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1. 发明申请

WO2011047432A1 FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS 审中-公开
标题翻译：抗纤维剂的熔融环形成
公开(公告)号：WO2011047432A1
公开(公告)日：2011-04-28
申请号：PCT/AU2010/001398
申请日：2010-10-21
申请人： FIBROTECH THERAPEUTICS PTY LTD , WILLIAMS, Spencer John , ZAMMIT, Steven , KELLY, Darren James
发明人： WILLIAMS, Spencer John , ZAMMIT, Steven , KELLY, Darren James
IPC分类号： C07D413/04 , C07D333/64 , C07D209/46 , C07D209/34 , C07D211/18 , C07D215/233 , C07D241/42 , C07D265/24 , C07D239/88 , C07D241/44 , C07D215/58 , C07D235/26 , C07D209/12 , C07D235/28 , C07D235/12 , C07D335/06 , C07D311/08 , C07D317/70 , C07D403/12 , C07D311/76 , C07D307/87 , C07D235/16 , C07D333/62 , C07D405/12 , C07D401/04 , C07D409/12 , C07D311/04 , C07D401/12 , C07D261/20 , C07D275/04 , C07D277/70 , C07D263/56 , C07D277/62 , C07D263/58 , C07D277/68 , C07D417/04 , C07D235/06 , C07D277/64 , C07D265/22 , C07D239/91 , C07D403/04 , C07D291/08 , C07D265/36 , C07D279/16 , C07C233/81 , A61K31/517 , A61K31/4184 , A61K31/498 , A61K31/343 , A61K31/424 , A61K31/506 , A61K31/352 , A61K31/428 , A61K31/536 , A61K31/381 , A61K31/5365 , A61K31/382 , A61K31/429 , A61K31/538 , A61K31/403 , A61K31/435 , A61K31/5383 , A61K31/4035 , A61K31/4355 , A61K31/5415 , A61K31/404 , A61K31/4365 , A61K31/416 , A61K31/437 , A61P35/00 , A61P11/00 , A61P17/02 , A61P9/00 , A61P13/12 , A61P29/00
CPC分类号： C07D498/04 , C07C235/40 , C07C235/56 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D233/64 , C07D235/12 , C07D235/24 , C07D235/26 , C07D239/91 , C07D241/44 , C07D263/56 , C07D265/22 , C07D265/36 , C07D277/64 , C07D285/24 , C07D307/85 , C07D311/16 , C07D333/62 , C07D333/70 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.
摘要翻译：本发明涉及可用作抗纤维化剂的芳基羰基和杂芳基羰基邻氨基苯甲酸酯化合物。本发明还涉及其制备方法，含有这些化合物的药物组合物和这些化合物在治疗障碍中的用途。

2. 发明申请

WO2010144959A1 ANALOGUES OF ANTI-FIBROTIC AGENTS 审中-公开
标题翻译：抗纤维剂的模拟物
公开(公告)号：WO2010144959A1
公开(公告)日：2010-12-23
申请号：PCT/AU2010/000745
申请日：2010-06-16
申请人： FIBROTECH THERAPEUTICS PTY LTD , WILLIAMS, Spencer John , ZAMMIT, Steven , KELLY, Darren James , JAMES, Ian William
发明人： WILLIAMS, Spencer John , ZAMMIT, Steven , KELLY, Darren James , JAMES, Ian William
IPC分类号： C07C65/40 , C07C235/40 , C07C235/68 , C07C217/80 , C07C235/42 , C07C225/22 , C07C235/84 , C07C229/56 , C07C217/62 , C07C235/36 , C07C317/22 , C07C311/13 , C07C317/36 , C07C311/35 , C07C317/38 , C07C311/39 , C07C317/46 , C07C311/16 , C07D317/46 , C07D319/20 , C07D257/04 , C07D213/80 , C07D213/79 , C07D213/75 , C07D213/81 , C07D239/47 , C07D239/28 , C07D413/12 , C07D405/12 , C07D233/90 , A61K31/165 , A61K31/196 , A61K31/44 , A61K31/18 , A61K31/435 , A61K31/195 , A61K31/4353 , A61P1/16 , A61P11/00 , A61P9/00 , A61P13/12 , A61P17/00 , A61P43/00 , C07C237/30
CPC分类号： C07D239/42 , C07C51/09 , C07C51/353 , C07C51/367 , C07C51/373 , C07C217/62 , C07C217/80 , C07C225/22 , C07C229/56 , C07C235/36 , C07C235/40 , C07C235/42 , C07C235/68 , C07C235/84 , C07C237/30 , C07C237/42 , C07C255/41 , C07C255/43 , C07C255/46 , C07C259/10 , C07C311/27 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/40 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D231/40 , C07D233/90 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/12 , C07C62/38 , C07C62/34 , C07C65/40
摘要： The present invention relates to analogues of anti-fibrotic agents having the formula (I) with the substituents as described within the specification. The present invention also relates to methods for their preparation.
摘要翻译：本发明涉及具有式（I）的具有取代基的抗纤维化剂的类似物，如本说明书所述。本发明还涉及其制备方法。

3. 发明申请

WO2008003141A1 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2008003141A1
公开(公告)日：2008-01-10
申请号：PCT/AU2007/000934
申请日：2007-07-05
申请人： FIBROTECH THERAPEUTICS PTY LTD , THE UNIVERSITY OF MELBOURNE , WILLIAMS, Spencer, John , STAPLETON, David , ZAMMIT, Steven , KELLY, Darren, James , GILBERT, Richard, Ernest , KRUM, Henry
发明人： WILLIAMS, Spencer, John , STAPLETON, David , ZAMMIT, Steven , KELLY, Darren, James , GILBERT, Richard, Ernest , KRUM, Henry
IPC分类号： C07C235/38 , A61P13/12 , C07D213/643 , A61K31/435 , A61P35/00 , A61P11/00 , C07D213/16 , A61K31/426 , A61P29/00 , C07D295/03 , C07C231/02 , A61K31/4192 , C07D261/08 , A61P9/10 , A61K31/196 , A61P17/02 , C07D253/04 , A61K31/5375 , A61P43/00
CPC分类号： A61K31/196 , A61K31/4192 , A61K31/42 , A61K31/4409 , A61K31/5375 , C07C235/38 , C07C237/20 , C07C237/30 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D213/30 , C07D213/56 , C07D213/64 , C07D249/04 , C07D261/08 , C07D265/22 , C07D295/088 , C07D295/108
摘要： Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogues thereof, pharmaceutically acceptable salts thereof, and metabolites thereof; with the proviso that the compound is not Tranilast.
摘要翻译：具有抗纤维化活性的取代的肉桂酰基邻氨基苯甲酸酯化合物; 或其衍生物，其类似物，其药学上可接受的盐及其代谢物; 条件是该化合物不是Tranilast。

4. 发明申请

WO2009079692A1 HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS 审中-公开
标题翻译：抗纤维化学试剂的重组类似物
公开(公告)号：WO2009079692A1
公开(公告)日：2009-07-02
申请号：PCT/AU2008/001868
申请日：2008-12-19
申请人： FIBROTECH THERAPEUTICS PTY LTD , THE UNIVERSITY OF MELBOURNE , KELLY, Darren, James , WILLIAMS, Spencer, John , ZAMMIT, Steven
发明人： KELLY, Darren, James , WILLIAMS, Spencer, John , ZAMMIT, Steven
IPC分类号： C07C235/38 , A61P17/02 , C07C231/10 , A61P35/00 , A61K31/167 , C07C23/02 , A61P29/00
CPC分类号： C07C45/004 , C07C45/71 , C07C47/575 , C07C49/84 , C07C235/38
摘要： The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrqtic agents. The present invention also relates to methods for their preparation.
摘要翻译：本发明涉及具有本说明书中描述的取代基的式（I）的卤代化合物。这些化合物可用作抗纤维蛋白剂。本发明还涉及其制备方法。

5. 发明申请

WO2008052288A1 DITHIOLE COMPOUNDS AS COX INHIBITORS 审中-公开
标题翻译：几何化合物作为COX抑制剂
公开(公告)号：WO2008052288A1
公开(公告)日：2008-05-08
申请号：PCT/AU2007/001687
申请日：2007-11-02
申请人： NEURO THERAPEUTICS LIMITED , JARROTT, Bevyn , ZANATTA, Shannon Dean , WILLIAMS, Spencer John
发明人： JARROTT, Bevyn , ZANATTA, Shannon Dean , WILLIAMS, Spencer John
IPC分类号： C07D339/04 , A61K31/381 , A61P29/00
CPC分类号： C07D339/04
摘要： A compound of formula (I) wherein: R 1 and R 2 are the same or different and are independently selected from H and a shielding group; X and Y are each independently selected from N and CH; R 3 is hydroxy, alkoxy, acyloxy or an ester group; R 4 is a direct bond to R 5 , -CH 2 - or -CH=; the broken line ----- represents an optional double bond between R 4 and R 5 ; and R 5 is a 5- or 6-membered substituted or unsubstituted unsaturated heterocyclic or heteroaromatic ring, or R 5 is a substituted heterocyclic ring containing the substituent = O or = S, wherein the heteroatom is selected from S, O or P, and wherein R 5 is optionally attached to R 4 through a substituent on the heterocyclic or heteroaromatic ring; or a pharmaceutically acceptable prodrug, metabolite, ester, salt, derivative, tautomer or isomer thereof. The compounds have utility as COX-inhibitors and for use in the treatment of pain, inflammation or a neurodegenerative disease.
摘要翻译：式（I）的化合物，其中：R 1和R 2相同或不同，独立地选自H和屏蔽基团; X和Y各自独立地选自N和CH; R 3是羟基，烷氧基，酰氧基或酯基; R 4是与R 5，-CH 2 - 或-CH =的直接键合。虚线-----表示R 4和R 5之间的任选的双键; 并且R 5是5-或6-元取代或未取代的不饱和杂环或杂芳环，或者R 5是含有取代基= O或= S的取代杂环其中所述杂原子选自S，O或P，并且其中R 5任选地通过杂环或杂芳环上的取代基连接到R 4上; 或其药学上可接受的前药，代谢物，酯，盐，衍生物，互变异构体或异构体。这些化合物可用作COX抑制剂，并用于治疗疼痛，炎症或神经变性疾病。

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