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1. 发明申请

WO2004027377A3 ELECTROACTIVE MICROSPHERES AND METHODS 审中-公开
标题翻译：电活性微球和方法
公开(公告)号：WO2004027377A3
公开(公告)日：2004-09-23
申请号：PCT/US0329029
申请日：2003-09-19
申请人： UNIV NEW MEXICO STATE TECH TRA , WANG JOSEPH , POLSKY RONEN , TURNER KATHRYN L
发明人： WANG JOSEPH , POLSKY RONEN , TURNER KATHRYN L
IPC分类号： G01N33/543 , G01N33/553 , G01N33/53 , G01N21/00 , G01N21/76 , G01N33/533 , G01N33/536 , G01N33/538
CPC分类号： G01N33/54346 , C12Q1/6825 , G01N33/54326 , G01N33/553 , Y10S436/801 , Y10S436/805 , Y10S436/81 , Y10S436/815 , C12Q2537/125 , C12Q2563/116 , C12Q2563/149
摘要： Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair to be detected is bound, directly or through one or more intermediates, to the microsphere. Multiple specific binding pair members may be detected by use of electrochemically distinguishable electroactive markers. Microspheres with incorporated electroactive markers may include one or more functional groups for binding members of specific binding pairs, and are preferably insoluble in aqueous solvents but soluble in selected organic solvents.
摘要翻译：使用具有引入的电活性标记的微球体特异性结合对成员的电化学检测的方法和装置，其中要检测的特异性结合对的成员直接或通过一个或多个中间体结合到微球体。可以通过使用电化学上可区分的电活性标记来检测多个特异性结合对成员。具有引入的电活性标记的微球可以包括用于结合特异性结合对成员的一个或多个官能团，并且优选不溶于水性溶剂，但可溶于选定的有机溶剂。

2. 发明申请

WO02086077A2 CO-EXPRESSION OF ZEIN PROTEINS 审中-公开
标题翻译： IN蛋白的共表达
公开(公告)号：WO02086077A2
公开(公告)日：2002-10-31
申请号：PCT/US0212646
申请日：2002-04-18
申请人： UNIV NEW MEXICO STATE TECH TRA , KEMP JOHN D , RANDALL JENNIFER J
发明人： KEMP JOHN D , RANDALL JENNIFER J
IPC分类号： C07K14/425 , C12N15/62 , C12N15/82 , C12N
CPC分类号： C12N15/62 , C07K14/425 , C07K2319/02 , C12N15/8251
摘要： Methods and constructs for transformed plants and plant tissues that are capable of expressing high levels of stable proteins localized as protein bodies within the plant cell. Transformed plants co-expressing high levels of both the 15 kD and 10 kD zein proteins are disclosed which accumulate to high levels as protein bodies in the vegetative tissue of the plant. Transformed plants co-expressing the 15 kD and 10 kD zein proteins are useful for providing forage crops containing increased levels of sulfur containing amino acids, such as methionine, in the diet of animals that normally feed on such crops. In one embodiment, a stable protein body is expressed in a plant or plant tissue as a fusion protein comprising both the 15 kD and 10 kD zein proteins operably linked by a polypeptide or peptide linker. The protein bodies provided in the present invention are resistant to rumin digestion or environmental degradation.
摘要翻译：能够表达高水平的稳定蛋白质的转化植物和植物组织的方法和构建体，其定位为植物细胞内的蛋白质体。公开了共表达高水平的15kD和10kD玉米醇溶蛋白的转化植物，其在植物的营养组织中作为蛋白质体累积到高水平。共同表达15kD和10kD玉米醇溶蛋白的转化植物可用于在通常饲养这种作物的动物的饮食中提供含有含量高的含硫氨基酸（例如甲硫氨酸）的饲料作物。在一个实施方案中，稳定的蛋白质体在作为融合蛋白的植物或植物组织中表达，所述融合蛋白包含通过多肽或肽接头可操作地连接的15kD和10kD的玉米醇溶蛋白。在本发明中提供的蛋白质体对抗紫苏消化或环境降解是有抗性的。

3. 发明申请

WO0052465A3 BIOCHEMICAL MARKERS OF BRAIN FUNCTION 审中-公开
标题翻译：脑功能生物化学标记
公开(公告)号：WO0052465A3
公开(公告)日：2001-07-26
申请号：PCT/US0005592
申请日：2000-03-03
申请人： UNIV NEW MEXICO , BROOKS WILLIAM M , FRIEDMAN SETH D , JUNG REX J , PETROPOULOS HELEN , SIBBITT WILMER L , YEO RONALD
发明人： BROOKS WILLIAM M , FRIEDMAN SETH D , JUNG REX J , PETROPOULOS HELEN , SIBBITT WILMER L , YEO RONALD
IPC分类号： G01R33/28 , G01R33/48 , G01N33/483 , G01R33/483
CPC分类号： G01R33/483 , G01R33/4806
摘要： The present invention provides methods for determining brain functioning in an individual by measuring the amount of either N-acetylaspartate or choline in an individual's brain. The present invention also provides methods for determining a change in an individual's brain functioning due to a change in the concentration of N-acetylaspartate or choline in the individual's brain.
摘要翻译：本发明提供了通过测量个体脑中N-乙酰天冬氨酸或胆碱的量来测定个体脑功能的方法。本发明还提供了用于确定个体脑中N-乙酰天冬氨酸或胆碱浓度变化的个体脑功能变化的方法。

4. 发明申请

WO0065092A3 BLOCKING NON-SPECIFIC BINDING OF GRANULOCYTES IN MICROORGANISM DETECTION 审中-公开
标题翻译：微生物检测中颗粒细胞非特异性结合的阻断
公开(公告)号：WO0065092A3
公开(公告)日：2001-07-19
申请号：PCT/US0010873
申请日：2000-04-21
申请人： SCIENCE & TECHNOLOGY CORP , UNIV NEW MEXICO , THOMPSON CURTIS T , SPIDLE JOSEPH A , ALBERTSON DONNA G , SEGRAVES RICK
发明人： THOMPSON CURTIS T , SPIDLE JOSEPH A , ALBERTSON DONNA G , SEGRAVES RICK
IPC分类号： C12Q1/68 , G01N1/31 , B01L7/00
CPC分类号： C12Q1/689 , C12Q1/6806 , G01N1/312 , C12Q2527/125
摘要： This invention provides novel methods for detecting microorganisms is biological samples. The methods utilize in situ hybridization techniques. In one preferred embodiment, the methods involve blocking binding of nucleic acid probe(s) to granulocytes. The method typically involves contacting a biological sample with a nucleic acid probe that specifically hybridizes under stringent conditions to a nucleic acid of a microorganism and a blocking reagent that is a non-coding nucleic acid, washing the biological sample to remove probe that is not hybridized to a nucleic acid of the microorganism, and detecting the probe where the presence of remaining probe indicates the presence of the microorganism.
摘要翻译：本发明提供了检测微生物的新方法是生物样品。该方法利用原位杂交技术。在一个优选的实施方案中，所述方法包括阻断核酸探针与粒细胞的结合。该方法通常包括使生物样品与在严格条件下与微生物核酸和作为非编码核酸的封闭试剂特异性杂交的核酸探针接触，洗涤生物样品以除去未杂交的探针涉及微生物的核酸，并检测其中存在的探针表明存在微生物的探针。

5. 发明申请

WO0065093A2 IN SITU HYBRIDIZATION METHODS FOR REDUCING THE OCCURRENCE OF FALSE POSITIVES AND FOR TARGETING MULTIPLE MICROORGANISMS 审中-公开
标题翻译：用于减少虚拟活动的现象和用于指导多个微生物的现场混合方法
公开(公告)号：WO0065093A2
公开(公告)日：2000-11-02
申请号：PCT/US0010874
申请日：2000-04-21
申请人： SCIENCE & TECHNOLOGY CORP , UNIV NEW MEXICO , THOMPSON CURTIS T , SPIDLE JOSEPH A
发明人： THOMPSON CURTIS T , SPIDLE JOSEPH A
IPC分类号： C12Q1/68 , G01N1/31 , B01L7/00
CPC分类号： C12Q1/689 , C12Q1/6841 , G01N1/312
摘要： This invention provides novel methods for detecting microorganisms in biological samples. The methods utilize in situ hybridization techniques. In one preferred embodiment, the methods performing an in situ hybridization using two or more probes specific to the same target microorganism where the probes are each labeled with different and distinguishable label or are themselves different and distinguishable. When the probes co-localize to the same feature they are scored as positive for the target microorganism corresponding to those eprobes. Where only a single probe localizes to the target the result is scored as negative and/or, optionally subject to re-testing or other further analysis.
摘要翻译：本发明提供用于检测生物样品中微生物的新方法。该方法利用原位杂交技术。在一个优选实施方案中，使用两种或更多种对同一靶微生物特异性的探针进行原位杂交的方法，其中探针各自用不同和可区分的标记物标记，或者本身不同且可区分。当探针共定位到相同的特征时，它们对于与这些eprobes相对应的靶微生物被评分为阳性。当只有一个探针定位到目标时，结果被评分为阴性和/或可选择进行重新测试或其他进一步的分析。

6. 发明申请

WO2006133347A3 METAL OXIDE NANOPARTICLES AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：金属氧化物纳米颗粒及其制备方法
公开(公告)号：WO2006133347A3
公开(公告)日：2008-11-20
申请号：PCT/US2006022245
申请日：2006-06-08
申请人： TOYOTA ENG & MFG NORTH AMERICA , UNIV NEW MEXICO , FANSON PAUL T , PHILLIPS JONATHAN , LUHRS CLAUDIA
发明人： FANSON PAUL T , PHILLIPS JONATHAN , LUHRS CLAUDIA
IPC分类号： B23K10/00
CPC分类号： C01G25/00 , B01J23/002 , B01J23/10 , B01J2523/00 , B82Y30/00 , C01B13/185 , C01F17/0025 , C01F17/0043 , C01G1/00 , C01G1/02 , C01G23/047 , C01G25/02 , C01P2002/34 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/32 , C01P2004/34 , C01P2004/53 , C01P2004/64 , C01P2004/82 , C01P2004/84 , C01P2006/12 , C09C1/3661 , Y10T428/2991 , B01J2523/31 , B01J2523/3712 , B01J2523/48
摘要： There is disclosed a process for producing metal oxide nanoparticles. The process includes the steps of: a) providing at least two precursor metal salt materials, b) passing the at least two precursor metal salt materials through a plasma torch forming a vaporized material, and then c) condensing the vaporized material forming a metal oxide nanoparticle.
摘要翻译：公开了一种生产金属氧化物纳米颗粒的方法。该方法包括以下步骤：a）提供至少两种前体金属盐材料，b）使至少两种前体金属盐材料通过形成气化材料的等离子体焰炬，然后c）冷凝形成金属氧化物的气化材料纳米粒子。

7. 发明申请

WO2008067002A3 AZOLE NUCLEOSIDES AND USE AS INHIBITORS OF RNA AND DNA VARIAL POLYMERASES 审中-公开
标题翻译：单核苷酸和用作RNA和DNA多肽的抑制剂
公开(公告)号：WO2008067002A3
公开(公告)日：2008-11-06
申请号：PCT/US2007078139
申请日：2007-09-11
申请人： SOUTHERN RES INST , UNIV NEW MEXICO , ARTERBURN JEFFREY B , JONSSON COLLEEN B , PARKER WILLIAM B
发明人： ARTERBURN JEFFREY B , JONSSON COLLEEN B , PARKER WILLIAM B
IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H5/06 , C07H19/044 , C07H19/056
CPC分类号： C07H5/04 , C07H5/06 , C07H19/044 , C07H19/056
摘要： Azole nucleosides represented by the formulae (I) and (II); wherein A = C or N B = C or N X = H; C 1 -C 6 alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclo, halogen such as F, C1, Br and I; OH, NH 2 , NH-(C 1 -C 6 alkyl, cycloalkyl, aryl, or heterocyclo); Z = H; C 1 -C 6 alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclo, halogen such as F, Cl, Br, I; OH, NH 2 , NH-(C 1 -C 6 alkyl, cycloalkyl, aryl, or heterocyclo; E= (CH 2 )HONHR 1 ; n is an integer from 0-6 and more typically 0-3; R 1 = aryl or heterocyclo; each of W, Y, R is individually selected from the group consisting of H; C 1 -C 6 alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclo; halogen such as F, Cl, Br, and I; O, OH, Oalkyl, Oaryl, NH 2 , NH-(C 1 -C 6 alkyl, cycloalkyl, aryl, or heterocyclo); provided that at least one of W, Y, and R is other than H and wherein both W and Y together can be =O; and each D individually is OH, Oalkyl, Oaryl, Fl and H;pharmaceutically acceptable salts thereof, prodrugs thereof and mixtures thereof are provided. Compounds of this disclosure are useful as inhibitors of viral RNA and DNA polymerases such as, but not limited to, Influenza, Hantaan Virus, Crimean Congo hemorrhagic fever virus, hepatitis B, hepatitis C, Polio, Coxsackie A and B, Rhino, Echo, orthopoxvirus (small pox), HIV, Ebola, and West Nile virus polymerases; and especially orthopoxvirus, HIV, and hepatitis B.
摘要翻译：由式（I）和（II）表示的唑类核苷; 其中A = C或N B = C或N X = H; C 1 -C 6烷基，环烷基，烯基，环烯基，炔基，芳基，杂环基，卤素如F，Cl，Br和I; OH，NH 2，NH-（C 1 -C 6烷基，环烷基，芳基或杂环）; Z = H; C 1 -C 6烷基，环烷基，烯基，环烯基，炔基，芳基，杂环基，卤素如F，Cl，Br，I; OH，NH 2，NH-（C 1 -C 6烷基，环烷基，芳基或杂环; E =（CH 3） 2 HONHR 1; n是0-6，更典型地0-3的整数; R 1 =芳基或杂环; W，Y R 1独立地选自H; C 1 -C 6烷基，环烷基，烯基，环烯基，炔基，芳基，杂环;卤素如F， Cl，Br和I; O，OH，O烷基，芳基，NH 2，NH-（C 1 -C 6烷基，环烷基，芳基或杂环基）;条件是W，Y和R中的至少一个不是H，并且其中W和Y一起可以是= O;并且每个D分别是OH，O烷基，芳基，F 1和H; 本公开的化合物可用作病毒RNA和DNA聚合酶的抑制剂，例如但不限于流感，汉坦病毒，克里米亚刚果出血热病毒，乙型肝炎，肝炎 C，脊髓灰质炎，柯萨奇A和B，犀牛，回声，正痘病毒（小痘），HIV，埃博拉和西尼罗病毒聚合酶; 尤其是正痘病毒，艾滋病毒和乙型肝炎。

8. 发明申请

WO02086451A3 ORGANOBORON ROUTE AND PROCESS FOR PREPARATION OF BORON NITRIDE 审中-公开
标题翻译： ORGANOBORON路线和制备硝酸硼的方法
公开(公告)号：WO02086451A3
公开(公告)日：2002-12-27
申请号：PCT/US0213082
申请日：2002-04-24
申请人： UNIV NEW MEXICO , PAINE ROBERT T , KROENKE WILLIAM J , PRUSS EUGENE A , WOOD GARY L , JANIK JERZY F
发明人： PAINE ROBERT T , KROENKE WILLIAM J , PRUSS EUGENE A , WOOD GARY L , JANIK JERZY F
IPC分类号： C01B21/064 , C01B21/082 , C04B41/50 , C04B41/87 , C30B25/00 , C01B3/10
CPC分类号： C30B25/005 , B82Y30/00 , C01B21/0646 , C01B21/0828 , C01P2002/01 , C01P2002/76 , C01P2004/03 , C01P2004/04 , C01P2004/10 , C01P2004/22 , C01P2004/32 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2006/80 , C04B41/009 , C04B41/5064 , C04B41/87 , C30B29/10 , C30B29/403 , C04B41/0072 , C04B41/4519 , C04B41/4545 , C04B35/04 , C04B35/10 , C04B35/48
摘要： An organoboron route and process for preparation of boron nitride utilizing aerosol assited vapor phase synthesis (AAVS) wherein organoboron precursors are nitrided in one or two heating steps, and wherein a boron oxide nitride intermediary composition is formed after the first heating step and may be further nitrided to form resultant sphroidal boron nitride powders including spheroidal particles that are smooth, bladed, have protruding whiskers, and are of turbostratic or hexagonal crystalline structure. The aerosol assisted vapor phase reactor system (AAVS) 10 comprises aerosol generator assembly 12, inert carrier gas source 14, nitriding source 16, connection systems 18, 18,'18," furnance 20, preferably, collection device 41.
摘要翻译：一种利用气溶胶气相合成（AAVS）制备氮化硼的有机硼路线和方法，其中有机硼前体在一个或两个加热步骤中被氮化，并且其中在第一加热步骤之后形成氧化硼氮化物中间体组合物，并且可以进一步氮化以形成所得的球形氮化硼粉末，其包括平滑，叶片的球形颗粒，具有突出的晶须，并且具有涡流或六方晶结构。气溶胶辅助气相反应器系统（AAVS）10包括气溶胶发生器组件12，惰性载气源14，氮化源16，连接系统18,18'，18，优选地为收集装置41的炉20。

9. 发明申请

WO0139715A3 ADJUSTABLE SUPPORT 审中-公开
标题翻译：可调整的支持
公开(公告)号：WO0139715A3
公开(公告)日：2002-01-10
申请号：PCT/US0032466
申请日：2000-11-29
申请人： UNIV NEW MEXICO , SLISHMAN SAMUEL
发明人： SLISHMAN SAMUEL
IPC分类号： A45B9/00 , A61F5/01 , A61F5/04 , A61F5/058 , A61H3/02 , F16B7/10 , A61F5/00
CPC分类号： A45B9/00 , A45B2009/007 , A61F5/01 , A61F5/04 , A61F5/05841 , A61H3/02 , F16B7/10
摘要： The present invention provides an adjustable support (300) that may be telescopically extendable, coarsely (322) and finely (344) adjustable, and providing a mechanical advantage while being readily transportable. The adjustable support may have two to three telescoping members (302, 308, 314) that next inside one another when not in use, and may be triangular, rectangular, or circular in cross section. The adjustable support may be used as a traction splint, a walking stick, ski pole, or a crutch.
摘要翻译：本发明提供了可调节的支撑件（300），其可伸缩地（322）和精细（344）可调节，并且在容易运输的同时提供机械优点。可调节的支撑件可以具有两到三个伸缩构件（302,308,314），其在不使用时彼此相邻，并且可以是三角形，矩形或圆形横截面。可调节支撑件可用作牵引夹板，手杖，滑雪杖或拐杖。

10. 发明申请

WO9952647B1 NON-PLANAR MICRO-OPTICAL STRUCTURES 审中-公开
标题翻译：非平面微光结构
公开(公告)号：WO9952647B1
公开(公告)日：1999-12-02
申请号：PCT/US9908279
申请日：1999-04-15
申请人： UNIV NEW MEXICO
发明人： PEAKE GREGORY , HERSEE STEPHEN , SARAGAN ANDREW
IPC分类号： B29D11/00 , C23C16/04 , G02B3/00 , G02B6/12 , G02B6/124 , H01L31/0232 , H01S3/00 , H01S5/026 , H01S5/10 , H01S5/183 , B05D1/32 , G02B6/32 , G02B27/10 , G02F1/33 , H01L29/20 , H01S3/08
CPC分类号： G02B3/0056 , B29D11/00365 , C23C16/045 , G02B6/1245 , G02B2006/12102 , G02B2006/12121 , H01L31/02327 , H01S5/0267 , H01S5/1089 , H01S5/18327 , H01S5/18388
摘要： In one embodiment, the present invention provides a microlens having very small focal length. The present invention also provides a non-planar microstructure having a covering layer which is slowly oxidizing or substantially free of oxygen. The present invention also provides methods for forming such microlenses and microstructures. In addition, the present invention provides a VCSEL which includes one or more non-planar microstructures of the present invention.
摘要翻译：在一个实施方案中，本发明提供了具有非常小的焦距的微透镜。本发明还提供了具有缓慢氧化或基本上不含氧的覆盖层的非平面微结构。本发明还提供了形成这种微透镜和微结构的方法。此外，本发明提供了一种VCSEL，其包括本发明的一个或多个非平面微结构。

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