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1. 发明申请

WO2007117258A9 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型HEPATITIS病毒在细胞培养中的生长
公开(公告)号：WO2007117258A9
公开(公告)日：2008-04-17
申请号：PCT/US2006024748
申请日：2006-06-26
申请人： US GOV HEALTH & HUMAN SERV , KAPLAN GERARDO , KONDURU KRISHNAMURTHY
发明人： KAPLAN GERARDO , KONDURU KRISHNAMURTHY
IPC分类号： C12N15/86 , C12N5/00
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供重组甲型肝炎病毒（HAV）核酸和允许其生长和复制的宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一种异源核酸片段。异源核酸可以编码选择性标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码在含有重组HAV核酸的细胞中希望表达的疫苗抗原或其它表达产物。本发明进一步提供允许生长和复制野生型HAV或HAV的细胞系，所述野生型HAV或HAV在细胞培养物中生长具有最小的突变。本发明还提供了用于生产HAV疫苗和用于监测HAV存在的环境和患者样品的方法。

2. 发明申请

WO2008064031A3 POTENT ACTIVATION OF ANTIGEN PRESENTING CELLS BY THE HEPATITIS A VIRUS CELLULAR RECEPTOR 1 AND ITS ROLE IN THE REGULATION OF IMMUNE RESPONSES 审中-公开
标题翻译：抗生素存在细胞由乙型肝炎病毒细胞受体1的作用及其在免疫应答调节中的作用
公开(公告)号：WO2008064031A3
公开(公告)日：2009-03-12
申请号：PCT/US2007084600
申请日：2007-11-13
申请人： US GOV HEALTH & HUMAN SERV , KAPLAN GERARDO , TAMI MARIA CECILIA , MANANGEESWARAN MOHANRAJ , DEKRUYFF ROSEMARIE , UMETSU DALE , FREEMAN GORDON
发明人： KAPLAN GERARDO , TAMI MARIA CECILIA , MANANGEESWARAN MOHANRAJ , DEKRUYFF ROSEMARIE , UMETSU DALE , FREEMAN GORDON
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2319/30
摘要： The present invention relates to the identification of IgA? as a ligand for HAVCR1/TIM1, the receptor for Hepatitis A Virus. The invention provides compositions for inhibiting or promoting this interaction, and methods for influencing immunologic responses to antigens by administration of compounds that affect binding of IgA? to HAVCR1/TIM1.
摘要翻译：本发明涉及IgA的鉴定作为HAVCR1 / TIM1的配体，甲型肝炎病毒的受体。本发明提供了用于抑制或促进该相互作用的组合物，以及通过施用影响IgA的结合的化合物来影响对抗原的免疫应答的方法。到HAVCR1 / TIM1。

3. 发明申请

WO2012154203A2 FILOVIRUS FUSION PROTEINS AND THEIR USES 审中-公开
标题翻译： FILOVIRUS融合蛋白及其用途
公开(公告)号：WO2012154203A2
公开(公告)日：2012-11-15
申请号：PCT/US2011/058418
申请日：2011-10-28
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES` , KAPLAN, Gerardo , KONDURU, Krishnamurthy , JACQUES, Jerome , BAVARI, Sina , BRADFUTE, Steven
发明人： KAPLAN, Gerardo , KONDURU, Krishnamurthy , JACQUES, Jerome , BAVARI, Sina , BRADFUTE, Steven
IPC分类号： A61K39/12
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
摘要翻译：本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。融合蛋白也可用于诊断测定法以检测病毒感染。

4. 发明申请

WO2009064290A1 STRUCTURE OF TIM FAMILY MEMBERS 审中-公开
标题翻译： TIM家族成员的结构
公开(公告)号：WO2009064290A1
公开(公告)日：2009-05-22
申请号：PCT/US2007/084601
申请日：2007-11-13
申请人： GOVERNMENT OF THE UNITED STATES as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , KAPLAN, Gerardo , SANTIAGO, Cesar , CASASNOVAS, Jose M.
发明人： KAPLAN, Gerardo , SANTIAGO, Cesar , CASASNOVAS, Jose M.
IPC分类号： G06F19/00 , G01N33/68
CPC分类号： G01N33/566 , C07K14/70503 , C07K2299/00 , G01N2333/10 , G01N2500/02
摘要： The present invention provides crystal structures of the N-terminal Cys-rich Ig-like ligand-binding domain of the murine Tim-1, Tim-2, and Tim-4 receptors and models for the murine Tim-3 receptor and the human HAVCR1/TIM1, TM3, and TIM4 receptors based on the said crystal structures, and so provide materials and methods for identifying mimetics of the natural ligands for these receptors and also antagonists of those ligands. The structures also reveal a homophilic interaction for each receptor, which is confirmed biochemically. This invention provides materials and methods to target specific mutations on the TIM family receptors based on their crystal structure to modulate (enhance, reduce, or inhibit) homophilic and/or heterophilic interactions as well as binding to natural ligands. The resulting TIM receptor mutants could be used as therapeutic agents. Thus, the invention also provides materials and methods for identifying agonists and antagonists of TIM family members homophilic and heterophilic interactions. HAVCR1/TIM1 is the receptor for Hepatitis A Virus, and thus the invention also provides materials and methods for identifying inhibitors of HAV infection.
摘要翻译：本发明提供了鼠Tim-1，Tim-2和Tim-4受体的N末端富含Cys的Ig样配体结合结构域和用于鼠Tim-3受体和人HAVCR1的模型的晶体结构 / TIM1，TM3和基于所述晶体结构的TIM4受体，因此提供用于鉴定这些受体的天然配体的模拟物以及这些配体的拮抗剂的材料和方法。该结构还揭示了每种受体的亲和相互作用，这是通过生物化学证实的。本发明提供了基于它们的晶体结构来靶向TIM族受体的特异性突变以调节（增强，减少或抑制）亲和和/或异亲相互作用以及与天然配体结合的材料和方法。所得的TIM受体突变体可用作治疗剂。因此，本发明还提供用于鉴定TIM家族成员亲和和亲和相互作用的激动剂和拮抗剂的材料和方法。 HAVCR1 / TIM1是甲型肝炎病毒的受体，因此本发明还提供用于鉴定HAV感染抑制剂的材料和方法。

5. 发明申请

WO2008064031A2 POTENT ACTIVATION OF ANTIGEN PRESENTING CELLS BY THE HEPATITIS A VIRUS CELLULAR RECEPTOR 1 AND ITS ROLE IN THE REGULATION OF IMMUNE RESPONSES 审中-公开
标题翻译：抗生素存在细胞由乙型肝炎病毒细胞受体1的作用及其在免疫调节中的作用
公开(公告)号：WO2008064031A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084600
申请日：2007-11-13
申请人： US GOV HEALTH & HUMAN SERV , KAPLAN GERARDO , TAMI MARIA CECILIA , MANANGEESWARAN MOHANRAJ , DEKRUYFF ROSEMARIE , UMETSU DALE , FREEMAN GORDON
发明人： KAPLAN GERARDO , TAMI MARIA CECILIA , MANANGEESWARAN MOHANRAJ , DEKRUYFF ROSEMARIE , UMETSU DALE , FREEMAN GORDON
IPC分类号： C12N5/00
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2319/30
摘要： The present invention relates to the identification of IgA? as a ligand for HAVCR1/TIM1, the receptor for Hepatitis A Virus. The invention provides compositions for inhibiting or promoting this interaction, and methods for influencing immunologic responses to antigens by administration of compounds that affect binding of IgA? to HAVCR1/TIM1.
摘要翻译：本发明涉及IgA的鉴定作为HAVCR1 / TIM1的配体，甲型肝炎病毒的受体。本发明提供了用于抑制或促进该相互作用的组合物，以及通过施用影响IgA结合的化合物来影响对抗原的免疫应答的方法。到HAVCR1 / TIM1。

6. 发明申请

WO2007084567A3 DETECTION AND DISCRIMINATION OF HEPATITIS C VIRUS, HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 AND HEPATITIS B VIRUS 审中-公开
标题翻译：丙型肝炎病毒，人免疫缺陷病毒-1型和乙型肝炎病毒的检测和鉴定
公开(公告)号：WO2007084567A3
公开(公告)日：2007-12-13
申请号：PCT/US2007001241
申请日：2007-01-17
申请人： US GOV HEALTH & HUMAN SERV , HSIA CHU CHIEH , KAPLAN GERARDO , CHIZHIKOV VLADIMIR E , SELVAPANDIYAN ANGAMURHU , YANG AMY X , NAKHASI HIRA , PURI RAJ K
发明人： HSIA CHU CHIEH , KAPLAN GERARDO , CHIZHIKOV VLADIMIR E , SELVAPANDIYAN ANGAMURHU , YANG AMY X , NAKHASI HIRA , PURI RAJ K
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/703 , C12Q1/706 , C12Q1/707
摘要： The present disclosure provides isolated nucleic acid primers and probes that can be used to detect hepatitis B (HBV), hepatitis C (HCV), human immunodeficiency virus type 1 (HIV-I), or combinations thereof (for example simultaneously), in a biological sample. In particular examples, the disclosed methods can discriminate 3-10 genomic equivalents (gEq) of HBV, 10-20 gEq of HCV, and 20 gEq of HIV-I. Also provided are arrays that include the viral-specific probes, as well as kits that include the isolated nucleic acid primers, probes, arrays, or combinations thereof. The method and arrays can be used for example, for diagnosis of these viruses in clinics and in high-risk groups, as discriminatory confirmation assay in screening of blood donors, and in research laboratories.
摘要翻译：本公开提供了分离的核酸引物和探针，其可用于检测乙型肝炎（HBV），丙型肝炎（HCV），1型人免疫缺陷病毒（HIV-1）或其组合（例如同时）生物样品。在具体的例子中，所公开的方法可以区分HBV的3-10基因组当量（gEq），10-20gEq的HCV和20gEq的HIV-1。还提供了包括病毒特异性探针的阵列，以及包括分离的核酸引物，探针，阵列或其组合的试剂盒。该方法和阵列可用于例如在诊所和高风险群体中诊断这些病毒，作为在献血者筛查中的区分性确认测定以及在研究实验室中。

7. 发明申请

WO2007117258A2 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型HEPATITIS病毒在细胞培养中的生长
公开(公告)号：WO2007117258A2
公开(公告)日：2007-10-18
申请号：PCT/US2006/024748
申请日：2006-06-26
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KAPLAN, Gerardo , KONDURU, Krishnamurthy
发明人： KAPLAN, Gerardo , KONDURU, Krishnamurthy
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供重组甲型肝炎病毒（HAV）核酸和允许其生长和复制的宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一种异源核酸片段。异源核酸可以编码选择性标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码在含有重组HAV核酸的细胞中希望表达的疫苗抗原或其它表达产物。本发明进一步提供允许生长和复制野生型HAV或HAV的细胞系，所述野生型HAV或HAV在细胞培养物中生长具有最小的突变。本发明还提供了用于生产HAV疫苗和用于监测HAV存在的环境和患者样品的方法。

8. 发明申请

WO2007084567A2 DETECTION AND DISCRIMINATION OF HEPATITIS C VIRUS, HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 AND HEPATITIS B VIRUS 审中-公开
标题翻译： HEPATITIS C病毒，人类免疫缺陷病毒1型和乙型肝炎病毒的检测与鉴定
公开(公告)号：WO2007084567A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001241
申请日：2007-01-17
申请人： THE GOV. OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEP. OF HEALTH AND HUMAN SERVICES , HSIA, Chu, Chieh , KAPLAN, Gerardo , CHIZHIKOV, Vladimir, E. , SELVAPANDIYAN, Angamurhu , YANG, Amy, X. , NAKHASI, Hira , PURI, Raj, K.
发明人： HSIA, Chu, Chieh , KAPLAN, Gerardo , CHIZHIKOV, Vladimir, E. , SELVAPANDIYAN, Angamurhu , YANG, Amy, X. , NAKHASI, Hira , PURI, Raj, K.
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/703 , C12Q1/706 , C12Q1/707
摘要： The present disclosure provides isolated nucleic acid primers and probes that can be used to detect hepatitis B (HBV), hepatitis C (HCV), human immunodeficiency virus type 1 (HIV-I), or combinations thereof (for example simultaneously), in a biological sample. In particular examples, the disclosed methods can discriminate 3-10 genomic equivalents (gEq) of HBV, 10-20 gEq of HCV, and 20 gEq of HIV-I. Also provided are arrays that include the viral-specific probes, as well as kits that include the isolated nucleic acid primers, probes, arrays, or combinations thereof. The method and arrays can be used for example, for diagnosis of these viruses in clinics and in high-risk groups, as discriminatory confirmation assay in screening of blood donors, and in research laboratories.
摘要翻译：本公开提供分离的核酸引物和探针，其可用于检测乙型肝炎（HBV），丙型肝炎（HCV），1型人类免疫缺陷病毒（HIV-1）或其组合（例如同时）生物样品。在具体实例中，所公开的方法可以区分HBV的3-10基因组当量（gEq），10-20gEq的HCV和20gEq的HIV-1。还提供了包括病毒特异性探针的阵列，以及包括分离的核酸引物，探针，阵列或其组合的试剂盒。该方法和阵列可用于例如诊断和高危组中这些病毒的诊断，作为筛选供血者的鉴别性确认测定，以及研究实验室。

9. 发明申请

WO2012154203A3 FILOVIRUS FUSION PROTEINS AND THEIR USES 审中-公开
标题翻译： FILOVIRUS融合蛋白及其用途
公开(公告)号：WO2012154203A3
公开(公告)日：2013-03-21
申请号：PCT/US2011058418
申请日：2011-10-28
申请人： US GOV HEALTH & HUMAN SERV , U S ARMY MEDICAL RES INST OF INFECTIOUS DISEASES , KAPLAN GERARDO , KONDURU KRISHNAMURTHY , JACQUES JEROME , BAVARI SINA , BRADFUTE STEVEN
发明人： KAPLAN GERARDO , KONDURU KRISHNAMURTHY , JACQUES JEROME , BAVARI SINA , BRADFUTE STEVEN
IPC分类号： A61K39/12 , A61P31/14 , G01N33/50
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
摘要翻译：本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。融合蛋白也可用于诊断测定法以检测病毒感染。

10. 发明申请

WO2007117258A3 GROWTH OF WILD-TYPE HEPATITIS A VIRUS IN CELL CULTURE 审中-公开
标题翻译：野生型甲型肝炎病毒在细胞培养中的生长
公开(公告)号：WO2007117258A3
公开(公告)日：2008-06-12
申请号：PCT/US2006024748
申请日：2006-06-26
申请人： US GOV HEALTH & HUMAN SERV , KAPLAN GERARDO , KONDURU KRISHNAMURTHY
发明人： KAPLAN GERARDO , KONDURU KRISHNAMURTHY
IPC分类号： C12N15/86 , C12N5/00
CPC分类号： C12N15/86 , C12N7/00 , C12N2770/32443 , C12N2770/32461
摘要： The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable marker gene and such recombinant HAV nucleic acids are useful for selecting cells that are permissive for growth and replication of wild type HAV. Alternatively, the heterologous nucleic acid may encode a vaccine antigen or other expression product that is desirable to express in a cell harboring the recombinant HAV nucleic acid. The invention further provides cell lines permissive for growth and replication of wild type HAV or HAV having minimal mutations for growth in cell culture. The invention further provides methods for producing HAV vaccines and for monitoring environmental and patient samples for the presence of HAV.
摘要翻译：本发明提供了允许其生长和复制的重组甲型肝炎病毒（HAV）核酸和宿主细胞。重组甲型肝炎病毒核酸没有特别限制，除了它们掺入至少一个异源核酸片段。异源核酸可以编码选择标记基因，并且这种重组HAV核酸可用于选择允许野生型HAV生长和复制的细胞。或者，异源核酸可以编码希望在携带重组HAV核酸的细胞中表达的疫苗抗原或其他表达产物。本发明进一步提供了允许野生型HAV或HAV生长和复制的细胞系，所述野生型HAV或HAV具有细胞培养物生长的最小突变。本发明进一步提供了产生HAV疫苗和监测环境和患者样品中HAV存在的方法。

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