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1. 发明申请

WO2005019182A1 PYRAZOLYLMETHYLBENZAMIDE DERIVATIVES AS P2XT-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为P2XT-受体拮抗剂的吡唑并苯并噻吩衍生物
公开(公告)号：WO2005019182A1
公开(公告)日：2005-03-03
申请号：PCT/EP2004/009172
申请日：2004-08-16
申请人： BAYER HEALTHCARE AG , CONCEPCION, Arnel , INOUE, Tadashi , MOCHIZUKI, Yuki , MURAMATSU, Aiko , GANTNER, Florian , NAKASHIMA, Kosuke , URBAHNS, Klaus , BACON, Kevin, B.
发明人： CONCEPCION, Arnel , INOUE, Tadashi , MOCHIZUKI, Yuki , MURAMATSU, Aiko , GANTNER, Florian , NAKASHIMA, Kosuke , URBAHNS, Klaus , BACON, Kevin, B.
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07D403/06 , C07D405/12
摘要： The present invention relates to novel pyrazolylmethylbenzamide derivatives of formula (I), processes for preparing them and pharmaceutical preparations containing them. The pyrazolylmethylbenzamide derivatives of the present invention exhibit enhanced potency for P2X7 receptor antagonism and can be used for the prophylaxis and treatment of diseases associated with P2X7 receptor activity. More specifically, the pyrazolylmethylbenzamide derivatives of the. present invention are useful for treatment and prophylaxis of diseases as follows: rheumatoid arthritis, osteoarthritis, psoriasis, allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), hyperresponsiveness of the airway, septic shock, glomerulonephritis, irritable bowel disease, Crohn's disease, ulcerative: colitis, atherosclerosis, growth and metastases of malignant cells, myoblastic leukaemia, diabetes, Alzheimer's disease, meningitis, osteoporosis, burn injury, ischaemic heart disease, stroke and varicose veins.
摘要翻译：本发明涉及式（I）的新型吡唑基甲基苯甲酰胺衍生物，其制备方法和含有它们的药物制剂。本发明的吡唑基甲基苯甲酰胺衍生物对P2X7受体拮抗作用表现出增强的效力，可用于预防和治疗与P2X7受体活性相关的疾病。更具体地，吡唑基甲基苯甲酰胺衍生物。本发明可用于治疗和预防疾病如下：类风湿性关节炎，骨关节炎，牛皮癣，过敏性皮炎，哮喘，慢性阻塞性肺病（COPD），气道高反应性，败血性休克，肾小球性肾炎，肠易激综合征，克罗恩病，溃疡性结肠炎，动脉粥样硬化，恶性细胞的生长和转移，成肌细胞性白血病，糖尿病，阿尔茨海默氏病，脑膜炎，骨质疏松症，烧伤，缺血性心脏病，中风和静脉曲张。

2. 发明申请

WO2005014556A1 2-AMINOPYRIMIDINE DERIVATIVES 审中-公开
标题翻译： 2-氨基嘧啶衍生物
公开(公告)号：WO2005014556A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008225
申请日：2004-07-23
申请人： BAYER HEALTHCARE AG , SATO, Hiroki , FUKUSHIMA, Keiko , SHIMAZAKI, Makoto , URBAHNS, Klaus , SAKAI, Katsuya , GANTER, Florian , BACON, Kevin
发明人： SATO, Hiroki , FUKUSHIMA, Keiko , SHIMAZAKI, Makoto , URBAHNS, Klaus , SAKAI, Katsuya , GANTER, Florian , BACON, Kevin
IPC分类号： C07D239/04
CPC分类号： C07D239/48 , C07D403/04
摘要： The present invention relates to novel 2-aminopyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The 2-aminopyrimidine derivatives of the present invention exhibit enhanced potency for histamine H4 receptor antagonism and can be used for the prophylaxis and treatment of diseases associated with histamine H4 receptor activity. More specifically, the 2-aminopyrimidine derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: asthma, rhinitis, allergic diseases, chronic obstructed pulmonary disease (CORD), atherosclerosis and rheumatoid arthritis.
摘要翻译：本发明涉及新的2-氨基嘧啶衍生物，其制备方法和含有它们的药物制剂。本发明的2-氨基嘧啶衍生物对组胺H 4受体拮抗作用表现出增强的效力，可用于预防和治疗与组胺H 4受体活性相关的疾病。更具体地，本发明的2-氨基嘧啶衍生物可用于治疗和预防以下疾病：哮喘，鼻炎，过敏性疾病，慢性阻塞性肺疾病（CORD），动脉粥样硬化和类风湿性关节炎。

3. 发明申请

WO2003095420A1 HYDROXY TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES 审中-公开
标题翻译：羟基四氢萘基衍生物
公开(公告)号：WO2003095420A1
公开(公告)日：2003-11-20
申请号：PCT/EP2003/004395
申请日：2003-04-28
申请人： BAYER AKTIENGESELLSCHAFT , YURA, Takeshi , MOGI, Muneto , URBAHNS, Klaus , FUJISHIMA, Hiroshi , MASUDA, Tsutomu , MORIWAKI, Toshiya , YOSHIDA, Nagahiro , KOKUBO, Toshio , SHIROO, Masahiro , TAJIMI, Masaomi , TSUKIMI, Yasuhiro , YAMAMOTO, Noriyuki
发明人： YURA, Takeshi , MOGI, Muneto , URBAHNS, Klaus , FUJISHIMA, Hiroshi , MASUDA, Tsutomu , MORIWAKI, Toshiya , YOSHIDA, Nagahiro , KOKUBO, Toshio , SHIROO, Masahiro , TAJIMI, Masaomi , TSUKIMI, Yasuhiro , YAMAMOTO, Noriyuki
IPC分类号： C07C275/32
CPC分类号： C07C275/42 , C07C275/32 , C07C275/40
摘要： This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence, inflammatory disorders such as asthma and COPD.
摘要翻译：本发明涉及四氢萘衍生物及其盐，其可用作药物制剂的活性成分。本发明的四氢萘衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗急性尿失禁，膀胱过度活动症，慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，失禁，炎症性疾病如哮喘和COPD。

4. 发明申请

WO1996002547A1 DIOXO-THIOPYRANO-PYRIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：二氧thiopyranopyridine羧酸衍生物及其作为药物
公开(公告)号：WO1996002547A1
公开(公告)日：1996-02-01
申请号：PCT/EP1995002546
申请日：1995-06-30
申请人： BAYER AKTIENGESELLSCHAFT , URBAHNS, Klaus , HEINE, Hans-Georg , JUNGE, Bodo , SCHOHE-LOOP, Rudolf , SOMMERMEYER, Henning , GLASER, Thomas , WITTKA, Reilinde , DE VRY, Jean-Marie-Viktor
发明人： BAYER AKTIENGESELLSCHAFT
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Dioxo-thiopyrano-pyridine carboxylic acid derivatives of formula (I) are produced by reacting corresponding aldehydes with aminocrotonic acid ester and tetrahydrothiopyrane-3-one-1,1 dioxyde and oxidising the products thus obtained. The substances of the invention can be used as active agents in medicaments. They are selective modulators of the calcium-dependent potassium channels of high conductivity.
摘要翻译：二氧代噻喃并 - 吡啶羧酸的式（I）的羧酸衍生物可以通过用氨基巴豆酸酯和四氢噻喃-3-酮-1,1-二氧化物相应的醛反应，可以制备和氧化由此得到的产品。新颖的物质可被用作药品的活性成分。它们是钙依赖性钾通道具有大电导率的选择性调节剂。

5. 发明申请

WO2005040100A1 TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES 审中-公开
标题翻译：四氢萘和尿素衍生物
公开(公告)号：WO2005040100A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011008
申请日：2004-10-02
申请人： BAYER HEALTHCARE AG , BOUCHON, Axel , DIEDRICHS, Nicole , HERMANN, Achim , LUSTIG, Klemens , MEIER, Heinrich , PERNERSTORFER, Josef , REIßMÜLLER, Elke , MOGI, Muneto , YURA, Takeshi , FUJISHIMA, Hiroshi , SEKI, Masaomi , KORIYAMA, Yuji , YASOSHIMA, Kayo , MISAWA, Keiko , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , URBAHNS, Klaus , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang
发明人： BOUCHON, Axel , DIEDRICHS, Nicole , HERMANN, Achim , LUSTIG, Klemens , MEIER, Heinrich , PERNERSTORFER, Josef , REIßMÜLLER, Elke , MOGI, Muneto , YURA, Takeshi , FUJISHIMA, Hiroshi , SEKI, Masaomi , KORIYAMA, Yuji , YASOSHIMA, Kayo , MISAWA, Keiko , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , URBAHNS, Klaus , HAYASHI, Fumihiko , TSUKIMI, Yasuhiro , GUPTA, Jang
IPC分类号： C07C275/32
CPC分类号： C07C275/32 , A61K31/167 , A61K31/17 , A61K31/357 , A61K31/42 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/455 , A61K31/4706 , A61K31/472 , A61K31/517 , A61K47/54 , C07C233/29 , C07C233/75 , C07C235/24 , C07C235/38 , C07C235/56 , C07C235/64 , C07C237/04 , C07C275/30 , C07C275/38 , C07C2602/08 , C07C2602/10 , C07D209/18 , C07D213/40 , C07D213/56 , C07D213/89 , C07D215/46 , C07D217/22 , C07D239/94 , C07D261/14 , C07D285/06 , C07D317/66
摘要： This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD). BHC 03 2 001-Foreign-Countries - 66 - BHC 03 2 001-Foreign-Countries - 65 -
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢萘和脲衍生物及其盐。本发明的四氢萘和脲衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗泌尿系统疾病或病症，如逼尿肌过度活动（膀胱过度活动），尿失禁，神经源性逼尿肌反应性（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。 BHC 03 2 001 - 外国 - 66 - BHC 03 2 001 - 外国 - 65 -

6. 发明申请

WO2004052846A1 TETRAHYDRO-NAPHTHALENE DERIVATIVES 审中-公开
标题翻译：四氢萘衍生物
公开(公告)号：WO2004052846A1
公开(公告)日：2004-06-24
申请号：PCT/EP2003/013453
申请日：2003-11-28
申请人： BAYER HEALTHCARE AG , TAJIMI, Masaomi , KOKUBO, Toshio , SHIROO, Masahiro , TSUKIMI, Yasuhiro , YURA, Takeshi , URBAHNS, Klaus , YAMAMOTO, Noriyuki , MOGI, Muneto , FUJISHIMA, Hiroshi , MASUDA, Tsutomu , YOSHIDA, Nagahiro , MORIWAKI, Toshiya
发明人： TAJIMI, Masaomi , KOKUBO, Toshio , SHIROO, Masahiro , TSUKIMI, Yasuhiro , YURA, Takeshi , URBAHNS, Klaus , YAMAMOTO, Noriyuki , MOGI, Muneto , FUJISHIMA, Hiroshi , MASUDA, Tsutomu , YOSHIDA, Nagahiro , MORIWAKI, Toshiya
IPC分类号： C07C275/32
CPC分类号： C07D295/088 , C07C233/29 , C07C233/75 , C07C235/42 , C07C237/40 , C07C275/32 , C07C275/38 , C07C275/40 , C07C275/42 , C07C317/32 , C07C323/44 , C07C2602/10 , C07D207/27 , C07D211/22 , C07D211/46 , C07D211/62 , C07D295/135
摘要： This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
摘要翻译：本发明涉及四氢萘衍生物及其盐，其可用作药物制剂的活性成分。本发明的四氢萘衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁，膀胱过度活动症，急性尿失禁，慢性疼痛，神经性疼痛，手术后疼痛，类风湿关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，炎症性疾病，哮喘和COPD。

7. 发明申请

WO2004029055A1 FUSED AZOLE-PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：熔融的偶氮吡啶衍生物
公开(公告)号：WO2004029055A1
公开(公告)日：2004-04-08
申请号：PCT/EP2003/010377
申请日：2003-09-18
申请人： BAYER HEALTHCARE AG , SHIMADA, Mitsuyuki , MURATA, Toshiki , FUCHIKAMI, Kinji , TSUJISHITA, Hideki , OMORI, Naoki , KATO, Issei , MIURA, Mami , URBAHNS, Klaus , GANTNER, Florian , BACON, Kevin
发明人： SHIMADA, Mitsuyuki , MURATA, Toshiki , FUCHIKAMI, Kinji , TSUJISHITA, Hideki , OMORI, Naoki , KATO, Issei , MIURA, Mami , URBAHNS, Klaus , GANTNER, Florian , BACON, Kevin
IPC分类号： C07D487/04
CPC分类号： C07D471/14 , C07D487/04
摘要： The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (P13K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with P13K and particularly with P13K-γ activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoixnmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis. The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to P13K activity in a human or animal subject.
摘要翻译：本发明涉及霍夫唑唑吡啶衍生物，其制备方法和含有它们的药物制剂。本发明的稠合唑类嘧啶衍生物对磷脂酰肌醇-3-激酶（P13K）抑制的效力显着增强，特别是PI3K-γ抑制作用，可用于预防和治疗与P13K相关的疾病，特别是P13K-γ活性。更具体地说，本发明的唑类衍生物可用于治疗和预防以下疾病：炎性和免疫调节性疾病，如哮喘，特应性皮炎，鼻炎，过敏性疾病，慢性阻塞性肺病（COPD），脓毒性休克，关节疾病，自身免疫性疾病如类风湿性关节炎，格雷夫斯病，癌症，心肌收缩性疾病，心力衰竭，血栓栓塞，缺血和动脉粥样硬化。本发明的化合物还可用于肺动脉高压，肾衰竭，心脏肥大，以及神经变性疾病如帕金森病，阿尔茨海默病，糖尿病和局灶性缺血，因为这些疾病还涉及人或动物中的P13K活性学科。

8. 发明申请

WO2003055848A3 UREA DERIVATIVES AS VR1- ANTAGONISTS 审中-公开
公开(公告)号：WO2003055848A3
公开(公告)日：2003-07-10
申请号：PCT/EP2002/014216
申请日：2002-12-13
申请人： BAYER AKTIENGESELLSCHAFT , YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutomu , KOKUBO, Toshio , URBAHNS, Klaus , YOSHIDA, Nagahiro , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , TAKESHITA, Keisuke , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
发明人： YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutomu , KOKUBO, Toshio , URBAHNS, Klaus , YOSHIDA, Nagahiro , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , TAKESHITA, Keisuke , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
IPC分类号： C07C275/24
摘要： This invention relates to urea derivatives of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: (I) wherein Y is R 1 - R 6 and X have the same meanings given in the description, which is useful as an active ingredient of pharmaceutical preparations. The urea derivatives of the present invention has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.

9. 发明申请

WO2003055484A1 UREA DERIVATIVES 审中-公开
标题翻译：尿素衍生物
公开(公告)号：WO2003055484A1
公开(公告)日：2003-07-10
申请号：PCT/EP2002/014215
申请日：2002-12-13
申请人： BAYER AKTIENGESELLSCHAFT , YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutomu , KOKUBO, Toshio , URBAHNS, Klaus , YOSHIDA, Nagahiro , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , TAKESHITA, Keisuke , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
发明人： YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutomu , KOKUBO, Toshio , URBAHNS, Klaus , YOSHIDA, Nagahiro , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , TAKESHITA, Keisuke , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
IPC分类号： A61K31/428
CPC分类号： C07D333/54 , A61K31/365 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/428 , C07D209/08 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/10 , C07D249/18 , C07D277/62 , C07D277/64 , C07D277/72 , C07D277/74 , C07D307/83
摘要： A medicament which contains a urea derivative or a salt thereof as an active ingredient is disclosed. The medicament has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.
摘要翻译：公开了含有脲衍生物或其盐作为活性成分的药物。该药物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗急性尿失禁，膀胱过度活动症，慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，酸痛，神经损伤，局部缺血，神经变性，中风，失禁和/或炎症性疾病。

10. 发明申请

WO2003022277A1 ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗炎症和免疫疾病的CCR3拮抗剂的磺酰苯胺衍生物
公开(公告)号：WO2003022277A1
公开(公告)日：2003-03-20
申请号：PCT/EP2002/009873
申请日：2002-09-04
申请人： BAYER AKTIENGESELLSCHAFT , LI, Yingfu , WATANABE, Akihiko , LOWINGER, Timothy, B. , BACON, Kevin , KAWAMURA, Norihiro , SHINTANI, Takuya , KIKUCHI, Tetsuo , MORIWAKI, Toshiya , URBAHNS, Klaus , FUKUSHIMA, Keiko , NUNAMI, Noriko , YOSHINO, Takashi , MURATA, Toshiki , YAMAUCHI, Megumi , YOSHINO, Hiroko
发明人： LI, Yingfu , WATANABE, Akihiko , LOWINGER, Timothy, B. , BACON, Kevin , KAWAMURA, Norihiro , SHINTANI, Takuya , KIKUCHI, Tetsuo , MORIWAKI, Toshiya , URBAHNS, Klaus , FUKUSHIMA, Keiko , NUNAMI, Noriko , YOSHINO, Takashi , MURATA, Toshiki , YAMAUCHI, Megumi , YOSHINO, Hiroko
IPC分类号： A61K31/445
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译：本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。

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