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1. 发明申请

WO2006042201A1 METHOD AND SYSTEM FOR ULTRASOUND TISSUE TREATMENT 审中-公开
标题翻译：超声组织治疗方法与系统
公开(公告)号：WO2006042201A1
公开(公告)日：2006-04-20
申请号：PCT/US2005/036377
申请日：2005-10-06
申请人： GUIDED THERAPY SYSTEMS, L.L.C. , BARTHE, Peter G. , SLAYTON, Michael H. , MAKIN, Inder Raj S. , O'CONNOR, Brian D.
发明人： BARTHE, Peter G. , SLAYTON, Michael H. , MAKIN, Inder Raj S. , O'CONNOR, Brian D.
IPC分类号： A61N7/02 , A61B8/08
CPC分类号： A61N7/02 , A61B5/682 , A61B5/6842 , A61B8/08 , A61B8/0858 , A61B8/12 , A61B8/13 , A61B8/4209 , A61B8/4281 , A61B8/4455 , A61B8/4483 , A61B8/461 , A61B8/483 , A61B8/546 , A61B17/320068 , A61H23/0245 , A61H2201/5007 , A61N7/00 , A61N2007/0008 , A61N2007/0034 , A61N2007/0052 , A61N2007/027 , G01S15/8909
摘要： A method and system (100) for noninvasive tissue treatment are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat tissue regions (106), such as, for example, the SMAS region, photoaged tissue, acne and sebaceous glands, and/or sweat glands. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the tissue region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
摘要翻译：公开了一种用于无创组织处理的方法和系统（100）。配置示例性方法和处理系统用于成像，监测和热损伤以处理组织区域（106），例如SMAS区域，光老化组织，痤疮和皮脂腺和/或汗腺。根据示例性实施例，所述示例性方法和系统被配置用于通过首先对所述感兴趣区域进行成像以处理所述组织区域，以对所述治疗区域和周围结构进行定位;其次，在深度，分布，时间和能量水平，以达到预期的治疗效果，第三是监测治疗前，治疗期间和治疗后的治疗区域，以计划和评估结果和/或提供反馈。

2. 发明申请

WO2008036773A1 METHOD AND SYSTEM FOR TREATING MUSCLE, TENDON, LIGAMENT AND CARTILAGE TISSUE 审中-公开
标题翻译：用于治疗肌肉，腱，绒毛和牙齿组织的方法和系统
公开(公告)号：WO2008036773A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/078945
申请日：2007-09-19
申请人： GUIDED THERAPY SYSTEMS, LLC , BARTHE, Peter G. , MAKIN, Inder Raj S. , SLAYTON, Michael H.
发明人： BARTHE, Peter G. , MAKIN, Inder Raj S. , SLAYTON, Michael H.
IPC分类号： A61N7/00 , A61B8/08 , A61B17/00
CPC分类号： A61N7/02 , A61B8/08 , A61B8/4281 , A61B8/4483 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for treating subcutaneous tissue with energy such as ultrasound energy is disclosed. In various exemplary embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Certain exemplary procedures include a brow lift, a blepharoplasty, and treatment of cartilage tissue.
摘要翻译：公开了一种用诸如超声波能量来治疗皮下组织的方法和系统。在各种示例性实施例中，在感兴趣的区域施加超声能量以通过切割，消融，微消融，凝固或以其它方式影响皮下组织来影响组织，以进行传统上以非侵入性方式侵入地进行的许多方法。某些示例性程序包括眉毛抬高，眼睑成形术和软骨组织的治疗。

3. 发明申请

WO2008137948A1 METHOD AND SYSTEM FOR COMBINED ENERGY THERAPY PROFILE 审中-公开
标题翻译：用于组合能量治疗概况的方法和系统
公开(公告)号：WO2008137948A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/062936
申请日：2008-05-07
申请人： GUIDED THERAPY SYSTEMS, LLC. , SLAYTON, Michael H , BARTHE, Peter G , MAKIN, Inder Raj S.
发明人： SLAYTON, Michael H , BARTHE, Peter G , MAKIN, Inder Raj S.
IPC分类号： A61N7/00 , A61N7/02
CPC分类号： A61N7/02 , A61B8/4281 , A61N2007/0008 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.
摘要翻译：公开了一种用组合治疗方案处理组织的方法和系统。在一个示例性实施例中，使用超声能量来治疗感兴趣区域内的组织的许多深度，并且改变超声能量的空间和时间属性以进行更有效的治疗。本发明的方法和系统被配置为从表面上向下处理所有的组织，而不是备用的中间组织。

4. 发明申请

WO2008137942A1 METHODS AND SYSTEMS FOR MODULATING MEDICANTS USING ACOUSTIC ENERGY 审中-公开
标题翻译：使用声学能量调制药物的方法和系统
公开(公告)号：WO2008137942A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/062930
申请日：2008-05-07
申请人： GUIDED THERAPY SYSTEMS, LLC. , MAKIN, Inder Raj S. , SLAYTON, Michael H , BARTHE, Peter G
发明人： MAKIN, Inder Raj S. , SLAYTON, Michael H , BARTHE, Peter G
IPC分类号： A61M37/00
CPC分类号： A61M37/0092 , A61B8/4281 , A61B2090/378 , A61M2037/0007 , A61M2205/3375 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0043 , A61N2007/0056
摘要： This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system (14) for enhancing medicant delivery and/or effectiveness comprises a control system (20), a probe (18), and a display (22) or indicator (22) system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。在示例性实施例中，本文公开的方法和系统能够调制多层组织。在示例性实施例中，能量是声能（例如，超声）。在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合形式或能量吸收器如冷却。首先通过扩散，循环和/或注射将药物引入感兴趣的区域。用于增强药物输送和/或有效性的示例性系统（14）包括控制系统（20），探针（18）和显示器（22）或指示器（22）系统。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

5. 发明申请

WO2008036622A2 METHOD AND SYSTEM FOR NON-ABLATIVE ACNE TREATMENT AND PREVENTION 审中-公开
标题翻译：非侵入性ACNE治疗和预防方法与系统
公开(公告)号：WO2008036622A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/078712
申请日：2007-09-18
申请人： GUIDED THERAPY SYSTEMS, LLC , MAKIN, Inder Raj S. , BARTHE, Peter G.
发明人： MAKIN, Inder Raj S. , BARTHE, Peter G.
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B2017/00747 , A61B2017/22008 , A61B2018/00666 , A61M37/0092 , A61N7/00 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.
摘要翻译：公开了一种用于非烧蚀性痤疮治疗和预防的方法和系统。该方法利用针对感兴趣区域的超声能量来治疗现有的痤疮并防止将来的痤疮形成。超声能量的应用导致许多治疗痤疮的生理效应。这些生理作用中的一些包括减少皮脂，增加感兴趣区域的灌注，在感兴趣的区域变性蛋白质，在感兴趣的区域产生不适宜的环境，在感兴趣的区域启动程序性细胞死亡并引发机械效应在感兴趣的地区。

6. 发明申请

WO2014178944A1 METHODS AND DEVICES FOR WOUND THERAPY 审中-公开
标题翻译：治疗方法和设备
公开(公告)号：WO2014178944A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/019974
申请日：2014-03-03
申请人： VOMARIS INNOVATIONS, INC. , SKIBA, Jeffry , MAKIN, Inder Raj S.
发明人： SKIBA, Jeffry , MAKIN, Inder Raj S.
IPC分类号： A61N1/18 , A61N1/02
CPC分类号： A61N1/0468 , A61F13/00038 , A61F13/00051 , A61F13/00063 , A61F13/02 , A61F2013/0028 , A61G10/026 , A61M1/0088 , A61M35/00 , A61M2202/0208 , A61N1/0428 , A61N1/0464 , A61N1/0476 , A61N1/0492 , A61N1/205 , A61N1/30 , A61N1/325 , A61N1/326
摘要： A system for wound treatment includes adjunctive wound therapy devices and substrates comprising multiple first reservoirs and multiple second reservoirs. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
摘要翻译：用于伤口治疗的系统包括辅助伤口治疗装置和包括多个第一储存器和多个第二储存器的基底。所述多个第一储存器中的选定的储存器包括还原剂，并且所述多个第一储存器中的所选多个第一储存器中的第一储存器表面靠近第一基板表面。多个第二储存器中的选定的储存器包括氧化剂，并且多个第二储存器中选定的多个第二储存器的第二储存器表面靠近第一基板表面。

7. 发明申请

WO2014178943A1 METHODS AND DEVICES FOR CELLULAR ACTIVATION 审中-公开
标题翻译：细胞激活的方法和装置
公开(公告)号：WO2014178943A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/019972
申请日：2014-03-03
申请人： VOMARIS INNOVATIONS, INC. , SKIBA, Jeffry , MAKIN, Inder Raj S.
发明人： SKIBA, Jeffry , MAKIN, Inder Raj S.
IPC分类号： C12M1/42
CPC分类号： A61N1/0468 , A61F13/00038 , A61F13/00051 , A61F13/00063 , A61F13/02 , A61F2013/0028 , A61G10/026 , A61M1/0088 , A61M35/00 , A61M2202/0208 , A61N1/0428 , A61N1/0464 , A61N1/0476 , A61N1/0492 , A61N1/205 , A61N1/30 , A61N1/325 , A61N1/326
摘要： An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
摘要翻译：一种装置包括多个第一储存器和与基板连接的多个第二储存器。所述多个第一储存器中的选定的储存器包括还原剂，并且所述多个第一储存器中的所选多个第一储存器中的第一储存器表面靠近第一基板表面。多个第二储存器中的选定的储存器包括氧化剂，并且多个第二储存器中选定的多个第二储存器的第二储存器表面靠近第一基板表面。

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