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1. 发明申请

WO2013166444A3 BIOMARKER ANALYSIS USING SCODAPHORESIS 审中-公开
标题翻译：使用SCODAPHORESIS的生物标记分析
公开(公告)号：WO2013166444A3
公开(公告)日：2015-02-05
申请号：PCT/US2013039553
申请日：2013-05-03
申请人： BOREAL GENOMICS CORP , UNIV BRITISH COLUMBIA
发明人： MARZIALI ANDREA , WIGGIN MATTHEW , SHIBAHARA GOSUKE , VYSOTSKAIA VALENTINA SEMENOVNA
IPC分类号： C07K1/26 , C12Q1/68 , G01N27/447
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6816 , C12Q2565/607 , C12Q2565/125
摘要： The invention discloses methods and apparatus for characterizing trace nucleic acids that are biomarkers for disease. The methods and apparatus provide increased sensitivity to such trace nucleic acids, and allow analysis of nucleic acids present in a sample at only 0.01% of the wild-type sequences. The methods and apparatus are also designed for straightforward multiplexing, thus allowing pooling of clinical samples.
摘要翻译：本发明公开了用于表征作为疾病的生物标志物的痕量核酸的方法和装置。所述方法和装置提供对这些痕量核酸的增加的敏感性，并且允许仅在0.01％的野生型序列中分析样品中存在的核酸。该方法和装置也被设计用于简单的多路复用，从而允许汇集临床样品。

2. 发明申请

WO2015013596A2 METHOD AND DEVICE FOR MANUFACTURING POLYMER PARTICLES CONTAINING A THERAPEUTIC MATERIAL 审中-公开
标题翻译：用于制造含有治疗药物的聚合物颗粒的方法和装置
公开(公告)号：WO2015013596A2
公开(公告)日：2015-01-29
申请号：PCT/US2014048165
申请日：2014-07-25
申请人： UNIV BRITISH COLUMBIA
发明人： RAMSAY EUAN , TAYLOR ROBERT JAMES , WILD ANDRE , LEAVER TIM , WALSH COLIN
IPC分类号： A61K9/14
CPC分类号： A61K47/48923 , A61K9/5161 , A61K31/337 , A61K47/6939 , C12N15/87
摘要： Methods and devices for manufacturing polymer particles containing a therapeutic material and polymer conjugate particles.
摘要翻译：用于制造含有治疗材料和聚合物共轭物颗粒的聚合物颗粒的方法和装置。

3. 发明申请

WO2009089620A8 PROTEIN C RS2069915 AS A RESPONSE PREDICTOR TO SURVIVAL AND ADMINISTRATION OF ACTIVATED PROTEIN C OR PROTEIN C-LIKE COMPOUND 审中-公开
标题翻译：蛋白C RS2069915作为活化蛋白C或蛋白C类化合物的生存和施用的反应预测
公开(公告)号：WO2009089620A8
公开(公告)日：2012-04-26
申请号：PCT/CA2009000037
申请日：2009-01-15
申请人： UNIV BRITISH COLUMBIA , SIRIUS GENOMICS INC , WALLEY KEITH R , RUSSELL JAMES A , SIDDIQUI ASIM SAROSH , GORDON ANTHONY , WILLIAMS MARK D , MACIAS WILLIAM L , KIRKWOOD SANDRA CLOSE , LILLY CO ELI
发明人： WALLEY KEITH R , RUSSELL JAMES A , SIDDIQUI ASIM SAROSH , GORDON ANTHONY , WILLIAMS MARK D , MACIAS WILLIAM L , KIRKWOOD SANDRA CLOSE
IPC分类号： C40B40/06 , A61K38/48 , A61K45/00 , C07H21/00 , C12N9/64 , C12N15/57 , C12Q1/68 , C40B30/00 , G06F19/18 , G06F19/24
CPC分类号： A61K31/7088 , A61K38/4866 , A61K45/06 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18 , G06F19/24 , Y02A90/26 , A61K2300/00
摘要： Provided herein are methods, oligonucleotides and peptide nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C-like compound or susceptibility to major organ dysfunction or susceptibility to an inflammatory condition. The method generally comprises determining a genotype of said subject at one or more of polymorphic sites in the subject's protein C gene selected from one or more of the following: rs20069915 and one or more polymorphism sites in linkage disequilibrium thereto, selected from one or more of the following: rs2069910; rs2069916; rs2069924; rs2069931; rsl799808; rs2069920; and rs6714364 and may further involve comparing the determined genotype with known genotypes for the polymorphism that correspond with an improved response to treatment with activated protein C or protein C-like compound or correspond to susceptibility to major organ dysfunction or susceptibility to an inflammatory condition. Also provided are methods of treating subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
摘要翻译：本文提供的方法，寡核苷酸和肽核酸，组合物和试剂盒用于预测受试者对用活化蛋白C或蛋白质C样化合物治疗或对主要器官功能障碍或对炎性病症易感性的敏感性的反应。该方法通常包括在受试者的蛋白C基因中的一个或多个多态性位点确定所述受试者的基因型，所述多态性位点选自以下一个或多个：rs20069915和与其连锁不平衡的一个或多个多态性位点，其选自以下的一个或多个如下：rs2069910; rs2069916; rs2069924; rs2069931; rsl799808; rs2069920; 和rs6714364，并且可以进一步涉及将所确定的基因型与已知的多态性基因型进行比较，所述基因型对应于用活化的蛋白C或蛋白质C样化合物治疗的改善的应答，或对应于对主要器官功能障碍或对炎性病症的易感性的易感性。还提供了基于受试者的基因型用抗炎剂或抗凝血剂治疗受试者的方法。

4. 发明申请

WO2009109037A8 SELF-CONTAINED CAPILLARY ELECTROPHORESIS SYSTEM FOR INTERFACING WITH MASS SPECTROMETRY 审中-公开
标题翻译：包含大量光谱的自包含毛细管电泳系统
公开(公告)号：WO2009109037A8
公开(公告)日：2010-12-23
申请号：PCT/CA2009000242
申请日：2009-03-06
申请人： UNIV BRITISH COLUMBIA , MAXWELL ELIZABETH JANE , ZHONG XUEFEI , ZHANG HONG , CHEN DAVID DA YONG
发明人： MAXWELL ELIZABETH JANE , ZHONG XUEFEI , ZHANG HONG , CHEN DAVID DA YONG
IPC分类号： G01N27/447 , G01N30/60 , H01J49/26
CPC分类号： G01N27/4473 , B05B5/0255 , G01N27/447 , G01N30/7266 , H01J49/0431 , H01J49/167
摘要： A complete capillary electrophoresis (CE) system that is capable of providing a continuous flow of effluent at the exit of the flow-through outlet vial is provided. A self- contained capillary electrophoresis system with a flow-through outlet vial for interfacing with mass spectrometry includes a capillary having an upstream inlet end and a downstream terminus end; an electrically conductive hollow needle having an inner wall defining an internal tapered chamber, the internal tapered chamber dimensioned and configured to slidably accept the terminus end of the capillary, the capillary longitudinally inserted into and mounted within the internal tapered chamber to a distance whereby the terminus end of the capillary abuts the inner wall of the needle at the taper; and wherein a micro-reservoir is formed between the terminus end of the capillary and the downstream exit orifice.
摘要翻译：提供了一种完整的毛细管电泳（CE）系统，其能够在流过出口小瓶的出口处提供连续的流出物流。具有用于与质谱联用的流通出口小瓶的自包含毛细管电泳系统包括具有上游入口端和下游末端的毛细管; 导电中空针头，其具有限定内部锥形腔室的内壁，所述内部锥形腔室的尺寸和构造可滑动地接纳毛细管的末端，毛细管纵向插入并安装在内部锥形腔室内一段距离，毛细管的端部以锥度与针头的内壁相接; 并且其中在所述毛细管的末端和所述下游出口之间形成微贮器。

5. 发明申请

WO2009000070A1 ADAPTIVE SUNLIGHT REDIRECTOR 审中-公开
标题翻译：自适应太阳能重组器
公开(公告)号：WO2009000070A1
公开(公告)日：2008-12-31
申请号：PCT/CA2008001144
申请日：2008-06-16
申请人： UNIV BRITISH COLUMBIA , WHITEHEAD LORNE A , SCOTT JON DAVID EDWARD
发明人： WHITEHEAD LORNE A , SCOTT JON DAVID EDWARD
IPC分类号： F21V7/00 , F21S11/00 , G02B5/08 , G02B5/12
CPC分类号： F24J2/5417 , F24J2/067 , F24J2/14 , F24J2/16 , F24J2/18 , F24J2002/5482 , G02B17/061 , G02B26/0816 , Y02E10/47 , Y10T428/24083
摘要： Longitudinally adjacent plane mirrors (106?114) are pivotally interconnected in a columnar array (56) by non-stretching linkages (120) which constrain movement of the mirrors such that their normal vectors (115) remain parallel. Pivotable couplings (122, 124) in two mirrors permit movement of the mirrors with respect to mutually perpendicular axes (x, y) and prevent movement of the mirrors with respect to a third axis (z). Two actuators (117A, 117B) coupled to one of the pivotable couplings controllably move a selected mirror with respect to the mutually perpendicular axes (x, y). A first frame (116) couples the mirror columns together so that movement of the selected mirror moves all the mirrors in unison. The actuators controllably move the mirrors to orient the normal vectors such that the mirrors specularly reflect incident light in a preselected direction.
摘要翻译：纵向相邻的平面镜（106〜114）通过非拉伸连杆（120）以柱状阵列（56）枢转地相互连接，这限制了反射镜的运动，使得它们的法向矢量（115）保持平行。两个反射镜中的可转动联轴器（122,124）允许反射镜相对于相互垂直的轴线（x，y）移动，并防止反射镜相对于第三轴线（z）移动。联接到可枢转联接器之一的两个致动器（117A，117B）可相对于相互垂直的轴线（x，y）可控地移动所选择的反射镜。第一框架（116）将镜柱连接在一起，使得所选择的镜子的运动一致地移动所有的镜子。执行器可控制地移动反射镜以使法向矢量定向，使得反射镜以预选的方向镜面反射入射光。

6. 发明申请

WO2008019187A3 DETECTING AND TREATING DEMENTIA 审中-公开
标题翻译：检测和治疗痴呆症
公开(公告)号：WO2008019187A3
公开(公告)日：2008-04-17
申请号：PCT/US2007070008
申请日：2007-05-30
申请人： MAYO FOUNDATION , UNIV MANCHESTER , UNIV BRITISH COLUMBIA , VIB VZW , UNIV ANTWERPEN , HUTTON MICHAEL L , BAKER MATTHEW COLIN , GASS JENNIFER MAE , RADEMAKERS ROSA , ERIKSEN JASON , PICKERING-BROWN STUART M , MACKENZIE IAN REID ALEXANDER , FELDMAN HOWARD , KUMAR-SINGH SAMIR , VAN BROECKHOVEN CHRISTINE , CRUTS MARC
发明人： HUTTON MICHAEL L , BAKER MATTHEW COLIN , GASS JENNIFER MAE , RADEMAKERS ROSA , ERIKSEN JASON , PICKERING-BROWN STUART M , MACKENZIE IAN REID ALEXANDER , FELDMAN HOWARD , KUMAR-SINGH SAMIR , VAN BROECKHOVEN CHRISTINE , CRUTS MARC
IPC分类号： A61K38/16
CPC分类号： A61K48/005 , C07K14/435 , C12Q1/6809 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
摘要翻译：本文件涉及检测可能与痴呆相关的突变的方法和材料。例如，提供了用于检测PGRN核酸内的一个或多个突变的方法和材料。本文件还提供了检测颗粒体蛋白前体表达水平的方法和材料。另外，该文献涉及用于治疗患有神经退行性病症（例如痴呆）的哺乳动物的方法和材料。例如，提供了用于增加哺乳动物中PGRN多肽水平的方法和材料，以及用于鉴定可用于增加哺乳动物中PGRN多肽水平的试剂的方法和材料。

7. 发明申请

WO2007134460A8 PANCREATIC B-CELLS EXPRESSING ABCA1 AND USES THEREOF 审中-公开
标题翻译：胰腺B细胞表达ABCA1及其用途
公开(公告)号：WO2007134460A8
公开(公告)日：2008-03-13
申请号：PCT/CA2007000926
申请日：2007-05-23
申请人： UNIV BRITISH COLUMBIA , BRUNHAM LIAM , HAYDEN MICHAEL , VERCHERE BRUCE
发明人： BRUNHAM LIAM , HAYDEN MICHAEL , VERCHERE BRUCE
IPC分类号： C12Q1/02 , A61K48/00 , A61P3/10 , C12Q1/54 , C12Q1/60 , G01N33/74
CPC分类号： G01N33/507 , A61K48/00 , G01N2333/705
摘要： Methods for identifying ATP-binding cassette A1 (ABCA1) agonists using pancreatic B-cells capable of expressing ABCA1 are disclosed. Methods for increasing the expression of ABCA 1 in pancreatic B cells by providing an expression vector comprising pancreatic B-cell control sequences and a nucleic acid encoding ABCA1 are also disclosed. Pancreatic B-cells which express ABCA1 and agonists of ABCA 1 which modulate pancreatic B-cell function are used in treating and preventing the onset of type 2 diabetes mellitus.
摘要翻译：公开了使用能够表达ABCA1的胰腺B细胞鉴定ATP结合盒A1（ABCA1）激动剂的方法。还公开了通过提供包含胰腺B细胞控制序列的表达载体和编码ABCA1的核酸来增加胰腺B细胞中ABCA1表达的方法。表达ABCA1的胰腺B细胞和调节胰腺B细胞功能的ABCA1的激动剂用于治疗和预防2型糖尿病的发作。

8. 发明申请

WO2007112545A8 METHOD AND APPARATUS OF FUELLING AN INTERNAL COMBUSTION ENGINE WITH HYDROGEN AND METHANE 审中-公开
标题翻译：燃料燃烧内燃机与氢气和甲烷的方法与装置
公开(公告)号：WO2007112545A8
公开(公告)日：2008-02-14
申请号：PCT/CA2007000431
申请日：2007-03-13
申请人： WESTPORT POWER INC , UNIV BRITISH COLUMBIA , MUNSHI SANDEEP , MCTAGGART-COWAN GORDON P , ROGAK STEVEN N , BUSHE W KENDAL
发明人： MUNSHI SANDEEP , MCTAGGART-COWAN GORDON P , ROGAK STEVEN N , BUSHE W KENDAL
IPC分类号： F02D19/08 , F02B69/04 , F02M21/02 , F02M25/00
CPC分类号： F02M25/10 , C10L3/06 , F02B3/06 , F02B23/0657 , F02B23/0696 , F02B29/0468 , F02B37/00 , F02B43/10 , F02B69/04 , F02B2275/14 , F02B2275/16 , F02D19/022 , F02D19/024 , F02D19/0605 , F02D19/0644 , F02D19/0689 , F02D19/081 , F02D19/10 , F02M21/0215 , F02M21/0224 , F02M26/23 , F02M43/04 , F02M2200/46 , Y02T10/121 , Y02T10/123 , Y02T10/32 , Y02T10/36
摘要： A gaseous-fuelled internal combustion engine and a method of operating same are provided for improving combustion stability and reducing emissions of NOx, PM, and unburned hydrocarbons. The method comprises fuelling an internal combustion engine with hydrogen and natural gas, which can be directly injected into the combustion chamber together or introduced separately. Of the total gaseous fuel delivered to the engine, at least 5% by volume at standard temperature and pressure is hydrogen. For at least one engine operating condition, the ratio of fuel rail pressure to peak in-cylinder pressure is at least 1.5: 1. The engine comprises a combustion chamber defined by a cylinder, a cylinder head, and a piston movable within the cylinder; and a fuel injection valve operable for introducing the gaseous fuel mixture directly into the combustion chamber, or two separate fuel injection valves for introducing the methane and hydrogen separately. An electronic controller is in communication with actuator(s) for the fuel injection valve(s) for controlling timing for operating the fuel injection valve(s). The engine has a compression ratio of at least 14:1.
摘要翻译：提供一种气体燃料内燃机及其操作方法，用于提高燃烧稳定性并减少NOx，PM和未燃碳氢化合物的排放。该方法包括用氢气和天然气对内燃机进行燃料加注，其可以一起直接喷射到燃烧室中或分开引入。在发送到发动机的总气体燃料中，在标准温度和压力下至少5体积％是氢气。对于至少一个发动机操作条件，燃料轨压力与缸内压力之间的比率至少为1.5:1。发动机包括由气缸，气缸盖和在气缸内可移动的活塞限定的燃烧室; 以及可操作用于将气体燃料混合物直接引入燃烧室的燃料喷射阀或用于单独引入甲烷和氢气的两个单独的燃料喷射阀。电子控制器与用于燃料喷射阀的致动器连通，用于控制用于操作燃料喷射阀的定时。发动机的压缩比至少为14：1。

9. 发明申请

WO2006007730A8 METHOD OF ELECTROLYTICALLY DEPOSITING A PHARMACEUTICAL COATING ONTO A CONDUCTIVE OSTEAL IMPLANT 审中-公开
标题翻译：电导沉积导电性皮质植入物的药物涂层方法
公开(公告)号：WO2006007730A8
公开(公告)日：2006-08-17
申请号：PCT/CA2005001157
申请日：2005-07-21
申请人： UNIV BRITISH COLUMBIA , WANG RIZHI , DUAN KE , FAN YUWEI , BURT HELEN M , OXLAND THOMAS R , GARBUZ DONALD S , MASRI BASSAM A , DUNCAN CLIVE P
发明人： WANG RIZHI , DUAN KE , FAN YUWEI , BURT HELEN M , OXLAND THOMAS R , GARBUZ DONALD S , MASRI BASSAM A , DUNCAN CLIVE P
IPC分类号： A61L27/32 , A61L27/04 , A61L27/14 , A61L27/30 , A61L27/54 , C25D11/36
CPC分类号： A61L27/54 , A61L27/32 , A61L2300/112 , A61L2300/412 , A61L2300/606 , C25D9/04
摘要： A method of electrolytically depositing a pharmaceutical coating onto a conductive osteal implant. The implant is submerged into an electrolytic cell containing an electrolysis solution of the pharmaceutical and acts as a cathode. When current is applied to the electrolytic cell, the pharmaceutical coating forms on the implant. The pharmaceutical can comprise bisphosphonates, including calcium salts. The implants can comprise any conductive material suitable for use as an osteal implant. The implants can also be electrolytically coated with calcium phosphate before coating with a pharmaceutical.
摘要翻译：将药物涂层电解沉积到导电性骨植入物上的方法。将植入物浸入含有药物的电解溶液的电解池中，作为阴极。当电流施加到电解槽时，在植入物上形成药物涂层。药物可以包含二膦酸盐，包括钙盐。植入物可以包括适合用作骨植入物的任何导电材料。在用药物涂覆之前，植入物也可以用磷酸钙电解涂覆。

10. 发明申请

WO2004109286A3 METHODS FOR DETECTING AND TREATING CANCER USING PODOCALYXIN AND/OR ENDOGLYCAN 审中-公开
标题翻译：检测和治疗癌症的方法使用PODOCALYXIN和/或内吞
公开(公告)号：WO2004109286A3
公开(公告)日：2005-04-21
申请号：PCT/CA2004000857
申请日：2004-06-09
申请人： UNIV BRITISH COLUMBIA , MCNAGNY KELLY M , ROSKELLEY CALVIN , MERKENS HELEN , SOMASIRI ARUNA , HUNTSMAN DAVID
发明人： MCNAGNY KELLY M , ROSKELLEY CALVIN , MERKENS HELEN , SOMASIRI ARUNA , HUNTSMAN DAVID
IPC分类号： C07K16/28 , C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57415 , G01N33/574
摘要： Methods and kits for detecting cancer and monitoring cancer progression are described. The method involves analyzing a sample containing nucleic acids or proteins from a patient for decreased expression of endoglycan and/or increased expression of podocalyxin.
摘要翻译：描述了用于检测癌症和监测癌症进展的方法和试剂盒。该方法包括分析来自患者的含有核酸或蛋白质的样品，以降低内聚糖的表达和/或增加的足球蛋白的表达。

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