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1. 发明申请

WO2009112910A1 VEHICLE LIGHTING DEVICE AND LIGHTING METHOD 审中-公开
标题翻译：车辆照明设备和照明方法
公开(公告)号：WO2009112910A1
公开(公告)日：2009-09-17
申请号：PCT/IB2009/000380
申请日：2009-03-02
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , WATANABE, Shinya
发明人： WATANABE, Shinya
IPC分类号： B60Q1/08
CPC分类号： B60Q1/085 , B60Q2300/054 , B60Q2300/056 , B60Q2300/312 , B60Q2300/42 , B60Q2300/45
摘要： The light distribution region of headlights (12) is divided into a plurality of regions, and each of the divided regions can be irradiated or non-irradiated by light, and the light distribution characteristic can be changed separately for each divided region. The radiation or non-radiation of light to each divided region is controlled by a light distribution control ECU (14). Besides, light reflection/emission regions (hatched portions in FIG 4) are detected by detecting light regions of reflection, such as white lines, reflectors, etc., and light regions of light emission, such as street lights or the like, are detected. Then, divided regions corresponding to light distribution region irradiated by the headlights (12) which correspond to the detected light reflection/emission regions are specifically determined, and the headlights (12) are controlled so that the light radiated to the specifically determined divided regions 22 becomes dark in light distribution relative to other regions.
摘要翻译：头灯（12）的配光区域被分成多个区域，并且每个分割区域可以被光照射或不被照射，并且可以针对每个分割区域分别改变光分布特性。光分配控制ECU（14）控制对每个分割区域的光的辐射或非辐射。此外，通过检测诸如白线，反射器等的反射的光区域来检测光反射/发射区域（图4中的阴影部分），并且检测诸如路灯等的发光的光区域。然后，具体地确定与由所检测的光反射/发射区域相对应的由前灯（12）照射的配光区域对应的分割区域，并且控制前灯（12），使得照射到特定确定的分割区域22的光相对于其他区域的光分布变暗。

2. 发明申请

WO1997024355A1 PYRIDO (2,3-B) PYRAZINE DERIVATIVES 审中-公开
标题翻译：吡嗪（2,3-B）吡嗪衍生物
公开(公告)号：WO1997024355A1
公开(公告)日：1997-07-10
申请号：PCT/JP1996003666
申请日：1996-12-13
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , SHIMAZAKI, Norihiko , SAWADA, Akihiko , WATANABE, Shinya
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , Y02P20/55
摘要： Compounds of formula (I), wherein R is pyridyl(lower)alkyl, N-oxidopyridyl(lower)alkyl or imidazolyl(lower)alkyl; R is aminophenyl, [protected amino]phenyl, [[[halophenyl](lower)alkenoyl]amino]phenyl, [[pyridyl(lower)alkenoyl]amino]phenyl, [[[N-oxidopyridyl](lower)alkenoyl]-amino]phenyl, [[[protected aminopyridyl](lower)alkenoyl]amino]-phenyl, [thiazolylcarbonylamino]phenyl which may have pyridyl, naphthyl having lower alkoxy and halogen, [dihalophenyl](lower)alkenyl, [N-oxidopyridyl](lower)alkenyl, [aminopyridyl](lower)alkenyl, [protected aminopyridyl](lower)alkenyl, [carboxypyridyl](lower)alkenyl, [protected carboxypyridyl](lower)alkenyl, [[pyridyl(lower)alkenyl]pyridyl](lower)alkenyl, [[carboxy(lower)alkenyl]pyridyl](lower)alkenyl, [[protected carboxy(lower)alkenyl]pyridyl](lower)-alkenyl, [pyridyl(lower)alkenyl]pyridyl, lower alkylbenzothiazolyl or [halopyridylcarbonyl]amino, with proviso that when R is [[4-pyridyl(lower)alkenoyl]-amino]phenyl, aminophenyl, [lower alkanoylamino]phenyl or [dihalophenyl](lower)alkenyl, then R is N-oxidopyridyl(lower)alkyl or imidazolyl(lower)alkyl, possess a strong phosphodiesterase IV (PDE IV)-inhibitory activity and a strong inhibitory activity on the production of tumor necrosis factor (TNF).
摘要翻译：式（I）化合物，其中R 1是吡啶基（低级）烷基，N-氧化吡啶基（低级）烷基或咪唑基（低级）烷基; 苯基，[[吡啶基（低级）烯酰基]氨基]苯基，[[[N-氧化吡啶基]（低级）烯酰基 ] - 氨基]苯基，[[保护的氨基吡啶基]（低级）烯酰基]氨基] - 苯基，[噻唑基羰基氨基]苯基，其可具有吡啶基，具有低级烷氧基和卤素的萘基，[二卤苯基]（低级）烯基，[N-氧化吡啶基（低级）烯基，[氨基吡啶基]（低级）烯基，[保护的氨基吡啶基]（低级）烯基，[羧基吡啶基]（低级）烯基，[保护的羧基吡啶基] （低级）烯基，[[羧基（低级）烯基]吡啶基]（低级）链烯基，[[保护的羧基（低级）烯基]吡啶基]（低级） - 烯基，[吡啶基（低级）烯基]吡啶基，低级烷基苯并噻唑基或[ 卤代吡啶基羰基]氨基，条件是当R 2为[[4-吡啶基（低级）烯酰基] - 氨基]苯基，氨基苯基，[低级烷酰基氨基]苯基或[二卤代苯基]（低级）烯基时，则R 1为烷氧基吡啶（低级）烷基或咪唑基（低级）烷基具有强的磷酸二酯酶IV（PDE IV） - 抑制活性和对肿瘤坏死因子（TNF）产生的强抑制活性。

3. 发明申请

WO1994018168A1 INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITORS 审中-公开
标题翻译：作为5-ALPHA-REDUCTASE抑制剂的吲哚衍生物
公开(公告)号：WO1994018168A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000093
申请日：1994-01-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OKADA, Satoshi , SAWADA, Kozo , KURODA, Akio , WATANABE, Shinya , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D209/12
CPC分类号： C07D209/12
摘要： A compound of formula (I), wherein R is a carboxy or protected carboxy, R is a lower alkyl, halo(lower)alkyl or phenyl, R is a lower alkyl, R is a hydrogen or halogen, and A is a lower alkylene, with the proviso that when R is a lower alkyl, R is a halogen, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosterone 5 alpha -reductase inhibitor and effective for testosterone 5 alpha -reductase-mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism), androgenic alopecia (or male-pattern baldness), acne (e.g. acne vulgaris, pimple), other hyperandrogenisms, and the like.
摘要翻译：式（I）化合物，其中R 1为羧基或保护的羧基，R 2为低级烷基，卤代（低级）烷基或苯基，R 3为低级烷基，R 4为低级烷基，是氢或卤素，并且A是低级亚烷基，条件是当R 2是低级烷基时，R 4是卤素及其药学上可接受的盐。本发明的化合物可用作睾丸激素5α-还原酶抑制剂，并且对于睾酮5α-还原酶介导的疾病如前列腺炎，前列腺肥大，前列腺癌，脱发，多毛症（例如雌性多毛症），雄激素性脱发（或男性型秃发），痤疮（例如寻常痤疮，疙瘩），其他雄激素过多等。

4. 发明申请

WO2014091289A3 VEHICLE LOWER STRUCTURE 审中-公开
公开(公告)号：WO2014091289A3
公开(公告)日：2014-06-19
申请号：PCT/IB2013/002719
申请日：2013-12-10
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , ITO, Keita , WATANABE, Shinya , FUKUNAGA, Hirokatsu , ISHIKAWA, Akihiko
发明人： ITO, Keita , WATANABE, Shinya , FUKUNAGA, Hirokatsu , ISHIKAWA, Akihiko
IPC分类号： B62D21/15 , B62D25/00
摘要： A vehicle lower structure (S1) includes a plurality of spat body portions (32, 40) and a guide portion (44). The spat body portions (32, 40) are provided side by side in a vehicle longitudinal direction (L) on a vehicle front side of a wheel (12), are protruded from an underfloor (18) of the vehicle (10^) toward a vehicle lower side, and extend in a vehicle width direction (W). The guide portion (44) constitutes vehicle-width-direction outer regions of the spat body portions (32, 40) in at least one of second and subsequent rows from a vehicle rear side, is inclined toward the vehicle rear side and outward in the vehicle width direction (W) to guide a traveling wind (F1), and has a vehicle-width-direction outer end that is arranged more outward in the vehicle width direction (W) than a vehicle-width-direction outer end of the spat body portion (40) that is adjacent to the vehicle rear side.

5. 发明申请

WO1994026710A1 INDOLE DERIVATIVES AS TESTOSTERONE 5alpha-REDUCTASE INHIBITORS 审中-公开
标题翻译：作为TESTOSTERONE5α-赖氨酸酶抑制剂的吲哚衍生物
公开(公告)号：WO1994026710A1
公开(公告)日：1994-11-24
申请号：PCT/JP1994000738
申请日：1994-05-02
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OKADA, Satoshi , SAWADA, Kozo , KURODA, Akio , WATANABE, Shinya , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D209/12
CPC分类号： C07D209/18
摘要： A compound of formula (I), wherein R is an optionally protected carboxy(lower)alkyl, R is a hydrogen, a lower alkyl or a halogen, R is a hydrogen or an optionally substituted lower alkyl, X is a methylene, -O- or -NH-, and R is a cycloalkyl, a nitro or a lower alkoxy and R is a hydrogen or a lower alkyl, or R and R are linked together to form a tetramethylene, or a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosterone 5 alpha -reductase inhibitor and effective for testosterone 5 alpha -reductase-mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism), androgenic alopecia (or male-pattern baldness), acne (e.g. acne vulgaris, pimple), other hyperandrogenisms, and the like.
摘要翻译：式（I）化合物，其中R 1为任选保护的羧基（低级）烷基，R 2为氢，低级烷基或卤素，R 3为氢或任选取代的低级烷基，X是亚甲基，-O-或-NH-，R 4是环烷基，硝基或低级烷氧基，R 5是氢或低级烷基，或R 4和R <5>连接在一起形成四亚甲基或其药学上可接受的盐。本发明的化合物可用作睾酮5α-还原酶抑制剂并且对于睾酮5α-还原酶介导的疾病如前列腺炎，前列腺肥大，前列腺癌，脱发，多毛症（例如雌性多毛症），雄激素性脱发（或男性型秃发），痤疮（例如寻常痤疮，疙瘩），其他雄激素过多等。

6. 发明申请

WO1993016996A1 INDOLE DERIVATIVES AS TESTOSTERONE-5-ALPHA-REDUCTASE INHIBITORS 审中-公开
标题翻译：作为TESTOSTERONE-5-ALPHA-REDUCTASE抑制剂的吲哚衍生物
公开(公告)号：WO1993016996A1
公开(公告)日：1993-09-02
申请号：PCT/JP1993000201
申请日：1993-02-18
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OKADA, Satoshi , SAWADA, Kozo , KURODA, Akio , WATANABE Shinya , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D219/12
CPC分类号： C07D209/12
摘要： A compound of formula (I), wherein R is carboxy or protected carboxy, R is hydrogen, lower alkyl or halogen, R is aryl which may have suitable substituent(s), A is lower alkylene, X is methylene, -O- or -NH-, and Y is lower alkylene substituted by lower alkoxy, lower alkenylene or lower alkynylene; or Y-R is alkyl, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosteron 5 alpha -reductase inhibitor and effective to testosteron 5 alpha -reductase mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism, etc.), androgenic alopecia (or malepattern baldness), acne (e.g. acne vulgaris, pimple, etc.), other hyperandrogenism, and the like.
摘要翻译：式（I）化合物，其中R 1为羧基或被保护的羧基，R 2为氢，低级烷基或卤素，R 3为可具有合适取代基的芳基，A为低级亚烷基，X为亚甲基，-O-或-NH-，Y为被低级烷氧基，低级亚烯基或低级亚炔基取代的低级亚烷基; 或Y-R 3为烷基，及其药学上可接受的盐。本发明的化合物可用作睾丸激素5α-还原酶抑制剂，并且对睾酮5α-还原酶介导的疾病如前列腺增生，前列腺肥大，前列腺癌，脱发，多毛症（例如雌性多毛症等）有效，雄激素性脱发（或恶病质秃发），痤疮（例如寻常痤疮，疙瘩等），其他雄激素过多症等。

7. 发明申请

WO9507279A3 PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES 审中-公开
标题翻译：制备衍生物衍生物的方法
公开(公告)号：WO9507279A3
公开(公告)日：1995-04-27
申请号：PCT/JP9401465
申请日：1994-09-06
申请人： FUJISAWA PHARMACEUTICAL CO , OKADA SATOSHI , SAWADA KOZO , KURODA AKIO , WATANABE SHINYA , TANAKA HIROKAZU
发明人： OKADA SATOSHI , SAWADA KOZO , KURODA AKIO , WATANABE SHINYA , TANAKA HIROKAZU
IPC分类号： A61K31/435 , A61P43/00 , C07D213/50 , C07D213/61 , C07D471/04
CPC分类号： C07D471/04 , C07D213/50
摘要： A new process for preparing a compound of formula (I).

8. 发明申请

WO1992017456A1 AMINO ACID DERIVATIVE AND SALT THEREOF 审中-公开
标题翻译：氨基酸衍生物及其盐
公开(公告)号：WO1992017456A1
公开(公告)日：1992-10-15
申请号：PCT/JP1992000349
申请日：1992-03-21
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Keiji , NEYA, Masahiro , WATANABE, Shinya , HASHIMOTO, Masashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D233/64
CPC分类号： C07D233/64 , A61K38/00 , C07K5/06078
摘要： A novel amino acid derivative having a renin inhibitory activity, represented by general formula (A), a salt thereof, and a process for producing the same.
摘要翻译：具有由通式（A）表示的肾素抑制活性的新型氨基酸衍生物及其盐及其制备方法。

9. 发明申请

WO2014091289A2 VEHICLE LOWER STRUCTURE 审中-公开
标题翻译：车辆下部结构
公开(公告)号：WO2014091289A2
公开(公告)日：2014-06-19
申请号：PCT/IB2013002719
申请日：2013-12-10
申请人： TOYOTA MOTOR CO LTD , ITO KEITA , WATANABE SHINYA , FUKUNAGA HIROKATSU , ISHIKAWA AKIHIKO
发明人： ITO KEITA , WATANABE SHINYA , FUKUNAGA HIROKATSU , ISHIKAWA AKIHIKO
IPC分类号： B62D21/15
CPC分类号： B62D35/02 , B62D25/18 , Y02T10/88
摘要： A vehicle lower structure includes a plurality of spat body portions and a guide portion. The spat body portions are provided side by side in a vehicle longitudinal direction on a vehicle front side of a wheel, are protruded from an underfloor of the vehicle toward a vehicle lower side, and extend in a vehicle width direction. The guide portion constitutes vehicle-width-direction outer regions of the spat body portions in at least one of second and subsequent rows from a vehicle rear side, is inclined toward the vehicle rear side and outward in the vehicle width direction to guide a traveling wind, and has a vehicle-width-direction outer end that is arranged more outward in the vehicle width direction than a vehicle-width-direction outer end of the spat body portion that is adjacent to the vehicle rear side.
摘要翻译：车辆下部结构包括多个臀部部分和引导部分。在车辆的车辆前侧沿车辆纵向方向并排设置的臀部部分从车辆的地板下方朝向车辆下侧突出，并且在车辆宽度方向上延伸。引导部分构成从车辆后侧到第二列和后续列中的至少一个中的臀部部分的车宽方向外部区域，朝向车辆后侧倾斜并且在车辆宽度方向上向外引导行驶风并且具有比与车辆后侧相邻的臀部部分的车宽方向外端在车宽方向上更向外配置的车宽方向外端。

10. 发明申请

WO1996001825A1 HETEROBICYCLIC DERIVATIVES 审中-公开
标题翻译：杂环衍生物
公开(公告)号：WO1996001825A1
公开(公告)日：1996-01-25
申请号：PCT/JP1995001366
申请日：1995-07-10
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Mitsue +hf , SHIMAZAKI, Norihiko , WATANABE, Shinya , SAWADA, Akihiko
发明人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Mitsue +hf , HEMMI, Keiji +di
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Heterobicyclic derivatives of formula (I) wherein R is aryl which may have suitable substituent(s), ar(lower)alkyl which may have suitable substituent(s), halo(lower)alkyl, protected carboxy(lower)alkyl, acyl(lower)alkyl, heterocyclic group or heterocyclic(lower)alkyl which may have suitable substituent(s), R is aryl which may have suitable substituent(s) or heterocyclic group, and R is hydrogen, lower alkoxy or arylthio, and a pharmaceutically acceptable salt thereof which are useful as PDE IV and TNF inhibitors.
摘要翻译：式（I）的杂双环衍生物，其中R 1为可具有合适取代基的芳基，可具有合适取代基的芳基（低级）烷基，卤代（低级）烷基，被保护的羧基（低级）烷基，可以具有合适取代基的酰基（低级）烷基，杂环基或杂环（低级）烷基，R 2是可具有合适取代基或杂环基的芳基，R 3是氢，低级烷氧基或芳硫基，及其药学上可接受的盐，可用作PDE IV和TNF抑制剂。

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