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1. 发明申请

WO2013148319A1 BACTERIAL IMAGING AGENTS AND METHODS OF USING SAME 审中-公开
标题翻译：细菌成像剂及其使用方法
公开(公告)号：WO2013148319A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/032126
申请日：2013-03-15
申请人： VISEN MEDICAL, INC.
发明人： HO, Guojie
IPC分类号： C12Q1/04 , G01N33/534 , G01N33/58
CPC分类号： A61K49/0002 , A61K49/0017 , C07C53/10 , C07D487/08 , C12Q1/04 , G01N21/6486 , G01N33/534 , G01N33/58
摘要： The invention provides a family of agents that target bacterial infection, which can be used as imaging agents or therapeutic agents. The agents can be used to image sites of bacterial infection as well as other physiological processes in a subject.
摘要翻译：本发明提供了可以用作成像剂或治疗剂的细菌感染的一系列试剂。该试剂可用于成像受试者中细菌感染的位点以及其它生理过程。

2. 发明申请

WO2007111669A2 COMBINED X-RAY AND OPTICAL TOMOGRAPHIC IMAGING SYSTEM 审中-公开
标题翻译：组合X射线和光学图像成像系统
公开(公告)号：WO2007111669A2
公开(公告)日：2007-10-04
申请号：PCT/US2006048785
申请日：2006-12-21
申请人： VISEN MEDICAL INC , YARED WAEL I
发明人： YARED WAEL I
CPC分类号： A61B6/032 , A61B5/0035 , A61B5/0059 , A61B5/0064 , A61B5/1077 , A61B6/4014 , A61B6/4417 , A61B6/482 , A61B6/485 , A61B6/508 , A61B6/5247 , A61B2503/40 , A61B2560/0223
摘要： The invention relates to a combined x-ray and optical (light-based) tomographic imaging system that provides functional information at greater resolution than can be achieved by optical tomography alone. The system is configured with one or more x-ray sources, x-ray detectors, light sources, and light detectors arranged on a gantry which rotates about an imaging chamber containing the object to be imaged. The system thereby allows both x-ray radiation and light to be directed into the object at multiple locations. Processing methods of the invention go beyond simple co-registration of images obtained from two or more imaging techniques. Both x-ray data and light data are used together in optical tomographic reconstruction to create the tomographic image, thereby allowing a more accurate and/or higher resolution final image.
摘要翻译：本发明涉及一种组合的x射线和光学（基于光的）断层成像系统，其以比仅通过光学层析成像可以实现的更高的分辨率提供功能信息。该系统配置有一个或多个X射线源，X射线检测器，光源和布置在围绕包含待成像对象的成像室旋转的台架的光检测器。因此，该系统允许x射线辐射和光在多个位置被引导到物体中。本发明的处理方法超出了从两种或更多种成像技术获得的图像的简单共同配准。 X射线数据和光数据在光学层析成像重建中一起使用以产生断层图像，从而允许更准确和/或更高分辨率的最终图像。

3. 发明申请

WO2007028163A8 BIOCOMPATIBLE FLUORESCENT IMAGING AGENTS 审中-公开
标题翻译：生物成分荧光成像剂
公开(公告)号：WO2007028163A8
公开(公告)日：2007-05-24
申请号：PCT/US2006034604
申请日：2006-09-01
申请人： VISEN MEDICAL INC , RAJOPADHYE MILIND , GROVES KEVIN
发明人： RAJOPADHYE MILIND , GROVES KEVIN
IPC分类号： C07D419/02 , A61K31/496 , A61K49/00 , C09B23/02 , G01N33/533 , G01N33/58
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译：本发明涉及被设计成连接到生物相容性分子以形成体内光学成像剂的新的荧光化学实体。

4. 发明申请

WO2007028163A1 BIOCOMPATIBLE FLUORESCENT IMAGING AGENTS 审中-公开
标题翻译：生物相容性荧光成像剂
公开(公告)号：WO2007028163A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/034604
申请日：2006-09-01
申请人： VISEN MEDICAL, INC. , RAJOPADHYE, Milind , GROVES, Kevin
发明人： RAJOPADHYE, Milind , GROVES, Kevin
IPC分类号： C07D419/02 , C09B23/02 , G01N33/533 , G01N33/58 , A61K49/00 , A61K31/496
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译：本发明涉及新的荧光化学实体，其被设计成附着于生物相容性分子以形成体内光学成像剂。

5. 发明申请

WO2007028118A2 NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES 审中-公开
标题翻译：尼古丁酸和PICOLINIC酸衍生的近红外荧光物质
公开(公告)号：WO2007028118A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034406
申请日：2006-09-01
申请人： VISEN MEDICAL, INC. , RAJOPADHYE, Milind , NARAYANAN, Narasimhachari , PETERSON, Jeffrey, D.
发明人： RAJOPADHYE, Milind , NARAYANAN, Narasimhachari , PETERSON, Jeffrey, D.
IPC分类号： C07D401/14 , C07D417/14
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译：本发明涉及新的荧光化学实体，包括包含羧基或羰基官能化吡啶部分的荧光分子。本发明还涉及这种分子的相应反应形式。本发明还涉及具有诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖及其用途的部分的相应缀合物。

6. 发明申请

WO2003057175A3 AMINE FUNCTIONALIZED SUPERPARAMAGNETIC NANOPARTICLES FOR THE SYNTHESIS OF BIOCONJUGATES AND USES THEREFOR 审中-公开
公开(公告)号：WO2003057175A3
公开(公告)日：2003-07-17
申请号：PCT/US2003/000051
申请日：2003-01-02
申请人： VISEN MEDICAL, INC. , GAW, Debra, A. , JOSEPHSON, Lee
发明人： GAW, Debra, A. , JOSEPHSON, Lee
IPC分类号： B32B5/16
摘要： Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.

7. 发明申请

WO2014144793A1 SUBSTITUTED SILAXANTHENIUM RED TO NEAR-INFRARED FLUOROCHROMES FOR IN VITRO AND IN VIVO IMAGING AND DETECTION 审中-公开
标题翻译：取代紫外线红附近的红外成像和血管成像和检测中的荧光素
公开(公告)号：WO2014144793A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029350
申请日：2014-03-14
申请人： VISEN MEDICAL, INC.
发明人： GROVES, Kevin , BUFF, Ryan
IPC分类号： C07F7/08 , A61K47/10 , A61K47/48 , C07K7/00 , C08L71/02
CPC分类号： A61K47/48023 , A61K47/48092 , A61K47/48384 , A61K49/0019 , A61K49/0021 , A61K49/0052 , A61K49/0054 , C07F7/0816 , C09B11/28 , C09B69/008 , G01N33/56966
摘要： The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.
摘要翻译：本发明提供一系列荧光化合物。这些化合物是可以与一种或多种生物分子如蛋白质，核酸和治疗性小分子化学连接的取代的硅氧烷henium化合物。该化合物可用于各种医学，生物和诊断应用中的成像。染料特别适用于体外，体内和离体成像应用。

8. 发明申请

WO2014028057A1 PROSTATE SPECIFIC ANTIGEN AGENTS AND METHODS OF USING SAME FOR PROSTATE CANCER IMAGING 审中-公开
标题翻译：前列腺特异性抗原代谢物及其使用方法用于前列腺癌成像
公开(公告)号：WO2014028057A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/032200
申请日：2013-03-15
申请人： VISEN MEDICAL, INC.
发明人： HO, Guojie
IPC分类号： A61K47/48 , A61K49/00
CPC分类号： C07K7/06 , A61K47/65 , A61K49/0056 , G01N21/6486
摘要： The invention provides a family of agents that target the prostate specific antigen, which can be used as imaging agents or therapeutic agents. The agents can be used to image prostate cancer as well as other physiological processes in a subject.
摘要翻译：本发明提供一种靶向前列腺特异性抗原的试剂家族，其可用作显像剂或治疗剂。这些药剂可以用于摄取前列腺癌以及受试者中的其他生理过程。

9. 发明申请

WO2012154885A2 CARBONIC ANHYDRASE TARGETING AGENTS AND METHODS OF USING SAME 审中-公开
标题翻译：碳酸酐靶向剂及其使用方法
公开(公告)号：WO2012154885A2
公开(公告)日：2012-11-15
申请号：PCT/US2012037166
申请日：2012-05-09
申请人： VISEN MEDICAL INC , GROVES KEVIN , BAO BAGNA
发明人： GROVES KEVIN , BAO BAGNA
IPC分类号： C07D417/14 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14
CPC分类号： C07D401/06 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/0002 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , C09B23/0008 , C09B23/0033 , C09B23/083 , C09B23/086 , G01N21/6458 , G01N33/582 , G01N2333/988
摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
摘要翻译：本发明提供靶向碳酸酐酶的试剂，其可用作显像剂或治疗剂。这些药剂可用于成像肿瘤缺氧以及受试者中的其他生理过程。

10. 发明申请

WO2009114776A3 INTEGRIN TARGETING AGENTS AND IN-VIVO AND IN-VITRO IMAGING METHODS USING THE SAME 审中-公开
公开(公告)号：WO2009114776A3
公开(公告)日：2009-09-17
申请号：PCT/US2009/037114
申请日：2009-03-13
申请人： VISEN MEDICAL, INC. , MERCK & CO., INC. , RAJOPADHYE, Milind , HO, Guojie , BEDNAR, Bohumil , DUONG, Le, T. , COLEMAN, Paul, J.
发明人： RAJOPADHYE, Milind , HO, Guojie , BEDNAR, Bohumil , DUONG, Le, T. , COLEMAN, Paul, J.
IPC分类号： A61K49/00 , A61K49/10 , A61K49/18 , A61K51/04 , G01N33/58 , G01N33/60 , A61K47/48
摘要： The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.

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