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1. 发明申请

WO2007120120A3 ATTENUATED HUMAN PARAINFLUENZA VIRUS, METHODS AND USES THEREOF 审中-公开
公开(公告)号：WO2007120120A3
公开(公告)日：2007-10-25
申请号：PCT/US2006/000666
申请日：2006-01-10
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SKIADOPOULOS, Mario H. , MURPHY, Brian R. , COLLINS, Peter L. , NOLAN, Sheila
发明人： SKIADOPOULOS, Mario H. , MURPHY, Brian R. , COLLINS, Peter L. , NOLAN, Sheila
IPC分类号： C12N7/04 , C07K14/115
摘要： The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.

2. 发明申请

WO2007117258A2 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型HEPATITIS病毒在细胞培养中的生长
公开(公告)号：WO2007117258A2
公开(公告)日：2007-10-18
申请号：PCT/US2006/024748
申请日：2006-06-26
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KAPLAN, Gerardo , KONDURU, Krishnamurthy
发明人： KAPLAN, Gerardo , KONDURU, Krishnamurthy
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供重组甲型肝炎病毒（HAV）核酸和允许其生长和复制的宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一种异源核酸片段。异源核酸可以编码选择性标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码在含有重组HAV核酸的细胞中希望表达的疫苗抗原或其它表达产物。本发明进一步提供允许生长和复制野生型HAV或HAV的细胞系，所述野生型HAV或HAV在细胞培养物中生长具有最小的突变。本发明还提供了用于生产HAV疫苗和用于监测HAV存在的环境和患者样品的方法。

3. 发明申请

WO2004091492A2 COMPUTER-BASED MODEL FOR IDENTIFICATION AND CHARACTERIZATION OF NON-COMPETITIVE INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTORS AND RELATED LIGAND-GATED ION CHANNEL RECEPTORS 审中-公开
标题翻译：基于计算机的非线性乙酰胆碱受体和相关配体离子通道受体非竞争性抑制剂鉴定和表征的模型
公开(公告)号：WO2004091492A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010978
申请日：2004-04-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , WAINER, Irving, W. , JOZWIAK, Krzysztof , MOADDEL, Ruin , RAVICHANDRAN, Sarangan , COLLINS, Jack, R.
发明人： WAINER, Irving, W. , JOZWIAK, Krzysztof , MOADDEL, Ruin , RAVICHANDRAN, Sarangan , COLLINS, Jack, R.
IPC分类号： A61K
CPC分类号： A61K31/43 , A61K31/00 , A61K38/00 , C07K1/00 , C07K14/70571 , G06F19/16 , G06F19/18
摘要： A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
摘要翻译：本发明提供了一种保存配体门控离子通道受体分子模型数据和/或用于建模所述受体的计算机系统的计算机可读介质。该分子模型可用于设计具有作为离子通道的非竞争性抑制剂的活性的新型化合物。本发明的优选实施方案涉及烟碱乙酰胆碱受体。还公开了具有作为配体门控离子通道受体的非竞争性抑制剂的活性的化合物以及用于抑制受体和治疗由受体功能介导的疾病或病症的方法。

4. 发明申请

WO2003101919A2 SCORPIONATE-LIKE PENDANT MACROCYCLIC LIGANDS, COMPLEXES AND COMPOSITIONS THEREOF, AND METHODS OF USING SAME 审中-公开
标题翻译：类似物的起始物大分子配体，其复合物及其组合物及其使用方法
公开(公告)号：WO2003101919A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/017460
申请日：2003-06-03
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BRECHBIEL, Martin, W. , CHONG, Hyun-Soon
发明人： BRECHBIEL, Martin, W. , CHONG, Hyun-Soon
IPC分类号： C07C
CPC分类号： C07D255/02 , A61K49/0002 , A61K51/0482
摘要： Substituted 1,4,7-triazacyclononane- N,N',N" -triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.
摘要翻译：取代的1,4,7-三氮杂环壬烷-N，N'，N“ - 三乙酸化合物与供体氨基侧基，其金属络合物，其组合物，以及用于诊断成像和治疗细胞病症的方法。

5. 发明申请

WO2003094860A2 USE OF HOMO SAPIENS CHROMOSOME 1 OPEN READING FRAME 28 (C1ORF28) IN THE DIAGNOSIS OF HYPERPARATHYROIDISM-JAW TUMOR SYNDROME 审中-公开
标题翻译： HOMO SAPIENS CHROMOSOME 1开放阅读框28（C1ORF28）在诊断高血压性肿瘤肿瘤综合征中的应用
公开(公告)号：WO2003094860A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/015081
申请日：2003-05-13
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , DUKE UNIVERSITY , CARPTEN, John , TRENT, Jeffrey , THAKKER, Rajesh
发明人： CARPTEN, John , TRENT, Jeffrey , THAKKER, Rajesh
IPC分类号： A61K
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156
摘要： The present invention provides an isolated or purified oligonucleotide consisting essentially of the nucleotide sequence of Clorf28 and comprising a mutation; a fragment of the oligonucleotide; a vector comprising the oligonucleotide or fragment thereof; a cell comprising the vector; an isolated or purified polypeptide encoded by the above oligonucleotide or fragment thereof; a method of detecting HPT-JT or a predisposition to HPT-JT in a human, which method comprises detecting either at least one mutation in a nucleic acid comprising the nucleotide sequence of C1orf28 or a mutant C1orf28 protein; and an antibody which binds to a mutant C1orf28 protein.
摘要翻译：本发明提供基本上由Clorf28的核苷酸序列组成并包含突变的分离或纯化的寡核苷酸; 寡核苷酸的片段; 包含寡核苷酸或其片段的载体; 包含载体的细胞; 由上述寡核苷酸或其片段编码的分离或纯化的多肽; 检测HPT-JT或人类HPT-JT倾向的方法，该方法包括检测包含C1orf28的核苷酸序列或突变体C1orf28蛋白的核酸中的至少一个突变; 和结合突变型C1orf28蛋白的抗体。

6. 发明申请

WO2003092630A2 IDENTIFICATION OF NOVEL BROADLY CROSS-REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES USING SEQUENTIAL ANTIGEN PANNING OF PHAGE DISPLAY LIBRARIES 审中-公开
标题翻译：使用噬菌体展示图案的序列抗原标记来鉴定新的广泛的交叉反应性中和人类单克隆抗体
公开(公告)号：WO2003092630A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/014292
申请日：2003-05-06
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , DIMITROV, Dimiter, S. , ZHANG, Mei-Yun
发明人： DIMITROV, Dimiter, S. , ZHANG, Mei-Yun
IPC分类号： A61K
CPC分类号： C12N15/1037 , A61K2039/505 , C07K16/005 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/73
摘要： The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
摘要翻译：本发明提供了使用噬菌体展示文库，根据这种方法获得的抗体以及包含其的融合蛋白和缀合物以及相关的分离或纯化的核酸分子的序列抗原淘选来鉴定新的广泛交叉反应性中和单克隆抗体的方法，载体，宿主细胞，组合物和用于抑制感染的方法，降低感染的严重性，治疗感染和抑制癌症。

7. 发明申请

WO2003090780A1 DIRECT CELL TARGET ANALYSIS 审中-公开
标题翻译：直接细胞目标分析
公开(公告)号：WO2003090780A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012734
申请日：2003-04-25
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , EMMERT-BUCK, Michael, R. , AHRAM, Mamoun
发明人： EMMERT-BUCK, Michael, R. , AHRAM, Mamoun
IPC分类号： A61K39/395
CPC分类号： H04B10/0731 , G01N33/5091 , G01N33/567 , G01N33/6857 , G01N2333/908 , H04B10/2916
摘要： Disclosed herein are Direct Cell Target Analysis ("DCTA") molecules and Direct Cell Target ("DCT") methods for directly targeting and acting upon biomolecules. These methods and molecules can be used with specific cells within complex, heterogeneous tissue such that target biomolecules can be procured for subsequent analysis or directly analyzed without the need for physical separation of the biomolecules from other cells or cell components in the population. In general, the methods involve use of a fusion molecule having a first moiety to identify and localize target cells within a tissue sample, and a second moiety to generate detectable products within the target cells that may be detected and subsequently analyzed, and optionally isolated.
摘要翻译：本文公开了用于直接靶向和作用于生物分子的直接细胞靶分析（“DCTA”）分子和直接细胞靶（“DCT”）方法。这些方法和分子可以与复杂的异质组织中的特定细胞一起使用，使得靶生物分子可以被采购用于随后的分析或直接分析，而不需要生物分子与群体中其他细胞或细胞组分的物理分离。通常，所述方法包括使用具有第一部分的融合分子来鉴定和定位组织样品中的靶细胞，以及第二部分以在靶细胞内产生可被检测和随后分析并任选分离的可检测产物。

8. 发明申请

WO2003062261A3 DMT-TIC DI- AND TRI-PEPTIDIC DERIVATIVES AND RELATED COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2003062261A3
公开(公告)日：2003-07-31
申请号：PCT/US2002/040770
申请日：2002-12-20
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , LAZARUS, Lawrence, H. , SALVADORI, Severo
发明人： LAZARUS, Lawrence, H. , SALVADORI, Severo
IPC分类号： C07K5/08
摘要： A compound of formula: wherein X is a spacer comprising one or more amino acid residues and Y comprises an aromatic group and related compositions and methods of use.

9. 发明申请

WO2003052079A2 MUTANTS OF HUMAN INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3) AND USES THEREOF 审中-公开
标题翻译：人胰岛素样生长因子结合蛋白-3（IGFBP-3）的突变体及其应用
公开(公告)号：WO2003052079A2
公开(公告)日：2003-06-26
申请号：PCT/US2002/040561
申请日：2002-12-17
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA represented by The Secretary, Department of Health and Human Services. , RECHLER, Mathew, M.
发明人： RECHLER, Mathew, M.
IPC分类号： C12N
CPC分类号： C07K14/4743 , A61K38/00
摘要： An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a mutant human IGFBP-3, which can inhibit DNA synthesis, can induce apoptosis, binds to neither human insulin growth factor-I (IGF-I), nor human insulin growth factor-II (IGF-II), and comprises a mutation at Y57; a vector comprising the same, a cell comprising and expressing the same, optionally in the form of a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a mutant human IGFBP-3, which can inhibit DNA synthesis, can induce apoptosis, binds to neither human IGF-I nor human IGF-II and comprises a mutation at Y57; a composition comprising the same; and a method of inducing apoptosis in a cell, which method comprises administering to the cell the nucleic acid molecule or polypeptide molecule, in an amount sufficient to induce apoptosis in the cell, whereupon apoptosis is induced in the cell.
摘要翻译：基本上由编码可抑制DNA合成的突变人IGFBP-3的核苷酸序列组成的分离或纯化的核酸分子可诱导细胞凋亡，既不与人胰岛素生长因子-I（IGF -I），也不是人胰岛素生长因子-II（IGF-II），并且在Y57包含突变; 包含其的载体，包含并表达其的细胞，任选地以载体的形式; 基本上由编码可抑制DNA合成的突变人IGFBP-3的氨基酸序列组成的分离或纯化的多肽分子可诱导细胞凋亡，既不与人IGF-I也不与人IGF-II结合，且在Y57包含突变; 包含该组合物的组合物; 以及诱导细胞凋亡的方法，该方法包括以足以诱导细胞凋亡的量向细胞施用核酸分子或多肽分子，随后在细胞中诱导凋亡。

10. 发明申请

WO2003047515A3 P2X7 RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2003047515A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038126
申请日：2002-11-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , JACOBSON, Kenneth, A.
发明人： JACOBSON, Kenneth, A.
IPC分类号： A61K31/495
摘要： Disclosed are antagonists of the P2X7 receptor in an animal, for example, an antagonist of the formula (I) which may be monomeric or dimeric; wherein R1-R3, for example, are aryl sulfonyl or heteroaryl sulfonyl; and R4 is H or alkyl. Also disclosed are pharmaceutical compositions comprising one or more of these antagonists and methods of using these antagonists, including blocking an ATP-induced toxic process in the blood cell of an animal, for example, in the treatment or prevention of septic shock, inflammation, stroke or neurodegenerative disease.

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