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1. 发明申请

WO2006127096A3 CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES 审中-公开
公开(公告)号：WO2006127096A3
公开(公告)日：2006-11-30
申请号：PCT/US2006/009771
申请日：2006-03-17
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , HERZ, Jeffrey, M. , GOMBOTZ, Wayne, R. , SHEN, Hui-Rong
发明人： DEMOPULOS, Gregory, A. , HERZ, Jeffrey, M. , GOMBOTZ, Wayne, R. , SHEN, Hui-Rong
IPC分类号： A61K9/22
摘要： Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

2. 发明申请

WO2013020021A1 STABLE ANTI-INFLAMMATORY SOLUTIONS FOR INJECTION 审中-公开
标题翻译：稳定的抗炎解决方案
公开(公告)号：WO2013020021A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049463
申请日：2012-08-03
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , GOMBOTZ, Wayne, R. , SHEN, Hui-rong
发明人： DEMOPULOS, Gregory, A. , GOMBOTZ, Wayne, R. , SHEN, Hui-rong
IPC分类号： A61K9/00
CPC分类号： A61K47/12 , A61K9/0019 , A61K9/08 , A61K31/137 , A61K31/192 , A61K31/4174 , A61K47/10 , A61K47/183 , A61K2300/00
摘要： The present invention relates to stable liquid formulations of ketoprofen, amitriptyline, and oxymetazoline.
摘要翻译：本发明涉及酮洛芬，阿米替林和羟甲唑啉的稳定液体制剂。

3. 发明申请

WO2012064667A2 TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS 审中-公开
标题翻译：使用PDE7抑制剂治疗ADI和IMPULSE-CONTROL DISDERS
公开(公告)号：WO2012064667A2
公开(公告)日：2012-05-18
申请号：PCT/US2011/059626
申请日：2011-11-07
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , GAITANARIS, George, A.
发明人： DEMOPULOS, Gregory, A. , GAITANARIS, George, A.
IPC分类号： A61K31/55 , A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/4439 , A61K31/4162 , A61K31/4178 , A61K31/485 , A61K31/454 , A61K31/44 , A61P25/30 , A61P25/36 , A61P25/32 , A61P25/34 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/08
CPC分类号： A61K31/00 , A61K31/135 , A61K31/137 , A61K31/197 , A61K31/337 , A61K31/357 , A61K31/381 , A61K31/385 , A61K31/4015 , A61K31/4025 , A61K31/4178 , A61K31/44 , A61K31/454 , A61K31/485 , A61K31/4985 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/55 , A61K2300/00
摘要： This disclosure is directed to treatment of addictions and primary impulse-control disorders using phosphodiesterase 7 (PDE7) inhibitors, alone or in combination with other therapeutic agents.
摘要翻译：本公开涉及使用磷酸二酯酶7（PDE7）抑制剂单独或与其它治疗剂组合治疗成瘾和初次冲动控制障碍。

4. 发明申请

WO2018071701A1 METHODS FOR REDUCING PROTEINURIA IN A HUMAN SUBJECT SUFFERING FROM IMMUNOGLOBULIN A NEPHROPATHY 审中-公开
标题翻译：减少免疫球蛋白A肾病患者体内蛋白尿的方法
公开(公告)号：WO2018071701A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/056386
申请日：2017-10-12
申请人： UNIVERSITY OF LEICESTER , OMEROS CORPORATION , BRUNSKILL, Nigel, John , DEMOPULOS, Gregory, A. , DUDLER, Tom , SCHWAEBLE, Hans-Wilhelm
发明人： BRUNSKILL, Nigel, John , DEMOPULOS, Gregory, A. , DUDLER, Tom , SCHWAEBLE, Hans-Wilhelm
IPC分类号： A61K31/7105 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00
摘要： In one aspect, the invention provides methods for reducing proteinuria in a human subject suffering, or at risk of developing Immunoglobulin A Nephropathy (IgAN). The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory antibody effective to inhibit MASP-2-dependent complement activation.
摘要翻译：在一个方面，本发明提供用于减少患有免疫球蛋白A肾病（IgAN）或处于发展免疫球蛋白A肾病（IgAN）的风险中的人受试者中的蛋白尿的方法。所述方法包括向有需要的受试者施用有效抑制MASP-2依赖性补体激活的量的MASP-2抑制性抗体的步骤。

5. 发明申请

WO2011047346A1 METHODS FOR TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION 审中-公开
标题翻译：通过抑制MASP-2依赖性补体激活治疗传染性血管内凝血的方法
公开(公告)号：WO2011047346A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052954
申请日：2010-10-15
申请人： OMEROS CORPORATION , UNIVERSITY OF LEICESTER , SCHWAEBLE, Hans-wilhelm , DUDLER, Thomas, A. , TEDFORD, Clark, E. , PARENT, James, B. , DEMOPULOS, Gregory, A.
发明人： SCHWAEBLE, Hans-wilhelm , DUDLER, Thomas, A. , TEDFORD, Clark, E. , PARENT, James, B. , DEMOPULOS, Gregory, A.
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C12Y304/21104
摘要： In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating a subject suffering from a complement mediated coagulation disorder, such as disseminated intravascular coagulation. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.
摘要翻译：一方面，本发明提供抑制活体受试者中MASP-2依赖性补体活化的作用的方法。在一个实施方案中，本发明提供了治疗患有补体介导的凝血障碍（例如弥散性血管内凝血）的受试者的方法。所述方法包括向有需要的受试者施用一定量的有效抑制MASP-2依赖性补体活化的MASP-2抑制剂的步骤。在一些实施方案中，MASP-2抑制剂抑制与MASP-2介导的替代补体途径活化相关的细胞损伤，同时保持免疫系统的经典（Clq依赖性）通路组分完整。在另一方面，本发明提供了用于抑制凝集素依赖性补体活化的作用的组合物，其包含治疗有效量的MASP-2抑制剂和药学上可接受的载体。

6. 发明申请

WO2004010894A2 OPHTHALMOLOGIC IRRIGATION SOLUTIONS AND METHOD 审中-公开
标题翻译：眼科灌注解决方案及方法
公开(公告)号：WO2004010894A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023871
申请日：2003-07-30
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , PALMER, Pamela, Pierce , HERZ, Jeffrey, M.
发明人： DEMOPULOS, Gregory, A. , PALMER, Pamela, Pierce , HERZ, Jeffrey, M.
IPC分类号： A61F
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/08 , A61K31/00 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/4164 , A61K31/4174 , A61K31/4409 , A61K31/445 , A61K31/5377 , A61K45/06
摘要： Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein the multiple agents are selected to target multiple molecular targets to achieve multiple differing physiologic functions, and are included in dilute concentrations in a balanced salt solution carrier.
摘要翻译：提供了眼科手术中连续灌注围手术期眼内应用的解决方案。这些溶液包括用于抑制炎症，抑制疼痛，影响瞳孔扩大（瞳孔扩张）和/或降低眼内压的多种试剂，其中选择多种试剂靶向多种分子靶标以达到多种不同的生理功能，并且包含在平衡盐溶液载体中的稀释浓度。

7. 发明申请

WO2018045054A1 HIGHLY CONCENTRATED LOW VISCOSITY MASP-2 INHIBITORY ANTIBODY FORMULATIONS, KITS, AND METHODS 审中-公开
标题翻译：高度浓缩的低粘度MASP-2抑制性抗体制剂，试剂盒和方法
公开(公告)号：WO2018045054A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049415
申请日：2017-08-30
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , FERGUSON, Kenneth, M. , LAMBERT, William, Joseph , WHITAKER, John, Steven
发明人： DEMOPULOS, Gregory, A. , FERGUSON, Kenneth, M. , LAMBERT, William, Joseph , WHITAKER, John, Steven
IPC分类号： A61K9/08 , A61K39/395 , A61K47/00
摘要： The present invention relates to stable, high-concentration low-viscosity formulations of MASP-2 inhibitory antibodies, kits comprising the formulations and therapeutic methods using the formulations and kits for inhibiting the adverse effects of MASP-2 dependent complement activation.
摘要翻译：本发明涉及稳定的，高浓度的低粘度MASP-2抑制性抗体制剂，试剂盒包含使用该制剂和试剂盒的制剂和治疗方法，用于抑制MASP-2的不利作用依赖补体激活。

8. 发明申请

WO2004043479A1 IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION 审中-公开
标题翻译：灌注溶液和抑制肿瘤细胞粘附，疼痛和炎症的方法
公开(公告)号：WO2004043479A1
公开(公告)日：2004-05-27
申请号：PCT/US2002/036675
申请日：2002-11-12
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , PALMER, Pamela, Pierce , HERZ, Jeffrey, M. , TANELIAN, Darrell
发明人： DEMOPULOS, Gregory, A. , PALMER, Pamela, Pierce , HERZ, Jeffrey, M. , TANELIAN, Darrell
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K31/495 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/70 , A61K38/06 , A61K38/08 , A61K38/177 , A61K38/178 , A61K2300/00
摘要： A method and solution for perioperatively inhibiting tumor cell adhesion and a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one anti-tumor cell adhesion agent and multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit tumor cell adhesion, pain and inflammation includes at least one anti-tumor cell adhesion agent, a serotonin 2 antagonist, a serotonin¿3 ?antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin l antagonist, a neurokinin 2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin l antagonist, a bradykinin 2 antagonist and a μ-opioid agonist.
摘要翻译：用于围手术期抑制肿瘤细胞粘附的方法和解决方案，以及来自一般外科手术（包括口腔/牙科手术）的伤口处的各种疼痛和炎症过程。溶液优选包含至少一种抗肿瘤细胞粘附剂和在生理载体例如盐水或乳酸林格氏溶液中稀释浓度的多种疼痛和炎症抑制剂。该溶液通过在外科手术期间连续冲洗伤口来施用，用于先期抑制疼痛，同时避免与口服，肌肉内，皮下或静脉内施用较大剂量的药剂相关的不期望的副作用。抑制肿瘤细胞粘附，疼痛和炎症的一种优选的解决方案包括至少一种抗肿瘤细胞粘附剂，5-羟色胺2拮抗剂，5-羟色胺3拮抗剂，组胺拮抗剂，5-羟色胺激动剂，环加氧酶抑制剂，神经激肽拮抗剂，神经激肽2拮抗剂嘌呤受体拮抗剂，ATP敏感性钾通道开放剂，钙通道拮抗剂，缓激肽拮抗剂，缓激肽2拮抗剂和μ-类兴奋剂。

9. 发明申请

WO2020146795A1 METHODS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2020146795A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/013183
申请日：2020-01-10
申请人： OMEROS CORPORATION , CICIRELLI, Michael , CUTSHALL, Neil, S. , DEMOPULOS, Gregory, A. , GAITANARIS, George, A. , GAVIN, Marc, A. , GRAGEROV, Alexander , LITTLE, Thomas, L. , ONRUST, Rene
发明人： CICIRELLI, Michael , CUTSHALL, Neil, S. , DEMOPULOS, Gregory, A. , GAITANARIS, George, A. , GAVIN, Marc, A. , GRAGEROV, Alexander , LITTLE, Thomas, L. , ONRUST, Rene
IPC分类号： C07K14/705 , C07K14/54 , A61K35/17
摘要： This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).

10. 发明申请

WO2017214186A1 MONOCLONAL ANTIBODIES, COMPOSITIONS AND METHODS FOR DETECTING MUCIN -LIKE PROTEIN (MLP) AS A BIOMARKER FOR OVARIAN AND PANCREATIC CANCER 审中-公开
标题翻译：检测粘蛋白 - 蛋白（MLP）作为卵巢癌和胰腺癌生物标志物的单克隆抗体，组合物和方法
公开(公告)号：WO2017214186A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036204
申请日：2017-06-06
申请人： UNIVERSITY OF LEICESTER , OMEROS CORPORATION , SCHWAEBLE, Hans-Wilhelm , DEMOPULOS, Gregory, A.
发明人： SCHWAEBLE, Hans-Wilhelm , DEMOPULOS, Gregory, A.
IPC分类号： A61K39/00 , C12P21/08 , C12N15/02
摘要： In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such as ovarian or pancreatic cancer.
摘要翻译：在各种实施方案中，本发明提供了用于检测MLP作为粘蛋白分泌型癌症如卵巢癌或胰腺癌的生物标志物的抗粘蛋白样蛋白（MLP）单克隆抗体，组合物和方法。 / p>

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