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1. 发明申请

WO1993010144A1 NEW ENDOTHELIN ANTAGONISTS AND THEIR PREPARATION 审中-公开
标题翻译：新的内皮素拮抗剂及其制备
公开(公告)号：WO1993010144A1
公开(公告)日：1993-05-27
申请号：PCT/JP1992001405
申请日：1992-10-30
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Keiji , NEYA, Masahiro , FUKAMI, Naoki , HASHIMOTO, Masashi , TANAKA, Hirokazu , KAYAKIRI, Natsuko
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07K05/06
CPC分类号： C07K5/06156 , A61K38/00 , C07K5/0808 , C07K5/1005 , C07K5/1024
摘要： A compound of the formula (I), where R -R and A have the meanings disclosed in the description; or a pharmaceutically acceptable salt thereof; display endothelm antagonistic activity.
摘要翻译：式（I）的化合物，其中R 1 -R 5和A具有说明书中公开的含义; 或其药学上可接受的盐; 显示内皮拮抗活性。

2. 发明申请

WO1990012004A1 NEW NAPHTHALENE COMPOUNDS AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：新的萘磺酸化合物及其生产方法
公开(公告)号：WO1990012004A1
公开(公告)日：1990-10-18
申请号：PCT/JP1990000466
申请日：1990-04-06
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , NAMIKI, Takayuki , KATAYAMA, Akira , HEMMI, Keiji , HASHIMOTO, Masashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/08
CPC分类号： C07D207/08 , Y02P20/55
摘要： Naphthalene compounds represented by general formula (I), and pharmaceutically acceptable salts thereof, useful as a phospholipase A2 inhibitor and an antiinflammatory agent; wherein R represents hydrogen, lower alkyl or amino-protective group; R and R represent each hydrogen or halogen; and A represents lower alkylene. The invention further discloses a method of producing these compounds, pharmaceutical preparations containing the same as the active ingredient, and a method of preventing and/or treating inflammatory diseases of man and animal.
摘要翻译：由通式（I）表示的萘化合物及其药学上可接受的盐可用作磷脂酶A2抑制剂和抗炎剂; 其中R 1表示氢，低级烷基或氨基保护基; R 2和R 3各自表示氢或卤素; A代表低级亚烷基。本发明还公开了一种制备这些化合物的方法，含有该活性成分的药物制剂，以及预防和/或治疗人和动物炎性疾病的方法。

3. 发明申请

WO1995019959A1 AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS 审中-公开
标题翻译：氨基酸衍生物及其作为磷脂酶A2抑制剂的用途
公开(公告)号：WO1995019959A1
公开(公告)日：1995-07-27
申请号：PCT/JP1995000068
申请日：1995-01-23
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TAKASE, Shigehiro , SHIGEMATSU, Nobuharu , YOSHIMURA, Seiji , OKADA, Satoshi , HEMMI, Keiji , TANAKA, Hirokazu , OTSUKA, Takanao , TSURUMI, Yasuhisa , OKAMOTO, Masanori , OKUHARA, Masakuni , FUKAMI, Naoki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C271/22
CPC分类号： C07D213/40 , C07C235/08 , C07C235/12 , C07C271/22 , C07C271/54 , C07C275/16 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/64 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/32 , C07D317/58 , C07D471/04
摘要： The present invention relates to a novel fatty acid derivative of formula (I) wherein R is acyl group, etc.; R is acyl(lower)alkyl; R is lower alkyl, etc.; R is hydrogen, etc.; and X is -O-, etc.; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
摘要翻译：本发明涉及式（I）的新型脂肪酸衍生物，其中R 1为酰基等; R 2是酰基（低级）烷基; R 3是低级烷基等; R 4是氢等; X为-O-等。和其药学上可接受的盐，其可用作药物; 所述脂肪酸衍生物或其盐的制备方法; 包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物; 等等

4. 发明申请

WO1992017456A1 AMINO ACID DERIVATIVE AND SALT THEREOF 审中-公开
标题翻译：氨基酸衍生物及其盐
公开(公告)号：WO1992017456A1
公开(公告)日：1992-10-15
申请号：PCT/JP1992000349
申请日：1992-03-21
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Keiji , NEYA, Masahiro , WATANABE, Shinya , HASHIMOTO, Masashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D233/64
CPC分类号： C07D233/64 , A61K38/00 , C07K5/06078
摘要： A novel amino acid derivative having a renin inhibitory activity, represented by general formula (A), a salt thereof, and a process for producing the same.
摘要翻译：具有由通式（A）表示的肾素抑制活性的新型氨基酸衍生物及其盐及其制备方法。

5. 发明申请

WO1995029152A1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS 审中-公开
标题翻译：苯甲酸衍生物作为VASOPRESSIN ANTAGONISTS
公开(公告)号：WO1995029152A1
公开(公告)日：1995-11-02
申请号：PCT/JP1995000788
申请日：1995-04-21
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , SETOI, Hiroyuki , OHKAWA, Takehiko , ZENKOH, Tatsuya , HEMMI, Keiji , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C237/42
CPC分类号： C07D209/48 , C07C237/42 , C07C237/44 , C07C251/38 , C07C251/60 , C07C255/60 , C07C271/16 , C07C271/48 , C07C281/06 , C07C323/52 , C07C2601/08 , C07C2601/14 , C07D213/56 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D295/088 , C07D295/096 , C07D295/15 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D401/12
摘要： This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I), wherein R is aryl optionally substituted with lower alkyl, etc., R is lower alkyl, etc., R is hydrogen, etc., R is aryl, etc., X is CH or N, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及具有加压素拮抗作用的新型苯甲酰胺衍生物等，并由通式（I）表示，其中R 1为任选被低级烷基取代的芳基等，R 2为低级烷基等。 R 3为氢等，R 4为芳基等，X为CH或N，Y为CH或N及其药学上可接受的盐，用于其制备方法和药物包含它的组合物。

6. 发明申请

WO1995000537A1 NEW COMPOUND AND ITS PREPARATION 审中-公开
标题翻译：新化合物及其制备
公开(公告)号：WO1995000537A1
公开(公告)日：1995-01-05
申请号：PCT/JP1994001042
申请日：1994-06-28
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HEMMI, Keiji , NEYA, Masahiro , FUKAMI, Naoki , KAYAKIRI, Natsuko , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07K05/08
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0207 , C07K5/0827 , Y02P20/55
摘要： A compound of formula (1) in which R is acyl, R is lower alkyl, R is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl, R is lower alkyl or lower alkylthio(lower)alkyl, R is carboxy or protected carboxy, A is lower alkylene, Z is a group of formula (2) wherein R is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl, R is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, and R is optionally substituted heterocyclic(lower)alkyl, and m is an integer of 0 to 2, or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.
摘要翻译：式（1）的化合物，其中R 4是酰基，R 5是低级烷基，R 6是任选取代的芳（低级）烷基或任选取代的杂环 - （低级）烷基，R 7是是低级烷基或低级烷硫基（低级）烷基，R 8是羧基或保护的羧基，A是低级亚烷基，Z是式（2）的基团，其中R 1是氢，低级烷基，常见的氨基保护基基团或任选取代的芳（低级）烷基，R 2是氢，低级烷基，任选取代的芳（低级）烷基，任选取代的杂环 - （低级）烷基，任选取代的环（低级）烷基氨基（或保护的氨基）（低级）烷基，任选取代的杂环 - 羰基或环（低级）烷基，R 3是任选取代的杂环（低级）烷基，m是0至 2或其药学上可接受的盐，其可用作内皮素拮抗剂。

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