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1. 发明申请

WO2015017413A1 ASSAY CARTRIDGE PROCESSING SYSTEMS AND METHODS AND ASSOCIATED ASSAY CARTRIDGES 审中-公开
标题翻译：测量盒加工系统和方法及相关的测定盒
公开(公告)号：WO2015017413A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/048620
申请日：2014-07-29
申请人： MBIO DIAGNOSTICS, INC. , GIVENS, Monique , ROWLEY, Keagan, B. , VOGEL, Kurt, R. , SUPON, Frank, William , LOCHHEAD, Michael, J.
发明人： GIVENS, Monique , ROWLEY, Keagan, B. , VOGEL, Kurt, R. , SUPON, Frank, William , LOCHHEAD, Michael, J.
IPC分类号： C12M1/34
CPC分类号： G01N1/38 , B01F11/0022 , B01F11/0266 , B01F13/0818 , B01F15/00253 , B01F15/00409 , B01L3/502715 , B01L3/502723 , B01L2200/06 , B01L2200/14 , B01L2300/02 , B01L2300/0672 , B01L2300/0838 , G01N2001/386
摘要： An assay cartridge processing system includes an agitation source for agitating assay components within an assay cartridge, and a timing module for controlling timing of agitation. An assay cartridge processing method includes applying agitation to an assay cartridge to mix assay components, and electronically controlling timing of agitation. An assay cartridge processing system includes a puncture device for puncturing an assay cartridge to allow fluid flow, and a timing module for controlling timing of puncturing. An assay cartridge processing method includes puncturing a vent of a capillary channel of an assay cartridge to allow fluid flow from an inlet port of the assay cartridge into the capillary channel, and electronically controlling timing of the step of puncturing. An assay cartridge includes a capillary channel, an inlet port, and a vent including a frangible seal for preventing fluid flow from into the capillary channel when the frangible seal is intact.
摘要翻译：分析盒处理系统包括用于搅拌测定盒内的测定组分的搅拌源和用于控制搅拌时间的定时模块。测定盒处理方法包括将搅拌施加到测定盒以混合测定组分，以及电子控制搅拌的时间。分析盒处理系统包括用于刺穿分析盒以允许流体流动的穿刺装置，以及用于控制穿刺定时的定时模块。分析盒处理方法包括刺穿分析盒的毛细通道的通气口，以允许流体从分析盒的入口流入毛细管通道，以及电子地控制穿刺步骤的定时。分析盒包括毛细通道，入口端口和通风口，其包括易碎密封件，用于当易碎密封件完好时防止流体流入毛细通道。

2. 发明申请

WO2012051206A1 SYSTEM AND METHOD FOR CELL ANALYSIS 审中-公开
标题翻译：细胞分析的系统和方法
公开(公告)号：WO2012051206A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/055817
申请日：2011-10-11
申请人： MBIO DIAGNOSTICS, INC. , GIVENS, Monique , IVES, Jeffrey , LOCHHEAD, Michael, J. , DELANEY, Marie, J. , MOLL, Kevin, D. , ROWLEY, Keagan, B. , VOGEL, Kurt, R. , MYATT, Christopher, J.
发明人： GIVENS, Monique , IVES, Jeffrey , LOCHHEAD, Michael, J. , DELANEY, Marie, J. , MOLL, Kevin, D. , ROWLEY, Keagan, B. , VOGEL, Kurt, R. , MYATT, Christopher, J.
IPC分类号： G01N21/00 , G01N33/543
CPC分类号： G01N21/648 , G01N21/0303 , G01N21/7703 , G01N33/54373 , G01N2015/008 , G01N2015/1486
摘要： Although each of the aforedescribed embodiments have been illustrated with various components having particular respective orientations, it should be understood that the system as described in the present disclosure may take on a variety of specific configurations with the various components being located in a variety of positions and mutual orientations and still remain within the spirit and scope of the present disclosure. For example, it should be noted that the present configuration may be applicable for systems in which the core refractive index is greater than the refractive indices of the substrates, such as if a solid core material is used, as long as the surrounding medium refractive index is less than those of the substrates. Additionally, in the various figures described above, the gasket may be eliminated and replaced with direct laser welding of first and second substrates. Furthermore, suitable equivalents may be used in place of or in addition to the various components, the function and use of such substitute or additional components being held to be familiar to those skilled in the art and are therefore regarded as falling within the scope of the present disclosure. Therefore, the present examples are to be considered as illustrative and not restrictive, and the present disclosure is not to be limited to the details given herein but may be modified within the scope of the appended claims.
摘要翻译：尽管已经用具有特定相应取向的各种部件示出了上述实施例中的每一个，但是应当理解，本公开中描述的系统可以采用各种特定配置，其中各种部件位于各种位置，并且相互取向，仍然在本公开的精神和范围内。例如，应当注意，本构造可以适用于芯折射率大于基板的折射率的系统，例如使用固体芯材料时，只要周围介质折射率小于底物。此外，在上述各种图中，垫圈可以被消除，并由第一和第二基板的直接激光焊接代替。此外，可以使用合适的等同物来替代或除了各种组分，这些替代或附加组分的功能和用途被认为是本领域技术人员熟悉的，因此被认为属于本公开。因此，本实施例被认为是说明性的而不是限制性的，并且本公开不限于本文给出的细节，而是可以在所附权利要求的范围内进行修改。

3. 发明申请

WO2012037369A1 SYSTEM AND METHOD FOR DETECTING MULTIPLE MOLECULES IN ONE ASSAY 审中-公开
标题翻译：用于在一个测定中检测多个分子的系统和方法
公开(公告)号：WO2012037369A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/051791
申请日：2011-09-15
申请人： MBIO DIAGNOSTICS, INC. , LOCHHEAD, Michael, J. , IVES, Jeffrey , TODOROF, Kathryn , GREEF, Charles , DELANEY, Marie, J. , MOLL, Kevin, D. , VOGEL, Kurt, R. , ROWLEY, Keagan, B. , WOODRUFF, Evelyn, S. , DUNN, John, S. , MYATT, Christopher, J. , NIEUWLANDT, Daniel, T.
发明人： LOCHHEAD, Michael, J. , IVES, Jeffrey , TODOROF, Kathryn , GREEF, Charles , DELANEY, Marie, J. , MOLL, Kevin, D. , VOGEL, Kurt, R. , ROWLEY, Keagan, B. , WOODRUFF, Evelyn, S. , DUNN, John, S. , MYATT, Christopher, J. , NIEUWLANDT, Daniel, T.
IPC分类号： G01N21/00 , G01N33/543
CPC分类号： G01N33/54373 , B01L3/502715 , B01L9/52 , B01L2300/0636 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , G01N21/6452 , G01N21/648 , G01N21/7703
摘要： A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
摘要翻译：描述了使用少量血液，血清或血浆提供一组血清学测定结果的快速诊断系统。该系统包括基于平面波导成像技术的一次性盒和读取器。该盒在流体通道中结合重组抗原和抗体对照的微阵列，为单个样品提供多个平行的荧光测定结果。

4. 发明申请

WO2010141122A1 WAVEGUIDE WITH INTEGRATED LENS 审中-公开
标题翻译：波形与集成镜头
公开(公告)号：WO2010141122A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/025172
申请日：2010-02-24
申请人： PRECISION PHOTONICS CORPORATION , MOLL, Kevin , VOGEL, Kurt , DELANEY, Marie , LOCHHEAD, Michael , MYATT, Christopher
发明人： MOLL, Kevin , VOGEL, Kurt , DELANEY, Marie , LOCHHEAD, Michael , MYATT, Christopher
IPC分类号： G02B6/10 , G02B6/32
CPC分类号： G01N21/552 , G02B6/12004 , G02B6/4206 , G02B2006/12102
摘要： A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.
摘要翻译：可以使用包括光源，平面波导和折射体积的装置照亮样品进行分析。光源沿着传播矢量提供光。平面波导取向为使得传播矢量垂直于平面波导的法线向量并且平行于平面波导的方向平行于平面波导的法向矢量。折射体积位于平面波导附近，并且可将由光源提供的光光学耦合到平面波导。

5. 发明申请

WO2008011601A3 KINASE AND UBIQUINATION ASSAYS 审中-公开
公开(公告)号：WO2008011601A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/074031
申请日：2007-07-20
申请人： INVITROGEN CORPORATION , VOGEL, Kurt, W. , RIDDLE, Steven, M. , HORTON, Robert, A. , ROBERS, Mathew, B. , MICHAUD, Gregory, A.
发明人： VOGEL, Kurt, W. , RIDDLE, Steven, M. , HORTON, Robert, A. , ROBERS, Mathew, B. , MICHAUD, Gregory, A.
IPC分类号： C12Q1/48
摘要： Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity) using resonance energy transfer (RET) are provided.

6. 发明申请

WO2008011601A2 KINASE AND UBIQUINATION ASSAYS 审中-公开
标题翻译：激光和荧光测定
公开(公告)号：WO2008011601A2
公开(公告)日：2008-01-24
申请号：PCT/US2007074031
申请日：2007-07-20
申请人： INVITROGEN CORP , VOGEL KURT W , RIDDLE STEVEN M , HORTON ROBERT A , ROBERS MATHEW B , MICHAUD GREGORY A
发明人： VOGEL KURT W , RIDDLE STEVEN M , HORTON ROBERT A , ROBERS MATHEW B , MICHAUD GREGORY A
CPC分类号： C12Q1/485 , C12Q1/25 , C12Q1/37
摘要： Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity) using resonance energy transfer (RET) are provided.
摘要翻译：提供了使用共振能量转移（RET）的组合物，包括抗体，多肽和有机分子，试剂盒和用于探测分子相互作用（例如，去泛素化，泛素化和激酶活性）的方法。

7. 发明申请

WO0210750A2 BIOSENSORS, REAGENTS AND DIAGNOSTIC APPLICATIONS OF DIRECTED EVOLUTION 审中-公开
标题翻译：生物传感器，试剂和指导性进化的诊断应用
公开(公告)号：WO0210750A2
公开(公告)日：2002-02-07
申请号：PCT/US0124182
申请日：2001-07-31
申请人： MAXYGEN INC , MINSHULL JEREMY , DAVIS S CHRISTOPHER , WELCH MARK , RAILLARD SUN AI , VOGEL KURT , KREBBER CLAUS
发明人： MINSHULL JEREMY , DAVIS S CHRISTOPHER , WELCH MARK , RAILLARD SUN AI , VOGEL KURT , KREBBER CLAUS
IPC分类号： C12N9/12 , C12N15/10 , C12P19/34 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/1252 , C12N15/1055 , C12P19/34 , C12Q1/6888
摘要： Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.
摘要翻译：提供使用生物聚合物阵列感测测试刺激的方法。提供了生物聚合物，核酸变体和由核酸变体编码的表达产物的文库。提供了可重用库数组及其使用方法。

8. 发明申请

WO2008112008A9 SENSOR PROTEINS AND ASSAY METHODS 审中-公开
标题翻译：传感器蛋白质和测定方法
公开(公告)号：WO2008112008A9
公开(公告)日：2008-11-20
申请号：PCT/US2007075705
申请日：2007-08-10
申请人： INVITROGEN CORP , RIDDLE STEVEN , NEWMAN RHONDA , VOGEL KURT
发明人： RIDDLE STEVEN , NEWMAN RHONDA , VOGEL KURT
IPC分类号： C12N15/09 , C07H21/04 , C07K14/00 , G01N33/53
CPC分类号： G01N33/542 , G01N33/84 , Y10T436/16
摘要： The present invention relates to biosensors. In some embodiments, the biosensors are modified ligand binding molecules. In some embodiments, the modified ligand binding molecule is a phosphate binding protein (PBP). In some embodiments, the modified ligand binding molecules are labeled to be capable of RET, e.g., comprising a donor and acceptor moiety. In some embodiments of the invention, there is a detectable change in RET (e.g., FRET) when the modified ligand binding molecule binds and/or releases the ligand (e.g., phosphate). The invention also provides related methods, reactions and assays.
摘要翻译：本发明涉及生物传感器。在一些实施方案中，生物传感器是修饰的配体结合分子。在一些实施方案中，修饰的配体结合分子是磷酸结合蛋白（PBP）。在一些实施方案中，修饰的配体结合分子被标记为能够RET，例如包含供体和受体部分。在本发明的一些实施方案中，当修饰的配体结合分子结合和/或释放配体（例如磷酸盐）时，在RET（例如，FRET）中存在可检测的变化。本发明还提供相关方法，反应和测定。

9. 发明申请

WO2007051207A3 KINASE AND UBIQUINATION ASSAYS 审中-公开
标题翻译：激光和荧光测定
公开(公告)号：WO2007051207A3
公开(公告)日：2007-07-19
申请号：PCT/US2006060373
申请日：2006-10-30
申请人： INVITROGEN CORP , VOGEL KURT WILLIAM , RIDDLE STEVEN MICHAEL , HORTON ROBERT ARON , ROBERS MATTHEW BRIAN , MICHAUD GREGORY ALLEN , MACHLEIDT THOMAS , VEDVIK KEVIN , HUWILER KRISTIN G
发明人： VOGEL KURT WILLIAM , RIDDLE STEVEN MICHAEL , HORTON ROBERT ARON , ROBERS MATTHEW BRIAN , MICHAUD GREGORY ALLEN , MACHLEIDT THOMAS , VEDVIK KEVIN , HUWILER KRISTIN G
IPC分类号： G01N33/533
CPC分类号： G01N33/542 , C12Q1/37
摘要： Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity), e.g., using resonance energy transfer (RET) are provided.
摘要翻译：提供了组合物，包括抗体，多肽和有机分子，试剂盒和用于探测分子相互作用（例如，去泛素化，泛素化和激酶活性）的方法，例如使用共振能量转移（RET）。

10. 发明申请

WO2005026730A3 MULTIPLEX BINDING AND ACTIVITY ASSAYS 审中-公开
公开(公告)号：WO2005026730A3
公开(公告)日：2005-03-24
申请号：PCT/US2004/029099
申请日：2004-09-08
申请人： INVITROGEN CORPORATION , VOGEL, Kurt
发明人： VOGEL, Kurt
IPC分类号： G01N33/58
摘要： Compositions, including antibodies, polypeptides, and organic molecules, kits, apparatuses, and methods for probing molecular interactions using fluorescence polarization (FP) and/or time-resolved resonance energy transfer (TR-RET) are provided.

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