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1. 发明申请

WO2018049516A1 APPARATUS AND METHOD FOR MONITORING AND CONTROLLING THE ASEPTIC FILLING AND SEALING OF PHARMACEUTICAL CONTAINERS WITH A PHARMACEUTICAL FLUID USING ROTARY STAGE 审中-公开
标题翻译：监测和控制药物流体使用旋转台进行无菌灌装和密封药物容器的装置和方法
公开(公告)号：WO2018049516A1
公开(公告)日：2018-03-22
申请号：PCT/CA2017/051071
申请日：2017-09-12
申请人： VANRX PHARMASYSTEMS INC.
发明人： NAING, Juvenal , GOFMAN, Yakov , CICHY, Marcin , SENGER, John , GUERRERO, Carlos Alberto Diaz
IPC分类号： B65B55/12 , A61J1/00 , A61L2/24 , B65B3/04
CPC分类号： A61L2/24 , A61J1/00 , A61L2/07 , A61L2/202 , A61L2/206 , A61L2/208 , A61L2202/122 , A61L2202/14 , A61L2202/21 , B65B3/003 , B65B43/60 , B65B55/027
摘要： The system of the invention involves monitoring and controlling in a sterilizable environment the peeling of a cover from a tub sealed by the cover. The system and associated method employs a platform having a fiducial source locating structure for holding the tub, a cover removal station disposed to engage with the cover and to peel the cover from the tub. The container assembly for holding nested pharmaceutical container parts comprises a bottom, a top lip that provides a horizontal top sealing surface that has a peripheral outline, and sidewalls located between the bottom and the top lip, a peelable container cover consisting of a sheet of flexible material sealed to the sealing surface of the top lip of the rectangular container to seal the contents of the container, and a cover removal fixture on the container cover.
摘要翻译：本发明的系统涉及在可消毒的环境中监测和控制盖子从被盖子密封的桶中剥离。该系统和相关方法采用具有用于保持桶的基准源定位结构的平台，设置用于与盖接合并将盖从桶中剥离的盖移除台。用于保持嵌套的药物容器部件的容器组件包括底部，顶部唇缘，其提供具有周边轮廓的水平顶部密封表面以及位于底部和顶部唇缘之间的侧壁，可剥离容器盖由柔性片材料密封到矩形容器的上唇的密封表面以密封容器的内容物，以及容器盖上的盖移除夹具。

2. 发明申请

WO2013156851A2 ARTICULATED ARM APPARATUS AND SYSTEM 审中-公开
标题翻译：武器装置和系统
公开(公告)号：WO2013156851A2
公开(公告)日：2013-10-24
申请号：PCT/IB2013/000801
申请日：2013-02-08
申请人： VANRX PHARMASYSTEMS, INC. , GOLD, Ross, M.
发明人： GOLD, Ross, M. , PROCYSHYN, Christopher, A. , IMMERZEEL, Jeroen , PARK, Steve, Sang, Joon
IPC分类号： A61J3/00
CPC分类号： B25J9/0009 , B25J9/0075 , B25J18/04 , B25J19/0075 , B25J21/00
摘要： A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber is disclosed. In one general aspect, it comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, interconnected hermetically sealed arm segments operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the arm segments. The rotational shaft can further be a linear motion shaft for which the sealing member is a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber can be compatible with an aseptic and cleanable environment and the surfaces of the arm segments can be shaped to avoid pooling of contaminants.
摘要翻译：公开了一种用于密封隔离器室内的气密密封多轴铰接臂装置。在一个一般方面，其包括通过腔室中的开口的旋转轴，设置在腔室内的密封构件，用于将轴密封到腔室的内表面，互连的气密密封臂段，可操作地连接到直线运动轴 ; 可操作地连接到臂段中的端子臂段的末端执行器和用于驱动和控制轴和臂段的至少一个完全封闭的驱动系统。旋转轴还可以是密封构件是波纹管的直线运动轴。暴露于室的气氛中的设备部件的材料可以与无菌和可清洁的环境兼容，并且臂段的表面可以被成形以避免污染物的汇集。

3. 发明申请

WO2020093141A1 FILL NEEDLE SYSTEM 审中-公开
公开(公告)号：WO2020093141A1
公开(公告)日：2020-05-14
申请号：PCT/CA2019/051524
申请日：2019-10-29
申请人： VANRX PHARMASYSTEMS INC.
发明人： NAING, Juvenal , CICHY, Marcin , GUERRERO, Carlos Alberto Diaz
IPC分类号： B65B3/04 , A61J1/20 , B65B3/10 , B65B55/00
摘要： A fill needle system (414) for aseptically dispensing a pharmaceutical fluid in an aseptic chamber (420) comprises a fill needle tubing in communication with a pharmaceutical fluid source (401) via flexible tubing (405) and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath (503') shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system (513) configured to compress the flexible tubing to dislodge droplets (708) of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. A method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.

4. 发明申请

WO2018025092A1 APPARATUS AND METHOD FOR ASEPTICALY FILLING PHARMACEUTICAL CONTAINERS WITH A PHARMACEUTICAL FLUID 审中-公开
标题翻译：用药物流体来恒温充填药物容器的装置和方法
公开(公告)号：WO2018025092A1
公开(公告)日：2018-02-08
申请号：PCT/IB2017/001183
申请日：2017-08-03
申请人： VANRX PHARMASYSTEMS INC
发明人： PROCYSHYN, Christopher , NIANG, Juvenal , SENGER, John , CICHY, Marcin
IPC分类号： A61J1/20 , A61J1/06 , B65B55/00 , B65B3/04
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
摘要翻译：公开了用药物流体无菌灌装药物容器的系统和方法。在一个总体方面，这些基于无菌密封的腔室，其包括传送壁，无菌地将预密封的药物源和接收容器安装到传送壁上。机器人臂和注射器存储器与灭菌设备一起设置在腔室内，以在腔室中建立无菌状态。机器人手臂可握持和操作注射器，以通过用注射器的针刺穿它们的封闭件从容器注射和/或抽取药物产品。

5. 发明申请

WO2017178895A1 METHOD AND APPARATUS FOR LOADING A LYOPHILIZATION SYSTEM 审中-公开
标题翻译：用于加载LYOPHILIZATION系统的方法和设备
公开(公告)号：WO2017178895A1
公开(公告)日：2017-10-19
申请号：PCT/IB2017/000576
申请日：2017-04-12
申请人： VANRX PHARMASYSTEMS INC.
发明人： SENGER, John , PROCYSHYN, Christopher , NAING, Juvenal
IPC分类号： B65B43/42 , A61J1/00 , A61J3/00 , A61J3/02 , B25J9/02 , B25J9/12 , B65B1/04
摘要： Disclosed are systems and methods for aseptically filling pharmaceutical containers with a pharmaceutical substance and then lyophilizing it. In one general aspect, the system and method can employ a lyophilizer loader subsystem having an interior chamber in communication with an interior chamber of a lyophilizer subsystem via a portal with a sealable door, with the collective interior being aseptically sealable. An articulated robotic arm can be employed to batch transfer to the lyophilizer subsystem container nests bearing the pharmaceutical containers. In one embodiment, the nests may be transferred serially to the loader subsystem, with the articulated robotic arm being configured to transfer the nests of containers in batches to the lyophilizer subsystem. The articulated robotic arm can also be configured to be used to move batches of nests within the lyophilizer subsystem. One implementation includes two articulated arms and a joint rotary wrist driven by two rotary shoulders.
摘要翻译：公开了用药物无菌填充药物容器然后冻干它的系统和方法。在一个总体方面，所述系统和方法可以采用具有内部腔室的冻干器加载器子系统，所述内部腔室经由具有可密封门的入口与冷冻干燥器子系统的内部腔室连通，所述集体内部是无菌密封的。可以使用铰接式机器人臂将其分批传送至装有药物容器的冻干机子系统容器巢。在一个实施例中，巢可以顺序地传送到装载机子系统，其中关节式机器人臂被配置成将容器的巢成批地传送到冻干机子系统。铰接机器人手臂也可以配置成用于移动冻干器子系统内的一批巢。一种实施方式包括两个铰接臂和一个由两个旋转肩膀驱动的联合旋转腕。

6. 发明申请

WO2017072591A1 ASEPTIC ROBOTIC FILLING SYSTEM AND METHOD 审中-公开
标题翻译：无菌机器人充填系统和方法
公开(公告)号：WO2017072591A1
公开(公告)日：2017-05-04
申请号：PCT/IB2016/001739
申请日：2016-10-28
申请人： VANRX PHARMASYSTEMS INC.
发明人： DIAZ, Carlos
IPC分类号： B65B3/04 , A61J1/22 , B25J19/04 , B25J9/18
CPC分类号： A61J1/22 , B25J19/021 , B25J21/005 , B65B3/04
摘要： In one general aspect, a system for aseptically filling a tray of pharmaceutical containers with a pharmaceutical product is disclosed, which consists of an aseptic chamber, one or more articulated arms within the chamber, a sensor aseptically disposed with respect to the chamber, and a controller. The controller determines the locations of openings of the containers based on the image information from the sensor, and automatically guides one of the arms to fill the containers with the product. In order to obtain suitable contrast for accurately identifying the openings, an illuminator illuminates the tray with substantially collimated light. The sensor images the tray and containers using collimated light reflected from a reflective surface such as a retroreflector under the tray. To this end, the sensor may be disposed at a large enough distance from the retroreflector to collect largely the retroreflected light, or the sensor may employ a telecentric lens or a Fresnel lens. Further articulated arms move the tray and stopper the containers.
摘要翻译：在一个总体方面，公开了一种用药物产品无菌填充药物容器托盘的系统，其包括无菌腔室，腔室内的一个或多个铰接臂，无菌地布置的传感器相对于腔室，和一个控制器。控制器基于来自传感器的图像信息确定容器的开口的位置，并自动引导臂中的一个以用产品填充容器。为了获得用于准确识别开口的合适对比度，照明器用基本准直的光照亮托盘。传感器使用从反射表面（例如托盘下的回射器）反射的准直光来对托盘和容器成像。为此，传感器可以设置在距后向反射器足够大的距离处，以大量收集回射光，或者传感器可以采用远心透镜或菲涅耳透镜。进一步铰接的手臂移动托盘并塞住容器。

7. 发明申请

WO2015023924A2 METHOD, DEVICE AND SYSTEM FOR FILLING PHARMACEUTICAL CONTAINERS 审中-公开
标题翻译：方法，用于填充药物容器的装置和系统
公开(公告)号：WO2015023924A2
公开(公告)日：2015-02-19
申请号：PCT/US2014/051223
申请日：2014-08-15
申请人： VANRX PHARMASYSTEMS INC. , GOLD, Ross, M.
发明人： GOLD, Ross, M. , BROADBENT, Nick , IMMERZEEL, Jeroen , PROCYSHYN, Christopher, A. , PARK, Steve, Sang, Joon
IPC分类号： B65B55/04
CPC分类号： B65B7/161 , B65B3/003 , B65B7/2821 , B65B55/027 , B65B55/04 , B65B55/08 , B65B55/10 , B65B63/08 , B65D1/0246 , B65D51/00 , B65D51/002
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
摘要翻译：在一个一般方面，公开了一种用药物产品填充多个容器的方法，其包括在传送室中对密封的嵌套材料进行去污染，从密封的嵌套材料中去除容纳多个容器的容器嵌套中的一个或两个，以及封闭嵌套保持多个封闭件，从转移室转移到受控的环境中，包围所移除的嵌套，用药物产品无菌地填充容器，并且用多个封闭件封闭容器。巢被配置为允许同时密集多个闭合和容器同时闭合并同时闭合。封闭套管上的弹簧保持结构允许其可释放地将多个封闭件保持在相应的多个容器上方。在一些实施例中，弹簧加载特征与闭合套筒整体地集成。产品可以在部分密封的容器中冻干，同时密封封盖由封闭套管可释放地保持。

8. 发明申请

WO2020243824A1 PERISTALTIC PUMP-BASED APPARATUS AND METHOD FOR THE CONTROLLED DISPENSING OF FLUIDS 审中-公开
公开(公告)号：WO2020243824A1
公开(公告)日：2020-12-10
申请号：PCT/CA2020/050749
申请日：2020-06-01
申请人： VANRX PHARMASYSTEMS INC.
发明人： CICHY, Marcin , GUERRERO, Carlos Alberto Diaz
IPC分类号： F04B43/08 , A61J1/20 , B65B3/12 , B65B55/02 , F04B49/06
摘要： The present invention involves a rotary peristaltic pump and associated method employing the relaxation of pressure on flexible tubing between the rotor and stator of the pump to restore the rotor to a start angle while a valve on the output of the pump is closed to avoid progress of fluid through the system. Three different implementations of the pump and method are presented including reciprocating the stator, reciprocating the rotor, and retracting the idler rollers of the rotor into the rotor to relieve the pressure on the flexible tubing. A controller ensures the appropriate switching and timing of the valve and rotor of the pump. The pump and associated method are directed to the precision dispensing of pharmaceutical fluids into containers, including containers held in container nests.

9. 发明申请

WO2019213746A1 METHOD, DEVICE AND SYSTEM FOR FILLING PHARMACEUTICAL CONTAINERS 审中-公开
公开(公告)号：WO2019213746A1
公开(公告)日：2019-11-14
申请号：PCT/CA2019/050556
申请日：2019-04-29
申请人： VANRX PHARMASYSTEMS INC.
发明人： GUERRERO, Carlos Alberto Diaz
IPC分类号： G01B21/20 , A61J1/18 , B65B31/00 , B65B5/00 , B65B55/00 , B65B57/00 , B65B7/00 , G01B11/24
摘要： The invention involves apparatus and method for confirming the presence/absence of closures (120) in a closure nest (100) inside an aseptic chamber (20). The apparatus comprises a topographical profiler (37, 41) disposed to monitor the closure nests. Vertical displacements in topographical maps obtained by the profiler are compared with information from a database about the nest and closure combinations. Vertical displacements falling outside predetermined upper and lower bounds are deemed absences of closures. The topographical profiler may be disposed outside the aseptic chamber. The system may be automated via a controller (51) and software. In some embodiments the nests are disposed in the monitored area by robotic articulated arms (22). In other embodiments the closure nests are moved by vacuum pickup systems (86). The system/method may also be employed to assess the suitability of a closure nest for closing in an aseptic chamber containers in a container nest (70).

10. 发明申请

WO2017098331A1 METHOD FOR PROTECTING AND UNPROTECTING THE FLUID PATH IN A CONTROLLED ENVIRONMENT ENCLOSURE 审中-公开
标题翻译：在受控环境中保护和防止流体路径的方法
公开(公告)号：WO2017098331A1
公开(公告)日：2017-06-15
申请号：PCT/IB2016/001958
申请日：2016-12-09
申请人： VANRX PHARMASYSTEMS INC
发明人： PROCYSHYN, Chris , CICHY, Marcin
IPC分类号： B65B3/04 , A61J1/14 , A61J1/20 , B25J9/18 , B65B55/12
CPC分类号： G01N35/10 , A61J1/14 , A61J1/20 , B01L3/02 , B01L2200/026 , B01L2200/0689 , B01L2200/141 , B01L2300/0609 , B65B3/003 , B65B3/04 , B65B55/12 , G01N35/00029 , G01N35/0099 , G01N2035/00148 , G01N2035/00277
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.
摘要翻译：受控环境外壳包括机器人手臂操纵系统，该机器人手臂操纵系统用于保护和解除受保护环境外壳内的流体路径和拭子。该设备允许流体路径在受控环境外壳被净化之前防止危险的净化蒸气和化学物质。该设备允许流体路径在没有使用手套或其他手段的情况下不受保护，这在完成去污时会降低受控环境外壳的完整性。该设备和方法允许保护，解除保护和去污染序列的自动化。在一些实施例中，流体路径包括填充针，填充针可以用一次性单片注塑聚合物填充针护套可移除地和无菌地密封。该设备和方法还允许使用置于拭子支架中的拭子，该拭子无菌且可去除地密封于拭子帽以保护拭子免受去污蒸气的侵害。

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