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1. 发明申请

WO2007133249A2 COMPOSITIONS AND METHODS TO TREAT SKIN DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS 审中-公开
标题翻译：细胞增殖和血管生成特征的组合物和治疗皮肤疾病的方法
公开(公告)号：WO2007133249A2
公开(公告)日：2007-11-22
申请号：PCT/US2006040242
申请日：2006-10-12
申请人： PALOMA PHARMACEUTICALS INC , SHERRIS DAVID I
发明人： SHERRIS DAVID I
IPC分类号： H03K3/00
CPC分类号： A61K31/353 , A61K8/37 , A61K8/4926 , A61K8/4953 , A61K8/498 , A61K31/19 , A61K31/352 , A61K31/366 , A61K31/37 , A61K31/382 , A61K31/473 , A61K31/517 , A61Q17/04 , A61Q19/08
摘要： Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photodamaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin, involving aberrant angiogenesis and hyperplasia employing one or more benzo[c]chromen-6-one derivatives.
摘要翻译：本文描述了用于预防和/或治疗皮肤疾病的组合物和方法，包括但不限于牛皮癣和特应性皮炎，以及提供抗衰老益处，其导致皱纹和老化皮肤的出现减少，皮肤颜色改善，治疗皮肤光泽改善，透明度和光洁度的改善，皮肤整体健康和年轻的外观，涉及使用一种或多种苯并[c]色精-6-酮衍生物的异常血管生成和增生。

2. 发明申请

WO2003075005A1 FUNGAL ANTIGENS AND EOSINOPHIL ACTIVITY 审中-公开
标题翻译：真菌抗原和爱滋病活动
公开(公告)号：WO2003075005A1
公开(公告)日：2003-09-12
申请号：PCT/US2003/006380
申请日：2003-02-28
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , PONIKAU, Jens , KITA, Hirohito , SHERRIS, David, A.
发明人： PONIKAU, Jens , KITA, Hirohito , SHERRIS, David, A.
IPC分类号： G01N33/48
CPC分类号： G01N33/505 , A61K36/06 , C12Q1/18 , G01N33/5047 , G01N2333/37 , G01N2333/38 , G01N2333/40 , G01N2800/26
摘要： The invention provides methods and materials related to T cell activation, eosinophil activation, and the ability of eosinophils to attack fungi. The invention also provides animals having a fungal antigen-induced eosinophilic response as well as methods of making such animals and method of using such animals to identify compounds that inhibit an eosinophilic response in an animal.
摘要翻译：本发明提供了与T细胞活化，嗜酸性粒细胞活化以及嗜酸性粒细胞攻击真菌的能力相关的方法和材料。本发明还提供具有真菌抗原诱导的嗜酸性反应的动物以及制备这种动物的方法以及使用这些动物鉴定在动物中抑制嗜酸性反应的化合物的方法。

3. 发明申请

WO2008027459A2 DETECTING A BACTERIAL PROCESS IN CHRONIC RHINOSINUSITIS 审中-公开
标题翻译：检测慢性RHINOSINITIS中的细菌过程
公开(公告)号：WO2008027459A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/019055
申请日：2007-08-30
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , PONIKAU, Jens , SHERRIS, David , KITA, Hirohito
发明人： PONIKAU, Jens , SHERRIS, David , KITA, Hirohito
IPC分类号： C12Q1/02 , C12Q1/37 , G01N33/53
CPC分类号： G01N33/56972 , G01N33/5091 , G01N2333/908 , G01N2333/966 , G01N2800/26
摘要： The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection of released (i.e., "free") granule content markers such as neutrophil elastase or myeloperoxidase. Based on an accurate determination of the cause of sinusitis as described herein, an appropriate treatment can be instituted.
摘要翻译：本发明提供了鉴定细菌诱导的鼻鼻窦炎的方法。该方法包括获得鼻或鼻旁粘液样品并检测粘液样品中嗜中性粒细胞脱粒的存在。嗜中性粒细胞的脱颗粒可以通过粘液中的细胞的形态学分析或通过检测释放的（即游离的）颗粒含量标记如嗜中性粒细胞弹性蛋白酶或髓过氧化物酶来确定。基于如本文所述的正确确定鼻窦炎的原因，可以进行适当的治疗。

4. 发明申请

WO2007101247A2 COMPOSITIONS AND METHODS TO TREAT DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS 审中-公开
标题翻译：组织和方法治疗以细胞增殖和血管生成为特征的疾病
公开(公告)号：WO2007101247A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062971
申请日：2007-02-28
申请人： PALOMA PHARMACEUTICALS, INC. , SHERRIS, David, I.
发明人： SHERRIS, David, I.
CPC分类号： C07D311/80 , A61K31/192 , A61K31/235 , A61K31/352 , A61K31/353 , A61K31/366 , A61K31/382 , A61K31/4433 , A61K31/473 , A61K31/517 , A61K45/06 , C07C65/40 , C07C69/78 , C07D239/90 , C07D311/16 , C07D311/18 , C07D405/06 , C07D405/12 , Y02A50/401 , A61K2300/00
摘要： Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.
摘要翻译：本文描述了用于使用一种或多种苯并[c]苯并吡喃-6-酮衍生物预防和/或治疗涉及异常血管生成的疾病的组合物和方法。

5. 发明申请

WO0065341A9 EOSINOPHIL DEGRANULATING CONDITIONS 审中-公开
标题翻译： EOSINOPHIL退化条件
公开(公告)号：WO0065341A9
公开(公告)日：2001-07-26
申请号：PCT/US0010971
申请日：2000-04-21
申请人： MAYO FOUNDATION , PONIKAU JENS , SHERRIS DAVID A , KERN EUGENE
发明人： PONIKAU JENS , SHERRIS DAVID A , KERN EUGENE
IPC分类号： G01N33/50 , G01N33/68 , G01N33/00 , C12Q1/28 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/567
CPC分类号： G01N33/5094 , G01N33/6893
摘要： The invention provides methods and materials related to the diagnosis of eosinophil degranulating conditions. Specifically, the invention provides methods and materials that involve visual types of analysis (e.g., microscopic analysis) that are used to determine the presence or absence of a horseshoe-shaped eosinophil granule structure within a mucus sample collected from a mammal. The presence of a horseshoe-shaped eosinophil granule structure within a patient's mucus indicates that the patient has an eosinophil degranulating condition. In addition, the invention provides methods and materials that involve immunological types of analysis (e.g., immunoassays) that are used to determine if a patient's mucus contains a tissue-damaging amount of eosinophil granule content that is outside the eosinophil granule and within the mucus. Like the presence of a horseshoe-shaped eosinophil granule structure, the presence of a tissue-damaging amount of eosinophil granule content outside the eosinophil granule and within the mucus indicates that the patient has an eosinophil degranulating condition. Further, the invention provides diagnostic kits that can be used to determine whether or not a patient has an eosinophil degranulating condition.
摘要翻译：本发明提供了与嗜酸性粒细胞脱粒条件的诊断相关的方法和材料。具体地说，本发明提供了涉及用于确定从哺乳动物收集的粘液样品内是否存在马蹄形嗜酸性粒细胞结构的分析的视觉类型（例如，微观分析）的方法和材料。患者粘液中马蹄形嗜酸粒细胞颗粒结构的存在表明患者具有嗜酸性粒细胞脱颗粒状态。此外，本发明提供了涉及用于确定患者的粘液是否包含嗜酸性粒细胞颗粒外部和粘液内的组织损伤量的嗜酸性粒细胞颗粒含量的分析免疫学类型（例如免疫测定）的方法和材料。像马蹄形嗜酸粒细胞结构的存在一样，嗜酸性粒细胞颗粒内部和粘液内存在组织损伤量的嗜酸性粒细胞颗粒含量表示患者具有嗜酸性粒细胞脱颗粒状态。此外，本发明提供可用于确定患者是否具有嗜酸性粒细胞脱颗粒状况的诊断试剂盒。

6. 发明申请

WO0024419A8 METHODS FOR ENHANCING WOUND HEALING 审中-公开
标题翻译：加强治疗方法
公开(公告)号：WO0024419A8
公开(公告)日：2001-03-15
申请号：PCT/US9924182
申请日：1999-10-15
申请人： MAYO FOUNDATION , GASSNER HOLGER G , SHERRIS DAVID A
发明人： GASSNER HOLGER G , SHERRIS DAVID A
IPC分类号： A61K45/00 , A61K31/137 , A61K31/167 , A61K31/445 , A61K31/505 , A61K31/519 , A61K31/529 , A61K38/00 , A61K38/16 , A61P17/02 , A61K39/08
CPC分类号： A61K31/505 , A61K31/335 , A61K31/519 , A61K31/529 , A61K38/164 , A61K38/4886 , A61K2300/00
摘要： A method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is illustrated by detailing the mean differences of the scores of the paired experimental and control scars across three observers.
摘要翻译：描述了一种用于治疗患有伤口的患者的方法。该方法包括施用一定量的化学修饰剂，使得伤口愈合得到增强。通过详细说明三个观察者对成对实验和对照瘢痕的得分的平均差异来说明该方法。

7. 发明申请

WO2008027459A3 DETECTING A BACTERIAL PROCESS IN CHRONIC RHINOSINUSITIS 审中-公开
标题翻译：慢性鼻窦炎细菌感染的检测
公开(公告)号：WO2008027459A3
公开(公告)日：2008-12-24
申请号：PCT/US2007019055
申请日：2007-08-30
申请人： UNIV NEW YORK STATE RES FOUND , PONIKAU JENS , SHERRIS DAVID , KITA HIROHITO
发明人： PONIKAU JENS , SHERRIS DAVID , KITA HIROHITO
IPC分类号： G01N33/53 , C12Q1/00 , G01N33/00
CPC分类号： G01N33/56972 , G01N33/5091 , G01N2333/908 , G01N2333/966 , G01N2800/26
摘要： The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection of released (i.e., "free") granule content markers such as neutrophil elastase or myeloperoxidase. Based on an accurate determination of the cause of sinusitis as described herein, an appropriate treatment can be instituted.
摘要翻译：本发明提供了鉴定细菌诱导的鼻鼻窦炎的方法。该方法包括获得鼻腔或副鼻腔粘液样本并检测粘液样本中嗜中性粒细胞脱粒的存在。嗜中性粒细胞的脱粒可以通过粘液中细胞的形态学分析或通过检测释放（即“游离”）颗粒含量标记如嗜中性粒细胞弹性蛋白酶或髓过氧化物酶来测定。基于本文所述的准确确定鼻窦炎的原因，可以进行适当的治疗。

8. 发明申请

WO2007133249A3 COMPOSITIONS AND METHODS TO TREAT SKIN DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS 审中-公开
公开(公告)号：WO2007133249A3
公开(公告)日：2007-11-22
申请号：PCT/US2006/040242
申请日：2006-10-12
申请人： PALOMA PHARMACEUTICALS, INC. , SHERRIS, David, I.
发明人： SHERRIS, David, I.
IPC分类号： A61K8/30 , A61K8/36 , A61K8/49
摘要： Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photodamaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin, involving aberrant angiogenesis and hyperplasia employing one or more benzo[c]chromen-6-one derivatives.

9. 发明申请

WO2006020915A2 DETECTING FUNGI IN HUMAN SAMPLES 审中-公开
标题翻译：检测人类样本中的真菌
公开(公告)号：WO2006020915A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028821
申请日：2005-08-12
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , KITA, Hirohito , SQUILLACE, Diane , SHERRIS, David A. , PONIKAU, Jens , SWANSON, Mark
发明人： KITA, Hirohito , SQUILLACE, Diane , SHERRIS, David A. , PONIKAU, Jens , SWANSON, Mark
IPC分类号： G01N33/569
CPC分类号： G01N33/56961
摘要： Methods and materials involved in detecting fungi in human samples are provided herein.
摘要翻译：本文提供了检测人体样品中真菌的方法和材料。

10. 发明申请

WO1995008560A1 NOVEL PEPTIDES USEFUL FOR INHIBITING BINDING OF LIPOPOLYSACCHARIDES (LPS) BY LIPOPOLYSACCHARIDE BINDING PROTEIN (LBP) 审中-公开
标题翻译：用于通过脂多糖结合蛋白（LBP）抑制脂多糖（LPS）结合的新型肽
公开(公告)号：WO1995008560A1
公开(公告)日：1995-03-30
申请号：PCT/US1994010760
申请日：1994-09-22
申请人： CENTOCOR, INC. , HEAVNER, George, A. , TAYLOR, Alexander, Harrison , SHERRIS, David
发明人： CENTOCOR, INC.
IPC分类号： C07K01/02
CPC分类号： C07K7/08 , A61K38/00 , C07K14/195 , C07K14/47
摘要： The present invention provides novel peptides derived from portions of the sequence of amino acids 95-104 of lipopolysaccharide binding protein (LBP). The invention also provides pharmaceutical compositions comprising the peptides of the invention, and diagnostic and therapeutic methods utilizing the peptides and pharmaceutical compositions of the invention.
摘要翻译：本发明提供衍生自脂多糖结合蛋白（LBP）的氨基酸95-104的部分序列的新型肽。本发明还提供包含本发明的肽的药物组合物，以及利用本发明的肽和药物组合物的诊断和治疗方法。

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