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1. 发明申请

WO1995008354A1 IMPLANTATION MATERIAL 审中-公开
标题翻译：植物材料
公开(公告)号：WO1995008354A1
公开(公告)日：1995-03-30
申请号：PCT/JP1994001565
申请日：1994-09-22
申请人： TAKIRON CO., LTD. , SHIKINAMI, Yasuo
发明人： TAKIRON CO., LTD.
IPC分类号： A61L27/00
CPC分类号： A61L27/56 , A61F2/0063 , A61F2/0077 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2/30965 , A61F2002/0068 , A61F2002/30009 , A61F2002/30062 , A61F2002/30199 , A61F2002/30261 , A61F2002/30909 , A61F2002/30914 , A61F2002/30915 , A61F2002/3092 , A61F2210/0004 , A61F2230/0063 , A61F2230/0082 , A61F2250/0028 , A61F2310/00592 , A61F2310/00796 , A61L27/00 , A61L27/50 , Y10T428/1362 , Y10T428/1369
摘要： An implantation material is provided which has a high three-dimensional mechanical strength, a durability and the nature of synchronizing itself with the deformation characteristics of the surrounding organic tissue, and which is capable of having organic tissue enter voids in tissue, and burying itself in the interior of the body for a long period of time whithout causing any reaction of extraneous matter or by being combined with organic tissue positively. A bulked structure which is formed by organic fiber in the form of three-dimensional woven or knitted tissue or complex tissue of a combination of such woven tissue and knitted tissue, and which has biocompatibility, is used as a base material, a voidage in the tissue being preferably set to 20-90 vol%. More preferably, the surface of the organic fiber constituting the bulked structure is subjected to an organism activation treatment or an organism deactivation treatment.
摘要翻译：提供了具有高三维机械强度，耐久性和与周围有机组织的变形特性同步的本质的植入材料，并且能够使有机组织进入组织中的空隙，并将其自身埋入身体的内部长时间没有引起外来物质的任何反应或与有机组织积极结合。以三维机织或针织组织形式的有机纤维或这种机织组织和针织组织的组合的复合组织形成并且具有生物相容性的膨化结构被用作基础材料，组织优选设定为20〜90体积％。更优选地，构成膨化结构的有机纤维的表面进行生物体活化处理或生物体失活处理。

2. 发明申请

WO1995004094A1 BASE POLYMER FOR PERCUTANEOUSLY ABSORBABLE PREPARATION 审中-公开
标题翻译：基础聚合物可用于可吸收制剂
公开(公告)号：WO1995004094A1
公开(公告)日：1995-02-09
申请号：PCT/JP1994001253
申请日：1994-07-29
申请人： TAKIRON CO., LTD. , SHIKINAMI, Yasuo
发明人： TAKIRON CO., LTD.
IPC分类号： C08G18/48
CPC分类号： C08G18/4833 , A61K9/7023 , C08G18/283 , C08G18/4808
摘要： A base polymer for percutaneously absorbable preparations that is solid at ordinary temperatures but turns into a low-viscosity liquid near the human skin temperature, contains a hydrophilic segment, is responsive to heat and water, and enables drugs which have been difficult to compound into a percutaneously absorbable preparation to be stored stably for long and absorbed percutaneously with a high releasability and a high sustained releasability without causing much skin stimulation. The polymer comprises a heat-responsive segmented polyurethane represented by the general formula R-A-(U)-C-(U)-B-R , wherein A and B represent each independently a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof; R and R represent each H, CH3, C2H5, C3H7 or C4H9 as the terminal group of A and B, respectively; C represents a residue of a diisocyanate compound; and (U) represents a urethane linkage; and wherein at least one of A and B is hydrophilic and at the same time will melt near the human skin temperature.
摘要翻译：用于经皮吸收制剂的基础聚合物，其在常温下为固体但在人体皮肤温度附近变成低粘度液体，含有亲水性片段，对热和水有反应，并且使难以复合的药物经皮吸收制剂经长时间保存并经皮吸收，具有高释放性和高持久释放性，而不引起皮肤刺激。聚合物包含由通式RA-（U）-C-（U）-BR 1表示的热响应性分段聚氨酯，其中A和B各自独立地表示环氧乙烷，环氧丙烷，四氢呋喃或 1,2-环氧丁烷或其无规或嵌段共聚物; R和R 1分别表示作为A和B的末端基团的H，CH 3，C 2 H 5，C 3 H 7或C 4 H 9; C表示二异氰酸酯化合物的残基; （U）表示氨基甲酸酯键; 并且其中A和B中的至少一个是亲水性的，并且同时将在人的皮肤温度附近熔化。

3. 发明申请

WO1989006143A1 SURGICAL MATERIAL WHICH IS DEGRADABLE AND ABSORBABLE IN VIVO AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：外科手术材料可以降解和吸收，以及其制备方法
公开(公告)号：WO1989006143A1
公开(公告)日：1989-07-13
申请号：PCT/JP1988001337
申请日：1988-12-27
申请人： BIOMATERIALS UNIVERSE, INC. , TAKIRON CO., LTD. , HYON, Suong-Hyu , IKADA, Yoshito , SHIKINAMI, Yasuo , TSUTA, Kaoru , BOUTANI, Hidekazu
发明人： BIOMATERIALS UNIVERSE, INC. , TAKIRON CO., LTD.
IPC分类号： A61L31/00
CPC分类号： A61L31/148 , A61L31/06 , A61L31/14 , A61B17/58 , C08L67/04
摘要： A surgical material which is degradable and absorbable in vivo comprising a molecularly oriented molding of polylactic acid or a copolymer of lactic acid with glycolic acid, which has a compression bending strength of 1.6 x 103 to 2.5 x 103 kg/cm2, compression bending modulus of 5.5 x 102 to 24.0 x 102 kg/mm2, a crystallinity of 10 to 60 % as determined by densitometry, and a viscosity-average molecular weight of 200,000 or more after melt-molding, and which can maintain 80 % or more of the initial strength even after being dipped in physiological saline at 37°C for 3 months.

4. 发明申请

WO1997010010A1 OSTEOSYNTHETIC MATERIAL, COMPOSITED IMPLANT MATERIAL, AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：合成材料，复合植入材料及其制备方法
公开(公告)号：WO1997010010A1
公开(公告)日：1997-03-20
申请号：PCT/JP1996002642
申请日：1996-09-13
申请人： TAKIRON CO., LTD. , SHIKINAMI, Yasuo , OKUNO, Masaki
发明人： TAKIRON CO., LTD.
IPC分类号： A61L27/00
CPC分类号： C08L67/04 , A61L27/46 , A61L27/58 , A61L31/06 , A61L31/127 , A61L31/14 , A61L31/148 , A61L31/18 , B29C43/02 , B29C43/16 , B29C2791/001 , B29K2067/043 , B29K2067/046 , B29K2105/0005 , B29K2105/16 , B29K2105/251 , B29K2105/255 , B29K2267/043 , B29K2995/0041 , B29K2995/0051 , B29K2995/0059 , B29K2995/006 , B29L2031/7532 , A61L27/18 , A61F2/28 , A61B17/58
摘要： A high-bending-strength and high-density osteosynthetic material and a high-strength implant material, comprising either a biodegradable and bioabsorbable crystalline thermoplastic polymer material or a composite material comprising the above polymer material and a bioceramic powder having a particle diameter of 0.2 to 50 mu m dispersed therein, wherein crystals of the polymer material are pressure-oriented essentially parallel to a plurality of reference axes rather than uniaxially; and a process for preparing the above materials by pressure orientation, comprising preparing either a biodegradable and bioabsorbable crystalline thermoplastic polymer material or a mixture comprising a dispersion of a biodegradable and bioabsorbable crystalline thermoplastic polymer material and a dispersion of a bioceramic powder, melt-forming the mxiture into a preform, and pressure filling the preform into a cavity of a closed mold to prepare an oriented form. This process enables the preparation of ideal biomaterials, i.e., an osteosynthetic material and an implant material comprising an oriented form with crystals oriented parallel to a plurality of reference axes and possessing low anisotropy, high denseness, and high strength, which have suitable hydrolyzability, can retain satisfactory strength for a period of time necessary for bone coaptation and, after the recovery of the fractured portion, is degraded and adsorbed at such a rate as will not cuase any inflammation, thus eliminating the need to conduct reoperation.
摘要翻译：高抗弯强度和高密度骨接合材料和高强度植入材料，其包括可生物降解和生物可吸收的结晶热塑性聚合物材料或包含上述聚合物材料的复合材料和粒径为0.2至 50μm分散在其中，其中聚合物材料的晶体基本上平行于多个参考轴而不是单轴压力取向; 以及通过压力取向制备上述材料的方法，包括制备可生物降解和生物可吸收的结晶热塑性聚合物材料或包含可生物降解和生物可吸收的结晶热塑性聚合物材料的分散体和生物陶瓷粉末的分散体的混合物，将预成型件浇注到预成型件中，并且将预成型件的压力填充到封闭模具的空腔中以制备取向形式。该方法使得能够制备理想的生物材料，即，包括具有平行于多个参考轴定向且具有低各向异性，高致密度和高强度的晶体的定向形式的骨接合材料和植入材料，其具有合适的可水解性，可以在骨接合所需的时间内保持令人满意的强度，并且在破裂部分恢复之后，以不会引起任何炎症的速度降解和吸附，因此不需要进行再手术。

5. 发明申请

WO1995003879A1 PHASE SEPARATED MEMBRANE 审中-公开
标题翻译：相分离膜
公开(公告)号：WO1995003879A1
公开(公告)日：1995-02-09
申请号：PCT/JP1994001254
申请日：1994-07-29
申请人： TAKIRON CO., LTD. , SHIKINAMI, Yasuo
发明人： TAKIRON CO., LTD.
IPC分类号： B01D71/54
CPC分类号： A61K9/7084 , B01D67/003 , B01D69/141 , B01D71/54 , B01D71/74 , B01D2325/34
摘要： A phase separated membrane for facilitating the control of permeation rate of a minute amount of medicine and other chemical materials and the regulation of permeation amount of the same. The membrane is constituted such that a bridged gelatin phase 1 and a non-bridged segmented polyurethane phase 2 are mixed but phase-separated. The segmented polyurethane phase is solid at normal temperature but is dissolved to become liquid at 30 to 40 DEG C which is close to the skin temperature of human being.
摘要翻译：相分离膜，用于控制微量药物和其他化学物质的渗透速率以及其渗透量的调节。构成膜，使得桥接的明胶相1和非桥连的分段聚氨酯相2混合但相分离。分段聚氨酯相在常温下为固体，但在接近人体皮肤温度的30〜40℃下溶解成液体。

6. 发明申请

WO1995009008A1 PERCUTANEOUSLY ABSORBABLE PREPARATION 审中-公开
标题翻译： PERCUTANEOUSYOUSLY可吸收制剂
公开(公告)号：WO1995009008A1
公开(公告)日：1995-04-06
申请号：PCT/JP1994001584
申请日：1994-09-27
申请人： TAKIRON CO., LTD. , ONO PHARMACEUTICAL CO., LTD. , SHIKINAMI, Yasuo , HATA, Kunihiro , SASATANI, Seiei , SUDOH, Masao
发明人： TAKIRON CO., LTD. , ONO PHARMACEUTICAL CO., LTD.
IPC分类号： A61K47/30
CPC分类号： A61K9/7084
摘要： A percutaneously absorbable preparation which can long stably preserve a water-soluble drug capable of exhibiting the effect in a small dose and being readily decomposable, solid at ordinary temperature and difficultly absorbable percutaneously and which can sustainedly release the drug percutaneously at a high rate when applied to the skin. The preparation comprises a drug store layer wherein a drug is incorporated and a drug release control membrane for coating the drug release surface of the drug store layer. This layer is made from a heat-sensitive segmented polyurethane which is represented by the following general formula: R-A-(U)-F-(U)-B-R', (wherein A and B represent each a homopolymer or a random or block copolymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide; R and R' represent each H, CH3, C2H5, C3H7 or C4H9 as the terminal of each of A nad B; A=B or A NOTEQUAL B; R=R' or R NOTEQUAL R'; F represents the residue of a diisocyanate compound; and (U) represents a urethane bond) and wherein at least one of A and B is hydrophilic and at least one of them will melt near the human skin temperature. The drug release control membrane comprises a phase-separation membrane wherein a cross-linked gelatin phase and a non-cross-linked segmented polyurethane phase are intermingled.
摘要翻译：一种经皮吸收制剂，其可以长期稳定地保持能够以小剂量显示效果并且易于分解的常温下的固体，并且经皮难以吸收的水溶性药物，并且其可以在施用时以高速率经皮持续释放药物到皮肤。该制剂包括其中掺入药物的药物储存层和用于涂覆药物储存层的药物释放表面的药物释放控制膜。该层由热敏分段聚氨酯制成，其由以下通式表示：RA-（U）-F-（U）-B-R'，（其中A和B各自表示均聚物或随机或环氧乙烷，环氧丙烷，四氢呋喃或1,2-环氧丁烷的嵌段共聚物; R和R'表示作为A nad B各自的H，CH 3，C 2 H 5，C 3 H 7或C 4 H 9; A = B或A B; R = R'或R“等式R”; F表示二异氰酸酯化合物的残基;（U）表示氨基甲酸酯键），并且其中A和B中的至少一个是亲水性的，并且其中至少一个将在近人体皮肤温度。药物释放控制膜包括其中交联的凝胶相和非交联的分段的聚氨酯相混合的相分离膜。

7. 发明申请

WO1993008796A1 SELF-ADHESIVE FOR PERCUTANEOUSLY ABSORBABLE PREPARATION 审中-公开
标题翻译：自粘性可吸收制剂
公开(公告)号：WO1993008796A1
公开(公告)日：1993-05-13
申请号：PCT/JP1991001507
申请日：1991-11-02
申请人： TAKIRON CO., LTD. , SHIKINAMI, Yasuo , HATA, Kunihiro
发明人： TAKIRON CO., LTD.
IPC分类号： A61K09/70
CPC分类号： A61K9/7069 , A61L15/58 , C08G18/10 , C08G18/283 , C08G18/4837 , C08G2170/40 , C08G2270/00 , C08L75/04 , C08G18/48
摘要： A self-adhesive for percutaneously absorbable preparations comprising segmented polyurethane which can control the solubility and releasability of a wide variety of drugs which are solid at ordinary temperature, wherein the segment comprises an alkylene oxide chain which is liquid around ordinary or body temperature, and either contains both of hydrophilic and hydrophobic alkylene oxide chains or is composed of one or both of these chains and an alkylene oxide chain containing hydrophilic and hydrophobic parts.
摘要翻译：用于经皮吸收制剂的自粘合剂，其包含能够控制在常温下为固体的各种各样的药物的溶解性和脱模性的分段聚氨酯，其中所述片段包含在常温或体温下为液体的环氧烷链，含有亲水和疏水环氧烷链，或由这些链中的一个或两个和含有亲水和疏水部分的烯化氧链组成。

8. 发明申请

WO1985002977A1 PEST-REPELLENT 审中-公开
标题翻译： PEST拒
公开(公告)号：WO1985002977A1
公开(公告)日：1985-07-18
申请号：PCT/JP1984000630
申请日：1984-12-28
申请人： TAKIRON CO., LTD. , EARTH CHEMICAL CO., LTD. , SHIKINAMI, Yasuo , HATA, Kunihiro , UTSUMI, Kiyoshi , KIMURA, Hiroshi
发明人： TAKIRON CO., LTD. , EARTH CHEMICAL CO., LTD.
IPC分类号： A01N25/10
CPC分类号： A01N25/10 , A01N25/18
摘要： A pest-repellent prepared by molding a mixture of chlorinated polyethylene, a thermoplastic elastomer, and a pest-repellent, which serves to keep pests, such as flies, flees, ticks, or cockroaches away from, particularly, food-treating places.

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