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1. 发明申请

WO2011109717A1 METHODS AND PROCESSES FOR COLLECTING, PRESERVING, AND CULTURING ADULT STEM CELLS OBTAINED FROM LOCHIA AND RELATED COMPOSITIONS OF MATTER 审中-公开
标题翻译：用于收集，保存和培养从LOCHIA获得的成熟干细胞的方法和方法及相关成分
公开(公告)号：WO2011109717A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027205
申请日：2011-03-04
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G.
IPC分类号： A61K35/14 , A01N63/00
CPC分类号： A01N1/0278 , A61K35/12
摘要： A method is provided for collecting and isolating stem-like cells from lochia. The method includes cryopreserving, thawing, and culturing isolated cells. The isolated lochia cells may be combined with a pharmaceutically-acceptable excipient, a cosmeceutical agent, a therapeutic agent, or a media.
摘要翻译：提供了一种用于收集和分离来自lochia的干细胞的方法。该方法包括冷冻保存，解冻和培养分离的细胞。分离的lochia细胞可以与药学上可接受的赋形剂，药用化妆品，治疗剂或培养基组合。

3. 发明申请

WO2007146106A2 PROCUREMENT, ISOLATION AND CRYOPRESERVATION OF MATERNAL PLACENTAL CELLS 审中-公开
标题翻译：采购，分离和重组的细胞体细胞
公开(公告)号：WO2007146106A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013482
申请日：2007-06-05
申请人： CRYO- CELL INTERNATIONAL, INC. , ALLICKSON, Julie, G.
发明人： ALLICKSON, Julie, G.
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , A01N1/02
摘要： Methods, processes and systems for procuring, isolating and cryopreserving at least one viable, multipotent maternal placental stem cell is provided. Viable maternal placental stem cells are also provided. The maternal placental stem cell of the invention expresses the cell surface marker CDl 17 and at least one of the cell surface markers selected from the group consisting of CD29, CD44, CD73, CD90, CD105, CD166, SSEA-3 and SSEA-4 and has low or no expression of at least one of the cell surface markers selected from the group consisting of CD34, CD45, CD133, TRA-1-60 and TRA-1-81. The methods and process comprise generally obtaining a piece of placental tissue from a whole placenta, disaggregating the placental tissue with mechanical separation or enzymatic digestion, collecting and concentrating placental cells comprising maternal placental cells with centrifugation and optionally cryopreserving the placental cells. Additional steps for selecting and culturing the maternal placental stem cells is provided.
摘要翻译：提供了用于采购，分离和冷冻保存至少一种可行的，多能的母体胎盘干细胞的方法，过程和系统。还提供了可行的母体胎盘干细胞。本发明的母体胎盘干细胞表达细胞表面标志物CD17和选自CD29，CD44，CD73，CD90，CD105，CD166，SSEA-3和SSEA-4的细胞表面标志物中的至少一种，以及具有选自CD34，CD45，CD133，TRA-1-60和TRA-1-81中的至少一种细胞表面标志物的低表达或没有表达。方法和方法包括通常从整个胎盘获得一片胎盘组织，用机械分离或酶消化分解胎盘组织，通过离心收集和浓缩包含母体胎盘细胞的胎盘细胞，并任选冷冻保存胎盘细胞。提供了选择和培养母体胎盘干细胞的附加步骤。

4. 发明申请

WO2007146105A2 PROCUREMENT, ISOLATION AND CRYOPRESERVATION OF FETAL PLACENTAL CELLS 审中-公开
标题翻译：采购，隔离和胎儿细胞的CRYOPRESVATION
公开(公告)号：WO2007146105A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013481
申请日：2007-06-05
申请人： CRYO-CELL INTERNATIONAL, INC. , ALLICKSON, Julie, G.
发明人： ALLICKSON, Julie, G.
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , A01N1/02
摘要： Methods, processes and systems for procuring, isolating and cryopreserving fetal placental cells are provided. A population of fetal placental cells is also provided.
摘要翻译：提供了采购，分离和冷冻保存胎儿胎盘细胞的方法，过程和系统。还提供了胎盘胎盘细胞群。

5. 发明申请

WO1993003891A1 STORAGE APPARATUS, PARTICULARLY WITH AUTOMATIC INSERTION AND RETRIEVAL 审中-公开
标题翻译：存储设备，特别是自动插入和检索
公开(公告)号：WO1993003891A1
公开(公告)日：1993-03-04
申请号：PCT/US1992006880
申请日：1992-08-17
申请人： CRYO-CELL INTERNATIONAL, INC.
发明人： CRYO-CELL INTERNATIONAL, INC. , KNIPPSCHEER, Hermann , RICHARD, Daniel, D. , ROSENBERG, Stanley , MURPHY, Michael , VICKERY, John
IPC分类号： B25G01/00
CPC分类号： F25D29/001 , A01N1/0252 , B01L7/50 , F25D3/102 , F25D25/00 , G01N2035/00346 , G01N2035/0465
摘要： A storage unit comprises a housing (20) defining a storage chamber (22) and a plurality of specimen carriers in the form of annular shelves (24) disposed one below the other inside the chamber (22). A rotary drive (36) is operatively connected to the carriers for rotating the carriers independently about a vertical axis. The housing (20) is provided with an access opening (48) for enabling access to the chamber (22) from above the carrier, while an insertion and removal mechanism serves to alternately insert and remove specimens from the chamber (22) via the access opening (48). The insertion and removal mechanism (106) includes a lifting device disposed at least partially inside the storage chamber (22) for moving specimens vertically between the access opening and the respective carriers. Specimen-containing vials are disposed on trays which in turn are supported by the carriers. The lifting mechanism operates to lift entire trays from the respective carriers towards the access opening.

6. 发明申请

WO1992013634A1 APPARATUS FOR PREPARING AN ELONGATE FLUID-CONTAINING MEMBER AND RELATED APPARATUS FOR REMOVING FLUID FROM SUCH MEMBER 审中-公开
标题翻译：用于制备用于从这种成员中除去流体的含有ELENATE流体的构件的装置和相关装置
公开(公告)号：WO1992013634A1
公开(公告)日：1992-08-20
申请号：PCT/US1991000516
申请日：1991-02-05
申请人： CRYO-CELL INTERNATIONAL, INC.
发明人： CRYO-CELL INTERNATIONAL, INC. , RICHARD, Daniel, D. , KNIPPSCHEER, Hermann
IPC分类号： B01J19/00
CPC分类号： B65B51/04 , A01N1/0263 , A61B10/0045 , A61B10/0096 , A61B17/128 , A61B17/32 , A61B17/42
摘要： An apparatus for preparing an elongate fluid-containing member (10) such as an umbilical cord comprises a housing (14) and support elements (30) in the housing (14) for maintaining the umbilical cord (12) in substantially linear configuration. The support elements (30) are generally horizontally oriented and are pivotally mounted to the housing. A clamping device (42) in the housing (14) applies at least four clamps or staples (50) to the umbilical cord (12) while a severing device (58) divides the umbilical cord (12) to form at least two separate sections (114). A transfer mechanism (80) in the housing (14) automatically transfers the severed umbilical cord sections (114) to respective receptacles (74), the transfer mechanism (80) including a device operatively connected to the support elements (30) for tilting those elements, the transfer mechanism (80) further including guide funnels (36) disposed in the housing (14) below the support elements (30) for guiding the severed sections of the umbilical cord (114) into the receptacles (74). A closure assembly (150) is provided for automatically closing the receptacles.
摘要翻译：用于制备诸如脐带缆的细长流体容纳构件（10）的装置包括壳体（14）和壳体（14）中的支撑元件（30），用于将脐带（12）维持在大致线性构型。支撑元件（30）通常水平定向并且枢转地安装到壳体。壳体（14）中的夹紧装置（42）将至少四个夹子或钉（50）施加到脐带（12），同时切断装置（58）将脐带（12）分开以形成至少两个分开的部分（114）。壳体（14）中的传送机构（80）自动地将切断的脐带部分（114）传送到相应的插座（74），传送机构（80）包括可操作地连接到支撑元件（30）的装置，转移机构（80）还包括设置在支撑元件（30）下方的壳体（14）中的引导漏斗（36），用于将脐带（114）的切断部分引导到插座（74）中。提供闭合组件（150）以自动关闭容器。

7. 发明申请

WO1991002203A1 STORAGE APPARATUS, PARTICULARLY WITH AUTOMATIC INSERTION AND RETRIEVAL 审中-公开
标题翻译：存储设备，特别是自动插入和检索
公开(公告)号：WO1991002203A1
公开(公告)日：1991-02-21
申请号：PCT/US1990004158
申请日：1990-07-24
申请人： CRYO-CELL INTERNATIONAL, INC.
发明人： CRYO-CELL INTERNATIONAL, INC. , KNIPPSCHEER, Hermann , RICHARD, Daniel, D.
IPC分类号： F25D23/02
CPC分类号： A01N1/0263 , A01N1/0242 , A01N1/0257 , B65G1/127 , B65G1/1371 , F25D3/11 , F25D25/04 , G01N1/42 , G01N35/021 , Y10S206/822 , Y10S220/13
摘要： A low-temmperature storage apparatus comprises a housing (1) with an automatically operated access door (19). A holder device (324) disposed in the housing (1) supports a plurality of specimen-containing ampules (16), while a conveyor (3) moves the holder device (324), together with the plurality of ampules (16), through cooling fluid in the housing (1) along a path preferably including a snaking portion (105) with verticallly extending folds (109). An inverted L-shaped cooling container (18) with an opened upper side is disposed in the housing (1) for maintaining the cooling fluid at a predetermined low temperature. An extraction mechanism disposed outside of the housing (1) at the access door (19) serves to remove a selectable ampule (16) positioned in the housing (1) in juxtaposition to the door (19).
摘要翻译：低温存储装置包括具有自动操作的检修门（19）的外壳（1）。设置在所述壳体（1）中的保持装置（324）支撑多个包含标本的安瓿（16），而输送机（3）与所述多个安瓿（16）一起移动所述保持装置（324）壳体（1）中的冷却流体沿着优选地包括具有竖直延伸的折叠（109）的蛇形部分（105）的路径。具有敞开的上侧的倒L形冷却容器（18）设置在壳体（1）中，用于将冷却流体保持在预定的低温。在进出门（19）处设置在壳体（1）外部的提取机构用于移除与门（19）并置的位于壳体（1）中的可选安瓿（16）。

8. 发明申请

WO2011123779A1 CELL THERAPY TO IMPROVE WOUND HEALING AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译：细胞疗法改善伤口愈合及相关成分及方法
公开(公告)号：WO2011123779A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030939
申请日：2011-04-01
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G. , GARCIA-MORALES, Rolando, O.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G. , GARCIA-MORALES, Rolando, O.
IPC分类号： C12N5/071
CPC分类号： A61K35/48 , A61K35/14 , C12N5/0682
摘要： Therapeutic compositions for improving wound healing and related methods of formulation and use are provided. The therapeutic compositions comprise a dosage of MSCs seeded to any one of a biodegradable matrix, a gel, or a solution suitable for subcutaneous injection. The dosage of MSCs may range from about 1X10 6 MSCs to about 1X10 10 per administration. The administration regime may be daily, weekly, or monthly. The dosage and treatment intervals may be adjusted depending upon a patient's response to treatment. The therapeutic compositions may be co-administered, such as for example, topical application of a seeded matrix or gel combined with simultaneous or other recurring subcutaneous injection of MSCs.
摘要翻译：提供了用于改善伤口愈合的治疗组合物和相关的制剂和用途方法。治疗组合物包含接种到生物可降解基质，凝胶或适于皮下注射的溶液中的任何一种的MSCs的剂量。 MSC的剂量可以在每次施用约1×10 6个MSC至约1×10 10个范围内。管理制度可以是每天，每周或每月。可以根据患者对治疗的反应来调整剂量和治疗间隔。治疗组合物可以共同施用，例如局部施用接种的基质或凝胶，以及同时或其他重复的皮下注射MSC。

9. 发明申请

WO2009058365A1 METHODS FOR CO-CULTURING CORD BLOOD DERIVED CELLS WITH MENSTRUAL STEM CELLS 审中-公开
标题翻译：方法用于共培养具有淋巴细胞的骨髓细胞衍生细胞
公开(公告)号：WO2009058365A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012376
申请日：2008-10-31
申请人： CRYO-CELL INTERNATIONAL, INC. , ALLICKSON, Julie, G. , WALTON, Mercedes, A.
发明人： ALLICKSON, Julie, G. , WALTON, Mercedes, A.
IPC分类号： C12N5/08
CPC分类号： C12N5/0647 , C12N2502/137 , C12N2502/1388 , C12N2502/243
摘要： Methods are provided for obtaining expanded human cord blood cells expressing CD34. The methods involve seeding a sufficient amount of cord blood cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord blood cells, and co-culturing the cord blood cells with the menstrual cells under culture conditions that support at least two or more population doublings of the cord blood cells. Methods are also provided for growing expanded human cord blood cells to give rise to any one of colony forming units, colony forming unit granulocyte macrophages (CFU-GM), burst forming unit erythroids (BFU-E), and colony forming unit granulocyte erythrocyte macrophage megakaryocyte (CFU- GEMM) blood lineage precursor cells. The expanded cells may express CD34, SSEA-4, and HLA-II. Compositions of the expanded cells are also provided.
摘要翻译：提供用于获得表达CD34的扩增的人脐带血细胞的方法。所述方法包括在适于促进脐带血细胞扩张的共培养条件下，用足够数量的月经细胞接种足量的脐带血细胞，并在支持的培养条件下与月经细胞共培养脐带血细胞至少两个或多个脐带血细胞群体倍增。还提供了用于生长扩大的人脐带血细胞以产生集落形成单位，集落形成单位粒细胞巨噬细胞（CFU-GM），爆发形成单位红细胞（BFU-E）和集落形成单位粒细胞红细胞巨噬细胞巨核细胞（CFU-GEMM）血谱系前体细胞。扩增的细胞可以表达CD34，SSEA-4和HLA-II。还提供了扩展的细胞的组合物。

10. 发明申请

WO2013025189A1 METHODS FOR CO-CULTURING CORD BLOOD CELLS OR CORD TISSUE CELLS WITH MENSTRUAL MULTIPOTENT CELLS 审中-公开
标题翻译：用于同时培养具有多种细胞的细胞的骨髓细胞或脊髓组织细胞的方法
公开(公告)号：WO2013025189A1
公开(公告)日：2013-02-21
申请号：PCT/US2011/047631
申请日：2011-08-12
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G.
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N5/0665 , C12N2502/1388
摘要： Methods are provided for obtaining expanded human cord blood cells or cord tissue cells expressing CD34. The methods involve seeding a sufficient amount of human cord blood cells or cord tissue cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord cells, and co-culturing the cord cells with the menstrual cells under culture conditions that support at least two or more population doublings of the cord cells. Methods are also provided for growing expanded human cord cells to give rise to any one of colony forming units, colony forming unit granulocyte macrophages (CFU-GM), burst forming unit erythroids (BFU-E), and colony forming unit granulocyte erythrocyte macrophage megakaryocyte (CFU-GEMM) blood lineage precursor cells. The expanded cells may express CD34, SSEA-4, and HLA-II. Compositions of the expanded cells are also provided.
摘要翻译：提供了用于获得扩增的人脐带血细胞或表达CD34的脐带组织细胞的方法。所述方法包括在适合促进脐带细胞扩增的共培养条件下，用足量的月经细胞接种足量的人脐带血细胞或脐带组织细胞，并在培养物下与月经细胞共培养脐带细胞支持至少两个或更多个绳索细胞群体倍增的条件。还提供了用于生长扩大的人类绳状细胞以产生集落形成单位，集落形成单位粒细胞巨噬细胞（CFU-GM），爆发形成单位红细胞（BFU-E）和集落形成单位粒细胞红细胞巨噬细胞巨核细胞（CFU-GEMM）血谱系前体细胞。扩增的细胞可以表达CD34，SSEA-4和HLA-II。还提供了扩展的细胞的组合物。

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