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1. 发明申请

WO2005101993A9 METAL-CONTAINING NANOLAYERED COMPOSITES, AND APPLICATIONS THEREOF 审中-公开
标题翻译：含金属纳米复合材料及其应用
公开(公告)号：WO2005101993A9
公开(公告)日：2006-06-01
申请号：PCT/US2004043745
申请日：2004-12-23
申请人： TUFTS COLLEGE , VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
发明人： VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
IPC分类号： A61K47/48 , A61K49/18 , C07K14/435 , C07K14/78
CPC分类号： C07K14/78 , A61K47/62 , A61K49/0019 , A61K49/0056 , B82Y5/00 , C07K14/43586
摘要： Disclosed are peptide-metal composite materials that comprise small linear polypeptides at least some of which feature rare-earth metals coordinated to acids or bases in their side chains. The resulting composites crystallize in smectic-like arrays over length scales much longer than those of the molecular dimensions. The resulting crystals (1-2 mg) were insulating and transparent in the visible spectrum. The rare earths form quasi-two dimensional sheets with a separation distance determined by the linear dimension of the oligopeptide. The magnetization, M(B,T), was determined down to 2 K and in fields to 5.5 T using SQUID magnetometry. All samples were paramagnetic. Crystalline electric field modification of the magnetization was evident in isothermal M(B) for dysprosium (Dy)-based composites.
摘要翻译：公开了包含小线性多肽的肽 - 金属复合材料，其中至少一些具有在侧链中与酸或碱配位的稀土金属。所得到的复合材料在长度尺度上比在分子尺寸上长得多的近晶形阵列中结晶。所得晶体（1-2mg）在可见光谱中是绝缘的和透明的。稀土形成具有由寡肽的线性尺寸确定的间隔距离的准二维片。使用SQUID磁力计将磁化强度M（B，T）确定为2K，场测定为5.5T。所有样品均为顺磁性。在镝（Dy）基复合材料的等温M（B）中，磁化的结晶电场改变是明显的。

2. 发明申请

WO2004041845A2 TEMPLATED NATIVE SILK SMECTIC GELS 审中-公开
标题翻译：模压原丝绸SMECTIC GELS
公开(公告)号：WO2004041845A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034684
申请日：2003-10-31
申请人： TRUSTEES OF TUFTS COLLEGE , VALLUZZI, Regina , JIN, Hyoung-Joon , PARK, Jaehyung
发明人： VALLUZZI, Regina , JIN, Hyoung-Joon , PARK, Jaehyung
IPC分类号： C07K
CPC分类号： A61K47/42 , C07K14/43586 , Y10T436/25375
摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.
摘要翻译：本发明的一个方面涉及一种通过溶剂模板法制备纤维蛋白质近晶水凝胶的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 并收集所得到的纤维蛋白质近晶凝胶并使其干燥。本发明的另一方面涉及从外消旋混合物主要获得一种对映异构体的方法，其包括将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中的步骤; 密封容器并使其在约室温下老化; 允许外消旋混合物的对映体选择性地扩散到溶液中的近晶水凝胶中; 从溶液中除去近晶凝胶; 从近晶水凝胶的表面主要漂洗一种对映异构体; 并从近晶水凝胶的内部主要提取一种对映异构体。本发明还涉及根据上述方法制备的近晶型水凝胶。

3. 发明申请

WO2007075609A2 PRODUCTION OF CHIRAL MATERIALS USING CRYSTALLIZATION INHIBITORS 审中-公开
标题翻译：用结晶抑制剂生产手性材料
公开(公告)号：WO2007075609A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048312
申请日：2006-12-19
申请人： EVOLVED NANOMATERIAL SCIENCES, INC. , VALLUZZI, Regina , LIU, Liya
发明人： VALLUZZI, Regina , LIU, Liya
CPC分类号： C07B57/00 , B01D15/3833 , B01J20/24 , B01J20/26 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/28023 , B01J20/28047 , B01J20/28083 , B01J20/28095 , B01J20/285 , B01J20/287 , B01J20/29 , B01J20/3092 , B01J20/3208 , B01J20/3246 , B01J31/061 , B01J31/068 , B01J31/165 , B01J2220/4856 , B01J2220/54 , B01J2220/58 , Y10T428/2982
摘要： A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it to form a gel. The gel in wet or dried form is useful for performing chiral separations.
摘要翻译：公开了一种生产手性凝胶的方法。包含手性单体例如蛋白质的聚合物被溶解以产生溶胶，其任选透析。溶胶与结晶抑制剂接触，使其形成凝胶。湿或干燥形式的凝胶可用于进行手性分离。

4. 发明申请

WO2007075608A1 PARTICULATE CHIRAL SEPARATION MATERIAL 审中-公开
标题翻译：颗粒状分离材料
公开(公告)号：WO2007075608A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/048311
申请日：2006-12-19
申请人： EVOLVED NANOMATERIAL SCIENCES, INC. , VALLUZZI, Regina , LIU, Liya , SPROUT, Christopher , CHALONER-GILL, Benjamin
发明人： VALLUZZI, Regina , LIU, Liya , SPROUT, Christopher , CHALONER-GILL, Benjamin
IPC分类号： B01J20/29 , C07B57/00
CPC分类号： C07B57/00 , B01D15/3833 , B01J20/24 , B01J20/26 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/28023 , B01J20/28047 , B01J20/28083 , B01J20/28095 , B01J20/285 , B01J20/287 , B01J20/29 , B01J20/3092 , B01J20/3208 , B01J20/3246 , B01J31/061 , B01J31/068 , B01J31/165 , B01J2220/4856 , B01J2220/54 , B01J2220/58 , Y10T428/2982
摘要： A chiral particulate material and method of making the same are provided. The material includes a fibrous protein or chiral synthetic polymer, optionally crosslinked, organized into a multilayered chiral structure including nanoscale chiral pores or channels. The particles are useful for performing chiral separations, including in chromatographic applications.
摘要翻译：提供手性颗粒材料及其制备方法。该材料包括任选交联的纤维蛋白质或手性合成聚合物，其被组织成包括纳米级手性孔或通道的多层手性结构。这些颗粒可用于进行手性分离，包括色谱应用。

5. 发明申请

WO2005101993A2 METAL-CONTAINING NANOLAYERED COMPOSITES, AND APPLICATIONS THEREOF 审中-公开
标题翻译：含金属纳米复合材料及其应用
公开(公告)号：WO2005101993A2
公开(公告)日：2005-11-03
申请号：PCT/US2004/043745
申请日：2004-12-23
申请人： TRUSTEES OF TUFTS COLLEGE , VALLUZZI, Regina , HAAS, Terry, E. , GUERTIN, Robert, P. , HUANG, Jia , JIN, Hyoung-Joon
发明人： VALLUZZI, Regina , HAAS, Terry, E. , GUERTIN, Robert, P. , HUANG, Jia , JIN, Hyoung-Joon
IPC分类号： A61K47/48 , A61K49/18 , C07K14/435 , C07K14/78
CPC分类号： C07K14/78 , A61K47/62 , A61K49/0019 , A61K49/0056 , B82Y5/00 , C07K14/43586
摘要： Disclosed are peptide-metal composite materials that comprise small linear polypeptides at least some of which feature rare-earth metals coordinated to acids or bases in their side chains. The resulting composites crystallize in smectic-like arrays over length scales much longer than those of the molecular dimensions. The resulting crystals (1-2 mg) were insulating and transparent in the visible spectrum. The rare earths form quasi-two dimensional sheets with a separation distance determined by the linear dimension of the oligopeptide. The magnetization, M(B,T), was determined down to 2 K and in fields to 5.5 T using SQUID magnetometry. All samples were paramagnetic. Crystalline electric field modification of the magnetization was evident in isothermal M(B) for dysprosium (Dy)-based composites.
摘要翻译：公开了包含小线性多肽的肽 - 金属复合材料，其中至少一些具有在侧链中与酸或碱配位的稀土金属。所得到的复合材料在长度尺度上比分子尺寸长得多的近晶系阵列中结晶。所得晶体（1-2mg）在可见光谱中是绝缘的和透明的。稀土形成具有由寡肽的线性尺寸确定的间隔距离的准二维片。使用SQUID磁力计将磁化强度M（B，T）确定为2K，场测定为5.5T。所有样品均为顺磁性。在镝（Dy）基复合材料的等温M（B）中，磁化的结晶电场改变是明显的。

6. 发明申请

WO2005101993A3 METAL-CONTAINING NANOLAYERED COMPOSITES, AND APPLICATIONS THEREOF 审中-公开
标题翻译：含金属纳米复合材料及其应用
公开(公告)号：WO2005101993A3
公开(公告)日：2009-03-19
申请号：PCT/US2004043745
申请日：2004-12-23
申请人： TUFTS COLLEGE , VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
发明人： VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
IPC分类号： A61K38/00 , A61K47/48 , A61K49/18 , C07K14/435 , C07K14/78 , C07K17/00
CPC分类号： C07K14/78 , A61K47/62 , A61K49/0019 , A61K49/0056 , B82Y5/00 , C07K14/43586
摘要： Disclosed are peptide-metal composite materials that comprise small linear polypeptides at least some of which feature rare-earth metals coordinated to acids or bases in their side chains. The resulting composites crystallize in smectic-like arrays over length scales much longer than those of the molecular dimensions. The resulting crystals (1-2 mg) were insulating and transparent in the visible spectrum. The rare earths form quasi-two dimensional sheets with a separation distance determined by the linear dimension of the oligopeptide. The magnetization, M(B,T), was determined down to 2 K and in fields to 5.5 T using SQUID magnetometry. All samples were paramagnetic. Crystalline electric field modification of the magnetization was evident in isothermal M(B) for dysprosium (Dy)-based composites.
摘要翻译：公开了包含小线性多肽的肽 - 金属复合材料，其中至少一些具有在侧链中与酸或碱配位的稀土金属。所得到的复合材料在长度尺度上比分子尺寸长得多的近晶系阵列中结晶。所得晶体（1-2mg）在可见光谱中是绝缘的和透明的。稀土形成具有由寡肽的线性尺寸确定的间隔距离的准二维片。使用SQUID磁力计将磁化强度M（B，T）确定为2K，场测定为5.5T。所有样品均为顺磁性。在镝（Dy）基复合材料的等温M（B）中，磁化的结晶电场改变是明显的。

7. 发明申请

WO2007075609A3 PRODUCTION OF CHIRAL MATERIALS USING CRYSTALLIZATION INHIBITORS 审中-公开
标题翻译：使用结晶抑制剂生产手工材料
公开(公告)号：WO2007075609A3
公开(公告)日：2007-09-13
申请号：PCT/US2006048312
申请日：2006-12-19
申请人： EVOLVED NANOMATERIAL SCIENCES , VALLUZZI REGINA , LIU LIYA
发明人： VALLUZZI REGINA , LIU LIYA
IPC分类号： B01J20/29 , C07B57/00 , C07K14/435
CPC分类号： C07B57/00 , B01D15/3833 , B01J20/24 , B01J20/26 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/28023 , B01J20/28047 , B01J20/28083 , B01J20/28095 , B01J20/285 , B01J20/287 , B01J20/29 , B01J20/3092 , B01J20/3208 , B01J20/3246 , B01J31/061 , B01J31/068 , B01J31/165 , B01J2220/4856 , B01J2220/54 , B01J2220/58 , Y10T428/2982
摘要： A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it to form a gel. The gel in wet or dried form is useful for performing chiral separations.
摘要翻译：公开了一种用于制备手性凝胶的方法。将包含手性单体（例如蛋白质）的聚合物溶解以产生任选地透析的溶胶。将该溶胶与允许其形成凝胶的结晶抑制剂接触。湿或干燥形式的凝胶可用于进行手性分离。

8. 发明申请

WO2004041845A3 TEMPLATED NATIVE SILK SMECTIC GELS 审中-公开
标题翻译：模板天然丝绸SMECTIC凝胶
公开(公告)号：WO2004041845A3
公开(公告)日：2004-09-02
申请号：PCT/US0334684
申请日：2003-10-31
申请人： TUFTS COLLEGE , VALLUZZI REGINA , JIN HYOUNG-JOON , PARK JAEHYUNG
发明人： VALLUZZI REGINA , JIN HYOUNG-JOON , PARK JAEHYUNG
IPC分类号： A61K38/17 , C07K20060101 , C07K14/435
CPC分类号： A61K47/42 , C07K14/43586 , Y10T436/25375
摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.
摘要翻译：本发明的一个方面涉及一种通过溶剂模板化方法制备纤维蛋白质近晶水凝胶的方法，该方法包括以下步骤：将含水纤维蛋白质溶液倒入含有与水不混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 并收集得到的纤维蛋白质近晶水凝胶并使其干燥。本发明的另一方面涉及一种从外消旋混合物中主要获得一种对映体的方法，该方法包括以下步骤：将含水纤维蛋白质溶液倒入含有与水不混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 使外消旋混合物的对映体选择性地扩散到溶液中的近晶水凝胶中; 从溶液中除去近晶水凝胶; 主要从近晶型水凝胶表面漂洗一种对映体; 并从近晶状水凝胶内部主要提取一种对映体。本发明还涉及根据上述方法制备的近晶水凝胶。

9. 发明申请

WO2008088830A3 CHIRAL SEPARATING AGENTS WITH ACTIVE SUPPORT 审中-公开
标题翻译：有效支持的CHIRAL SEPARATING AGENTS
公开(公告)号：WO2008088830A3
公开(公告)日：2008-10-09
申请号：PCT/US2008000581
申请日：2008-01-16
申请人： EVOLVED NANOMATERIAL SCIENCES , VALLUZZI REGINA
发明人： VALLUZZI REGINA
IPC分类号： C02F1/28 , B01D21/28
CPC分类号： B01D15/3833 , B01J20/286 , B01J20/29 , G01N2030/027
摘要： A chiral stationary phase for use in chromatographic separation comprising a chiral selector compound and a chiral support material, wherein the chiral support material comprises a polymer comprising at least 30% chiral monomer of the same orientation.
摘要翻译：用于色谱分离的手性固定相包含手性选择剂化合物和手性载体材料，其中所述手性载体材料包含含有至少30％相同取向的手性单体的聚合物。

10. 发明申请

WO2008088830A2 CHIRAL SEPARATING AGENTS WITH ACTIVE SUPPORT 审中-公开
标题翻译：主动支持的CHIRAL分离代理
公开(公告)号：WO2008088830A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/000581
申请日：2008-01-16
申请人： EVOLVED NANOMATERIAL SCIENCES, INC. , VALLUZZI, Regina
发明人： VALLUZZI, Regina
IPC分类号： G01N30/02
CPC分类号： B01D15/3833 , B01J20/286 , B01J20/29 , G01N2030/027
摘要： A chiral stationary phase for use in chromatographic separation comprising a chiral selector compound and a chiral support material, wherein the chiral support material comprises a polymer comprising at least 30% chiral monomer of the same orientation.
摘要翻译：用于色谱分离的手性固定相，其包括手性选择剂化合物和手性载体材料，其中所述手性载体材料包含包含至少30％相同取向的手性单体的聚合物。

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