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1. 发明申请

WO2013156851A2 ARTICULATED ARM APPARATUS AND SYSTEM 审中-公开
标题翻译：武器装置和系统
公开(公告)号：WO2013156851A2
公开(公告)日：2013-10-24
申请号：PCT/IB2013/000801
申请日：2013-02-08
申请人： VANRX PHARMASYSTEMS, INC. , GOLD, Ross, M.
发明人： GOLD, Ross, M. , PROCYSHYN, Christopher, A. , IMMERZEEL, Jeroen , PARK, Steve, Sang, Joon
IPC分类号： A61J3/00
CPC分类号： B25J9/0009 , B25J9/0075 , B25J18/04 , B25J19/0075 , B25J21/00
摘要： A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber is disclosed. In one general aspect, it comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, interconnected hermetically sealed arm segments operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the arm segments. The rotational shaft can further be a linear motion shaft for which the sealing member is a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber can be compatible with an aseptic and cleanable environment and the surfaces of the arm segments can be shaped to avoid pooling of contaminants.
摘要翻译：公开了一种用于密封隔离器室内的气密密封多轴铰接臂装置。在一个一般方面，其包括通过腔室中的开口的旋转轴，设置在腔室内的密封构件，用于将轴密封到腔室的内表面，互连的气密密封臂段，可操作地连接到直线运动轴 ; 可操作地连接到臂段中的端子臂段的末端执行器和用于驱动和控制轴和臂段的至少一个完全封闭的驱动系统。旋转轴还可以是密封构件是波纹管的直线运动轴。暴露于室的气氛中的设备部件的材料可以与无菌和可清洁的环境兼容，并且臂段的表面可以被成形以避免污染物的汇集。

2. 发明申请

WO2015023924A2 METHOD, DEVICE AND SYSTEM FOR FILLING PHARMACEUTICAL CONTAINERS 审中-公开
标题翻译：方法，用于填充药物容器的装置和系统
公开(公告)号：WO2015023924A2
公开(公告)日：2015-02-19
申请号：PCT/US2014/051223
申请日：2014-08-15
申请人： VANRX PHARMASYSTEMS INC. , GOLD, Ross, M.
发明人： GOLD, Ross, M. , BROADBENT, Nick , IMMERZEEL, Jeroen , PROCYSHYN, Christopher, A. , PARK, Steve, Sang, Joon
IPC分类号： B65B55/04
CPC分类号： B65B7/161 , B65B3/003 , B65B7/2821 , B65B55/027 , B65B55/04 , B65B55/08 , B65B55/10 , B65B63/08 , B65D1/0246 , B65D51/00 , B65D51/002
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
摘要翻译：在一个一般方面，公开了一种用药物产品填充多个容器的方法，其包括在传送室中对密封的嵌套材料进行去污染，从密封的嵌套材料中去除容纳多个容器的容器嵌套中的一个或两个，以及封闭嵌套保持多个封闭件，从转移室转移到受控的环境中，包围所移除的嵌套，用药物产品无菌地填充容器，并且用多个封闭件封闭容器。巢被配置为允许同时密集多个闭合和容器同时闭合并同时闭合。封闭套管上的弹簧保持结构允许其可释放地将多个封闭件保持在相应的多个容器上方。在一些实施例中，弹簧加载特征与闭合套筒整体地集成。产品可以在部分密封的容器中冻干，同时密封封盖由封闭套管可释放地保持。

3. 发明申请

WO2013016248A1 METHOD FOR PROTECTING AND UNPROTECTING THE FLUID PATH IN A CONTROLLED ENVIRONMENT ENCLOSURE 审中-公开
标题翻译：控制环境环境中保护和保护流体路径的方法
公开(公告)号：WO2013016248A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047765
申请日：2012-07-20
申请人： VANRX PHARMACEUTICALS, INC. , IMMERZEEL, Jeroen , PROCYSHYN, Christopher, A. , GOLD, Ross, M. , PARK, Steve, Sang Joon
发明人： IMMERZEEL, Jeroen , PROCYSHYN, Christopher, A. , GOLD, Ross, M. , PARK, Steve, Sang Joon
IPC分类号： B01L1/00 , B25J21/00 , A61L2/00
CPC分类号： B01L1/025 , A61L2/07 , A61L2/16 , A61L2/24 , B01L2200/0689 , B01L2200/141 , B01L2300/0832 , B25J21/00 , C12M29/00 , C12M37/02 , C12M41/14 , G01N35/0099 , G01N2035/00277
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated.
摘要翻译：受控的环境外壳包括用于保护和取消保护受控环境外壳内的流体路径的机器人手臂操纵系统。该设备允许流体路径在被控制的环境外壳被净化之前被保护以防止危险的去污蒸汽和化学品，该方法不需要使用手套或其他降低受控环境外壳的完整性的手段。该装置类似地允许流体路径在不使用手套的情况下不受保护地使用，该方法不需要使用手套或在完成净化时降低受控环境外壳的完整性的其它方式。该装置和方法允许保护，不保护和净化序列被自动化。

4. 发明申请

WO2013166379A1 COVER REMOVAL SYSTEM FOR USE IN CONTROLLED ENVIRONMENT ENCLOSURES 审中-公开
标题翻译：用于控制环境的封盖拆除系统
公开(公告)号：WO2013166379A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039455
申请日：2013-05-03
申请人： VANRX PHARMACEUTICALS, INC. , GOLD, Ross, M.
发明人： GOLD, Ross, M. , PARK, Steve Sang Joon , PROCYSHYN, Christopher A. , IMMERZEEL, Jeroen , NOWACZYK, Paul
IPC分类号： B65B43/40
CPC分类号： B67B7/14 , B65B57/02 , B65B69/00 , B67B7/38
摘要： An apparatus and method are presented for removing container covers within a controlled environment enclosure without using gloves. The apparatus comprises an articulated arm apparatus and a gripping apparatus and can further comprise a controller. The articulated arm apparatus can be configurable for holding and moving a container in three dimensions; and the gripping apparatus can be configured for gripping a container cover sealing the container. The method comprises moving the container using the articulated arm apparatus while holding a gripping area of the container cover substantially stationary using the gripping apparatus. The apparatus can further comprise a sensor configured for supplying information to the controller for determining the location of the container cover gripping area and an orientation of the container cover. The method can further comprise inspecting the container cover using the sensor. The container can be moved along a path and within a space determined by the controller.
摘要翻译：提供了一种用于在不使用手套的情况下移除受控环境外壳内的容器盖的装置和方法。该装置包括铰接臂装置和夹持装置，并且还可包括控制器。铰接臂装置可以被配置成用于在三维中保持和移动容器; 并且夹持装置可以构造成用于夹紧密封容器的容器盖。该方法包括使用铰接臂装置移动容器，同时使用夹持装置将容器盖的抓握区域基本上保持固定。该装置还可以包括被配置为向控制器提供信息以确定容器盖夹持区域的位置和容器盖的取向的传感器。该方法还可以包括使用传感器检查容器盖。容器可以沿着路径移动并且在由控制器确定的空间内移动。

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