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1. 发明申请

WO2007117258A9 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型HEPATITIS病毒在细胞培养中的生长
公开(公告)号：WO2007117258A9
公开(公告)日：2008-04-17
申请号：PCT/US2006024748
申请日：2006-06-26
申请人： US GOV HEALTH & HUMAN SERV , KAPLAN GERARDO , KONDURU KRISHNAMURTHY
发明人： KAPLAN GERARDO , KONDURU KRISHNAMURTHY
IPC分类号： C12N15/86 , C12N5/00
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供重组甲型肝炎病毒（HAV）核酸和允许其生长和复制的宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一种异源核酸片段。异源核酸可以编码选择性标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码在含有重组HAV核酸的细胞中希望表达的疫苗抗原或其它表达产物。本发明进一步提供允许生长和复制野生型HAV或HAV的细胞系，所述野生型HAV或HAV在细胞培养物中生长具有最小的突变。本发明还提供了用于生产HAV疫苗和用于监测HAV存在的环境和患者样品的方法。

2. 发明申请

WO2012154203A3 FILOVIRUS FUSION PROTEINS AND THEIR USES 审中-公开
标题翻译： FILOVIRUS融合蛋白及其用途
公开(公告)号：WO2012154203A3
公开(公告)日：2013-03-21
申请号：PCT/US2011058418
申请日：2011-10-28
申请人： US GOV HEALTH & HUMAN SERV , U S ARMY MEDICAL RES INST OF INFECTIOUS DISEASES , KAPLAN GERARDO , KONDURU KRISHNAMURTHY , JACQUES JEROME , BAVARI SINA , BRADFUTE STEVEN
发明人： KAPLAN GERARDO , KONDURU KRISHNAMURTHY , JACQUES JEROME , BAVARI SINA , BRADFUTE STEVEN
IPC分类号： A61K39/12 , A61P31/14 , G01N33/50
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
摘要翻译：本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。融合蛋白也可用于诊断测定法以检测病毒感染。

3. 发明申请

WO2007117258A3 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型甲型肝炎病毒在细胞培养中的生长
公开(公告)号：WO2007117258A3
公开(公告)日：2008-06-12
申请号：PCT/US2006024748
申请日：2006-06-26
申请人： US GOV HEALTH & HUMAN SERV , KAPLAN GERARDO , KONDURU KRISHNAMURTHY
发明人： KAPLAN GERARDO , KONDURU KRISHNAMURTHY
IPC分类号： C12N15/86 , C12N5/00
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供了允许其生长和复制的重组甲型肝炎病毒（HAV）核酸和宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一个异源核酸片段。异源核酸可以编码选择标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码希望在携带重组HAV核酸的细胞中表达的疫苗抗原或其他表达产物。本发明进一步提供了允许野生型HAV或HAV生长和复制的细胞系，所述野生型HAV或HAV具有细胞培养物生长的最小突变。本发明进一步提供了产生HAV疫苗和监测环境和患者样品中HAV存在的方法。

4. 发明申请

WO2012154203A2 FILOVIRUS FUSION PROTEINS AND THEIR USES 审中-公开
标题翻译： FILOVIRUS融合蛋白及其用途
公开(公告)号：WO2012154203A2
公开(公告)日：2012-11-15
申请号：PCT/US2011/058418
申请日：2011-10-28
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES` , KAPLAN, Gerardo , KONDURU, Krishnamurthy , JACQUES, Jerome , BAVARI, Sina , BRADFUTE, Steven
发明人： KAPLAN, Gerardo , KONDURU, Krishnamurthy , JACQUES, Jerome , BAVARI, Sina , BRADFUTE, Steven
IPC分类号： A61K39/12
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
摘要翻译：本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。融合蛋白也可用于诊断测定法以检测病毒感染。

5. 发明申请

WO2007117258A2 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型HEPATITIS病毒在细胞培养中的生长
公开(公告)号：WO2007117258A2
公开(公告)日：2007-10-18
申请号：PCT/US2006/024748
申请日：2006-06-26
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KAPLAN, Gerardo , KONDURU, Krishnamurthy
发明人： KAPLAN, Gerardo , KONDURU, Krishnamurthy
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供重组甲型肝炎病毒（HAV）核酸和允许其生长和复制的宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一种异源核酸片段。异源核酸可以编码选择性标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码在含有重组HAV核酸的细胞中希望表达的疫苗抗原或其它表达产物。本发明进一步提供允许生长和复制野生型HAV或HAV的细胞系，所述野生型HAV或HAV在细胞培养物中生长具有最小的突变。本发明还提供了用于生产HAV疫苗和用于监测HAV存在的环境和患者样品的方法。

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