发明申请
WO2014027965A1 WOUND DRESSING NANOMESH IMPREGNATED WITH HUMAN UMBILICAL CORD WHARTON'S JELLY STEM CELLS
审中-公开
基本信息:
- 专利标题： WOUND DRESSING NANOMESH IMPREGNATED WITH HUMAN UMBILICAL CORD WHARTON'S JELLY STEM CELLS
- 专利标题（中）：用人体脐带蛇皮干细胞引发的伤口纳米线
- 申请号：PCT/SG2013000348 申请日：2013-08-15
- 公开(公告)号：WO2014027965A1 公开(公告)日：2014-02-20
- 发明人： FONG CHUI YEE , CHOOLANI MAHESH , BISWAS ARIJIT , BONGSO TUAN ARIFFEEN , RAMAKRISHNA SEERAM
- 申请人： UNIV SINGAPORE
- 专利权人： UNIV SINGAPORE
- 当前专利权人： UNIV SINGAPORE
- 优先权： US201261683391 2012-08-15
- 主分类号： A61K35/44
- IPC分类号： A61K35/44 ; A61K9/70 ; A61K36/886 ; A61P17/02 ; C12N5/0797
摘要：
The invention is directed to a method of treating a wound (e.g., to suppress scar formation) in an individual in need thereof comprising contacting the wound with an effective amount of a composition comprising (i) Wharton's jelly stem cells (WJSCs), (ii) a cell culture medium that has been conditioned with WJSCs, (iii) a lysate of WJSCs, (iv) a cell culture medium that has been conditioned with WJSCs exposed to apoptotic skin cells and keloid cells, or (v) a combination thereof. The invention is directed to a medical dressing (e.g., pharmaceutical compositions) comprising Wharton's jelly stem cells (WJSCs), a cell culture medium that has been conditioned with WJSCs, a lysate of WJSCs, a cell culture medium that has been conditioned with WJSCs exposed to apoptotic skin cells and keloid cells, or a combination thereof.
摘要（中）：
本发明涉及一种在有需要的个体中治疗伤口（例如，抑制瘢痕形成）的方法，包括使伤口与有效量的组合物接触，所述组合物包含（i）沃顿的果冻干细胞（WJSC），（ii 或已经用WJSC调理的细胞培养基，（iii）WJSCs的裂解物，（iv）用暴露于凋亡性皮肤细胞和瘢痕疙瘩细胞的WJSC调理的细胞培养基，或（v）其组合。 本发明涉及包含沃顿的果冻干细胞（WJSC）的药物敷料（例如药物组合物），已经用WJSC调理的细胞培养基，WJSCs的裂解物，用暴露于WJSC的WJSC调理的细胞培养基 凋亡皮肤细胞和瘢痕疙瘩细胞，或其组合。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |
| --------A61K35/02 | .来源于非生命物质的 |
| ----------A61K35/44 | ..眼；血管；脐带 |