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1. 发明申请

WO2012005783A1 BIODEGRADABLE SCAFFOLDS 审中-公开
标题翻译：生物可解的SCAFFOLDS
公开(公告)号：WO2012005783A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/029832
申请日：2011-03-24
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , FERRARI, Mauro , BUCHANAN, Rachel , SMID, Christine , TASCIOTTI, Ennio
发明人： FERRARI, Mauro , BUCHANAN, Rachel , SMID, Christine , TASCIOTTI, Ennio
IPC分类号： A61F13/00
CPC分类号： A61L27/56 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/3834 , A61L27/3847 , A61L27/446 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/406 , A61L2300/41 , A61L2300/44 , A61L2300/64 , A61L2430/02
摘要： In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects. Further embodiments of the present invention pertain to methods of making the compositions of the present invention.
摘要翻译：在一些实施方案中，本发明提供了组合物，其包含：（1）可生物降解的聚合物基质; 和（2）分散在基质中的至少一种可生物降解的增强粒子。在一些实施方案中，可生物降解的增强颗粒选自多孔氧化物颗粒和多孔半导体颗粒。在另外的实施方案中，本发明的组合物还包含也分散在基质中的（3）致孔剂颗粒。在另外的实施方案中，本发明的组合物也与一种或多种活性剂相关。在各种实施方案中，活性剂与可生物降解的聚合物基质，可生物降解的增强颗粒和/或致孔剂颗粒结合。在各种实施方案中，本发明的组合物可用作支架，例如用于治疗骨缺损的支架。本发明的其它实施方案涉及制备本发明组合物的方法。

2. 发明申请

WO2011156028A2 POROUS AND NON-POROUS NANOSTRUCTURES 审中-公开
标题翻译：多孔和非多孔纳米结构
公开(公告)号：WO2011156028A2
公开(公告)日：2011-12-15
申请号：PCT/US2011027746
申请日：2011-03-09
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
发明人： FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
IPC分类号： H01L29/06 , H01L21/306 , H01L23/48 , H01L23/532
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L2924/0002 , H01L2924/00
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.
摘要翻译：公开了各种微观和纳米尺度的多孔和无孔线状结构。例如，公开的是包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。还公开了制造和使用这种结构的方法。例如，本发明提供了通过以下步骤制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将所述衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

3. 发明申请

WO2007099087A1 FOLDING UNIT FOR PRODUCING SEALED PACKAGES OF POURABLE FOOD PRODUCTS 审中-公开
标题翻译：生产密封食品包装的折叠单元
公开(公告)号：WO2007099087A1
公开(公告)日：2007-09-07
申请号：PCT/EP2007/051818
申请日：2007-02-26
申请人： TETRA LAVAL HOLDINGS & FINANCE SA , FONTANAZZI, Paolo , RIMONDI, Fabrizio , PRADELLI, Massimo , MATTIOLI, Giorgio , FERRARI, Mauro
发明人： FONTANAZZI, Paolo , RIMONDI, Fabrizio , PRADELLI, Massimo , MATTIOLI, Giorgio , FERRARI, Mauro
IPC分类号： B65B61/24 , B65B49/08
CPC分类号： B65B49/08 , B65B51/144
摘要： A folding unit (1) for producing sealed packages (2) of pourable food products from respective packs (3), each having a main portion (49) folded into a desired shape, and opposite end portions (50a, 50b) to be folded to form respective folded ends (61, 62) of a relative finished package (2). The unit (1) has a first folding station (80), in turn having first retaining means (86, 87, 88) for securing each pack (3) by a relative first end portion (50b), and first folding means (90) for folding a relative second end portion (50a) of the pack (3); and the unit (1) has a second folding station (81) located downstream from the first folding station (80) in the travelling direction of the packs (3), and in turn having second retaining means (86, 87, 88) for securing each pack (3) by the relative folded second end portion (50a), and second folding means (130) for folding the relative first end portion (50b).
摘要翻译：一种折叠单元（1），用于从相应的包装（3）生产可折叠食品的密封包装（2），每个包装具有折叠成所需形状的主要部分（49）和折叠的相对端部（50a，50b）以形成相对成品包装（2）的折叠端（61,62）。单元（1）具有第一折叠站（80），其又具有用于通过相对的第一端部（50b）固定每个包装件（3）的第一保持装置（86,87,88），以及第一折叠装置），用于折叠所述包装（3）的相对第二端部（50a）; 并且所述单元（1）具有在所述包装（3）的行进方向上位于所述第一折叠站（80）的下游的第二折叠站（81），并且还具有第二保持装置（86,87,88），用于通过相对折叠的第二端部（50a）固定每个包装（3），以及用于折叠相对的第一端部（50b）的第二折叠装置（130）。

4. 发明申请

WO0168901A3 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO0168901A3
公开(公告)日：2001-12-27
申请号：PCT/EP0103027
申请日：2001-03-16
申请人： ROCHE DIAGNOSTICS GMBH , UNIV CALIFORNIA , ESSENPREIS MATTHIAS , DESAI TEJAL A , FERRARI MAURO , HANSFORD DEREK J
发明人： ESSENPREIS MATTHIAS , DESAI TEJAL A , FERRARI MAURO , HANSFORD DEREK J
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , C12M1/34 , C12Q1/00 , G01N27/327 , G01N27/40 , G01N27/416 , G01N33/66 , G01N33/68
CPC分类号： A61B5/14865 , C12Q1/006
摘要： An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.
摘要翻译：可植入分析物传感器包括基底，基底上的电极以及电极上的膜。该膜可以包含元素硅，并且在330分钟内具有至少1mg / dl的葡萄糖扩散测试结果，并且在420分钟内具有至多0.1g / dl的白蛋白扩散测试结果。

5. 发明申请

WO2021038323A1 FLUSH - MOUNTING DEVICE FOR THE MANUAL OR AUTOMATIC CROCKERY WASHING 审中-公开
公开(公告)号：WO2021038323A1
公开(公告)日：2021-03-04
申请号：PCT/IB2020/056606
申请日：2020-07-14
申请人： FERRARI, Mauro , ISINNOVA S.R.L.
发明人： ROMAIOLI, Alessandro , FRACASSI, Cristian
IPC分类号： A47L15/00
摘要： A device (1) for the automatic or manual washing of dishes (S) comprising a tub (10) and a washbasin (20). The latter can take a first operative position, in which it is inserted into the tub (10) to facilitate the manual washing of the dishes (S) or a second operative position, in which it acts as a lid for the tub (10) so as to facilitate the automatic washing of the dishes. In this second case, the tub (10) and the washbasin (20) can be hermetically coupled at the edges (11, 21) thereof so as to prevent any water spilling during washing.

6. 发明申请

WO2012150567A8 A CATHETER WITH ELECTROMAGNETIC POSITION SENSORS AND A LOCATION SYSTEM FOR CATHETERS AND GUIDE WIRES 审中-公开
标题翻译：带电磁位置传感器的导管和导线和导线的位置系统
公开(公告)号：WO2012150567A8
公开(公告)日：2013-07-25
申请号：PCT/IB2012052219
申请日：2012-05-03
申请人： UNIV PISA , CONDINO SARA , FERRARI VINCENZO , ALBERTI ALDO , FERRARI MAURO
发明人： CONDINO SARA , FERRARI VINCENZO , ALBERTI ALDO , FERRARI MAURO
IPC分类号： A61B5/06 , A61B19/00
CPC分类号： A61B5/062 , A61B34/20 , A61B2017/22038 , A61B2034/2051
摘要： Catheter (1) comprising a tubular body (3) to be introduced into a body cavity, and a plurality of electromagnetic position sensors (17, 19), each of which is positioned on a respective one of said catheter segments (7, 9), and is designed to generate, in response to an externally generated magnetic field, an electrical signal representative of the position and orientation of the respective catheter segment. Each of said electromagnetic position sensors has a substantially needle-shaped body having a longitudinal axis placed parallel to the longitudinal axis of the respective catheter segment, and is located at the wall of the respective catheter segment, eccentrically with respect to the longitudinal axis thereof.
摘要翻译：导管（1）包括被引入体腔的管体（3）和多个电磁位置传感器（17,19），每个电磁位置传感器位于所述导管段（7,9）中的相应一个上，并且被设计成响应于外部产生的磁场而产生代表相应导管段的位置和取向的电信号。每个所述电磁位置传感器具有基本上为针状的体，其具有平行于相应导管段的纵向轴线的纵向轴线，并且相对于其纵向轴线偏心地位于相应导管段的壁处。

7. 发明申请

WO2011156028A3 POROUS AND NON-POROUS NANOSTRUCTURES 审中-公开
公开(公告)号：WO2011156028A3
公开(公告)日：2011-12-15
申请号：PCT/US2011/027746
申请日：2011-03-09
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , FERRARI, Mauro , LIU, Xuewu , CHIAPPINI, Ciro , FAKHOURY, Jean, Raymond
发明人： FERRARI, Mauro , LIU, Xuewu , CHIAPPINI, Ciro , FAKHOURY, Jean, Raymond
IPC分类号： C01B31/02 , B82B1/00 , H01L21/70 , H01L21/762
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.

8. 发明申请

WO2011025602A1 COMBINATIONAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES 审中-公开
标题翻译：组合多元醇多糖和生物分子的分离，稳定和储存方法
公开(公告)号：WO2011025602A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/042557
申请日：2010-07-20
申请人： The Board of Regents of the University of Texas System , FERRARI, Mauro , LIU, Xuewu , TASCIOTTI, Ennio , BOUAMRANI, Ali , HU, Ye
发明人： FERRARI, Mauro , LIU, Xuewu , TASCIOTTI, Ennio , BOUAMRANI, Ali , HU, Ye
IPC分类号： B01D37/00
CPC分类号： G01N1/405 , G01N33/552
摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 III in a time as short as 30 minutes. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity.
摘要翻译：新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs在短至30分钟的时间内有效地产生复制生物样品的可重复提取物，至少为10μl。基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于选择个性化治疗组合，实时评估治疗功效和毒性。

9. 发明申请

WO2010120817A2 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
标题翻译：纳米通道器件及相关方法
公开(公告)号：WO2010120817A2
公开(公告)日：2010-10-21
申请号：PCT/US2010030937
申请日：2010-04-13
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , GRATTONI ALESSANDRO , GOODALL RANDY , HUDON LEE
发明人： FERRARI MAURO , LIU XUEWU , GRATTONI ALESSANDRO , GOODALL RANDY , HUDON LEE
IPC分类号： A61K9/48 , A61K9/16 , A61K9/50 , A61P19/00 , A61P19/02
CPC分类号： A61M31/002 , A61K9/0097 , A61M5/14276 , A61M2209/045
摘要： A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.
摘要翻译：配置用于体内再灌注治疗剂的胶囊。在某些实施方案中，胶囊可以含有甲氨蝶呤。

10. 发明申请

WO2010082910A1 POROUS STRUCTURES WITH MODIFIED BIODEGRADATION KINETICS 审中-公开
标题翻译：具有改良生物降解动力学的多孔结构
公开(公告)号：WO2010082910A1
公开(公告)日：2010-07-22
申请号：PCT/US2009/000239
申请日：2009-01-15
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , GODIN-VILENTCHOUK, Biana , FERRARI, Mauro
发明人： GODIN-VILENTCHOUK, Biana , FERRARI, Mauro
IPC分类号： A61K9/14
CPC分类号： A61K9/1641 , A61K9/0024
摘要： Biodegradation kinetics of biodegradable porous objects, such as porous silicon objects, can be controlled by a molecular weight of polymer chains, such as polyethylene glycol chains, disposed on an outer surface of the object. Provided are biodegradable porous objects, which have their biodegradation kinetics controlled by a molecular weight of the disposed polymer chains. Also provided are methods of making such biodegradable porous objects as well as methods of using such biodegradable porous objects for delivery of active agents, such as therapeutic agents and/or imaging agents.
摘要翻译：可生物降解的多孔物体如多孔硅物体的生物降解动力学可以通过设置在物体的外表面上的聚合物链如聚乙二醇链的分子量来控制。提供了可生物降解的多孔物体，其具有由所设置的聚合物链的分子量控制的其生物降解动力学。还提供了制造这种可生物降解的多孔物体的方法以及使用这种可生物降解的多孔物体用于递送活性剂如治疗剂和/或成像剂的方法。

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