专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004029055A1 FUSED AZOLE-PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：熔融的偶氮吡啶衍生物
公开(公告)号：WO2004029055A1
公开(公告)日：2004-04-08
申请号：PCT/EP2003/010377
申请日：2003-09-18
申请人： BAYER HEALTHCARE AG , SHIMADA, Mitsuyuki , MURATA, Toshiki , FUCHIKAMI, Kinji , TSUJISHITA, Hideki , OMORI, Naoki , KATO, Issei , MIURA, Mami , URBAHNS, Klaus , GANTNER, Florian , BACON, Kevin
发明人： SHIMADA, Mitsuyuki , MURATA, Toshiki , FUCHIKAMI, Kinji , TSUJISHITA, Hideki , OMORI, Naoki , KATO, Issei , MIURA, Mami , URBAHNS, Klaus , GANTNER, Florian , BACON, Kevin
IPC分类号： C07D487/04
CPC分类号： C07D471/14 , C07D487/04
摘要： The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (P13K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with P13K and particularly with P13K-γ activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoixnmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis. The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to P13K activity in a human or animal subject.
摘要翻译：本发明涉及霍夫唑唑吡啶衍生物，其制备方法和含有它们的药物制剂。本发明的稠合唑类嘧啶衍生物对磷脂酰肌醇-3-激酶（P13K）抑制的效力显着增强，特别是PI3K-γ抑制作用，可用于预防和治疗与P13K相关的疾病，特别是P13K-γ活性。更具体地说，本发明的唑类衍生物可用于治疗和预防以下疾病：炎性和免疫调节性疾病，如哮喘，特应性皮炎，鼻炎，过敏性疾病，慢性阻塞性肺病（COPD），脓毒性休克，关节疾病，自身免疫性疾病如类风湿性关节炎，格雷夫斯病，癌症，心肌收缩性疾病，心力衰竭，血栓栓塞，缺血和动脉粥样硬化。本发明的化合物还可用于肺动脉高压，肾衰竭，心脏肥大，以及神经变性疾病如帕金森病，阿尔茨海默病，糖尿病和局灶性缺血，因为这些疾病还涉及人或动物中的P13K活性学科。

IPRDB

热门服务

关于我们

友情链接

联系方式