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1. 发明申请

WO2011156028A2 POROUS AND NON-POROUS NANOSTRUCTURES 审中-公开
标题翻译：多孔和非多孔纳米结构
公开(公告)号：WO2011156028A2
公开(公告)日：2011-12-15
申请号：PCT/US2011027746
申请日：2011-03-09
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
发明人： FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
IPC分类号： H01L29/06 , H01L21/306 , H01L23/48 , H01L23/532
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L2924/0002 , H01L2924/00
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.
摘要翻译：公开了各种微观和纳米尺度的多孔和无孔线状结构。例如，公开的是包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。还公开了制造和使用这种结构的方法。例如，本发明提供了通过以下步骤制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将所述衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

2. 发明申请

WO2006113663A3 SYSTEM AND METHOD FOR SPECTROPHOTOMETRIC MEASUREMENT OF TOTAL ALKALINITY USING A LIQUID CORE WAVEGUIDE 审中-公开
标题翻译：使用液体核心波长的总碱度的光谱测量的系统和方法
公开(公告)号：WO2006113663A3
公开(公告)日：2007-11-08
申请号：PCT/US2006014474
申请日：2006-04-18
申请人： UNIV SOUTH FLORIDA , BYRNE ROBERT H , KALTENBACHER ERIC , LIU XUEWU
发明人： BYRNE ROBERT H , KALTENBACHER ERIC , LIU XUEWU
IPC分类号： G01N21/62
CPC分类号： G01N21/80 , G01N21/0303
摘要： A system and method for spectrophotometrically measuring the total alkalinity of a liquid sample. In a particular aspect, the method involves equilibration of a CO2 gas with a sample solution across the permeable walls of a Teflon AF 2400 liquid core waveguide. The waveguide acts as both an equilibration membrane and an optical cell in which spectrophotometric pH measurements are obtained via measurements of absorbance ratios.
摘要翻译：用于分光光度测量液体样品的总碱度的系统和方法。在一个特定方面，该方法包括使二氧化碳气体与样品溶液在Teflon AF400液芯波导的可渗透壁上平衡。波导作为平衡膜和光学电池，其中通过吸光度比的测量获得分光光度测量值。

3. 发明申请

WO2010120817A3 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
公开(公告)号：WO2010120817A3
公开(公告)日：2010-10-21
申请号：PCT/US2010/030937
申请日：2010-04-13
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , FERRARI, Mauro , LIU, Xuewu , GRATTONI, Alessandro , GOODALL, Randy , HUDON, Lee
发明人： FERRARI, Mauro , LIU, Xuewu , GRATTONI, Alessandro , GOODALL, Randy , HUDON, Lee
IPC分类号： A61K9/48 , A61K9/50 , A61K9/16 , A61P19/02 , A61P19/00
摘要： A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.

4. 发明申请

WO2006110771A3 SPECTROPHOMETRIC MEASUREMENTS OF PH IN-SITU 审中-公开
标题翻译： PH in-SITU的分光光度法测量
公开(公告)号：WO2006110771A3
公开(公告)日：2007-09-20
申请号：PCT/US2006013524
申请日：2006-04-12
申请人： UNIV SOUTH FLORIDA , BYRNE ROBERT H , KALTENBACHER ERIC , LIU XUEWU
发明人： BYRNE ROBERT H , KALTENBACHER ERIC , LIU XUEWU
IPC分类号： G01N31/22
CPC分类号： G01N21/80 , G01N21/0303
摘要： Automated in-situ instrumentation has been developed for sensitive, precise and accurate measurements of a variety of analytes in natural waters In this work we describe the use of 'SEAS' (Spectrophotometry Elemental Analysis System) instrumentation for measurements of solution pH SEAS-pH incorporates a CCD-based spectrophotometer, an incandescent light source, and dual pumps for mixing natural water samples with a sulfonephthalein indicator The SEAS-pH optical cell consists of either a liquid core waveguide (LCW, Teflon AF 2400) or custom-made PEEK tubing Long optical pathlengths allow use of indicators at low concentrations, thereby precluding indicator- induced pH perturbations Laboratory experiments show that pH measurements obtained using LCW and PEEK optical cells are indistinguishable from measurements obtained using conventional spectrophotometric cells and high-performance spectrophotometers Deployments in the Equatorial Pacific and the Gulf of Mexico demonstrate that the SEAS-pH instrument is capable of obtaining vertical pH profiles with high spatial resolution SEAS-pH deployments at a fixed river-site (Hillsborough River, FL) demonstrate the capability of SEAS for observations of diel pH cycles with high temporal resolution The in-situ precision of SEAS-pH is better than 0 002 pH units, and the system's measurement frequency is approximately 0 5 Hz This work indicates that in-situ instrumentation can be used to provide unique capabilities for observations of carbon-system transformations in the natural environment.
摘要翻译：已经开发了自动化原位仪器，用于敏感，精确和准确地测量天然水中的各种分析物在本工作中，我们描述了使用“SEAS”（分光光度法元素分析系统）仪器测量溶液pH值SEAS-pH 一种基于CCD的分光光度计，白炽光源和用于将天然水样品与磺酞指示剂混合的双泵SEAS-pH光电池由液芯波导（LCW，Teflon AF 2400）或定制的PEEK管Long 光程长度允许以低浓度使用指示剂，从而排除指示剂诱导的pH扰动实验室实验表明，使用LCW和PEEK光学电池获得的pH测量与使用常规分光光度计和高性能分光光度计获得的测量无差异，赤道太平洋和墨西哥湾证明了SEAS -pH仪器能够获得在固定河道（Hillsborough River，FL）上具有高空间分辨率SEAS-pH部署的垂直pH分布，证明SEAS能够观察到具有高时间分辨率的diel pH循环的能力原位精度的SEAS-pH优于0 002 pH单位，系统的测量频率约为0 5 Hz。这项工作表明，现场仪器可用于提供自然环境中碳系转化观测的独特能力。

5. 发明申请

WO2009134786A2 QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES 审中-公开
标题翻译：质量控制方法和微/纳米通道设备
公开(公告)号：WO2009134786A2
公开(公告)日：2009-11-05
申请号：PCT/US2009041957
申请日：2009-04-28
申请人： UNIV TEXAS , GRATTONI ALESSANDRO , FERRARI MAURO , LIU XUEWU
发明人： GRATTONI ALESSANDRO , FERRARI MAURO , LIU XUEWU
IPC分类号： G01N3/12 , B81B7/00 , B82B3/00
CPC分类号： B81C99/005 , B81B2201/058 , B81B2203/0338 , G01N11/08 , G01N35/00663
摘要： Embodiments of the present invention comprise a quality control system and method for testing micro- or nano-channeled devices. The system and method can utilize a pressure- driven gas flow for the detection and quantification of structural defects. The test method and system are non-destructive and allow defects to be detected and classified quickly based on measured factors, such as mass flow rate for a given pressure differential.
摘要翻译：本发明的实施例包括用于测试微通道或纳米通道器件的质量控制系统和方法。该系统和方法可以利用压力驱动气流来检测和定量结构缺陷。测试方法和系统是非破坏性的，并且基于测量因素（例如给定压力差的质量流率）来快速检测和分类缺陷。

6. 发明申请

WO2008134637A1 POROUS PARTICLES AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：多孔颗粒及其制备方法
公开(公告)号：WO2008134637A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061775
申请日：2008-04-28
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , FERRARI, Mauro , LIU, Xuewu , CHENG, Ming-cheng
发明人： FERRARI, Mauro , LIU, Xuewu , CHENG, Ming-cheng
IPC分类号： C01B33/12 , B82B1/00
CPC分类号： A61K9/0097 , A61K9/1611 , A61K9/1694 , B81C99/008 , B81C2201/0115 , B82Y30/00 , C01P2004/03 , C01P2004/61 , C01P2004/62 , C01P2006/14 , C09C1/30 , C09C1/3081
摘要： Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
摘要翻译：提供了包括与第一多孔区域不同的第一多孔区域和第二多孔区域的颗粒。还提供了具有湿蚀刻多孔区域并且确实具有与湿蚀刻相关联的成核层的颗粒。还提供了制造多孔颗粒的方法。

7. 发明申请

WO2006108054A2 DIFFUSION DELIVERY SYSTEM AND METHODS OF FABRICATION 审中-公开
标题翻译：扩散输送系统和制造方法
公开(公告)号：WO2006108054A2
公开(公告)日：2006-10-12
申请号：PCT/US2006012700
申请日：2006-04-05
申请人： UNIV OHIO STATE , FERRARI MAURO , LIU XUEWU , SINHA PIYUSH MOHAN , SMITH BRYAN , SHARMA SADHANA
发明人： FERRARI MAURO , LIU XUEWU , SINHA PIYUSH MOHAN , SMITH BRYAN , SHARMA SADHANA
IPC分类号： H01R13/648
CPC分类号： A61K9/0097 , A61F2/022 , A61M31/002 , A61N1/306 , B82Y30/00
摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nano engineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.
摘要翻译：本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程装置。该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。本发明还涉及含有扩散递送系统的胶囊。本发明还涉及制造扩散递送系统的方法。

8. 发明申请

WO2011156028A3 POROUS AND NON-POROUS NANOSTRUCTURES 审中-公开
公开(公告)号：WO2011156028A3
公开(公告)日：2011-12-15
申请号：PCT/US2011/027746
申请日：2011-03-09
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , FERRARI, Mauro , LIU, Xuewu , CHIAPPINI, Ciro , FAKHOURY, Jean, Raymond
发明人： FERRARI, Mauro , LIU, Xuewu , CHIAPPINI, Ciro , FAKHOURY, Jean, Raymond
IPC分类号： C01B31/02 , B82B1/00 , H01L21/70 , H01L21/762
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.

9. 发明申请

WO2011025602A1 COMBINATIONAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES 审中-公开
标题翻译：组合多元醇多糖和生物分子的分离，稳定和储存方法
公开(公告)号：WO2011025602A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/042557
申请日：2010-07-20
申请人： The Board of Regents of the University of Texas System , FERRARI, Mauro , LIU, Xuewu , TASCIOTTI, Ennio , BOUAMRANI, Ali , HU, Ye
发明人： FERRARI, Mauro , LIU, Xuewu , TASCIOTTI, Ennio , BOUAMRANI, Ali , HU, Ye
IPC分类号： B01D37/00
CPC分类号： G01N1/405 , G01N33/552
摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 III in a time as short as 30 minutes. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity.
摘要翻译：新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs在短至30分钟的时间内有效地产生复制生物样品的可重复提取物，至少为10μl。基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于选择个性化治疗组合，实时评估治疗功效和毒性。

10. 发明申请

WO2010120817A2 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
标题翻译：纳米通道器件及相关方法
公开(公告)号：WO2010120817A2
公开(公告)日：2010-10-21
申请号：PCT/US2010030937
申请日：2010-04-13
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , GRATTONI ALESSANDRO , GOODALL RANDY , HUDON LEE
发明人： FERRARI MAURO , LIU XUEWU , GRATTONI ALESSANDRO , GOODALL RANDY , HUDON LEE
IPC分类号： A61K9/48 , A61K9/16 , A61K9/50 , A61P19/00 , A61P19/02
CPC分类号： A61M31/002 , A61K9/0097 , A61M5/14276 , A61M2209/045
摘要： A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.
摘要翻译：配置用于体内再灌注治疗剂的胶囊。在某些实施方案中，胶囊可以含有甲氨蝶呤。

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