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1. 发明申请

WO2010056988A2 METHODS OF TREATING STROKE USING STEM CELL-LIKE MENSTRUAL BLOOD CELLS 审中-公开
标题翻译：使用干细胞样淋巴细胞治疗小肠的方法
公开(公告)号：WO2010056988A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064379
申请日：2009-11-13
申请人： UNIV SOUTH FLORIDA , SANERON CCEL THERAPEUTICS INC , CRYO CELL INT , MEDICAL COLLEGE OF GEORGIA , SANBERG PAUL R , BORLONGAN CESARIO V , ALLICKSON JULIE
发明人： SANBERG PAUL R , BORLONGAN CESARIO V , ALLICKSON JULIE
IPC分类号： A61K35/14 , A61K38/18 , A61P7/06 , A61P25/28
CPC分类号： A61K35/14 , A61K35/30 , A61K38/185 , A61K38/1866
摘要： A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell therapy. Menstrual blood is found to be another important source of stem cells. Assays of cultured menstrual blood reveal that they express embryonic like-stern cell phenotypic markers and neuronal phenotypic markers under appropriate conditioned media. Oxygen glucose deprivation stroke models show that OGD-exposed primary rat neurons, co- cultured with menstrual blood-derived stem cells or exposed to the media from cultured menstrual blood, exhibited significantly reduced cell death. Transplantation of menstrual blood-derived stem cells, either intracerebrally or intravenously, after experimentally induced ischemic stroke in adult rats also significantly reduced behavioral and histological impairments compared to vehicle-infused rats.
摘要翻译：与移植受体完全匹配的细胞类型似乎是最佳方案，以最小的并发症向大量患者群体开放治疗选择。已经提出使用自体骨髓或脐带血作为细胞治疗的干细胞的良好来源。月经血被认为是干细胞的另一个重要来源。培养的月经血液的测定显示，它们在合适的条件培养基下表达胚胎样细胞表型标记物和神经元表型标记物。氧葡萄糖剥夺中风模型显示，OGD暴露的原代大鼠神经元与月经血源干细胞共培养或暴露于来自培养的月经血液的培养基，显示出显着降低的细胞死亡。在实验性诱导的成年大鼠缺血性卒中后，月经血液或静脉内移植月经血源性干细胞，与载体输注大鼠相比，也显着降低了行为和组织学损伤。

2. 发明申请

WO2005107807A2 CEREBRAL INTRAVENTRICULAR TRANSPLANTATION AS METHOD OF TREATING AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：作为治疗左心室狭窄的方法，作为宫颈静脉输送
公开(公告)号：WO2005107807A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/016033
申请日：2005-05-06
申请人： UNIVERSITY OF SOUTH FLORIDA , GARBUZOVA-DAVIS, Svitlana , BALBER, Andrew , DAVIS-SANBERG, Cyndy , GENTRY, Tracy , KUZMIN-NICHOLS, Nicole , SANBERG, Paul, R. , WILLING, Alison
发明人： GARBUZOVA-DAVIS, Svitlana , BALBER, Andrew , DAVIS-SANBERG, Cyndy , GENTRY, Tracy , KUZMIN-NICHOLS, Nicole , SANBERG, Paul, R. , WILLING, Alison
IPC分类号： A61K45/00
CPC分类号： A61K35/28 , A61K9/0085 , A61K31/203 , A61K35/30 , A61K35/50 , A61K35/51 , A61K45/06 , A61K2035/124 , C12N5/0607 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/13 , C12N2501/385 , C12N2506/11 , A61K2300/00
摘要： A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH + ) expressing progenitor cells provides cell replacement and protection of motor neurons.
摘要翻译：使用从人脐带血分离的祖细胞来治疗患有神经变性疾病的患者（例如ALS）的方法。表达祖细胞的醛脱氢酶（ALDH +）的非侵入性移植提供了运动神经元的细胞替代和保护。

3. 发明申请

WO1996028174A1 SERTOLI CELLS AS TRANSPLANTATION FACILITATOR FOR CELL TRANSPLANTATION 审中-公开
标题翻译： SERTOLI细胞作为细胞移植的移植辅助细胞
公开(公告)号：WO1996028174A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003337
申请日：1996-03-12
申请人： UNIVERSITY OF SOUTH FLORIDA , SANBERG, Paul, R. , CAMERON, Don, F. , BORLONGAN, Cesario, V. , HELLER, Richard
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61K35/00
CPC分类号： C12N5/0683 , A61K35/12 , A61K35/30 , A61K35/48 , A61K2035/122 , C12N5/0618 , C12N2502/246
摘要： A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.
摘要翻译：通过移植靠近组织的Sertoli细胞来实现在局部组织中产生持续的局部免疫抑制作用的方法。

4. 发明申请

WO2009023814A3 HUCBC TREATMENT OF AMYLOID ASSOCIATED DISEASE 审中-公开
标题翻译： HUCBC治疗AMYLOID相关疾病
公开(公告)号：WO2009023814A3
公开(公告)日：2009-05-07
申请号：PCT/US2008073265
申请日：2008-08-15
申请人： UNIV SOUTH FLORIDA , TAN JUN , SANBERG PAUL R
发明人： TAN JUN , SANBERG PAUL R
IPC分类号： A61K35/14
CPC分类号： A61K35/16 , A61K35/44 , A61K2035/122
摘要： Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, A? phagocytic activity was increased and soluble and insoluble AB protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of AB 1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.
摘要翻译：人类脐带血细胞（HUCBC）或HUCBC衍生的血浆的施用用于治疗淀粉样疾病，例如阿尔茨海默氏病，亨廷顿舞蹈病，脑淀粉样蛋白抗肌病和II型糖尿病。通过输注HUCBC来调节炎症反应导致淀粉样斑块和免疫相关细胞损伤的显着减少。 HUCBC输注也显着减少小鼠模型中的脑淀粉样血管病。这些作用与抑制CD40-CD40L相互作用有关，并且在免疫细胞上观察到表面表达CD-40的减少。此外，A？吞噬活性增加，可溶性和不溶性AB蛋白水平通过治疗被调节。注射HUCBC的血清也显着增加AB 1-42肽的吞噬作用并抑制免疫细胞CD40表达并减少脑淀粉样血管病。

5. 发明申请

WO2007081478A3 PRENATAL ADMINISTRATION OF UMBILICAL CORD STEM CELLS FOR TREATMENT OF LYSOSOMAL STORAGE DISEASES 审中-公开
标题翻译：用于治疗淋巴细胞储存疾病的脐带干细胞的初步管理
公开(公告)号：WO2007081478A3
公开(公告)日：2008-03-27
申请号：PCT/US2006047368
申请日：2006-12-12
申请人： UNIV SOUTH FLORIDA , GARBUZOVA-DAVIS SVITLANA , SANBERG PAUL R , GOGRAFE SYLVIA
发明人： GARBUZOVA-DAVIS SVITLANA , SANBERG PAUL R , GOGRAFE SYLVIA
IPC分类号： C12N5/00
CPC分类号： A61K35/44
摘要： A method of treating a fetus or embryo suspected of having a congenital condition that involves an abnormal or missing protein, the method has the steps of a. providing a plurality of human umbilical cord blood cells in a form suitable for intravenous administration; and b. administering the human umbilical cord blood cells to a mother carrying a fetus or embryo suspected of having said congenital condition. Such congenital conditions include Sanfilippo's syndrome, Hunter's syndrome, Hurler's syndrome, Tay-Sachs disease, Gaucher' s disease, von Gierke's disease, Pompes disease, Cori disease, Andersen disease, McArdle's disease, Hers disease, Tauri's disease or Type IX glycogen storage disease.
摘要翻译：一种治疗怀疑患有涉及异常或缺失蛋白质的先天性病症的胎儿或胚胎的方法，具有以下步骤：a。以适于静脉内施用的形式提供多个人脐带血细胞; 和b。将人脐带血细胞施用于携带怀疑患有先天性疾病的胎儿或胚胎的母亲。这种先天性疾病包括Sanfilippo综合征，亨特综合征，赫勒综合征，泰沙病，戈谢病，冯·吉尔克病，庞培病，康利病，安徒生病，麦卡德尔病，赫斯病，牛磺病或1型糖原贮积病。

6. 发明申请

WO2005107807A3 CEREBRAL INTRAVENTRICULAR TRANSPLANTATION AS METHOD OF TREATING AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：作为治疗左心室狭窄的方法，作为宫颈静脉输送
公开(公告)号：WO2005107807A3
公开(公告)日：2006-01-19
申请号：PCT/US2005016033
申请日：2005-05-06
申请人： UNIV SOUTH FLORIDA , GARBUZOVA-DAVIS SVITLANA , BALBER ANDREW , DAVIS-SANBERG CYNDY , GENTRY TRACY , KUZMIN-NICHOLS NICOLE , SANBERG PAUL R , WILLING ALISON
发明人： GARBUZOVA-DAVIS SVITLANA , BALBER ANDREW , DAVIS-SANBERG CYNDY , GENTRY TRACY , KUZMIN-NICHOLS NICOLE , SANBERG PAUL R , WILLING ALISON
IPC分类号： A61K31/203 , A61K35/12 , A61K35/14 , A61K45/00 , A61K45/06 , C12N5/074 , C12N5/0789 , A01N1/02 , G01N33/53
CPC分类号： A61K35/28 , A61K9/0085 , A61K31/203 , A61K35/30 , A61K35/50 , A61K35/51 , A61K45/06 , A61K2035/124 , C12N5/0607 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/13 , C12N2501/385 , C12N2506/11 , A61K2300/00
摘要： A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH + ) expressing progenitor cells provides cell replacement and protection of motor neurons.
摘要翻译：使用从人脐带血分离的祖细胞来治疗患有神经变性疾病的患者（例如ALS）的方法。表达祖细胞的醛脱氢酶（ALDH + +）表达的非侵入性移植提供了运动神经元的细胞替代和保护。

7. 发明申请

WO2003065999A2 PROLIFERATED CELL LINES AND USES THEREOF 审中-公开
标题翻译：增殖细胞系及其用途
公开(公告)号：WO2003065999A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003753
申请日：2003-02-07
申请人： UNIVERSITY OF SOUTH FLORIDA , UNIVERSITY OF CHILE , CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
发明人： CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
IPC分类号： A61K
CPC分类号： A61K35/26 , C12N5/0018 , C12N2500/84 , C12N2502/078 , C12N2502/30 , C12N2503/02
摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, nonfertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.
摘要翻译：本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。本发明还涉及增殖因子和含有能够增加培养物中任何人或其他动物细胞的增殖潜力的因素的组合物。本发明还涉及通过使细胞与增殖因子接触来增殖培养细胞的方法。增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。任选地，可诱导细胞停止增殖。本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

9. 发明申请

WO2007081478A2 A NOVEL METHOD OF PRENATAL ADMINISTRATION OF MAMMALIAN UMBILICAL CORD STEM CELLS FOR THE INTRAUTERINE TREATMENT OF MAMMALIAN LYSOSOMAL STORAGE DISEASES 审中-公开
标题翻译： MAMMALIAN脐带血干细胞预防性治疗MAMMALIAN LYSOSOMAL存储疾病的新方法
公开(公告)号：WO2007081478A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/047368
申请日：2006-12-12
申请人： UNIVERSITY OF SOUTH FLORIDA , GARBUZOVA-DAVIS, Svitlana , SANBERG, Paul, R. , GOGRAFE, Sylvia
发明人： GARBUZOVA-DAVIS, Svitlana , SANBERG, Paul, R. , GOGRAFE, Sylvia
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： A61K35/44
摘要： A method of treating a fetus or embryo suspected of having a congenital condition that involves an abnormal or missing protein, the method has the steps of a. providing a plurality of human umbilical cord blood cells in a form suitable for intravenous administration; and b. administering the human umbilical cord blood cells to a mother carrying a fetus or embryo suspected of having said congenital condition. Such congenital conditions include Sanfilippo's syndrome, Hunter's syndrome, Hurler's syndrome, Tay-Sachs disease, Gaucher' s disease, von Gierke's disease, Pompes disease, Cori disease, Andersen disease, McArdle's disease, Hers disease, Tauri's disease or Type IX glycogen storage disease.
摘要翻译：一种治疗怀疑患有涉及异常或缺失蛋白质的先天性病症的胎儿或胚胎的方法，具有以下步骤：a。以适于静脉内施用的形式提供多个人脐带血细胞; 和b。将人脐带血细胞施用于携带怀疑患有先天性疾病的胎儿或胚胎的母亲。这种先天性疾病包括Sanfilippo综合征，亨特综合征，赫勒综合征，泰沙病，戈谢病，冯·吉尔克病，庞培病，康利病，安徒生病，麦卡德尔病，赫斯病，牛磺病或1型糖原贮积病。

10. 发明申请

WO2004022579A3 CELLULAR DELIVERY OF NATRIURETIC PEPTIDES 审中-公开
公开(公告)号：WO2004022579A3
公开(公告)日：2004-03-18
申请号：PCT/US2003/028157
申请日：2003-09-08
申请人： UNIVERSITY OF SOUTH FLORIDA , SANCHEZ-RAMOS, Juan , SONG, Shijie , SANBERG, Paul, R. , KAMATH, Siddharth, G.
发明人： SANCHEZ-RAMOS, Juan , SONG, Shijie , SANBERG, Paul, R. , KAMATH, Siddharth, G.
IPC分类号： A61K48/00
摘要： The present invention pertains to a method for treating deficits, such as neurological deficits, caused by focal or generalized edema associated with injury to the central nervous system, heart, liver, and kidney. The present invention further concerns a method for producing natriuretic peptides and pharmaceutical compositions comprising bone marrow stromal cells and effective amounts of retinoic acid and nerve growth factor to induce the bone marrow stromal cells to increase production of natriuretic peptides.

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