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1. 发明申请

WO2013012641A1 SYSTEMS AND METHODS FOR COUPLING AN ULTRASOUND SOURCE TO TISSUE 审中-公开
标题翻译：用于将超声波源与组织联接的系统和方法
公开(公告)号：WO2013012641A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046327
申请日：2012-07-11
申请人： GUIDED THERAPY SYSTEMS, LLC , SLAYTON, Michael, H. , JAEGER, Paul , BARTHE, Peter, G.
发明人： SLAYTON, Michael, H. , JAEGER, Paul , BARTHE, Peter, G.
IPC分类号： A61N7/00 , A61B18/00 , A61H23/00
CPC分类号： A61B8/546 , A61B8/4444 , A61B8/4483 , A61B2018/00678 , A61B2018/00732 , A61B2018/00779 , A61B2018/00791 , A61N7/00 , A61N7/02
摘要： Various embodiments provide a system for providing a constant average output of power from an ultrasound source. In some embodiments, the system comprises an ultrasound transducer coupled to a power supply; a controller in communication with the power supply; a chirp function in communication with and operable to monitor the ultrasound transducer; a feedback loop from the chirp function to the controller. In some embodiments, the controller is operable to change a parameter on the transducer based on the feedback to provide a constant average output of power from the ultrasound transducer.
摘要翻译：各种实施例提供一种用于从超声源提供恒定的平均功率输出的系统。在一些实施例中，该系统包括耦合到电源的超声换能器; 与电源通信的控制器; 啁啾功能，其与超声换能器通信并可操作以监测超声换能器; 从啁啾功能到控制器的反馈回路。在一些实施例中，控制器可操作以基于反馈改变换能器上的参数，以提供来自超声换能器的功率的恒定平均输出。

2. 发明申请

WO2012018386A2 SYSTEMS AND METHODS FOR ULTRASOUND TREATMENT 审中-公开
标题翻译：用于超声治疗的系统和方法
公开(公告)号：WO2012018386A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/001362
申请日：2011-08-02
申请人： GUIDED THERAPY SYSTEMS, LLC , SLAYTON, Michael, H. , BARTHE, Peter, G.
发明人： SLAYTON, Michael, H. , BARTHE, Peter, G.
IPC分类号： A61B18/00 , A61N7/00 , A61B8/00 , A61B8/08
CPC分类号： A61N7/00 , A61B8/13 , A61B8/14 , A61B8/4254 , A61B8/4272 , A61B8/485 , A61B8/5246 , A61B17/320068 , A61B2018/00642 , A61B2018/00898 , A61B2090/378 , A61N7/02 , A61N2007/0013 , A61N2007/0034 , A61N2007/0052 , A61N2007/006 , A61N2007/0065 , A61N2007/0091 , A61N2007/0095 , A61N2007/027
摘要： Various embodiments provide a method for an extended field of view treatment. The method can include the steps of imaging a region; targeting a region with directed ultrasound energy; monitoring the region; moving the imaging, treatment, and monitoring region while spatially correlating to one or more prior regions via imaging and/or position sensing; continuing the extended field of view treatment; and, achieving an ultrasound induced biological effect in the extended field of view treatment region.
摘要翻译：各种实施例提供用于扩展视野治疗的方法。该方法可以包括对区域进行成像的步骤; 针对具有定向超声能量的区域; 监测该地区; 移动成像，治疗和监测区域，同时经由成像和/或位置感测在空间上与一个或多个先前区域相关; 继续扩大视野治疗; 并且在扩展的视野治疗区域实现超声诱导的生物效应。

3. 发明申请

WO2008036773A1 METHOD AND SYSTEM FOR TREATING MUSCLE, TENDON, LIGAMENT AND CARTILAGE TISSUE 审中-公开
标题翻译：用于治疗肌肉，腱，绒毛和牙齿组织的方法和系统
公开(公告)号：WO2008036773A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/078945
申请日：2007-09-19
申请人： GUIDED THERAPY SYSTEMS, LLC , BARTHE, Peter G. , MAKIN, Inder Raj S. , SLAYTON, Michael H.
发明人： BARTHE, Peter G. , MAKIN, Inder Raj S. , SLAYTON, Michael H.
IPC分类号： A61N7/00 , A61B8/08 , A61B17/00
CPC分类号： A61N7/02 , A61B8/08 , A61B8/4281 , A61B8/4483 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for treating subcutaneous tissue with energy such as ultrasound energy is disclosed. In various exemplary embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Certain exemplary procedures include a brow lift, a blepharoplasty, and treatment of cartilage tissue.
摘要翻译：公开了一种用诸如超声波能量来治疗皮下组织的方法和系统。在各种示例性实施例中，在感兴趣的区域施加超声能量以通过切割，消融，微消融，凝固或以其它方式影响皮下组织来影响组织，以进行传统上以非侵入性方式侵入地进行的许多方法。某些示例性程序包括眉毛抬高，眼睑成形术和软骨组织的治疗。

4. 发明申请

WO2005086737A3 INTRA-CAVITARY ULTRASOUND MEDICAL SYSTEM AND METHOD 审中-公开
标题翻译：室内超声医疗系统及方法
公开(公告)号：WO2005086737A3
公开(公告)日：2007-01-25
申请号：PCT/US2005007233
申请日：2005-03-07
申请人： ETHICON ENDO SURGERY INC , MAKIN INDER RAJ S , AVIDOR YOAV , SLAYTON MICHAEL H , BARTHE PETER G
发明人： MAKIN INDER RAJ S , AVIDOR YOAV , SLAYTON MICHAEL H , BARTHE PETER G
IPC分类号： A61B8/00 , A61B8/12 , A61B8/14
CPC分类号： A61B17/42 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B17/2202 , A61B2017/2253 , A61B2017/4216
摘要： A method for medically employing ultrasound within a body cavity of a patient. An end effector is obtained having a medical ultrasound transducer assembly. A biocompatible hygroscopic substance is obtained having a non-expanded anhydrous state and having an expanded and fluidly-loculated hydrated state. The end effector, including the transducer assembly, and the substance in substantially its anhydrous state are inserted into a body cavity (such as endoscopically inserted into a uterus) of a patient. The transducer assembly is used to medically image and/or medically treat patient tissue (such as stopping blood flow to, and/or ablating, a uterine fibroid). A system for medically employing ultrasound includes the end effector and the substance. In another system, the end effector includes the substance. The substance in its hydrated state expands inside the body cavity providing acoustic coupling between the wall of the body cavity and the transducer assembly.
摘要翻译：一种在患者的体腔内医用超声波的方法。获得具有医学超声换能器组件的端部执行器。获得具有未膨胀无水状态并且具有膨胀和流动位置的水合状态的生物相容性吸湿性物质。末端执行器（包括换能器组件）和基本上其无水状态的物质插入患者的体腔（例如内窥镜插入子宫中）。换能器组件用于医疗图像和/或医学上治疗患者组织（例如阻止血液流向和/或消融子宫肌瘤）。用于医学使用超声波的系统包括末端执行器和物质。在另一系统中，末端执行器包括物质。其水合状态的物质在体腔内扩张，提供体腔壁与换能器组件之间的声耦合。

5. 发明申请

WO2006116480A2 METHOD AND SYSTEM FOR ENHANCING COMPUTER PERIPHERAL SAFTEY 审中-公开
标题翻译：用于增强计算机外周保护的方法和系统
公开(公告)号：WO2006116480A2
公开(公告)日：2006-11-02
申请号：PCT/US2006015779
申请日：2006-04-25
申请人： GUIDED THERAPY SYSTEMS LLC , BARTHE PETER G , SLAYTON MICHAEL H , VADIM KOUKLEV , JAEGER PAUL M
发明人： BARTHE PETER G , SLAYTON MICHAEL H , VADIM KOUKLEV , JAEGER PAUL M
IPC分类号： G06F1/26 , H02H7/20
CPC分类号： G06F1/263 , A61B2560/0214 , G06F1/266
摘要： A method and system for enhancing computer peripheral safety is provided. In accordance with various aspects of the present invention, the exemplary method and system are configured to monitor and/or isolate alternating current (A.C.) supplies with and/or from any peripheral subsystems or devices. An exemplary method and system comprises an A.C. supply, a host computer system, and a peripheral subsystem or device connected to the host computer system, such as an ultrasound imaging and/or therapy peripheral, and an isolation subsystem configured for monitoring and/or isolating the A.C. supply from the peripheral subsystem or device. In accordance with an exemplary embodiment, an isolation subsystem comprises application software and associated modules and functions that when executed continuously monitors and/or polls the host computer's hardware and/or operating system for the presence of an isolated source, such as a battery, or an unisolated power source, such as through a battery charger and/or other connection path to the A.C. main supply. In accordance with other exemplary embodiments, an isolation subsystem can comprises a wireless or other safe/isolated electrical link for connecting a patient contact device, and/or a verification link or other verification mechanisms configured between an isolation transformer and host computer to monitor or observe usage to power the host computer and peripheral subsystem.
摘要翻译：提供了一种增强计算机外围安全性的方法和系统。根据本发明的各个方面，示例性方法和系统被配置为监视和/或隔离具有和/或来自任何外围子系统或设备的交流（A.C.）电源。示例性方法和系统包括AC电源，主计算机系统以及连接到主计算机系统的外围子系统或设备，诸如超声成像和/或治疗外围设备，以及被配置用于监视和/或隔离的隔离子系统来自外围子系统或设备的AC电源。根据示例性实施例，隔离子系统包括应用软件和相关联的模块和功能，当执行连续地监视和/或轮询主计算机的硬件和/或操作系统以存在诸如电池的隔离源的存在时，或非隔离电源，例如通过电池充电器和/或到AC主电源的其它连接路径。根据其他示例性实施例，隔离子系统可以包括用于连接患者接触装置的无线或其他安全/隔离的电气连接和/或配置在隔离变压器和主计算机之间的验证链路或其他验证机制以监视或观察用于为主机和外围子系统供电。

6. 发明申请

WO2006042201A1 METHOD AND SYSTEM FOR ULTRASOUND TISSUE TREATMENT 审中-公开
标题翻译：超声组织治疗方法与系统
公开(公告)号：WO2006042201A1
公开(公告)日：2006-04-20
申请号：PCT/US2005/036377
申请日：2005-10-06
申请人： GUIDED THERAPY SYSTEMS, L.L.C. , BARTHE, Peter G. , SLAYTON, Michael H. , MAKIN, Inder Raj S. , O'CONNOR, Brian D.
发明人： BARTHE, Peter G. , SLAYTON, Michael H. , MAKIN, Inder Raj S. , O'CONNOR, Brian D.
IPC分类号： A61N7/02 , A61B8/08
CPC分类号： A61N7/02 , A61B5/682 , A61B5/6842 , A61B8/08 , A61B8/0858 , A61B8/12 , A61B8/13 , A61B8/4209 , A61B8/4281 , A61B8/4455 , A61B8/4483 , A61B8/461 , A61B8/483 , A61B8/546 , A61B17/320068 , A61H23/0245 , A61H2201/5007 , A61N7/00 , A61N2007/0008 , A61N2007/0034 , A61N2007/0052 , A61N2007/027 , G01S15/8909
摘要： A method and system (100) for noninvasive tissue treatment are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat tissue regions (106), such as, for example, the SMAS region, photoaged tissue, acne and sebaceous glands, and/or sweat glands. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the tissue region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
摘要翻译：公开了一种用于无创组织处理的方法和系统（100）。配置示例性方法和处理系统用于成像，监测和热损伤以处理组织区域（106），例如SMAS区域，光老化组织，痤疮和皮脂腺和/或汗腺。根据示例性实施例，所述示例性方法和系统被配置用于通过首先对所述感兴趣区域进行成像以处理所述组织区域，以对所述治疗区域和周围结构进行定位;其次，在深度，分布，时间和能量水平，以达到预期的治疗效果，第三是监测治疗前，治疗期间和治疗后的治疗区域，以计划和评估结果和/或提供反馈。

7. 发明申请

WO2006034000A1 METHOD AND SYSTEM FOR ULTRASOUND TREATMENT WITH A MULTI-DIRECTIONAL TRANSDUCER 审中-公开
标题翻译：用于多方向传感器超声处理的方法和系统
公开(公告)号：WO2006034000A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033046
申请日：2005-09-16
申请人： GUIDED THERAPY SYSTEMS, L.L.C. , BARTHE, Peter G. , SLAYTON, Michael H.
发明人： BARTHE, Peter G. , SLAYTON, Michael H.
IPC分类号： A61N7/02
CPC分类号： A61N7/022 , A61B8/4272 , A61B2017/00084 , A61B2090/378 , A61N2007/0078
摘要： A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises a transduction element configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction element can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction element can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.
摘要翻译：一种利用多向换能器来促进诸如在两个或更多个方向上的治疗和/或成像或其它组织参数监测的治疗的超声治疗的方法和系统。根据示例性实施例，多方向换能器包括换能元件，其被配置成在两个或更多个方向上提供超声能量，例如辐射，声能，热能，成像，位置信息和/或组织参数监测信号。转导元件可以包括用于提供超声能量或辐射的各种材料，例如具有和不具有匹配层的压电材料。此外，转导元件可以被配置为基本上均匀的，聚焦的和/或散焦的辐射图，以及用于单个，多元件和/或多元件阵列配置。此外，示例性多向换能器可以包括多个元件，并排，堆叠或阵列。

8. 发明申请

WO2013009784A2 SYSTEMS AND METHOD FOR ACCELERATING HEALING OF IMPLANTED MATERIAL AND/OR NATIVE TISSUE 审中-公开
标题翻译：用于加速植入材料和/或原始组织的加工的系统和方法
公开(公告)号：WO2013009784A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046122
申请日：2012-07-10
申请人： GUIDED THERAPY SYSTEMS, LLC , SLAYTON, Michael, H.
发明人： SLAYTON, Michael, H.
IPC分类号： A61N7/00 , A61B18/00 , A61B18/18 , A61N5/10 , A61N1/44
CPC分类号： A61N7/00 , A61B18/18 , A61B2018/00642 , A61M37/0092 , A61N7/02 , A61N2007/0004 , A61N2007/0017 , A61N2007/0034 , A61N2007/0039 , A61N2007/0052 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/027
摘要： Various embodiments provide methods and systems for ultrasound treatment of tissue are provided. Accordingly, a method can include locating an implant in a site in a body, directing a medicant to at least one of the implant and the site, directing ultrasound energy to the site, and accelerating healing of the implant and/or native tissue at the site.
摘要翻译：提供了各种实施例提供了用于组织超声处理的方法和系统。因此，一种方法可以包括将植入物定位在体内的部位中，将药物定向到至少一个植入物和位点，将超声能量引导到部位，以及加速植入物和/或天然组织的愈合现场。

9. 发明申请

WO2008137948A1 METHOD AND SYSTEM FOR COMBINED ENERGY THERAPY PROFILE 审中-公开
标题翻译：用于组合能量治疗概况的方法和系统
公开(公告)号：WO2008137948A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/062936
申请日：2008-05-07
申请人： GUIDED THERAPY SYSTEMS, LLC. , SLAYTON, Michael H , BARTHE, Peter G , MAKIN, Inder Raj S.
发明人： SLAYTON, Michael H , BARTHE, Peter G , MAKIN, Inder Raj S.
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61N7/02 , A61B8/4281 , A61N2007/0008 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.
摘要翻译：公开了一种用组合治疗方案处理组织的方法和系统。在一个示例性实施例中，使用超声能量来治疗感兴趣区域内的组织的许多深度，并且改变超声能量的空间和时间属性以进行更有效的治疗。本发明的方法和系统被配置为从表面上向下处理所有的组织，而不是备用的中间组织。

10. 发明申请

WO2008137942A1 METHODS AND SYSTEMS FOR MODULATING MEDICANTS USING ACOUSTIC ENERGY 审中-公开
标题翻译：使用声学能量调制药物的方法和系统
公开(公告)号：WO2008137942A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/062930
申请日：2008-05-07
申请人： GUIDED THERAPY SYSTEMS, LLC. , MAKIN, Inder Raj S. , SLAYTON, Michael H , BARTHE, Peter G
发明人： MAKIN, Inder Raj S. , SLAYTON, Michael H , BARTHE, Peter G
IPC分类号： A61M37/00
CPC分类号： A61M37/0092 , A61B8/4281 , A61B2090/378 , A61M2037/0007 , A61M2205/3375 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0043 , A61N2007/0056
摘要： This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system (14) for enhancing medicant delivery and/or effectiveness comprises a control system (20), a probe (18), and a display (22) or indicator (22) system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。在示例性实施例中，本文公开的方法和系统能够调制多层组织。在示例性实施例中，能量是声能（例如，超声）。在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合形式或能量吸收器如冷却。首先通过扩散，循环和/或注射将药物引入感兴趣的区域。用于增强药物输送和/或有效性的示例性系统（14）包括控制系统（20），探针（18）和显示器（22）或指示器（22）系统。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

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