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1. 发明申请

WO2005101993A9 METAL-CONTAINING NANOLAYERED COMPOSITES, AND APPLICATIONS THEREOF 审中-公开
标题翻译：含金属纳米复合材料及其应用
公开(公告)号：WO2005101993A9
公开(公告)日：2006-06-01
申请号：PCT/US2004043745
申请日：2004-12-23
申请人： TUFTS COLLEGE , VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
发明人： VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
IPC分类号： A61K47/48 , A61K49/18 , C07K14/435 , C07K14/78
CPC分类号： C07K14/78 , A61K47/62 , A61K49/0019 , A61K49/0056 , B82Y5/00 , C07K14/43586
摘要： Disclosed are peptide-metal composite materials that comprise small linear polypeptides at least some of which feature rare-earth metals coordinated to acids or bases in their side chains. The resulting composites crystallize in smectic-like arrays over length scales much longer than those of the molecular dimensions. The resulting crystals (1-2 mg) were insulating and transparent in the visible spectrum. The rare earths form quasi-two dimensional sheets with a separation distance determined by the linear dimension of the oligopeptide. The magnetization, M(B,T), was determined down to 2 K and in fields to 5.5 T using SQUID magnetometry. All samples were paramagnetic. Crystalline electric field modification of the magnetization was evident in isothermal M(B) for dysprosium (Dy)-based composites.
摘要翻译：公开了包含小线性多肽的肽 - 金属复合材料，其中至少一些具有在侧链中与酸或碱配位的稀土金属。所得到的复合材料在长度尺度上比在分子尺寸上长得多的近晶形阵列中结晶。所得晶体（1-2mg）在可见光谱中是绝缘的和透明的。稀土形成具有由寡肽的线性尺寸确定的间隔距离的准二维片。使用SQUID磁力计将磁化强度M（B，T）确定为2K，场测定为5.5T。所有样品均为顺磁性。在镝（Dy）基复合材料的等温M（B）中，磁化的结晶电场改变是明显的。

2. 发明申请

WO2005101993A3 METAL-CONTAINING NANOLAYERED COMPOSITES, AND APPLICATIONS THEREOF 审中-公开
标题翻译：含金属纳米复合材料及其应用
公开(公告)号：WO2005101993A3
公开(公告)日：2009-03-19
申请号：PCT/US2004043745
申请日：2004-12-23
申请人： TUFTS COLLEGE , VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
发明人： VALLUZZI REGINA , HAAS TERRY E , GUERTIN ROBERT P , HUANG JIA , JIN HYOUNG-JOON
IPC分类号： A61K38/00 , A61K47/48 , A61K49/18 , C07K14/435 , C07K14/78 , C07K17/00
CPC分类号： C07K14/78 , A61K47/62 , A61K49/0019 , A61K49/0056 , B82Y5/00 , C07K14/43586
摘要： Disclosed are peptide-metal composite materials that comprise small linear polypeptides at least some of which feature rare-earth metals coordinated to acids or bases in their side chains. The resulting composites crystallize in smectic-like arrays over length scales much longer than those of the molecular dimensions. The resulting crystals (1-2 mg) were insulating and transparent in the visible spectrum. The rare earths form quasi-two dimensional sheets with a separation distance determined by the linear dimension of the oligopeptide. The magnetization, M(B,T), was determined down to 2 K and in fields to 5.5 T using SQUID magnetometry. All samples were paramagnetic. Crystalline electric field modification of the magnetization was evident in isothermal M(B) for dysprosium (Dy)-based composites.
摘要翻译：公开了包含小线性多肽的肽 - 金属复合材料，其中至少一些具有在侧链中与酸或碱配位的稀土金属。所得到的复合材料在长度尺度上比分子尺寸长得多的近晶系阵列中结晶。所得晶体（1-2mg）在可见光谱中是绝缘的和透明的。稀土形成具有由寡肽的线性尺寸确定的间隔距离的准二维片。使用SQUID磁力计将磁化强度M（B，T）确定为2K，场测定为5.5T。所有样品均为顺磁性。在镝（Dy）基复合材料的等温M（B）中，磁化的结晶电场改变是明显的。

3. 发明申请

WO2006104700A1 MAGNETIC PROTEIN NANOSENSORS AND METHODS OF USE 审中-公开
标题翻译：磁性蛋白纳米传感器及其使用方法
公开(公告)号：WO2006104700A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/009487
申请日：2006-03-15
申请人： TUFTS UNIVERSITY , GOLDBERG, Edward, H. , GUERTIN, Robert, P. , HARRAH, Timothy, P.
发明人： GOLDBERG, Edward, H. , GUERTIN, Robert, P. , HARRAH, Timothy, P.
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/54326
摘要： Nanometer-scale sensors useful in the detection of biological and chemical entities are formed from a protein rod body portion (41), a magnetic particle (42) affixed to the protein rod body portion (41); and an analyte binding moiety (43) disposed on the protein rod body portion (41) at a location remote from the magnetic particle (42), The analyte binding moiety specifically binds to the analyte (44) to form a sensor-analyte complex. The protein rod body portion may be formed from a tail fiber protein from a T even bacteriophage or a derivative thereof. Because binding of analyte to the sensor will change the overall shape and size, and thus the ability of the sensor to move within a liquid sample in response to an applied magnetic field, binding can be observed as a change in magnetic susceptibility or in relaxation time compared to that of a sensor in the absence of the analyte.
摘要翻译：用于检测生物和化学实体的纳米级传感器由蛋白质棒体部分（41），固定在蛋白质棒体部分（41）上的磁性颗粒（42））形成。和分析物结合部分（43），其在远离磁性颗粒（42）的位置处设置在蛋白质棒体部分（41）上。分析物结合部分特异性结合分析物（44）以形成传感器 - 分析物复合物。蛋白质棒体部分可以由T型噬菌体或其衍生物的尾纤维蛋白形成。因为分析物与传感器的结合将改变整体形状和尺寸，并因此改变传感器响应于所施加的磁场而在液体样品内移动的能力，所以可以观察到结合作为磁化率或弛豫时间的变化与不存在分析物的传感器相比。

4. 发明申请

WO2005101993A2 METAL-CONTAINING NANOLAYERED COMPOSITES, AND APPLICATIONS THEREOF 审中-公开
标题翻译：含金属纳米复合材料及其应用
公开(公告)号：WO2005101993A2
公开(公告)日：2005-11-03
申请号：PCT/US2004/043745
申请日：2004-12-23
申请人： TRUSTEES OF TUFTS COLLEGE , VALLUZZI, Regina , HAAS, Terry, E. , GUERTIN, Robert, P. , HUANG, Jia , JIN, Hyoung-Joon
发明人： VALLUZZI, Regina , HAAS, Terry, E. , GUERTIN, Robert, P. , HUANG, Jia , JIN, Hyoung-Joon
IPC分类号： A61K47/48 , A61K49/18 , C07K14/435 , C07K14/78
CPC分类号： C07K14/78 , A61K47/62 , A61K49/0019 , A61K49/0056 , B82Y5/00 , C07K14/43586
摘要： Disclosed are peptide-metal composite materials that comprise small linear polypeptides at least some of which feature rare-earth metals coordinated to acids or bases in their side chains. The resulting composites crystallize in smectic-like arrays over length scales much longer than those of the molecular dimensions. The resulting crystals (1-2 mg) were insulating and transparent in the visible spectrum. The rare earths form quasi-two dimensional sheets with a separation distance determined by the linear dimension of the oligopeptide. The magnetization, M(B,T), was determined down to 2 K and in fields to 5.5 T using SQUID magnetometry. All samples were paramagnetic. Crystalline electric field modification of the magnetization was evident in isothermal M(B) for dysprosium (Dy)-based composites.
摘要翻译：公开了包含小线性多肽的肽 - 金属复合材料，其中至少一些具有在侧链中与酸或碱配位的稀土金属。所得到的复合材料在长度尺度上比分子尺寸长得多的近晶系阵列中结晶。所得晶体（1-2mg）在可见光谱中是绝缘的和透明的。稀土形成具有由寡肽的线性尺寸确定的间隔距离的准二维片。使用SQUID磁力计将磁化强度M（B，T）确定为2K，场测定为5.5T。所有样品均为顺磁性。在镝（Dy）基复合材料的等温M（B）中，磁化的结晶电场改变是明显的。

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