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1. 发明申请

WO2009157966A1 HIGH FREQUENCY MULTI-AXIS SIMULATION SYSTEM 审中-公开
标题翻译：高频多轴仿真系统
公开(公告)号：WO2009157966A1
公开(公告)日：2009-12-30
申请号：PCT/US2008/083721
申请日：2008-11-17
申请人： BOSE CORPORATION , DINGMANN, David L. , GAGNER, Eric T. , NICKEL, Troy D. , SEEMAN, Steven R. , WHITE, Andrew D.
发明人： DINGMANN, David L. , GAGNER, Eric T. , NICKEL, Troy D. , SEEMAN, Steven R. , WHITE, Andrew D.
IPC分类号： G01N3/32
CPC分类号： G01N3/32 , G01N2203/0008 , G01N2203/0026 , G01N2203/0208 , G01N2203/0264 , G01N2203/027
摘要： A multi-axis fatigue testing device includes a multi-axis test fixture having a multiple input, multiple output mechanical linkage driven by a plurality of actuators and a controller operating each of the plurality of actuators in real time and in synchronization to produce user-defined multiple fatigue cycle profiles. At least one of the actuators driving the mechanical linkage acts against an artificial load characterized by a stiffness. The stiffness is selected to increase a resonance frequency of the test fixture to allow fatigue testing at higher frequencies for a wider range of samples.
摘要翻译：多轴疲劳测试装置包括多轴测试夹具，其具有由多个致动器驱动的多输入多输出机械联动器和实时地并且同步地产生用户定义的多个致动器中的每一个的控制器多个疲劳循环曲线。驱动机械连杆的致动器中的至少一个作用于以刚度为特征的人造负载。选择刚度以增加测试夹具的共振频率，以允许在更宽范围的样品的较高频率下的疲劳测试。

2. 发明申请

WO2010011570A1 ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME 审中-公开
公开(公告)号：WO2010011570A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/050934
申请日：2009-07-17
申请人： H. LUNDBECK A/S , JIMENEZ, Hermogenes, N. , LI, Guiying , DOLLER, Dario , GRENON, Michel , WHITE, Andrew, D. , GUO, Maojun , MA, Gil
发明人： JIMENEZ, Hermogenes, N. , LI, Guiying , DOLLER, Dario , GRENON, Michel , WHITE, Andrew, D. , GUO, Maojun , MA, Gil
IPC分类号： C07C233/79 , A61K31/4412 , A61K31/444 , A61P25/00 , C07C233/00 , C07D213/81 , C07D215/48 , C07D231/14 , C07D241/44 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
CPC分类号： C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention provides adamantyl-diamide derivatives of formula (I): wherein R 1 and R 2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same
摘要翻译：本发明提供式（I）的金刚烷基 - 二酰胺衍生物：其中R 1和R 2如本文所定义，或其药学上可接受的盐; 以及使用其的药物组合物和方法

3. 发明申请

WO2014008092A1 CONTROLLING FLOW AND PRESSURE WAVEFORMS 审中-公开
标题翻译：控制流量和压力波形
公开(公告)号：WO2014008092A1
公开(公告)日：2014-01-09
申请号：PCT/US2013/048193
申请日：2013-06-27
申请人： BOSE CORPORATION , NICKEL, Troy D. , OWENS, Aaron M. , DINGMANN, David Louis , GRAEN, Matthew D. , WHITE, Andrew D.
发明人： NICKEL, Troy D. , OWENS, Aaron M. , DINGMANN, David Louis , GRAEN, Matthew D. , WHITE, Andrew D.
IPC分类号： G01N3/32 , C12M1/34
CPC分类号： G05D7/0682 , A61F2240/008 , G01N2203/0048 , G01N2203/0089 , Y10T137/0318 , Y10T137/85978
摘要： An apparatus for controlling fluid flow characteristics includes a fluid conduit (12) for containing a fluid, a first dynamic pump (16) connected to a first portion of the conduit, a second dynamic pump (18) connected to a second portion of the conduit and a controller (20) for operating the first and second dynamic pumps to control dynamic flow of the fluid and dynamic pressure in the fluid in the conduit.
摘要翻译：一种用于控制流体流动特性的装置包括用于容纳流体的流体导管（12），连接到导管的第一部分的第一动态泵（16），连接到导管的第二部分的第二动态泵以及用于操作第一和第二动态泵以控制流体的动态流动和管道中的流体中的动态压力的控制器（20）。

4. 发明申请

WO2015078374A1 SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：取代的苯甲酸及其使用方法
公开(公告)号：WO2015078374A1
公开(公告)日：2015-06-04
申请号：PCT/CN2014/092269
申请日：2014-11-26
申请人： GENENTECH, INC. , XENON PHARMACEUTICALS INC. , ANDREZ, Jean-Christophe , BICHLER, Paul Robert , CHEN, Chien-An , CHOWDHURY, Sultan , DECKER, Shannon Marie , DEHNHARDT, Christoph Martin , FOCKEN, Thilo , GRIMWOOD, Michael Edward , HEMEON, Ivan William , JIA, Qi , LI, Jun , LIU, Zhiguo , ORTWINE, Daniel F. , SAFINA, Brian , SUTHERLIN, Daniel , SHENG, Tao , SUN, Shaoyi , WHITE, Andrew D. , WILSON, Michael Scott , ZENOVA, Alla Yurevna , ZHU, Jiuxiang
发明人： ANDREZ, Jean-Christophe , BICHLER, Paul Robert , CHEN, Chien-An , CHOWDHURY, Sultan , DECKER, Shannon Marie , DEHNHARDT, Christoph Martin , FOCKEN, Thilo , GRIMWOOD, Michael Edward , HEMEON, Ivan William , JIA, Qi , LI, Jun , LIU, Zhiguo , ORTWINE, Daniel F. , SAFINA, Brian , SUTHERLIN, Daniel , SHENG, Tao , SUN, Shaoyi , WHITE, Andrew D. , WILSON, Michael Scott , ZENOVA, Alla Yurevna , ZHU, Jiuxiang
IPC分类号： C07D205/04 , C07D207/12 , C07D211/42 , C07D233/68 , C07D237/08 , C07D241/04 , C07D305/08 , A61K31/337 , A61K31/397 , A61K31/415 , A61K31/4412 , A61K31/495 , A61K31/4015 , A61P25/04
CPC分类号： A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
摘要： The invention provides compounds having the general formula I, and pharmaceutically acceptable salts thereof, wherein the variables R A , R AA , subscript n, ring A, X 2 , L, subscript m, X 1 , R 1 , R 2 , R 3 , R 4 , R 5 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译：本发明提供具有通式I的化合物及其药学上可接受的盐，其中变量RA，RAA，下标n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN 具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。

5. 发明申请

WO2010008674A3 SYSTEM AND METHOD FOR MULTI-AXIS SIMULATION 审中-公开
标题翻译：用于多轴模拟的系统和方法
公开(公告)号：WO2010008674A3
公开(公告)日：2010-05-14
申请号：PCT/US2009044604
申请日：2009-05-20
申请人： BOSE CORP , WHITE ANDREW D
发明人： WHITE ANDREW D
IPC分类号： G01N3/32
CPC分类号： G01N3/32 , G01N2203/0008 , G01N2203/0026 , G01N2203/0208 , G01N2203/0246 , G01N2203/0264 , G01N2203/027
摘要： A multi-axis fatigue testing device includes a multiple input, multiple output mechanical linkage driven by a plurality of actuators and a controller operating each of the plurality of actuators in real time and in synchronization to produce user-defined multiple fatigue cycle profiles. A startup method enables a sample mounted at an arbitrary multi-axis state to receive a desired simulation profile while maintaining the sample below any of the extremum values of the desired simulation profile.
摘要翻译：多轴疲劳测试装置包括由多个致动器驱动的多输入多输出机械联动器和实时地并且同步地操作多个致动器中的每一个的控制器，以产生用户定义的多个疲劳循环轮廓。启动方法使得以任意多轴状态安装的样本能够接收期望的模拟轮廓，同时将样本保持在期望模拟轮廓的任何极值之下。

6. 发明申请

WO2010008674A2 SYSTEM AND METHOD FOR MULTI-AXIS SIMULATION 审中-公开
标题翻译：用于多轴模拟的系统和方法
公开(公告)号：WO2010008674A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/044604
申请日：2009-05-20
申请人： BOSE CORPORATION , WHITE, Andrew, D.
发明人： WHITE, Andrew, D.
IPC分类号： G01N3/32
CPC分类号： G01N3/32 , G01N2203/0008 , G01N2203/0026 , G01N2203/0208 , G01N2203/0246 , G01N2203/0264 , G01N2203/027
摘要： A multi-axis fatigue testing device includes a multiple input, multiple output mechanical linkage driven by a plurality of actuators and a controller operating each of the plurality of actuators in real time and in synchronization to produce user-defined multiple fatigue cycle profiles. A startup method enables a sample mounted at an arbitrary multi-axis state to receive a desired simulation profile while maintaining the sample below any of the extremum values of the desired simulation profile.
摘要翻译：多轴疲劳测试装置包括由多个致动器驱动的多输入多输出机械联动装置和实时并同步操作多个致动器中的每一个的控制器，定义了多个疲劳周期轮廓。一种启动方法可使安装在任意多轴状态下的样品接收所需的模拟曲线，同时保持样品低于所需模拟曲线的任何极值。

7. 发明申请

WO1998055384A1 METHOD AND APPARATUS FOR REELING A TRAVELING PAPER WEB 审中-公开
标题翻译：用于卷取旅行纸的方法和装置
公开(公告)号：WO1998055384A1
公开(公告)日：1998-12-10
申请号：PCT/EP1997002962
申请日：1997-06-02
申请人： BELOIT TECHNOLOGIES, INC. , WHITE, Andrew, D.
发明人： BELOIT TECHNOLOGIES, INC.
IPC分类号： B65H18/26
CPC分类号： B65H18/26 , B65H18/10 , B65H2301/41342 , B65H2515/312
摘要： Apparatus (10) for reeling a traveling paper web (14) into a wound web roll (18) on a reel spool (22) having opposite ends, the apparatus comprising first and second generally parallel, generally horizontal rails (30, 34) each having an upper surface (38) for supporting a respective end of the reel spool, a support belt (54) mounted for movement along an endless path, the belt having an upper run (78) angled downwardly in the downstream direction (20), first and second carriages (114, 124) operatively associated with the first and second rails, respectively, for longitudinal movement parallel to the rails, each of the carriages being selectively operative to engage a respective end of the reel spool such that the reel spool moves with the carriages along the rails, a drive (136) for selectively engaging and rotating the reel spool when the reel spool is engaged by the carriages, and a positioning device for selectively positioning the carriages into an initial reeling position (162) in which the web is reeled onto a reel spool engaged by the carriages and in which the upper run of the belt is in nipping engagement (N2) with the web being wound onto the reel spool, and positioning the carriages downstream of the initial reeling position to control the nip pressure between the belt and the web being wound onto the reel spool during reeling of the wound web roll, whereby the wound web roll is moved downstream while being horizontally supported by the rails, rotatably driven by the drive, and nipped by the belt until the desired web roll diameter is reached.
摘要翻译：用于将行进的纸幅（14）卷绕到具有相对端的卷轴（22）上的卷绕卷筒纸（18）中的装置（10），该装置包括第一和第二大致平行的大致水平的导轨（30,34），每个导轨具有用于支撑所述卷轴的相应端部的上表面（38），安装成用于沿着环形路径移动的支撑带（54），所述带具有在所述下游方向（20）上向下倾斜的上行程（78）第一和第二托架（114,124）分别与第一和第二轨道分别操作地相关联，用于纵向运动平行于轨道，每个托架选择性地操作以接合卷轴的相应端部，使得卷轴滑动沿着轨道的滑架具有驱动器（136），用于当卷轴与托架接合时选择性地接合和旋转卷轴;以及定位装置，用于将托架选择性地定位到初始卷绕位置（162）中其中卷筒纸被卷绕到由托架接合的卷轴卷轴上，并且其中带的上部卷边处于夹紧接合（N2）中，卷材卷绕在卷轴上，并将托架定位在初始卷绕位置的下游，控制在卷绕卷筒纸卷绕期间卷带卷轴上的带和卷筒之间的辊隙压力，由此卷绕的卷筒纸辊由水平地被轨道支撑，由驱动器驱动旋转驱动并被夹持直到达到所需的卷筒纸直径。

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