专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006117166A3 MRI CONTRAST AGENTS ENDOWED WITH CONCENTRATION INDEPENDENT RESPONSIVENESS 审中-公开
标题翻译： MRI对照药物与浓度独立的反应一致
公开(公告)号：WO2006117166A3
公开(公告)日：2007-04-19
申请号：PCT/EP2006004023
申请日：2006-04-28
申请人： BRACCO IMAGING SPA , AIME SILVIO , TERRENO ENZO
发明人： AIME SILVIO , TERRENO ENZO
IPC分类号： A61K49/14 , A61K49/10
CPC分类号： A61K49/085 , A61K49/10
摘要： The present invention relates to a method for the in vivo, ex vivo, or in vitro determination of physical or chemical parameters of diagnostic interest by use of a slow tumbling paramagnetic agent that is responsive to changes of said physical or chemical parameter through changes in the R 2p /R 1p ratio allowing the determination of the said parameter in a manner that is independent on the actual agent concentration.
摘要翻译：本发明涉及一种通过使用缓慢翻滚顺磁剂体内，离体或体外测定诊断感兴趣的物理或化学参数的方法，所述缓慢翻滚顺磁剂通过改变所述物理或化学参数 R 2p / 2/1/2比例允许以与实际药剂浓度无关的方式确定所述参数。

2. 发明申请

WO2006117166A2 MRI CONTRAST AGENTS ENDOWED WITH CONCENTRATION INDEPENDENT RESPONSIVENESS 审中-公开
标题翻译： MRI对照药物与浓度独立的反应一致
公开(公告)号：WO2006117166A2
公开(公告)日：2006-11-09
申请号：PCT/EP2006/004023
申请日：2006-04-28
申请人： BRACCO IMAGING SPA , AIME, Silvio , TERRENO, Enzo
发明人： AIME, Silvio , TERRENO, Enzo
CPC分类号： A61K49/085 , A61K49/10
摘要： The present invention relates to a method for the in vivo, ex vivo, or in vitro determination of physical or chemical parameters of diagnostic interest by use of a slow tumbling paramagnetic agent that is responsive to changes of said physical or chemical parameter through changes in the R 2p /R 1p ratio allowing the determination of the said parameter in a manner that is independent on the actual agent concentration.
摘要翻译：本发明涉及一种通过使用缓慢翻滚顺磁剂体内，离体或体外测定诊断感兴趣的物理或化学参数的方法，所述缓慢翻滚顺磁剂通过改变所述物理或化学参数 R 2p / 2/1/2比例允许以与实际药剂浓度无关的方式确定所述参数。

3. 发明申请

WO2006095234A3 INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2006095234A3
公开(公告)日：2006-09-14
申请号：PCT/IB2006/000455
申请日：2006-03-03
申请人： BRACCO IMAGING S.P.A. , LATTUADA, Luciano , MOROSINI, Pierfrancesco , UGGERI, Fulvio , AIME, Silvio , TERRENO, Enzo , DELLI CASTELLI, Daniela , SCOLASTICO, Carlo , MANZONI, Leonardo , AROSIO, Daniela
发明人： LATTUADA, Luciano , MOROSINI, Pierfrancesco , UGGERI, Fulvio , AIME, Silvio , TERRENO, Enzo , DELLI CASTELLI, Daniela , SCOLASTICO, Carlo , MANZONI, Leonardo , AROSIO, Daniela
IPC分类号： C07D471/04 , C07K5/00 , A61K38/04
摘要： The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.

4. 发明申请

WO2003063912A1 RESPONSIVE PARAMAGNETIC MRI CONTRAST AGENTS 审中-公开
标题翻译：反应性PARAMAGNETIC MRI对比剂
公开(公告)号：WO2003063912A1
公开(公告)日：2003-08-07
申请号：PCT/EP2003/000796
申请日：2003-01-27
申请人： BRACCO IMAGING S.P.A. , AIME, Silvio , DELLI CASTELLI, Daniela , FEDELI, Franco , TERRENO, Enzo
发明人： AIME, Silvio , DELLI CASTELLI, Daniela , FEDELI, Franco , TERRENO, Enzo
IPC分类号： A61K49/06
CPC分类号： A61K49/0002 , A61K49/106
摘要： A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
摘要翻译：基于用于体内或体外测定物理或化学参数的CEST程序要求保护的方法，其包括使用响应性顺磁性CEST造影剂。

5. 发明申请

WO2006095234A2 INTEGRIN TARGETED SYNTHETIC LIGANDS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
标题翻译：用于诊断和治疗应用的INTEGRIN靶向合成配体
公开(公告)号：WO2006095234A2
公开(公告)日：2006-09-14
申请号：PCT/IB2006000455
申请日：2006-03-03
申请人： BRACCO IMAGING SPA , LATTUADA LUCIANO , MOROSINI PIERFRANCESCO , UGGERI FULVIO , AIME SILVIO , TERRENO ENZO , DELLI CASTELLI DANIELA , SCOLASTICO CARLO , MANZONI LEONARDO , AROSIO DANIELA
发明人： LATTUADA LUCIANO , MOROSINI PIERFRANCESCO , UGGERI FULVIO , AIME SILVIO , TERRENO ENZO , DELLI CASTELLI DANIELA , SCOLASTICO CARLO , MANZONI LEONARDO , AROSIO DANIELA
CPC分类号： C07K7/64 , C07D401/06 , C07D471/04 , C07K5/06139
摘要： The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
摘要翻译：本发明涉及一类新的诊断或治疗有效的化合物，其包含作为针对整联蛋白受体的靶向部分的基于新的氮杂 - 双环烷烃的环状肽。

6. 发明申请

WO2012059576A1 CEST SYSTEMS EXHIBITING A CONCENTRATION INDEPENDENT RESPONSIVENESS 审中-公开
标题翻译： CEST系统展示独立响应的浓度
公开(公告)号：WO2012059576A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069406
申请日：2011-11-04
申请人： Bracco Imaging SpA , AIME, Silvio , TERRENO, Enzo , DELLI CASTELLI, Daniela , LONGO, Dario Livio , FEDELI, Franco , UGGERI, Fulvio
发明人： AIME, Silvio , TERRENO, Enzo , DELLI CASTELLI, Daniela , LONGO, Dario Livio , FEDELI, Franco , UGGERI, Fulvio
IPC分类号： A61K49/10 , G01R33/48
CPC分类号： A61K49/106 , G01R33/5601
摘要： The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
摘要翻译：本发明涉及在基于比例的CEST成像方法中属于CEST试剂的NMR可区分立体异构体的非等效移动质子与在可用作浓度的溶液中显示至少两种NMR可区分立体异构体的镧系元素（III）络合物化合物的用途独立的CEST响应代理。

7. 发明申请

WO2010023132A1 MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS 审中-公开
标题翻译：基于非泛素化分析的MRI-CEST诊断技术
公开(公告)号：WO2010023132A1
公开(公告)日：2010-03-04
申请号：PCT/EP2009/060680
申请日：2009-08-18
申请人： Bracco Imaging S.p.A. , AIME, Silvio , DELLI CASTELLI, Daniela , LONGO, Dario Livio , STANCANELLO, Joseph , TERRENO, Enzo , UGGERI, Fulvio
发明人： AIME, Silvio , DELLI CASTELLI, Daniela , LONGO, Dario Livio , STANCANELLO, Joseph , TERRENO, Enzo , UGGERI, Fulvio
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , G01R33/5608
摘要： A solution in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system (100) includes input means (505-550) for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means (555,563) for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated in a non-punctual agent range of frequencies including the agent frequency e.g. by integrating the spectrum, and the reference value is calculated in a non-punctual reference range of frequencies including the reference frequency e.g. by integrating the spectrum. Comparison means (565) is then provided for calculating a parametric value for each selected location by comparison between the agent value and the reference value of the selected location.
摘要翻译：提出了MRI-CEST领域的解决方案，用于分析身体部位，其包括提供与身体部位的体基底的磁化转移的CEST代理。相应的诊断系统（100）包括输入装置（505-550），用于提供包括多个输入元件的输入图，每个输入元件各自用于身体部位的对应位置; 每个输入元件指示该位置的磁响应的频谱，该频谱包括在造影剂的谐振的代理频率处的磁响应（代理频率在代理偏移量的频率与主频率散装物质的共振），并且在与体积偏移的试剂相反的参考频率处。该系统还包括用于计算代理值的一个计算装置（555,563）和一组选定位置中的每一个的参考值; 代理值在非准时代理频率范围内计算，包括代理频率例如。通过对频谱进行积分，并且在包括参考频率的频率的非准时基准范围内计算参考值。通过整合光谱。然后提供比较装置（565），用于通过比较代理值和所选位置的参考值来计算每个选定位置的参数值。

8. 发明申请

WO2004089424A1 ADDUCTS BETWEEN MAGNETIC RESONANCE SHIFT REAGENTS AND SUBSTRATES CONTAINING EXCHANGEABLE PROTONS FOR “CEST” APPLICATIONS 审中-公开
标题翻译：磁共振移动试剂和含有“CEST”应用的可交换原子的基质之间的补充
公开(公告)号：WO2004089424A1
公开(公告)日：2004-10-21
申请号：PCT/EP2004/003684
申请日：2004-04-06
申请人： BRACCO IMAGING S.P.A. , AIME, Silvio , TERRENO, Enzo , DELLI CASTELLI, Daniela , GIOVENZANA, Giovanni, Battista
发明人： AIME, Silvio , TERRENO, Enzo , DELLI CASTELLI, Daniela , GIOVENZANA, Giovanni, Battista
IPC分类号： A61K49/08
CPC分类号： A61K49/085 , A61K49/10 , A61K49/146
摘要： Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
摘要翻译：公开了包含与包含选自铁（11）（高自旋构型），铁（111），钴（11），铑（11））的金属的顺磁螯合物（SR）结合的移动质子的底物（SH）的CEST顺磁性试剂 11），铜（11），镍（11），铈（111），镨（111），钕（111），镝（111），铒（111），铽（111），钬（111） III），镱（III）和铕（111）。

9. 发明申请

WO2003033479A1 ENHANCED SUBSTRATE IMAGING BY REVERSIBLE BINDING TO A PARAMAGNETIC COMPLEX 审中-公开
标题翻译：通过可逆绑定到参考复合体的增强基板成像
公开(公告)号：WO2003033479A1
公开(公告)日：2003-04-24
申请号：PCT/EP2002/011271
申请日：2002-10-09
申请人： BRACCO IMAGING S.P.A. , TERRENO, Enzo , AIME, Silvio , BOTTA, Mauro
发明人： TERRENO, Enzo , AIME, Silvio , BOTTA, Mauro
IPC分类号： C07D257/02
CPC分类号： A61K49/085 , A61K49/103 , C07D257/02
摘要： The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a reversible binding of the substrate molecule to a paramagnetic chelate complex, as well as to the use of a paramagnetic chelate complex in said method and the pharmaceutical composition for use therein.
摘要翻译：本发明涉及一种用于不同于水的底物分子的磁共振成像和磁共振光谱成像的方法，其中NMR信号通过底物分子与顺磁螯合物的可逆结合而增强，以及使用所述方法中的顺磁性螯合络合物和用于其中的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式