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1. 发明申请

WO2009045906A2 POLYNUCLEOTIDE BACKBONES FOR COMPLEXING PROTEINS 审中-公开
标题翻译：用于复合蛋白的多核苷酸反义
公开(公告)号：WO2009045906A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/077887
申请日：2008-09-26
申请人： AFFOMIX CORPORATION , WEINER, Michael P. , SHERMAN, Michael I.
发明人： WEINER, Michael P. , SHERMAN, Michael I.
IPC分类号： C12Q1/68
CPC分类号： C12P21/02 , C07K14/003 , C07K16/00 , C07K2317/622 , C07K2319/00 , C12P19/34 , C12Q1/68 , C12Q1/682 , G01N2458/10 , C12Q2563/179 , C12Q2521/501
摘要： We use the Tus- Ter interaction to enable the utilization of nucleic acid analytical methodologies for proteins. We also use the Tus- Ter interaction to make polymers and oligomers that have a nucleic acid backbone with protein functionalities. These methods are useful for molecular modeling, for efficiently running enzymatic pathway reactions, and for analyzing presence and/or amount of particular proteins.
摘要翻译：我们使用Tus-Ter相互作用来实现对蛋白质的核酸分析方法的利用。我们还使用Tus-Ter相互作用来制备具有蛋白质功能的核酸骨架的聚合物和低聚物。这些方法可用于分子建模，有效运行酶途径反应，以及分析特定蛋白质的存在和/或数量。

2. 发明申请

WO03043487A2 METHOD OF USING A NON-ANTIBODY PROTEIN TO DETECT AND MEASURE AN ANALYTE 审中-公开
标题翻译：使用非抗体蛋白质检测和测量分析物的方法
公开(公告)号：WO03043487A2
公开(公告)日：2003-05-30
申请号：PCT/US0236959
申请日：2002-11-19
申请人： PROTOMETRIX INC , SHERMAN MICHAEL I
发明人： SHERMAN MICHAEL I
IPC分类号： G01N33/53 , A61B20060101 , C12N1/00 , C12Q1/68 , G01N33/543 , G01N33/544 , G01N33/551 , G01N33/566 , G01N33/68 , G01N37/00 , A61B
CPC分类号： G01N33/54306
摘要： The present invention relates to diagnostics, particularly binding assays for detecting and/or measuring an analyte. The present invention relates to methods for determining the presence and/or amount of an analyte by means of association with one or more non-antibody molecules, in particular non-antibody molecules derived from a species different from that of the analyte. Further, the present invention relates to methods for diagnosing and staging diseases by detecting and/or measuring analytes associated with certain diseases.
摘要翻译：本发明涉及诊断，特别是用于检测和/或测量分析物的结合测定。本发明涉及通过与一种或多种非抗体分子，特别是衍生自不同于分析物的物种的非抗体分子缔合来测定分析物的存在和/或量的方法。此外，本发明涉及通过检测和/或测量与某些疾病相关的分析物来诊断和分期疾病的方法。

3. 发明申请

WO1994029479A1 OLIGONUCLEOTIDES WHICH INHIBIT HIV PROTEASE FUNCTION 审中-公开
标题翻译：抑制艾滋病病毒功能的寡核苷酸
公开(公告)号：WO1994029479A1
公开(公告)日：1994-12-22
申请号：PCT/US1994006456
申请日：1994-06-09
申请人： PHARMAGENICS, INC. , BEUTEL, Bruce, A. , SHERMAN, Michael, I. , COPPOLA, George, R.
发明人： PHARMAGENICS, INC.
IPC分类号： C12Q01/00
CPC分类号： C07H21/00 , C07K14/00
摘要： A method of inhibiting HIV protease function which comprises administering to a host an effective amount of an oligonucleotide which inhibits HIV protease function. Preferred oligonucleotides are RNA oligonucleotides which include at least one of the following oligonucleotide sequences: (a) 5' - GGAAAGUGGAC - 3'; (b) 5' - AANGU - 3'; and (c) 5' - ANUGGA - 3'; (d) 5' - GGAAAGUGGACRRR - 3'; (e) 5' - RGUGAGUGUGGGCR - 3'; (f) 5' - RGUGAGUGUGGGGCR - 3'; (g) 5' - AGUGUG - 3'; (h) 5' - UNGAUNY - 3'; (i) 5' - CCUC - 3'; and (j) 5' - GGUGNA - 3', wherein A is modified or unmodified adenine, C is modified or unmodified cytosine, G is modified or unmodified guanine, U is modified or unmodified uracil, R is modified or unmodified purine, Y is modified or unmodified pyrimidine, and N is modified or unmodified adenine, cytosine, guanine, or uracil. The oligonucleotide may include a looped region bounded by a base-paired stem region, and at least a portion of at least one of sequences (a) through (j) is contained in the looped region. Such oligonucleotides bind to HIV protease, thereby inhibiting HIV protease function and preventing HIV maturation.
摘要翻译：一种抑制HIV蛋白酶功能的方法，其包括向宿主施用有效量的抑制HIV蛋白酶功能的寡核苷酸。优选的寡核苷酸是RNA寡核苷酸，其包括以下寡核苷酸序列中的至少一个：（a）5'-GGAAAGUGGAC-3'; （b）5' - AANGU - 3'; 和（c）5' - ANUGGA-3'; （d）5' - GGAAAGUGGACRRR-3'; （e）5' - RGUGAGUGUGGGCR-3'; （f）5' - RGUGAGUGUGGGGCR-3'; （g）5' - AGUGUG - 3'; （h）5' - UNGAUNY - 3'; （i）5'-CCCUC-3'; 和（j）5'-GGUGNA-3'，其中A是修饰或未修饰的腺嘌呤，C是修饰的或未修饰的胞嘧啶，G是修饰的或未修饰的鸟嘌呤，U是修饰的或未修饰的尿嘧啶，R是修饰的或未修饰的嘌呤，Y是修饰或未修饰的嘧啶，N是修饰的或未修饰的腺嘌呤，胞嘧啶，鸟嘌呤或尿嘧啶。寡核苷酸可以包括由碱基配对的茎区限定的环状区域，并且在环状区域中包含序列（a）至（j）中的至少一个序列的至少一部分。这样的寡核苷酸结合HIV蛋白酶，从而抑制HIV蛋白酶功能并防止HIV成熟。

4. 发明申请

WO2009045906A3 POLYNUCLEOTIDE BACKBONES FOR COMPLEXING PROTEINS 审中-公开
标题翻译：用于复合蛋白质的多核苷酸骨架
公开(公告)号：WO2009045906A3
公开(公告)日：2009-05-22
申请号：PCT/US2008077887
申请日：2008-09-26
申请人： AFFOMIX CORP , WEINER MICHAEL P , SHERMAN MICHAEL I
发明人： WEINER MICHAEL P , SHERMAN MICHAEL I
IPC分类号： C12Q1/68
CPC分类号： C12P21/02 , C07K14/003 , C07K16/00 , C07K2317/622 , C07K2319/00 , C12P19/34 , C12Q1/68 , C12Q1/682 , G01N2458/10 , C12Q2563/179 , C12Q2521/501
摘要： We use the Tus-Ter interaction to enable the utilization of nucleic acid analytical methodologies for proteins. We also use the Tus-Ter interaction to make polymers and oligomers that have a nucleic acid backbone with protein functionalities. These methods are useful for molecular modeling, for efficiently running enzymatic pathway reactions, and for analyzing presence and/or amount of particular proteins.
摘要翻译：我们使用Tus-Ter相互作用来实现蛋白质核酸分析方法的应用。我们还使用Tus-Ter相互作用来制备具有蛋白质功能的核酸主链的聚合物和寡聚物。这些方法可用于分子建模，有效运行酶途径反应，以及分析特定蛋白质的存在和/或量。

5. 发明申请

WO2009039166A1 INCREASING SPECIFICITY IN A scFV SCREEN USING DUAL BAIT REPORTERS 审中-公开
标题翻译：使用双重记录器在scFV屏幕中增加特定性
公开(公告)号：WO2009039166A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/076662
申请日：2008-09-17
申请人： AFFOMIX CORPORATION , WEINER, Michael P. , SHERMAN, Michael I.
发明人： WEINER, Michael P. , SHERMAN, Michael I.
IPC分类号： C12N5/16
CPC分类号： C12Q1/025 , C07K16/00 , C07K16/18 , C07K16/40 , C07K2317/622 , G01N33/5008 , G01N33/6857
摘要： To increase the efficiency of the selection of antibodies of desired specificity, we create multi-bait strain(s) in which one bait is the target and one or more bait(s) are non-target. The non-target bait(s) may use one or more DNA-binding domain(s) that differ(s) from that of the target bait and thereby activate one or more different reporters from that activated by the target bait. Library hits that activate both sets of reporters are presumed to be inadequately specific and can be eliminated from further consideration. Alternatively, a non-target bait may be replaced with a second target bait, and hits selected that activate both sets of reporters. Other combinations of elements can be used.
摘要翻译：为了提高选择具有所需特异性的抗体的效率，我们产生多诱饵菌株，其中一个诱饵是靶，一个或多个诱饵是非靶标的。非目标诱饵可以使用与目标诱饵不同的一个或多个DNA结合结构域，从而激活一个或多个与靶诱饵激活的不同的记者。启动两套记者的图书馆命中假设被认为不够具体，可以从进一步考虑中消除。或者，可以用第二目标诱饵替换非目标诱饵，并且选择激活两组记者的命中。可以使用元素的其他组合。

6. 发明申请

WO2005051289A2 HOMOGENEOUS PREPARATIONS OF CHIMERIC PROTEINS 审中-公开
标题翻译：均质蛋白质的均质制备
公开(公告)号：WO2005051289A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/035517
申请日：2004-11-10
申请人： ICONIC THERAPEUTICS, INC. , TROWN, Patrick, W. , SHERMAN, Michael, I. , DORNBUSH, Kirk
发明人： TROWN, Patrick, W. , SHERMAN, Michael, I. , DORNBUSH, Kirk
IPC分类号： A61K
CPC分类号： C12N9/647 , A61K38/00 , C07K2319/30 , C12N9/6437 , C12Y304/21021
摘要： Variant forms of chimeric protein molecules comprising a Factor VII moiety and an Fe region of an IgG1 moiety provide improved properties. The variants are more resistant to proteolytic degradation. Thus preparations of the variant forms are more homogeneous and have a longer half-life. The variant forms are used for treating cancer, atherosclerosis, psoriasis, diabetic retinopathy, wet macular degeneration, and rheumatoid arthritis.
摘要翻译：包含因子VII部分和IgG1部分的Fe区的嵌合蛋白分子的变体形式提供了改进的性质。这些变体更能抵抗蛋白水解降解。因此，变体形式的制备更均匀并且具有更长的半衰期。变体形式用于治疗癌症，动脉粥样硬化，牛皮癣，糖尿病性视网膜病变，湿性黄斑变性和类风湿性关节炎。

7. 发明申请

WO2003043487A3 METHOD OF USING A NON-ANTIBODY PROTEIN TO DETECT AND MEASURE AN ANALYTE 审中-公开
公开(公告)号：WO2003043487A3
公开(公告)日：2003-05-30
申请号：PCT/US2002/036959
申请日：2002-11-19
申请人： PROTOMETRIX, INC. , SHERMAN, Michael, I.
发明人： SHERMAN, Michael, I.
IPC分类号： G01N33/53
摘要： The present invention relates to diagnostics, particularly binding assays for detecting and/or measuring an analyte. The present invention relates to methods for determining the presence and/or amount of an analyte by means of association with one or more non-antibody molecules, in particular non-antibody molecules derived from a species different from that of the analyte (Figure 1). Further, the present invention relates to methods for diagnosing and staging diseases by detecting and/or measuring analytes associated with certain diseases.

8. 发明申请

WO1995006751A1 METHODS FOR ISOLATION OF MOST ABUNDANT OLIGONUCLEOTIDES FROM COMPLEX MIXTURES 审中-公开
标题翻译：用于从复合混合物中分离最常见的寡核苷酸的方法
公开(公告)号：WO1995006751A1
公开(公告)日：1995-03-09
申请号：PCT/US1994009728
申请日：1994-08-26
申请人： PHARMAGENICS, INC. , BEUTEL, Bruce, A. , COPPOLA, George, R. , SHERMAN, Michael, I. , COOK, Alan, F. , FATHI, Reza , GAO, Hetian , RUDOLPH, M., Jonathan , BERTELSEN, Arthur, H.
发明人： PHARMAGENICS, INC.
IPC分类号： C12Q01/68
CPC分类号： C07H21/00 , B01J2219/00592 , C12Q1/6811 , C12Q1/6813
摘要： Double-stranded nucleic acids present in a mixture thereof are converted to the individual strands thereof which are renatured under conditions which favors reannealing of the nucleic acids present at higher than average concentrations in the original mixture. The procedure can be used for identifying nucleic acids which bind to a target molecule or other compounds which bind to a target molecule by using nucleic acids as a coding portion of a chimeric molecule which includes such compounds.
摘要翻译：存在于其混合物中的双链核酸被转化成其单链，其在有利于原始混合物中以高于平均浓度存在的核酸的重新退火的条件下复性。该方法可用于通过使用核酸作为包含这些化合物的嵌合分子的编码部分来鉴定结合靶分子或其它结合靶分子的化合物的核酸。

9. 发明申请

WO2005051289A3 HOMOGENEOUS PREPARATIONS OF CHIMERIC PROTEINS 审中-公开
标题翻译：嵌合蛋白的均匀制备
公开(公告)号：WO2005051289A3
公开(公告)日：2005-12-22
申请号：PCT/US2004035517
申请日：2004-11-10
申请人： ICONIC THERAPEUTICS INC , TROWN PATRICK W , SHERMAN MICHAEL I , DORNBUSH KIRK
发明人： TROWN PATRICK W , SHERMAN MICHAEL I , DORNBUSH KIRK
IPC分类号： A01N43/04 , A61K20060101 , A61K38/16 , A61K39/00 , A61K39/395 , A61K39/40 , A61K39/42 , C07K16/00 , C12P21/08
CPC分类号： C12N9/647 , A61K38/00 , C07K2319/30 , C12N9/6437 , C12Y304/21021
摘要： Variant forms of chimeric protein molecules comprising a Factor VII moiety and an Fe region of an IgG1 moiety provide improved properties. The variants are more resistant to proteolytic degradation. Thus preparations of the variant forms are more homogeneous and have a longer half-life. The variant forms are used for treating cancer, atherosclerosis, psoriasis, diabetic retinopathy, wet macular degeneration, and rheumatoid arthritis.
摘要翻译：包含因子VII部分和IgG1部分的Fe区的嵌合蛋白质分子的变体形式提供改进的性质。这些变体更耐蛋白水解降解。因此，变体形式的制备更均匀并且具有更长的半衰期。变体形式用于治疗癌症，动脉粥样硬化，牛皮癣，糖尿病性视网膜病，湿性黄斑变性和类风湿性关节炎。

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