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    • 6. 发明申请
    • METHOD AND APPARATUS FOR A USER TO AVOID UNINTENTIONAL CALLS IN A MOBILE TELEPHONE NETWORK
    • 用于在移动电话网络中避免非正式呼叫的用户的方法和装置
    • WO2002104051A1
    • 2002-12-27
    • PCT/EP2002/005974
    • 2002-05-31
    • TELEFONAKTIEBOLAGET L M ERICSSON (PUBL)SMITH, Bryan
    • SMITH, Bryan
    • H04Q7/32
    • H04W4/02H04W88/02H04W88/06
    • In a mobile telephone network, apparatus and method assist the user of a mobile station registered with a first network (-home network-) to abstain from completing a call when the mobile station gets involved with a foreign/international network other than the first network, which might result in unwanted charges. The mobile station includes first and second settings to identify respectively the first network and the foreign/international network. If the mobile station during roaming is connected to a foreign/international network, before a call is consummated, the mobile station produces an "indication" which may be distinct from a normal ringing tone, e.g., a distinct beep or noise or click or even a vibration of the hand held mobile station casing. Simultaneously and optionally, a graphic display in the user's mobile station indicates the identity of the foreign/international network, to show that the call indeed will be routed through a foreign/international network resulting in additional charges. The user thus has the
    • 在移动电话网络中,当移动台涉及除了第一网络之外的外国/国际网络时,装置和方法帮助注册在第一网络(-home网络)的移动站的用户不要完成呼叫 ,这可能会导致不必要的费用。 移动台包括分别识别第一网络和外国/国际网络的第一和第二设置。 如果漫游期间的移动台连接到外国/国际网络,则在呼叫完成之前,移动台产生可能与正常铃声不同的“指示”,例如,明显的蜂鸣或噪音或点击或甚至 手持移动台壳体的振动。 同时且可选地,用户移动站中的图形显示器指示外国/国际网络的身份,以显示呼叫确实将通过外部/国际网络路由,导致额外的费用。 用户因而拥有
    • 7. 发明申请
    • NOVEL REGIMENS OF TAFENOQUINE FOR PREVENTION OF MALARIA IN MALARIA-NAÏVE SUBJECTS
    • 疟疾预防疟疾的泰铢新规
    • WO2016089995A1
    • 2016-06-09
    • PCT/US2015/063425
    • 2015-12-02
    • 60 DEGREES PHARMACEUTICALS, LLCSMITH, Bryan L.JONES, John PaulSCHMUKLARSKY, MosheBUDDA, Balasubrahmanyan
    • SMITH, Bryan L.JONES, John PaulSCHMUKLARSKY, MosheBUDDA, BalasubrahmanyanDOW, Geoffrey S.
    • C07D215/40A61K31/47
    • A61K31/4706A61P33/06C07D215/40Y02A50/411
    • Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium , during potential exposure of a species of Plasmodium , and after potential exposure of a species of Plasmodium . The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects.
    • 包括向人受试者施用式(I)化合物,其药学上可接受的盐或包含式(I)化合物的药物组合物的方法,在疟疾初始的G6PD-正常人受试者中预防有症状的疟疾的方法。 一种式(I)化合物可以在潜在暴露一种疟原虫之前,潜在暴露于一种疟原虫之前,以及一种疟原虫种类潜在的暴露之后进行。 本发明的方法还涉及包含特定剂量的式(I),其药学上可接受的盐或包含式(I)化合物的药物组合物和给药剂量和频率的说明书的试剂盒。 本发明的方法还涉及确定符合药物在疟疾初始受试者中有效预防疟疾的一般调节要求的式(I)的剂量。 本发明的方法进一步涉及使用所描述的算法来推导给药方案,其可以在无疟疾,G6PD-正常受试者中提供针对症状性疟疾的保护。
    • 10. 发明申请
    • HAND HYGIENE NETWORK SYSTEM
    • 手卫生网络系统
    • WO2013106440A1
    • 2013-07-18
    • PCT/US2013/020847
    • 2013-01-09
    • SMITH, JudsonSMITH, Bryan, D.SMITH, Garrett, J.
    • SMITH, JudsonSMITH, Bryan, D.SMITH, Garrett, J.
    • A61L2/24A61L2/26H04Q9/00
    • A47K5/1202A47K5/1217A61L2/0088A61L2/16G08B3/10G08B5/22G08B21/245H04Q9/00H04Q2209/40
    • In a health care facility, within the immediate patient care zone, a method of providing a networked system for hand hygiene. At least one (1) health care worker (HCW) has the means to perform at least one (1) event of the "World Health Organization's (WHO) 5 Moments Hand Hygiene" protocol events utilizing a movable hand hygiene dispenser and/or fixedly mounted hand hygiene dispenser positioned within the patient care zone. The HCW's "WHO'S Hand Hygiene" events are monitored by a wireless network of transceivers, located within the patient care zone, which can communicate information between one another and/or to the health care facility's computer memory and processing center for the purposes of HCW's alerts, process steps, evaluation, reporting, etc., of the HCW's hand hygiene event activity and his/her compliance relative to the "WHO'S 5 Moments Hand Hygiene" events protocol.
    • 在医疗机构内,在即时的病人护理区内,提供一种网络化手卫生系统的方法。 至少有一(1)名医护人员(HCW)有能力使用可移动的手卫生分配器和/或固定地执行“世界卫生组织(WHO)5分钟手卫生”协议事件的至少一次事件 安装在卫生保健区内的手部卫生分配器。 HCW的“世卫组织手卫生”活动由位于病人护理区内的收发器的无线网络进行监控,该无线网络可以彼此之间和/或与卫生保健机构的计算机存储器和处理中心之间传达信息,以实现HCW的警报 ,手工卫生活动活动的过程步骤,评估,报告等,以及他/她遵守“世界卫生组织5个时刻手卫生”活动协议。