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1. 发明申请

WO2005010023A3 METHOD FOR PREDICTION OF AN EPITOPE 审中-公开
标题翻译：预测EPITOPE的方法
公开(公告)号：WO2005010023A3
公开(公告)日：2006-05-11
申请号：PCT/US2004023216
申请日：2004-07-19
申请人： PROTOMETRIX INC , PREDKI PAUL F , GUO HONG
发明人： PREDKI PAUL F , GUO HONG
IPC分类号： A61K39/395 , C07K20060101 , C07K16/00 , C07K16/40 , G01N33/48 , G01N33/50 , G01N33/53 , G06F19/00 , C12M1/34 , C12Q1/00
CPC分类号： C07K16/00 , C07K16/40 , C07K2317/34 , G01N33/6854 , G01N2440/00 , G06F19/18 , G06F19/22
摘要： The invention provides methods for the prediction of an epitope in a target protein. An epitope of the target protein can be bound by a given molecule, e.g., by an antibody. In particular, the methods of the invention comprise (i) identifying a plurality of cross-reactive proteins, i.e., proteins that can be bound by the same molecule, e.g., by the same antibody, as the target protein using, e.g., protein microarrays; and (ii) comparing the amino acid sequences of the target protein and the cross-reactive proteins with each other to identify windows of sequence homology, wherein the windows of sequence homology correspond to the epitope. Figure (1) illustates fluorescent images of antibody probings of the yeast proteome microarray.
摘要翻译：本发明提供了用于预测靶蛋白中的表位的方法。靶蛋白的表位可以通过给定的分子例如通过抗体结合。特别地，本发明的方法包括（i）鉴定多个交叉反应性蛋白质，即可以使用例如蛋白质微阵列，例如通过相同的抗体与靶蛋白结合的蛋白质，其可以被相同的分子结合 ; 和（ii）将目标蛋白质和交叉反应蛋白质的氨基酸序列彼此进行比较以鉴定序列同源性的窗口，其中序列同源性的窗口对应于表位。图（1）描述了酵母蛋白质组微阵列的抗体检测的荧光图像。

2. 发明申请

WO03043487A2 METHOD OF USING A NON-ANTIBODY PROTEIN TO DETECT AND MEASURE AN ANALYTE 审中-公开
标题翻译：使用非抗体蛋白质检测和测量分析物的方法
公开(公告)号：WO03043487A2
公开(公告)日：2003-05-30
申请号：PCT/US0236959
申请日：2002-11-19
申请人： PROTOMETRIX INC , SHERMAN MICHAEL I
发明人： SHERMAN MICHAEL I
IPC分类号： G01N33/53 , A61B20060101 , C12N1/00 , C12Q1/68 , G01N33/543 , G01N33/544 , G01N33/551 , G01N33/566 , G01N33/68 , G01N37/00 , A61B
CPC分类号： G01N33/54306
摘要： The present invention relates to diagnostics, particularly binding assays for detecting and/or measuring an analyte. The present invention relates to methods for determining the presence and/or amount of an analyte by means of association with one or more non-antibody molecules, in particular non-antibody molecules derived from a species different from that of the analyte. Further, the present invention relates to methods for diagnosing and staging diseases by detecting and/or measuring analytes associated with certain diseases.
摘要翻译：本发明涉及诊断，特别是用于检测和/或测量分析物的结合测定。本发明涉及通过与一种或多种非抗体分子，特别是衍生自不同于分析物的物种的非抗体分子缔合来测定分析物的存在和/或量的方法。此外，本发明涉及通过检测和/或测量与某些疾病相关的分析物来诊断和分期疾病的方法。

3. 发明申请

WO2006033972A9 PROTEIN ARRAYS AND METHODS OF USE THEREOF 审中-公开
标题翻译：蛋白质阵列及其使用方法
公开(公告)号：WO2006033972A9
公开(公告)日：2009-01-08
申请号：PCT/US2005032981
申请日：2005-09-15
申请人： PROTOMETRIX INC , SCHWEITZER BARRY , BALL JAMES A , PREDKI PAUL , MICHAUD GREGORY A , ZHOU FANG X
发明人： SCHWEITZER BARRY , BALL JAMES A , PREDKI PAUL , MICHAUD GREGORY A , ZHOU FANG X
IPC分类号： G01N33/53
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00725 , G01N33/552 , G01N33/6842 , G01N33/6845 , G06Q50/22 , Y02A90/22
摘要： The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positionally addressable array comprising at least 100 proteins immobilized on functionalized glass surface, and identifying a protein on the positionally addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least 1000 human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state.

4. 发明申请

WO2005003721A2 METHODS FOR CONDUCTING ASSAYS FOR ENZYME ACTIVITY ON PROTEIN MICROARRAYS 审中-公开
标题翻译：用于诱导蛋白微生物酶活性测定的方法
公开(公告)号：WO2005003721A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/018480
申请日：2004-06-09
申请人： PROTOMETRIX, INC. , ZHOU, Fang, X. , SCHWEITZER, Barry
发明人： ZHOU, Fang, X. , SCHWEITZER, Barry
IPC分类号： G01N
CPC分类号： C12Q1/00
摘要： The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.
摘要翻译：本发明涉及对用于蛋白质功能的大规模研究，筛选测定和酶促反应的高通量分析的微阵列上的酶活性进行测定的方法。本发明涉及使用蛋白质芯片来测定存在于蛋白质芯片上的蛋白质样品中的酶的存在，量，活性和/或功能的方法。特别地，本发明的方法涉及使用微阵列进行酶测定，其中将蛋白质和物质固定在固体支持物的表面上，并且其中所述蛋白质和所述物质彼此接近，足以发生物质与蛋白质之间的酶反应。本发明还涉及具有固定在其表面上的酶和底物的微阵列，其中酶和底物彼此接近充分，其中酶和底物相互接近足以产生酶反应在酶和底物之间。

5. 发明申请

WO2006020126A3 METHOD FOR PROVIDING PROTEIN MICROARRAYS 审中-公开
标题翻译：提供蛋白微量元素的方法
公开(公告)号：WO2006020126A3
公开(公告)日：2007-11-22
申请号：PCT/US2005025292
申请日：2005-07-14
申请人： PROTOMETRIX INC , PREDKI PAUL F , SCHWEITZER BARRY
发明人： PREDKI PAUL F , SCHWEITZER BARRY
IPC分类号： G01N33/53 , G06F19/20 , G06F19/28
CPC分类号： G01N33/6842 , G01N33/6845 , G06F19/20 , G06F19/28 , G06Q10/103 , G06Q30/0601
摘要： The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein micorarray can include, in certain aspects, a computer function for performing some of the steps of the methods. Methods and kits for labeling a probe can include a control array that includes a molecule that binds to a label of a probe.
摘要翻译：本申请涉及用于向客户提供蛋白质微阵列产品和相关产品和服务的方法，用于标记蛋白质微阵列的探针的方法，试剂盒和系统，以及使用蛋白质微阵列测定蛋白质浓度的方法。提供蛋白质微阵列的方法可以在某些方面包括用于执行所述方法的一些步骤的计算机功能。用于标记探针的方法和试剂盒可包括包含结合探针标记的分子的对照阵列。

6. 发明申请

WO2005003721A3 ENZYME ACTIVITY ASSAYS ON PROTEIN MICROARRAYS 审中-公开
标题翻译：酶蛋白微生物的酶活性测定
公开(公告)号：WO2005003721A3
公开(公告)日：2006-02-02
申请号：PCT/US2004018480
申请日：2004-06-09
申请人： PROTOMETRIX INC , ZHOU FANG X , SCHWEITZER BARRY
发明人： ZHOU FANG X , SCHWEITZER BARRY
IPC分类号： C12Q1/00 , C12N9/99 , C12N11/00 , C12Q1/40 , C12Q1/48 , G01N33/53 , G01N33/543
CPC分类号： C12Q1/00
摘要： The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.
摘要翻译：本发明涉及对用于蛋白质功能的大规模研究，筛选测定和酶促反应的高通量分析的微阵列上的酶活性进行测定的方法。本发明涉及使用蛋白质芯片来测定存在于蛋白质芯片上的蛋白质样品中的酶的存在，量，活性和/或功能的方法。特别地，本发明的方法涉及使用微阵列进行酶测定，其中将蛋白质和物质固定在固体支持物的表面上，并且其中所述蛋白质和所述物质彼此接近，足以发生物质与蛋白质之间的酶反应。本发明还涉及具有固定在其表面上的酶和底物的微阵列，其中酶和底物相互接近充分，其中酶和底物相互接近足以产生酶反应在酶和底物之间。

7. 发明申请

WO2006033972A2 PROTEIN ARRAYS AND METHODS OF USE THEREOF 审中-公开
标题翻译：蛋白质阵列及其使用方法
公开(公告)号：WO2006033972A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/032981
申请日：2005-09-15
申请人： PROTOMETRIX, INC. , SCHWEITZER, Barry , BALL, James, A. , PREDKI, Paul , MICHAUD, Gregory, A. , ZHOU, Fang, X.
发明人： SCHWEITZER, Barry , BALL, James, A. , PREDKI, Paul , MICHAUD, Gregory, A. , ZHOU, Fang, X.
IPC分类号： G01N33/53
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00725 , G01N33/552 , G01N33/6842 , G01N33/6845 , G06Q50/22 , Y02A90/22
摘要： The present invention provides human protein arrays that include at least (1000) human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positional addressable array comprising at least (100) proteins immobilized on functionalized glass surface, and identifying a protein on the positional addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least (1000) human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state.
摘要翻译：本发明提供了包含至少（1000）人蛋白质的人类蛋白质阵列。在另一个实施方案中，本发明提供了一种方法，

8. 发明申请

WO2006020126A2 METHOD FOR PROVIDING PROTEIN MICROARRAYS 审中-公开
标题翻译：提供蛋白微量元素的方法
公开(公告)号：WO2006020126A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025292
申请日：2005-07-14
申请人： PROTOMETRIX, INC. , PREDKI, Paul, F. , SCHWEITZER, Barry
发明人： PREDKI, Paul, F. , SCHWEITZER, Barry
IPC分类号： G06F19/00
CPC分类号： G01N33/6842 , G01N33/6845 , G06F19/20 , G06F19/28 , G06Q10/103 , G06Q30/0601
摘要： The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein micorarray can include, in certain aspects, a computer function for performing some of the steps of the methods. Methods and kits for labeling a probe can include a control array that includes a molecule that binds to a label of a probe.
摘要翻译：本申请涉及用于向客户提供蛋白质微阵列产品和相关产品和服务的方法，用于标记蛋白质微阵列的探针的方法，试剂盒和系统，以及使用蛋白质微阵列测定蛋白质浓度的方法。用于提供蛋白质微阵列的方法可以在某些方面包括用于执行所述方法的一些步骤的计算机功能。用于标记探针的方法和试剂盒可包括包含结合探针标记的分子的对照阵列。

9. 发明申请

WO2005010023A2 METHOD FOR PREDICTION OF AN EPITOPE 审中-公开
标题翻译：预测EPITOPE的方法
公开(公告)号：WO2005010023A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023216
申请日：2004-07-19
申请人： PROTOMETRIX, INC. , PREDKI, Paul, F. , GUO, Hong
发明人： PREDKI, Paul, F. , GUO, Hong
IPC分类号： C07K
CPC分类号： C07K16/00 , C07K16/40 , C07K2317/34 , G01N33/6854 , G01N2440/00 , G06F19/18 , G06F19/22
摘要： The invention provides methods for the prediction of an epitope in a target protein. An epitope of the target protein can be bound by a given molecule, e.g., by an antibody. In particular, the methods of the invention comprise (i) identifying a plurality of cross-reactive proteins, i.e., proteins that can be bound by the same molecule, e.g., by the same antibody, as the target protein using, e.g., protein microarrays; and (ii) comparing the amino acid sequences of the target protein and the cross-reactive proteins with each other to identify windows of sequence homology, wherein the windows of sequence homology correspond to the epitope.
摘要翻译：本发明提供了用于预测靶蛋白中的表位的方法。靶蛋白的表位可以通过给定的分子例如通过抗体结合。特别地，本发明的方法包括（i）鉴定多个交叉反应性蛋白质，即可以使用例如蛋白质微阵列，例如通过相同的抗体与靶蛋白结合的蛋白质，其可以被相同的分子结合 ; 和（ii）将目标蛋白质和交叉反应蛋白质的氨基酸序列彼此进行比较以鉴定序列同源性的窗口，其中序列同源性的窗口对应于表位。

10. 发明申请

WO2003043487A3 METHOD OF USING A NON-ANTIBODY PROTEIN TO DETECT AND MEASURE AN ANALYTE 审中-公开
公开(公告)号：WO2003043487A3
公开(公告)日：2003-05-30
申请号：PCT/US2002/036959
申请日：2002-11-19
申请人： PROTOMETRIX, INC. , SHERMAN, Michael, I.
发明人： SHERMAN, Michael, I.
IPC分类号： G01N33/53
摘要： The present invention relates to diagnostics, particularly binding assays for detecting and/or measuring an analyte. The present invention relates to methods for determining the presence and/or amount of an analyte by means of association with one or more non-antibody molecules, in particular non-antibody molecules derived from a species different from that of the analyte (Figure 1). Further, the present invention relates to methods for diagnosing and staging diseases by detecting and/or measuring analytes associated with certain diseases.

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