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1. 发明申请

WO2013063615A3 N-ACYLDIPEPTIDE DERIVATIVES AND THEIR USES 审中-公开
标题翻译： N-亚胺代谢衍生物及其用途
公开(公告)号：WO2013063615A3
公开(公告)日：2014-10-16
申请号：PCT/US2012062715
申请日：2012-10-31
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： A61K9/00 , A61K38/05
CPC分类号： A61K8/64 , A61K9/0014 , A61K38/05 , A61K2800/10 , A61K2800/92 , A61Q5/00 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06113 , C07K5/06147 , C07K5/06156 , C07K5/06165 , C07K5/06191
摘要： N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with a tumor, cancer, immune, nervous, vascular, musculoskeletal or cutaneous system, or other tissue or system in a subject.
摘要翻译：描述N-酰基二肽衍生物。包含N-酰基二肽衍生物的组合物对于局部或全身给药是治疗有效的，以缓解或改善与肿瘤，癌症，免疫，神经，血管，肌肉骨骼或皮肤系统或其他组织相关的病症，疾病，症状或综合征，或系统在一个主题。

2. 发明申请

WO2007047486A3 HYDROXY-OLIGOCARBOXYLIC ESTERS: EFFECTS ON NERVE AND USE FOR CUTANEOUS AND MUCOCUTANEOUS ORGANS OR SITES 审中-公开
标题翻译：羟基 - 低聚糖酸酯：对神经和对胰腺和肌肉组织或网站的影响
公开(公告)号：WO2007047486A3
公开(公告)日：2008-05-22
申请号：PCT/US2006040179
申请日：2006-10-13
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： A61K31/21
CPC分类号： A61K31/21 , A61K8/37 , A61Q5/006 , A61Q19/007 , A61Q19/02 , A61Q19/06 , Y10S514/844
摘要： A composition and method for producing a beneficial effect on a subject's nerve associated with at least one of a cosmetic condition, a dermatological indication and a dental indication and another condition. The composition comprises a hydroxy- oligocarboxylic ester and is formulated for topical administration of the product to a subject to produce the beneficial effect. The method includes topically applying to the subject in a region where the beneficial effect is desired a hydroxy-oligocarboxylic ester in an amount effective to produce the beneficial effect.
摘要翻译：用于产生与化妆品状况，皮肤病学指征和牙科指征以及其他症状中的至少一种相关的受试者神经的有益效果的组合物和方法。该组合物包含羟基 - 低聚羧酸酯，并配制用于向受试者局部施用该产品以产生有益效果。该方法包括在有效产生有益效果的量的羟基低聚羧酸酯的有益效果的区域中局部施用于受试者。

3. 发明申请

WO2005055947A3 ENLARGEMENT OF MUCOCUTANEOUS OR CUTANEOUS ORGANS AND SITES WITH TOPICAL COMPOSITIONS 审中-公开
标题翻译：木质素或丁酸成分与局部组合物的扩增
公开(公告)号：WO2005055947A3
公开(公告)日：2005-08-25
申请号：PCT/US2004041009
申请日：2004-12-08
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： A61K20060101 , A61K31/19 , A61K31/195 , A61K31/366
CPC分类号： A61K31/19 , A61K31/195
摘要： Compositions comprising a hydroxycarboxylic acid, N-acyl-aldosamine, Nacylamino acid or related compound on topical application are beneficial to plump and pout lips, enhance and firm eyelids, enlarge and augment breasts, elongate and expand penis. Because of antioxidant property, certain hydroxycarboxylic acids, N-acylaldosamines, N-acylamino acids and related compounds also are useful for topical administration to prevent occurrence of breast cancer or other forms of tumors and cancers.
摘要翻译：在局部应用中包含羟基羧酸，N-酰基 - 醛糖胺，酰胺基氨基酸或相关化合物的组合物有利于丰满和舔嘴唇，增强和巩固眼睑，增大和增加乳房，伸长和伸展阴茎。由于抗氧化性能，某些羟基羧酸，N-酰基醛胺，N-酰基氨基酸和相关化合物也可用于局部施用以防止乳腺癌或其它形式的肿瘤和癌症的发生。

4. 发明申请

WO2007082206A3 N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： N-（膦酰基） - 氨基酸，其衍生物及其组合物和使用方法
公开(公告)号：WO2007082206A3
公开(公告)日：2007-12-13
申请号：PCT/US2007060273
申请日：2007-01-09
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： C07F9/38
CPC分类号： C07F9/582 , A61K38/05 , C07F9/3808 , C07F9/5721 , C07F9/5728 , C07F9/65067 , C07F9/653
摘要： The present invention relates to anN-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phos?honoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non- stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)- glycine. Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.
摘要翻译：本发明涉及N-（膦酰基烷基） - 氨基酸，相关化合物或其衍生物，N-（膦酰基烷基） - 氨基酸，相关化合物或其衍生物以游离酸，盐，除N-（膦酰基甲基） - 甘氨酸或N，N-双（膦酰基甲基） - 甘氨酸外的部分盐，内酯，酰胺或酯，或以立体异构或非立体异构形式。还包括以游离酸，盐，部分盐，内酯，酰胺或酯的形式或以立体异构或非立体异构形式包含N-（膦酰基烷基） - 氨基酸，相关化合物或其衍生物的组合物以及用于局部或全身施用于哺乳动物受试者的化妆品或药学上可接受的载体，以及施用有效量的此类组合物用于缓解或改善与以下至少一种有关的病症，障碍，症状或综合征的方法：神经，血管，肌肉骨骼或皮肤系统。

5. 发明申请

WO2007103687A2 COMPOSITION AND METHOD FOR TOPICAL TREATMENT OF TAR-RESPONSIVE DERMATOLOGICAL DISORDERS 审中-公开
标题翻译：用于局部治疗反应性皮肤病的组合物和方法
公开(公告)号：WO2007103687A2
公开(公告)日：2007-09-13
申请号：PCT/US2007062975
申请日：2007-02-28
申请人： TRISTRATA INC , YU RUEY J , SCOTT EUGENE J VAN , LEE YALING
发明人： YU RUEY J , VAN SCOTT EUGENE J , LEE YALING
IPC分类号： A61K36/00
CPC分类号： A61K35/04 , A61K9/0014 , A61K36/00 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/32 , A61K47/38 , A61K47/44 , A61K2300/00
摘要： The present invention relates to a composition including a wax and a therapeutically effective amount of tar for topical treatment of a tar-responsive dermatological disorder, the composition being in liquid or light gel form when at a temperature selected from room temperature and a temperature of skin of a mammal upon application of the composition to the skin of the mammal. The invention also relates to a method of treating a tar-responsive dermatological disorder by topically applying the composition to skin of a mammal, preferably a human, that is involved with the disorder.
摘要翻译：本发明涉及包含蜡和用于局部治疗焦油反应性皮肤病的治疗有效量的焦油的组合物，所述组合物在选自室温和皮肤温度的温度下为液体或轻质凝胶形式在将组合物施用于哺乳动物的皮肤时。本发明还涉及一种通过将组合物局部施用于涉及该病症的哺乳动物，优选人的皮肤来治疗焦油反应性皮肤病的方法。

6. 发明申请

WO2006119283A2 ANTI-ODOR COMPOSITIONS AND THERAPEUTIC USE 审中-公开
标题翻译：抗气味组合物和治疗用途
公开(公告)号：WO2006119283A2
公开(公告)日：2006-11-09
申请号：PCT/US2006016823
申请日：2006-05-04
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： A61L9/00 , A61K8/46 , A61K8/49
CPC分类号： A61K8/46 , A61K8/34 , A61K8/345 , A61K8/35 , A61K8/37 , A61K8/41 , A61K8/447 , A61K8/4913 , A61K8/494 , A61K8/4953 , A61K8/606 , A61K8/64 , A61K31/095 , A61K2800/31 , A61L9/01 , A61Q5/00 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： This application discloses a composition comprising a malodor compound and an anti-odor ingredient effective for reducing the presence or production of malodor. The composition may be topically applied to a subject and is useful for cosmetic conditions, pharmaceutical indications, or other objectives.
摘要翻译：本申请公开了一种组合物，其包含恶臭化合物和有效减少恶臭存在或产生的抗臭味成分。组合物可以局部施用于受试者，并且可用于美容条件，药物适应症或其它目的。

7. 发明申请

WO2006101940A2 COMPOSITION COMPRISING N-PROPANOYL DERIVATIVES OF AMINO ACIDS, AMINOCARBOHYDRATES AND DERIVATIVES THEREOF 审中-公开
标题翻译：包含氨基酸，氨基碳酸酯及其衍生物的N-丙醇衍生物的组合物
公开(公告)号：WO2006101940A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009438
申请日：2006-03-16
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： VAN SCOTT EUGENE J
IPC分类号： A61K31/4172 , A61K31/198
CPC分类号： A61K31/195 , A61K31/198 , A61K31/4172 , A61K31/7008
摘要： The embodiments relate to compositions comprising therapeutically effective amounts of at least one N-propanoyl derivative of amino acids, aminocarbohydrates, and derivatives thereof. The compositions are useful the prevention and treatment of symptoms or syndromes associated with nervous, vascular, musculoskeletal, or cutaneous systems. The compositions may be topically or systemically administered to a subject in need thereof.
摘要翻译：实施方案涉及包含治疗有效量的至少一种氨基酸的N-丙酰基衍生物，氨基碳水化合物及其衍生物的组合物。该组合物可用于预防和治疗与神经，血管，肌肉骨骼或皮肤系统相关的症状或综合征。组合物可以局部或全身施用于有需要的受试者。

8. 发明申请

WO2004093722A3 TOPICAL TREATMENT OF DERMATOLOGICAL DISORDERS ASSOCIATED WITH REACTIVE OR DILATED BLOOD VESSELS 审中-公开
标题翻译：与反应性或稀释血液血管相关的病理性疾病的局部治疗
公开(公告)号：WO2004093722A3
公开(公告)日：2005-03-31
申请号：PCT/US2004010454
申请日：2004-04-05
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： A01N37/00 , A01N37/18 , A61F20060101 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/21 , A61K31/366
CPC分类号： A61K31/70 , A61K8/365 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要： The invention provides a method of topically treating a dermatological disorder. The method includes topically applying a therapeutically effective amount of a cosmetic or dermatological composition to an affected area of the skin. The composition includes at least one compound that is (i) a polyhydroxy-aldonic acid, (ii) a polyhydroxy-aldonic lactone, (iii) a polyhydroxy-alduronic acid, (iv) a polyhydroxy-alduronic lactone, (v) a polyhydroxy-aldaric acid; (vi) a polyhydroxy-aldaric lactone, and (vii) an organic acid lactone having two or more hydroxyl or ketohydroxyl groups. The dermatological disorder treated is one associated with reactive or dilated blood vessels. Also included in the invention are methods of treating dermatological disorders associated with reactive blood vessels that include topical application of a therapeutically effective amount of a composition. The composition includes at least one compound selected from a compound represented by formula (I), by formula (II) and by formula (III), and a lactone derived from an organic acid having two or more hydroxyl or ketohydroxyl groups.
摘要翻译：本发明提供了一种局部治疗皮肤病的方法。该方法包括将治疗有效量的化妆品或皮肤病学组合物局部施用于皮肤的受影响区域。组合物包括至少一种化合物，其为（i）多羟基 - 醛糖酸，（ii）多羟基 - 醛糖内酯，（iii）多羟基 - 醛糖醛酸，（iv）多羟基 - 醛糖醛酸内酯，（v）多羟基 - 醛糖醛酸内酯醛酸（vi）多羟基 - 醛缩酮内酯，和（vii）具有两个或多个羟基或酮羟基的有机酸内酯。所治疗的皮肤病是与反应性或扩张型血管相关的疾病。本发明还包括治疗与反应性血管相关的皮肤病学障碍的方法，其包括局部施用治疗有效量的组合物。该组合物包括选自式（I），式（II）和式（III）表示的化合物中的至少一种化合物和衍生自具有两个或多个羟基或酮羟基的有机酸的内酯。

9. 发明申请

WO2004089329A2 N-ACETYLAMINO ACIDS, RELATED N-ACETYL COMPOUNDS AND THEIR TOPICAL USE 审中-公开
标题翻译： N-乙酰氨基酸，相关N-乙酰化合物及其主题用途
公开(公告)号：WO2004089329A2
公开(公告)日：2004-10-21
申请号：PCT/US2004005041
申请日：2004-02-20
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： A61K8/41 , A61K8/44 , A61K8/49 , A61K8/60 , A61K9/06 , A61K31/13 , A61K31/132 , A61K31/16 , A61K31/198 , A61K31/495 , A61K31/522 , A61K31/7076 , A61K31/708 , A61P17/00 , A61P17/04 , A61P17/06 , A61Q3/00 , A61Q5/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/48
CPC分类号： A61K8/44 , A61K8/447 , A61K8/4913 , A61K8/60 , A61K9/06 , A61K31/13 , A61K31/132 , A61K31/16 , A61K31/198 , A61K31/495 , A61K31/7076 , A61K31/708 , A61Q3/00 , A61Q5/00 , A61Q5/006 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08 , Y10S514/844 , Y10S514/847 , A61K2300/00
摘要： Compositions comprising N-acetylamino acids and/or related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. The N-acetylamino acid and/or related N-acetyl compound composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.
摘要翻译：包含N-乙酰氨基酸和/或相关N-乙酰基化合物的组合物可用于缓解或改善各种美容条件和皮肤病学障碍，包括与内在老化和/或外在老化相关的皮肤，指甲和毛发的变化或损伤，以及由外在因素引起的变化或损害。 N-乙酰氨基酸和/或相关的N-乙酰基化合物组合物可以进一步包含化妆品，药物或其它外用剂，以增强或产生协同作用。

10. 发明申请

WO2013103634A3 N-ACYLPEPTIDE DERIVATIVES AND THEIR USES 审中-公开
标题翻译： N-乙酰基衍生物及其用途
公开(公告)号：WO2013103634A3
公开(公告)日：2013-11-14
申请号：PCT/US2013020015
申请日：2013-01-03
申请人： YU RUEY J , SCOTT EUGENE J VAN
发明人： YU RUEY J , VAN SCOTT EUGENE J
IPC分类号： C07K7/00
CPC分类号： A61K8/64 , A61K9/0014 , A61K38/00 , A61K38/06 , A61K38/08 , A61K38/10 , A61Q19/00 , C07K5/0812 , C07K5/10 , C07K5/1016 , C07K7/06 , C07K7/08
摘要： N-acylpeptide derivatives of 5-20 amino acids in length are described. Compositions comprising N-acylpeptide derivatives arc therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with tumors or cancers, immune, nervous, vascular, musculoskeletal, cutaneous system, or other tissues or systems in a subject.
摘要翻译：描述长度为5-20个氨基酸的N-酰基肽衍生物。包含N-酰基肽衍生物的组合物对于局部或全身给药具有治疗效果，以减轻或改善与免疫，神经，血管，肌肉骨骼，皮肤系统或其他组织或系统中的肿瘤或癌症相关的病症，疾病，疾病，症状或综合征课程。

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