新化合物
公开(公告)号：WO2003068807A2
公开(公告)日：2003-08-21
申请号：PCT/JP2003/001107
申请日：2003-02-04
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MIZUNO, Hiroaki , MATSUDA, Hiroshi , TODA, Ayako , MATSUYA, Takahiro , BARRETT, David , MATSUDA, Keiji
发明人： MIZUNO, Hiroaki , MATSUDA, Hiroshi , TODA, Ayako , MATSUYA, Takahiro , BARRETT, David , MATSUDA, Keiji
IPC分类号： C07K7/56
CPC分类号： C07K7/56
摘要： This invention relates to new lipopeptide compound represented by the following general formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or thereapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由以下通式I表示的新的脂肽化合物，其中R 1，R 2，R 3，R 4和R 5在描述中定义，或其盐，其具有抗菌活性特别是抗真菌活性，对β-1,3-葡聚糖合酶的抑制活性，其制备方法，包含其的药物组合物，以及用于预防和/或治疗感染性疾病的方法，包括卡氏肺囊虫感染例如人或动物卡氏肺囊虫肺炎。

5. 发明申请

WO2005005463A1 ANTIFUNGAL CYCLIC LIPOPEPTIDES 审中-公开
标题翻译：反义循环脂蛋白
公开(公告)号：WO2005005463A1
公开(公告)日：2005-01-20
申请号：PCT/JP2004/009695
申请日：2004-07-01
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MIZUNO, Hiroaki , MATSUDA, Hiroshi , MATSUYA, Takahiro , BARRETT, David
发明人： MIZUNO, Hiroaki , MATSUDA, Hiroshi , MATSUYA, Takahiro , BARRETT, David
IPC分类号： C07K7/56
CPC分类号： C07K7/56 , A61K38/00
摘要： This invention relates to new lipopeptide compound represented by the general formula (I): Wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由通式（I）表示的新的脂肽化合物：其中R 1，R 2，R 3，R 4，R 5和R 6如其具有抗微生物活性（特别是抗真菌活性），对β-1,3-葡聚糖合酶的抑制活性，其制备方法的描述或其盐包含其的药物组合物，以及预防和 /或治疗人类或动物中感染性疾病，包括卡氏肺囊虫感染（例如肺孢子虫肺炎）。

6. 发明申请

WO2004113368A1 CYCLIC LIPOPEPTIDES 审中-公开
标题翻译：周期性脂蛋白
公开(公告)号：WO2004113368A1
公开(公告)日：2004-12-29
申请号：PCT/JP2004/008511
申请日：2004-06-10
申请人： FUJISAWA PHARMACEUTICAL Co., LTD. , MATSUYA, Takahiro , MIZUNO, Hiroaki , TOJO, Takashi , MATSUDA, Hiroshi , BARRETT, David
发明人： MATSUYA, Takahiro , MIZUNO, Hiroaki , TOJO, Takashi , MATSUDA, Hiroshi , BARRETT, David
IPC分类号： C07K7/56
CPC分类号： C07K7/56 , A61K38/00
摘要： This invention relates to new lipopeptide compound represented by the following general formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on (3-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由以下通式（I）表示的新的脂肽化合物：其中R 1，R 2，R 3，R 4和R 5如说明书中所定义或其具有抗微生物活性（特别是抗真菌活性），对（3-1,3-葡聚糖合酶，其制备方法），含有该抗菌活性的药物组合物的预防和/或治疗的方法的抑制活性在人或动物中治疗感染性疾病，包括卡氏肺囊虫感染（例如肺孢子虫肺炎）。

7. 发明申请

WO2003068807A3 ECHINOCANDIN CYCLIC PEPTIDE DERIVATIVES 审中-公开
公开(公告)号：WO2003068807A3
公开(公告)日：2003-08-21
申请号：PCT/JP2003/001107
申请日：2003-02-04
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MIZUNO, Hiroaki , MATSUDA, Hiroshi , TODA, Ayako , MATSUYA, Takahiro , BARRETT, David , MATSUDA, Keiji
发明人： MIZUNO, Hiroaki , MATSUDA, Hiroshi , TODA, Ayako , MATSUYA, Takahiro , BARRETT, David , MATSUDA, Keiji
IPC分类号： C07K7/56
摘要： This invention relates to new lipopeptide compound represented by the following general formula (I) wherein R 1 , R 2 , R 3 , R4 and R 5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or thereapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal. In particular, R 4 is an alkyl moiety which is substituted with an eventually protected and/or further substituted selected from amino, carboxy, guanidino, heterocyclic-carbonyl, alkyl-carbamoyl.

8. 发明申请

WO02072621A3 CYCLOHEXAPEPTIDE HAVING ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：具有抗微生物活性的环磷酰胆碱
公开(公告)号：WO02072621A3
公开(公告)日：2003-05-30
申请号：PCT/JP0202109
申请日：2002-03-07
申请人： FUJISAWA PHARMACEUTICAL CO , TODA AYAKO , MIZUNO HIROAKI , MATSUYA TAKAHIRO , MATSUDA HIROSHI , MURANO KENJI , BARRETT DAVID , OGINO TAKASHI , MATSUDA KEIJI
发明人： TODA AYAKO , MIZUNO HIROAKI , MATSUYA TAKAHIRO , MATSUDA HIROSHI , MURANO KENJI , BARRETT DAVID , OGINO TAKASHI , MATSUDA KEIJI
IPC分类号： A61K38/00 , A61P31/00 , A61P31/10 , C07K1/113 , C07K7/50 , C07K7/56 , A61K38/12
CPC分类号： C07K7/56 , A61K38/00
摘要： This invention relates to new polypeptide compound represented by the following general formula (I): wherein R , R , R , R , R and R are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on beta -1, 3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由以下通式（I）表示的新的多肽化合物：其中R 1，R 2，R 3，R 4，R 5和R 6如上所定义在具有抗微生物活性（特别是抗真菌活性）的描述中，其对β-1,3-葡聚糖合酶的抑制活性，其制备方法，包含其的药物组合物，以及预防性方法和/或治疗性处理感染性疾病，包括人或动物的卡氏肺囊虫感染（例如肺孢子虫肺炎）。

9. 发明申请

WO1998011089A1 NOVEL BENZOTHIOPHENE DERIVATIVES, THEIR PREPARATION AND USE AS UROKINASE INHIBITORS 审中-公开
标题翻译：新型苯并噻吩衍生物，其制备和用作尿激酶抑制剂
公开(公告)号：WO1998011089A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003215
申请日：1997-09-12
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TANAKA, Akito , MIZUNO, Hiroaki , SAKURAI, Minoru
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D333/60
CPC分类号： C07D513/04 , C07D307/85 , C07D333/70 , C07D333/80 , Y02P20/55
摘要： A compound of formula (I) in which R is hydrogen, optionally substituted lower alkylcarbamoyl(lower)alkylidene, lower alkylidene, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbymoyl(lower)alkyl; R is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl; R is hydrogen or amidino-protective group; A is lower alkylene or carbonyl; X is (1), (2) or (3); Y is lower alkylene, -S- or -SO2-; Z is -S- or -O-; and the line: ----- is a single bond or a double bond, or pharmaceutically acceptable salts thereof, which is useful as a medicament.
摘要翻译：式（I）化合物，其中R 1为氢，任选取代的低级烷基氨基甲酰基（低级）亚烷基，低级亚烷基，低级烷基，任选取代的芳（低级）烷基，环（低级）烷基（低级）烷基，保护基羧基（低级）烷基，羧基（低级）烷基，羟基（低级）烷基，任选取代的低级烷基氨基甲酰基（低级）烷基，低级烷硫基（低级）烷基，羧基（低级）烷酰基，被保护的羧基（低级）烷酰基，芳酰基，烷酰基或任选取代的芳基羰基（低级）烷基; R 2是氢，羧基，保护的羧基，甲酰基或N-（低级）烷基-N-（低级）烷氧基氨基甲酰基; R 3是氢或脒基保护基; A是低级亚烷基或羰基; X为（1），（2）或（3）; Y是低级亚烷基，-S-或-SO 2 - ; Z是-S-或-O-; 并且线： ----- 是单键或双键，或其药学上可接受的盐，其可用作药物。

10. 发明申请

WO9604241A3 BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS 审中-公开
标题翻译：苯甲酰胺衍生物作为药物
公开(公告)号：WO9604241A3
公开(公告)日：1996-06-20
申请号：PCT/JP9501479
申请日：1995-07-25
申请人： FUJISAWA PHARMACEUTICAL CO , KUNO ATSUSHI , MIZUNO HIROAKI , YAMASAKI KUMI , INOUE YOSHIKAZU
发明人： KUNO ATSUSHI , MIZUNO HIROAKI , YAMASAKI KUMI , INOUE YOSHIKAZU
IPC分类号： C07D295/14 , A61K31/165 , A61K31/185 , A61K31/275 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/495 , A61P9/00 , A61P9/10 , A61P13/02 , A61P15/00 , C07C279/22 , C07D209/08 , C07D215/14 , C07D217/02 , C07D217/16 , C07D241/42 , C07D263/56 , C07D295/13 , C07D295/22 , C07D307/46 , C07D307/56 , C07D307/79 , C07D307/80 , C07D307/82 , C07D311/58 , C07D311/96 , C07D317/54 , C07D317/58 , C07D321/00 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/36 , C07D333/54 , C07D333/56 , C07D333/62 , C07D471/04 , A61K31/155 , A61K31/34 , C07D307/01 , C07D307/81 , C07D333/12 , C07D333/24 , C07D417/04
CPC分类号： C07D263/56 , C07C279/22 , C07C2601/10 , C07C2602/10 , C07C2602/12 , C07C2602/28 , C07D209/08 , C07D215/14 , C07D217/02 , C07D241/42 , C07D295/13 , C07D307/46 , C07D307/56 , C07D307/79 , C07D307/80 , C07D307/82 , C07D311/58 , C07D311/96 , C07D317/54 , C07D333/22 , C07D333/28 , C07D333/36 , C07D333/54 , C07D333/56 , C07D333/62 , C07D471/04
摘要： Guanidine derivatives of formula (I) wherein R1 is hydrogen, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, acyl(lower)alkoxy, acyl(lower)alkenyl, or acyl, and R2 is ar(lower)alkenyl; aryl substituted with two suitable substituents; indenyl, indanyl, dihydrobenzocycloheptenyl, di(or tetra or hexa or octa or deca)hydronaphthyl, cyclopentenyl, dihydrothienyl, dihydrofuryl or heterobicyclic group, each of which may have suitable substituent(s); lower alkylthienyl; mono(or di)halothienyl; mono(or di or tri)halo(lower)alkylthienyl; acylthienyl; halofuryl; or mono(or di or tri)halo(lower)alkylfuryl; and a pharmaceutically acceptable salt thereof, which is useful as a medicament.

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