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1. 发明申请

WO2018025092A1 APPARATUS AND METHOD FOR ASEPTICALY FILLING PHARMACEUTICAL CONTAINERS WITH A PHARMACEUTICAL FLUID 审中-公开
标题翻译：用药物流体来恒温充填药物容器的装置和方法
公开(公告)号：WO2018025092A1
公开(公告)日：2018-02-08
申请号：PCT/IB2017/001183
申请日：2017-08-03
申请人： VANRX PHARMASYSTEMS INC
发明人： PROCYSHYN, Christopher , NIANG, Juvenal , SENGER, John , CICHY, Marcin
IPC分类号： A61J1/20 , A61J1/06 , B65B55/00 , B65B3/04
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
摘要翻译：公开了用药物流体无菌灌装药物容器的系统和方法。在一个总体方面，这些基于无菌密封的腔室，其包括传送壁，无菌地将预密封的药物源和接收容器安装到传送壁上。机器人臂和注射器存储器与灭菌设备一起设置在腔室内，以在腔室中建立无菌状态。机器人手臂可握持和操作注射器，以通过用注射器的针刺穿它们的封闭件从容器注射和/或抽取药物产品。

2. 发明申请

WO2017178895A1 METHOD AND APPARATUS FOR LOADING A LYOPHILIZATION SYSTEM 审中-公开
标题翻译：用于加载LYOPHILIZATION系统的方法和设备
公开(公告)号：WO2017178895A1
公开(公告)日：2017-10-19
申请号：PCT/IB2017/000576
申请日：2017-04-12
申请人： VANRX PHARMASYSTEMS INC.
发明人： SENGER, John , PROCYSHYN, Christopher , NAING, Juvenal
IPC分类号： B65B43/42 , A61J1/00 , A61J3/00 , A61J3/02 , B25J9/02 , B25J9/12 , B65B1/04
摘要： Disclosed are systems and methods for aseptically filling pharmaceutical containers with a pharmaceutical substance and then lyophilizing it. In one general aspect, the system and method can employ a lyophilizer loader subsystem having an interior chamber in communication with an interior chamber of a lyophilizer subsystem via a portal with a sealable door, with the collective interior being aseptically sealable. An articulated robotic arm can be employed to batch transfer to the lyophilizer subsystem container nests bearing the pharmaceutical containers. In one embodiment, the nests may be transferred serially to the loader subsystem, with the articulated robotic arm being configured to transfer the nests of containers in batches to the lyophilizer subsystem. The articulated robotic arm can also be configured to be used to move batches of nests within the lyophilizer subsystem. One implementation includes two articulated arms and a joint rotary wrist driven by two rotary shoulders.
摘要翻译：公开了用药物无菌填充药物容器然后冻干它的系统和方法。在一个总体方面，所述系统和方法可以采用具有内部腔室的冻干器加载器子系统，所述内部腔室经由具有可密封门的入口与冷冻干燥器子系统的内部腔室连通，所述集体内部是无菌密封的。可以使用铰接式机器人臂将其分批传送至装有药物容器的冻干机子系统容器巢。在一个实施例中，巢可以顺序地传送到装载机子系统，其中关节式机器人臂被配置成将容器的巢成批地传送到冻干机子系统。铰接机器人手臂也可以配置成用于移动冻干器子系统内的一批巢。一种实施方式包括两个铰接臂和一个由两个旋转肩膀驱动的联合旋转腕。

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