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1. 发明申请

WO2018076348A1 BUILDING AND UPDATING A CONNECTED SEGMENT GRAPH 审中-公开
标题翻译：建立和更新连接的分段图
公开(公告)号：WO2018076348A1
公开(公告)日：2018-05-03
申请号：PCT/CN2016/104045
申请日：2016-10-31
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC , WEN, Ning , LIU, Dafan , SHEN, Hui , CHEN, Liang , HAN, Dianfei , HU, Jiazhang , LI, Jinglun , LI, Pu , ZHAO, Zhenyu , YANG, Mao , GUO, Zhenyu , ZHANG, Xiong
发明人： WEN, Ning , LIU, Dafan , SHEN, Hui , CHEN, Liang , HAN, Dianfei , HU, Jiazhang , LI, Jinglun , LI, Pu , ZHAO, Zhenyu , YANG, Mao , GUO, Zhenyu , ZHANG, Xiong
IPC分类号： G06F17/30
CPC分类号： G06F16/9024 , G06F16/00
摘要： The present disclosure provides a method for building a connected segment graph specific for a domain. The method may comprises: collecting entity data from a source associated with the domain to form an entity dataset for the domain; processing the entity dataset; and building the connected segment graph with the processed entity dataset, wherein the building comprising enriching the connected segment graph with a knowledge graph containing knowledge on a plurality of domains.
摘要翻译：本公开提供了一种用于构建特定于域的连接分段图的方法。该方法可以包括：从与该域相关联的源收集实体数据以形成该域的实体数据集; 处理实体数据集; 以及用所处理的实体数据集建立连接的分段图，其中该建筑物包括利用包含关于多个域的知识的知识图来丰富连接的分段图。

2. 发明申请

WO2012167145A3 GENOME-SCALE ANALYSIS OF ABERRANT DNA METHYLATION IN COLORECTAL CANCER 审中-公开
标题翻译：染色体癌细胞DNA甲基化的基因分析
公开(公告)号：WO2012167145A3
公开(公告)日：2013-02-28
申请号：PCT/US2012040547
申请日：2012-06-01
申请人： UNIV SOUTHERN CALIFORNIA , HINOUE TOSHINORI , SHEN HUI , WEISENBERGER DANIEL J , LAIRD PETER W
发明人： HINOUE TOSHINORI , SHEN HUI , WEISENBERGER DANIEL J , LAIRD PETER W
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Particular aspects provide methods and compositions (e.g., gene marker panels) having substantial utility for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive DNA methylation-based subgroups of CRC including CpG island methylator phenotype (CIMP) groups (e.g., CIMP-H and CIMP-L) and non-CIMP groups. Exemplary marker panels include: B3GAT2, FOXL2, KCNK13, RAB31 and SLIT1 (CIMP marker panel); and FAM78A, FSTL1, KCNC1, MYOCD, and SLC6A4 (CIMP-H marker panel). Further aspects relate to genetic mutations, and other epigenetic markers relating to said CRC subgroups that can be used in combination with the gene marker panels for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive CIMP and non-CIMP groups.
摘要翻译：特定方面提供方法和组合物（例如，基因标记物组），其具有与基于特异性DNA甲基化的CRC亚基（包括CpG岛）有关的结肠直肠癌（CRC）（例如肿瘤）的诊断，鉴定和分类中的至少一种的实质效用甲基化表型（CIMP）组（如CIMP-H和CIMP-L）和非CIMP组。示例性标记面板包括：B3GAT2，FOXL2，KCNK13，RAB31和SLIT1（CIMP标记物组）; 和FAM78A，FSTL1，KCNC1，MYOCD和SLC6A4（CIMP-H标记物组）。其它方面涉及遗传突变和与所述CRC亚组相关的其它表观遗传标记，其可以与基因标记物组合使用，用于诊断，鉴定和分类结肠直肠癌（CRC）（例如肿瘤）中的至少一种独特的CIMP和非CIMP组。

3. 发明申请

WO2011157176A3 PRE-CODING METHOD AND TRANSMITTER USED IN DISTRIBUTED MULTIPLE INPUT MULTIPLE OUTPUT SYSTEM 审中-公开
标题翻译：分布式多输入多输出系统中使用的预编码方法和发送器
公开(公告)号：WO2011157176A3
公开(公告)日：2012-05-03
申请号：PCT/CN2011075306
申请日：2011-06-03
申请人： HUAWEI TECH CO LTD , SHEN HUI , LI BIN , LUO YI , ZHU HUFEI
发明人： SHEN HUI , LI BIN , LUO YI , ZHU HUFEI
IPC分类号： H04B7/06
CPC分类号： H04B7/0413
摘要： Embodiments of the present invention disclose a pre-coding method and a transmitter used in a distributed multiple input multiple output (MIMO) system. The method comprises that a dual interference channel is constructed, an interference alignment iterative calculation is performed on a pre-coding matrix in an original channel by utilizing the transformation relationship between the dual interference channel and an original interference channel; on the one hand, as the times of iterative calculation increases, the calculated pre-coding matrix in the original channel can gradually converge, and on the other hand, the total mean square error (MSE) of the interference channel system calculated from the pre-coding matrix of the original channel obtained according to the final calculation also tends to the minimum, so that the minimum of the MSE is achieved, and the mutual interference of the signals between different users is reduced.
摘要翻译：本发明的实施例公开了在分布式多输入多输出（MIMO）系统中使用的预编码方法和发射机。该方法包括：构建双干道，通过利用双干扰信道与原干扰信道之间的变换关系，对原始信道中的预编码矩阵进行干扰对齐迭代计算; 一方面，随着迭代计算的次数增加，原始信道中计算的预编码矩阵可以逐渐收敛，另一方面，从预先计算的干扰信道系统的总均方误差（MSE）根据最终计算获得的原始信道的编码矩阵也趋向于最小，使得实现MSE的最小值，并且减少不同用户之间的信号的相互干扰。

4. 发明申请

WO2006037116A2 SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：半固体运载车辆和药物组合物
公开(公告)号：WO2006037116A2
公开(公告)日：2006-04-06
申请号：PCT/US2005035117
申请日：2005-09-27
申请人： A P PHARMA INC , NG STEVEN Y , SHEN HUI-RONG , HELLER JORGE
发明人： NG STEVEN Y , SHEN HUI-RONG , HELLER JORGE
IPC分类号： A61K31/765 , A61K8/85 , A61K8/86 , A61K9/06 , A61K9/16 , A61Q15/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K47/34 , A61K8/85 , A61K8/86 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1647 , A61K31/439 , A61K31/445 , A61K31/573 , A61K31/765 , A61K45/06 , A61K47/10 , A61Q15/00 , A61Q17/04 , A61Q19/00
摘要： A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
摘要翻译：半固体递送载体含有聚原酸酯和赋形剂，并且半固体药物组合物含有活性剂和递送载体。药物组合物可以是局部的，可注射的或可注射的制剂; 并适用于活性剂的局部递送。还公开了治疗方法。

5. 发明申请

WO2014040263A1 SEMANTIC RANKING USING A FORWARD INDEX 审中-公开
标题翻译：使用前进索引的语义排名
公开(公告)号：WO2014040263A1
公开(公告)日：2014-03-20
申请号：PCT/CN2012/081376
申请日：2012-09-14
申请人： MICROSOFT CORPORATION , BAI, Jing , SHEN, Hui , YANG, Xiao-song , YANG, Mao , LIU, Yue-Sheng , PEDERSEN, Jan
发明人： BAI, Jing , SHEN, Hui , YANG, Xiao-song , YANG, Mao , LIU, Yue-Sheng , PEDERSEN, Jan
IPC分类号： G06F17/30
CPC分类号： G06F17/30011 , G06F17/30616 , G06F17/30663 , G06F17/30684 , G06F17/30864
摘要： Methods, computer systems, and computer-readable media for generating semantic ranking features using a forward index are provided. A search query is received and is analyzed for one or more semantic units including semantic patterns, topical categories, and entities. A forward index comprising a plurality of documents is accessed and semantic units associated with each of the documents are analyzed. The semantic units include semantic patterns, topical categories, unigrams, bigrams, and entities. Documents who share substantially similar semantic units with the search query are identified, and the ranking of the identified documents is adjusted based on the substantially similar semantic units.
摘要翻译：提供了使用前向索引来生成语义排序特征的方法，计算机系统和计算机可读介质。接收搜索查询并分析包括语义模式，主题类别和实体的一个或多个语义单元。访问包括多个文档的前向索引并分析与每个文档相关联的语义单元。语义单位包括语义模式，主题类别，单字，双字组和实体。识别与搜索查询共享大致相似的语义单元的文档，并且基于基本相似的语义单元来调整所识别的文档的排名。

6. 发明申请

WO2012167145A2 GENOME-SCALE ANALYSIS OF ABERRANT DNA METHYLATION IN COLORECTAL CANCER 审中-公开
标题翻译：染色体癌细胞DNA甲基化的基因分析
公开(公告)号：WO2012167145A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/040547
申请日：2012-06-01
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , HINOUE, Toshinori , SHEN, Hui , WEISENBERGER, Daniel J. , LAIRD, Peter W.
发明人： HINOUE, Toshinori , SHEN, Hui , WEISENBERGER, Daniel J. , LAIRD, Peter W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Particular aspects provide methods and compositions (e.g., gene marker panels) having substantial utility for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive DNA methylation-based subgroups of CRC including CpG island methylator phenotype (CIMP) groups (e.g., CIMP-H and CIMP-L) and non-CIMP groups. Exemplary marker panels include: B3GAT2, FOXL2, KCNK13, RAB31 and SLIT1 (CIMP marker panel); and FAM78A, FSTL1, KCNC1, MYOCD, and SLC6A4 (CIMP-H marker panel). Further aspects relate to genetic mutations, and other epigenetic markers relating to said CRC subgroups that can be used in combination with the gene marker panels for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive CIMP and non-CIMP groups.
摘要翻译：特定方面提供方法和组合物（例如，基因标记物组），其具有与基于特异性DNA甲基化的CRC亚基（包括CpG岛）有关的结肠直肠癌（CRC）（例如肿瘤）的诊断，鉴定和分类中的至少一种的实质效用甲基化表型（CIMP）组（如CIMP-H和CIMP-L）和非CIMP组。示例性标记面板包括：B3GAT2，FOXL2，KCNK13，RAB31和SLIT1（CIMP标记物组）; 和FAM78A，FSTL1，KCNC1，MYOCD和SLC6A4（CIMP-H标记物组）。其它方面涉及遗传突变和与所述CRC亚组相关的其它表观遗传标记，其可以与基因标记物组合使用，用于诊断，鉴定和分类结肠直肠癌（CRC）（例如肿瘤）中的至少一种独特的CIMP和非CIMP组。

7. 发明申请

WO2016044306A1 LONG-ACTING SEMI-SOLID LIPID FORMULATIONS 审中-公开
标题翻译：长效半固体脂质制剂
公开(公告)号：WO2016044306A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050243
申请日：2015-09-15
申请人： SHEN, Hui, Rong , GAN, Na
发明人： SHEN, Hui, Rong , GAN, Na
IPC分类号： A61K9/00 , A61K47/14 , A61K9/06
CPC分类号： A61K47/14 , A61K9/0019 , A61K9/0051 , A61K9/06 , A61K31/00 , A61K31/215 , A61K31/439 , A61K31/519 , A61K31/5415 , A61K31/5575 , A61K31/573
摘要： What is described is a semi-solid controlled release composition comprising a semi-solid lipid pharmaceutical active agent in a solution or a homogenous suspension, methods of using the composition for treating a disease, and methods of manufacturing the composition.
摘要翻译：描述的是一种半固体控释组合物，其包含在溶液或均匀悬浮液中的半固体脂质药物活性剂，使用该组合物治疗疾病的方法，以及制备该组合物的方法。

8. 发明申请

WO2006127096A2 CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES 审中-公开
标题翻译：环磷酰胺抑制剂和钙通道拮抗剂组合物及其在泌尿系统中的应用方法
公开(公告)号：WO2006127096A2
公开(公告)日：2006-11-30
申请号：PCT/US2006009771
申请日：2006-03-17
申请人： OMEROS CORP , DEMOPULOS GREGORY A , HERZ JEFFREY M , GOMBOTZ WAYNE R , SHEN HUI-RONG
发明人： DEMOPULOS GREGORY A , HERZ JEFFREY M , GOMBOTZ WAYNE R , SHEN HUI-RONG
IPC分类号： A61K31/455 , A61K9/00 , A61K31/192
CPC分类号： A61K31/4422 , A61K9/0034 , A61K9/08 , A61K31/00 , A61K31/192 , A61K31/21 , A61K31/40 , A61K31/44 , A61K31/455 , A61L31/16 , A61L2300/402 , A61L2300/41 , A61L2300/432 , A61K2300/00
摘要： Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.
摘要翻译：液体载体中环加氧酶抑制剂和钙通道拮抗剂的组成。组合物可以在泌尿系统诊断，介入，手术和其他医学过程中施用于泌尿道。一种公开的组合物在液体灌洗载体中包含酮洛芬和硝苯地平，并且包括增溶剂，稳定剂和缓冲剂。

9. 发明申请

WO2006037116A3 SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS 审中-公开
公开(公告)号：WO2006037116A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/035117
申请日：2005-09-27
申请人： A.P. PHARMA, INC. , NG, Steven, Y. , SHEN, Hui-Rong , HELLER, Jorge
发明人： NG, Steven, Y. , SHEN, Hui-Rong , HELLER, Jorge
IPC分类号： A61K9/00 , A61K9/06 , A61K9/08 , A61K9/10
摘要： A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.

10. 发明申请

WO2013020021A1 STABLE ANTI-INFLAMMATORY SOLUTIONS FOR INJECTION 审中-公开
标题翻译：稳定的抗炎解决方案
公开(公告)号：WO2013020021A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049463
申请日：2012-08-03
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , GOMBOTZ, Wayne, R. , SHEN, Hui-rong
发明人： DEMOPULOS, Gregory, A. , GOMBOTZ, Wayne, R. , SHEN, Hui-rong
IPC分类号： A61K9/00
CPC分类号： A61K47/12 , A61K9/0019 , A61K9/08 , A61K31/137 , A61K31/192 , A61K31/4174 , A61K47/10 , A61K47/183 , A61K2300/00
摘要： The present invention relates to stable liquid formulations of ketoprofen, amitriptyline, and oxymetazoline.
摘要翻译：本发明涉及酮洛芬，阿米替林和羟甲唑啉的稳定液体制剂。

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