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1. 发明申请

WO1997010010A1 OSTEOSYNTHETIC MATERIAL, COMPOSITED IMPLANT MATERIAL, AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：合成材料，复合植入材料及其制备方法
公开(公告)号：WO1997010010A1
公开(公告)日：1997-03-20
申请号：PCT/JP1996002642
申请日：1996-09-13
申请人： TAKIRON CO., LTD. , SHIKINAMI, Yasuo , OKUNO, Masaki
发明人： TAKIRON CO., LTD.
IPC分类号： A61L27/00
CPC分类号： C08L67/04 , A61L27/46 , A61L27/58 , A61L31/06 , A61L31/127 , A61L31/14 , A61L31/148 , A61L31/18 , B29C43/02 , B29C43/16 , B29C2791/001 , B29K2067/043 , B29K2067/046 , B29K2105/0005 , B29K2105/16 , B29K2105/251 , B29K2105/255 , B29K2267/043 , B29K2995/0041 , B29K2995/0051 , B29K2995/0059 , B29K2995/006 , B29L2031/7532 , A61L27/18 , A61F2/28 , A61B17/58
摘要： A high-bending-strength and high-density osteosynthetic material and a high-strength implant material, comprising either a biodegradable and bioabsorbable crystalline thermoplastic polymer material or a composite material comprising the above polymer material and a bioceramic powder having a particle diameter of 0.2 to 50 mu m dispersed therein, wherein crystals of the polymer material are pressure-oriented essentially parallel to a plurality of reference axes rather than uniaxially; and a process for preparing the above materials by pressure orientation, comprising preparing either a biodegradable and bioabsorbable crystalline thermoplastic polymer material or a mixture comprising a dispersion of a biodegradable and bioabsorbable crystalline thermoplastic polymer material and a dispersion of a bioceramic powder, melt-forming the mxiture into a preform, and pressure filling the preform into a cavity of a closed mold to prepare an oriented form. This process enables the preparation of ideal biomaterials, i.e., an osteosynthetic material and an implant material comprising an oriented form with crystals oriented parallel to a plurality of reference axes and possessing low anisotropy, high denseness, and high strength, which have suitable hydrolyzability, can retain satisfactory strength for a period of time necessary for bone coaptation and, after the recovery of the fractured portion, is degraded and adsorbed at such a rate as will not cuase any inflammation, thus eliminating the need to conduct reoperation.
摘要翻译：高抗弯强度和高密度骨接合材料和高强度植入材料，其包括可生物降解和生物可吸收的结晶热塑性聚合物材料或包含上述聚合物材料的复合材料和粒径为0.2至 50μm分散在其中，其中聚合物材料的晶体基本上平行于多个参考轴而不是单轴压力取向; 以及通过压力取向制备上述材料的方法，包括制备可生物降解和生物可吸收的结晶热塑性聚合物材料或包含可生物降解和生物可吸收的结晶热塑性聚合物材料的分散体和生物陶瓷粉末的分散体的混合物，将预成型件浇注到预成型件中，并且将预成型件的压力填充到封闭模具的空腔中以制备取向形式。该方法使得能够制备理想的生物材料，即，包括具有平行于多个参考轴定向且具有低各向异性，高致密度和高强度的晶体的定向形式的骨接合材料和植入材料，其具有合适的可水解性，可以在骨接合所需的时间内保持令人满意的强度，并且在破裂部分恢复之后，以不会引起任何炎症的速度降解和吸附，因此不需要进行再手术。

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