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1. 发明申请

WO2010023132A1 MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS 审中-公开
标题翻译：基于非泛素化分析的MRI-CEST诊断技术
公开(公告)号：WO2010023132A1
公开(公告)日：2010-03-04
申请号：PCT/EP2009/060680
申请日：2009-08-18
申请人： Bracco Imaging S.p.A. , AIME, Silvio , DELLI CASTELLI, Daniela , LONGO, Dario Livio , STANCANELLO, Joseph , TERRENO, Enzo , UGGERI, Fulvio
发明人： AIME, Silvio , DELLI CASTELLI, Daniela , LONGO, Dario Livio , STANCANELLO, Joseph , TERRENO, Enzo , UGGERI, Fulvio
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , G01R33/5608
摘要： A solution in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system (100) includes input means (505-550) for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means (555,563) for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated in a non-punctual agent range of frequencies including the agent frequency e.g. by integrating the spectrum, and the reference value is calculated in a non-punctual reference range of frequencies including the reference frequency e.g. by integrating the spectrum. Comparison means (565) is then provided for calculating a parametric value for each selected location by comparison between the agent value and the reference value of the selected location.
摘要翻译：提出了MRI-CEST领域的解决方案，用于分析身体部位，其包括提供与身体部位的体基底的磁化转移的CEST代理。相应的诊断系统（100）包括输入装置（505-550），用于提供包括多个输入元件的输入图，每个输入元件各自用于身体部位的对应位置; 每个输入元件指示该位置的磁响应的频谱，该频谱包括在造影剂的谐振的代理频率处的磁响应（代理频率在代理偏移量的频率与主频率散装物质的共振），并且在与体积偏移的试剂相反的参考频率处。该系统还包括用于计算代理值的一个计算装置（555,563）和一组选定位置中的每一个的参考值; 代理值在非准时代理频率范围内计算，包括代理频率例如。通过对频谱进行积分，并且在包括参考频率的频率的非准时基准范围内计算参考值。通过整合光谱。然后提供比较装置（565），用于通过比较代理值和所选位置的参考值来计算每个选定位置的参数值。

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