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1. 发明申请

WO2005107807A2 CEREBRAL INTRAVENTRICULAR TRANSPLANTATION AS METHOD OF TREATING AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：作为治疗左心室狭窄的方法，作为宫颈静脉输送
公开(公告)号：WO2005107807A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/016033
申请日：2005-05-06
申请人： UNIVERSITY OF SOUTH FLORIDA , GARBUZOVA-DAVIS, Svitlana , BALBER, Andrew , DAVIS-SANBERG, Cyndy , GENTRY, Tracy , KUZMIN-NICHOLS, Nicole , SANBERG, Paul, R. , WILLING, Alison
发明人： GARBUZOVA-DAVIS, Svitlana , BALBER, Andrew , DAVIS-SANBERG, Cyndy , GENTRY, Tracy , KUZMIN-NICHOLS, Nicole , SANBERG, Paul, R. , WILLING, Alison
IPC分类号： A61K45/00
CPC分类号： A61K35/28 , A61K9/0085 , A61K31/203 , A61K35/30 , A61K35/50 , A61K35/51 , A61K45/06 , A61K2035/124 , C12N5/0607 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/13 , C12N2501/385 , C12N2506/11 , A61K2300/00
摘要： A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH + ) expressing progenitor cells provides cell replacement and protection of motor neurons.
摘要翻译：使用从人脐带血分离的祖细胞来治疗患有神经变性疾病的患者（例如ALS）的方法。表达祖细胞的醛脱氢酶（ALDH +）的非侵入性移植提供了运动神经元的细胞替代和保护。

2. 发明申请

WO2007081478A2 A NOVEL METHOD OF PRENATAL ADMINISTRATION OF MAMMALIAN UMBILICAL CORD STEM CELLS FOR THE INTRAUTERINE TREATMENT OF MAMMALIAN LYSOSOMAL STORAGE DISEASES 审中-公开
标题翻译： MAMMALIAN脐带血干细胞预防性治疗MAMMALIAN LYSOSOMAL存储疾病的新方法
公开(公告)号：WO2007081478A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/047368
申请日：2006-12-12
申请人： UNIVERSITY OF SOUTH FLORIDA , GARBUZOVA-DAVIS, Svitlana , SANBERG, Paul, R. , GOGRAFE, Sylvia
发明人： GARBUZOVA-DAVIS, Svitlana , SANBERG, Paul, R. , GOGRAFE, Sylvia
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： A61K35/44
摘要： A method of treating a fetus or embryo suspected of having a congenital condition that involves an abnormal or missing protein, the method has the steps of a. providing a plurality of human umbilical cord blood cells in a form suitable for intravenous administration; and b. administering the human umbilical cord blood cells to a mother carrying a fetus or embryo suspected of having said congenital condition. Such congenital conditions include Sanfilippo's syndrome, Hunter's syndrome, Hurler's syndrome, Tay-Sachs disease, Gaucher' s disease, von Gierke's disease, Pompes disease, Cori disease, Andersen disease, McArdle's disease, Hers disease, Tauri's disease or Type IX glycogen storage disease.
摘要翻译：一种治疗怀疑患有涉及异常或缺失蛋白质的先天性病症的胎儿或胚胎的方法，具有以下步骤：a。以适于静脉内施用的形式提供多个人脐带血细胞; 和b。将人脐带血细胞施用于携带怀疑患有先天性疾病的胎儿或胚胎的母亲。这种先天性疾病包括Sanfilippo综合征，亨特综合征，赫勒综合征，泰沙病，戈谢病，冯·吉尔克病，庞培病，康利病，安徒生病，麦卡德尔病，赫斯病，牛磺病或1型糖原贮积病。

3. 发明申请

WO2010031006A1 ISCHEMIC TISSUE CELL THERAPY 审中-公开
标题翻译：化学组织细胞治疗
公开(公告)号：WO2010031006A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056867
申请日：2009-09-14
申请人： CRYOPRAXIS CRIOBIOLOGIA LTDA. , UNIVERSIDADE FEDERAL DE SAO PAULO - UNIFESP , UNIVERSITY OF SOUTH FLORIDA , SANBERG, Paul, R. , HOSSNE, Nelson , WILLING, Alison, E. , INVITTI, Adriana
发明人： SANBERG, Paul, R. , HOSSNE, Nelson , WILLING, Alison, E. , INVITTI, Adriana
IPC分类号： C12N5/071
CPC分类号： A61K35/15 , A61K35/44 , A61K2035/124 , C12N5/0634 , C12N5/0645
摘要： The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocytes obtained from blood, including umbilical cord blood, peripheral blood, or bone marrow to an individual in need of treatment, wherein the drug is administered to the individual at a time point specifically determined to provide therapeutic efficacy. In one embodiment, the cells are for injection into ischemic myocardium for the treatment of angina.
摘要翻译：本发明涉及用于治疗缺血性疾病和病症，特别是心肌，CNS /脑和肢体缺血的组合物和方法。更具体地，本发明提供了通过从需要治疗的个体施用从血液（包括脐带血，外周血或骨髓）获得的单核细胞来治疗病症的方法，其中在具体时间点向个体施用药物确定提供治疗功效。在一个实施方案中，细胞用于注射到缺血心肌中用于治疗心绞痛。

4. 发明申请

WO2006047593A2 METHOD OF POTENTIATING INFLAMMATORY AND IMMUNE MODULATION FOR CELL AND DRUG THERAPY 审中-公开
标题翻译：潜在的炎症和免疫调节细胞和药物治疗方法
公开(公告)号：WO2006047593A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038565
申请日：2005-10-24
申请人： UNIVERSITY OF SOUTH FLORIDA , SANERON CCEL THERAPEUTICS, INC. , WILLING, Alison , SANBERG, Paul, R. , NEWMAN, Mary, B. , SANBERG, Cyndy, Davis
发明人： WILLING, Alison , SANBERG, Paul, R. , NEWMAN, Mary, B. , SANBERG, Cyndy, Davis
IPC分类号： A61K8/31
CPC分类号： G01N33/6863 , A61K35/51 , G01N2800/12 , G01N2800/324
摘要： A method for repairing animal tissue damage due to an inflammatory reaction in an animal has the steps of providing umbilical cord blood cells (UCBCs) in a pharmaceutically acceptable form; and administering a sufficient dose of UCBC at an optimal time thereby reducing the injury from the inflammatory reaction. Also provided are method of treating cerebrovascular accident, acute central nervous inflammation, multiple sclerosis, myocardial ischemia, and neonatal bronchopulmonary distress. For determining the optimal time of UCBCs administration, there is provided a kit containing antibodies for IL-8 and MCP-1.
摘要翻译：一种用于修复由于动物中的炎性反应引起的动物组织损伤的方法具有以药学上可接受的形式提供脐带血细胞（UCBC）的步骤; 并在最佳时间施用足够剂量的UCBC，从而减少炎症反应的损伤。还提供治疗脑血管意外，急性中枢神经炎，多发性硬化，心肌缺血和新生儿支气管肺窘迫的方法。为了确定UCBCs给药的最佳时间，提供了含有IL-8和MCP-1抗体的试剂盒。

5. 发明申请

WO2003065999A2 PROLIFERATED CELL LINES AND USES THEREOF 审中-公开
标题翻译：增殖细胞系及其用途
公开(公告)号：WO2003065999A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003753
申请日：2003-02-07
申请人： UNIVERSITY OF SOUTH FLORIDA , UNIVERSITY OF CHILE , CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
发明人： CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
IPC分类号： A61K
CPC分类号： A61K35/26 , C12N5/0018 , C12N2500/84 , C12N2502/078 , C12N2502/30 , C12N2503/02
摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, nonfertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.
摘要翻译：本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。本发明还涉及增殖因子和含有能够增加培养物中任何人或其他动物细胞的增殖潜力的因素的组合物。本发明还涉及通过使细胞与增殖因子接触来增殖培养细胞的方法。增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。任选地，可诱导细胞停止增殖。本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

6. 发明申请

WO2009023814A2 HUCBC TREATMENT OF AMYLOID ASSOCIATED DISEASE 审中-公开
标题翻译：乳腺癌相关疾病的治疗
公开(公告)号：WO2009023814A2
公开(公告)日：2009-02-19
申请号：PCT/US2008/073265
申请日：2008-08-15
申请人： UNIVERSITY OF SOUTH FLORIDA , TAN, Jun , SANBERG, Paul, R.
发明人： TAN, Jun , SANBERG, Paul, R.
IPC分类号： A61K48/00 , C12N5/08
CPC分类号： A61K35/16 , A61K35/44 , A61K2035/122
摘要： Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, A? phagocytic activity was increased and soluble and insoluble AB protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of AB 1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.
摘要翻译：使用人脐带血细胞（HUCBC）或HUCBC衍生血浆来治疗淀粉样蛋白病，如阿尔茨海默氏病，亨廷顿舞蹈病，脑淀粉样蛋白病和II型糖尿病。通过输注HUCBC调节炎症反应导致淀粉样蛋白斑块和免疫相关细胞损伤的显着减少。 HUCBC输注也显着降低了小鼠模型中的脑淀粉样血管病变。这些作用与CD40-CD40L相互作用的抑制有关，并且在免疫细胞上观察到表达CD-40的表达减少。此外，A？吞噬活性增加，可溶性和不溶性AB蛋白水平通过处理调节。 HUCBC输注的血清也显着增加了AB 1-42肽的吞噬作用，抑制了免疫细胞CD40的表达，降低了脑淀粉样血管病变。

7. 发明申请

WO2003065999A3 PROLIFERATED CELL LINES AND USES THEREOF 审中-公开
公开(公告)号：WO2003065999A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003753
申请日：2003-02-07
申请人： UNIVERSITY OF SOUTH FLORIDA , UNIVERSITY OF CHILE , CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
发明人： CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
IPC分类号： A01N1/00 , A01N1/02 , A61K38/00 , A61K39/00 , A01N37/18 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/53
摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, nonfertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

8. 发明申请

WO2004022579A3 CELLULAR DELIVERY OF NATRIURETIC PEPTIDES 审中-公开
公开(公告)号：WO2004022579A3
公开(公告)日：2004-03-18
申请号：PCT/US2003/028157
申请日：2003-09-08
申请人： UNIVERSITY OF SOUTH FLORIDA , SANCHEZ-RAMOS, Juan , SONG, Shijie , SANBERG, Paul, R. , KAMATH, Siddharth, G.
发明人： SANCHEZ-RAMOS, Juan , SONG, Shijie , SANBERG, Paul, R. , KAMATH, Siddharth, G.
IPC分类号： A61K48/00
摘要： The present invention pertains to a method for treating deficits, such as neurological deficits, caused by focal or generalized edema associated with injury to the central nervous system, heart, liver, and kidney. The present invention further concerns a method for producing natriuretic peptides and pharmaceutical compositions comprising bone marrow stromal cells and effective amounts of retinoic acid and nerve growth factor to induce the bone marrow stromal cells to increase production of natriuretic peptides.

9. 发明申请

WO2005059115A1 COMPOSITIONS AND METHODS FOR ENHANCING NEUROPROTECTION VIA ADMINISTRATION OF STEM CELLS AND BLOOD BRAIN BARRIER PERMEABILIZERS 审中-公开
标题翻译：用于通过干细胞和血液脑膜阻滞剂的施用来增强神经保护的组合物和方法
公开(公告)号：WO2005059115A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/042043
申请日：2004-12-15
申请人： UNIVERSITY OF SOUTH FLORIDA , BORLONGAN, Cesario, V. , SANBERG, Paul, R.
发明人： BORLONGAN, Cesario, V. , SANBERG, Paul, R.
IPC分类号： C12N5/00
CPC分类号： C12N5/0634 , A61K9/0019 , A61K35/12 , A61K47/26 , A61K47/42
摘要： The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells and a substance capable of permeabilizing the blood brain barrier. In one embodiment, the blood brain barrier permeabilizer is mannitol. In another embodiment, the blood brain barrier permeabilizer is Cereport.
摘要翻译：本发明提供了增强脐带血细胞神经保护作用的组合物和方法。更具体地，本发明提供了通过施用脐带血细胞和能够渗透血脑屏障的物质来治疗神经变性疾病的方法。在一个实施方案中，血脑屏障渗透剂是甘露糖醇。在另一个实施方案中，血脑屏障渗透剂是Cereport。

10. 发明申请

WO2005013910A2 CHOLINERGIC MODULATION OF MICROGLIAL ACTIVATION VIA ALPHA-7 NICOTINIC RECEPTORS 审中-公开
标题翻译： ALP-7烟碱受体对微粒体活化的胆碱能调节
公开(公告)号：WO2005013910A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/025714
申请日：2004-08-09
申请人： UNIVERSITY OF SOUTH FLORIDA , SHYTLE, Douglas , TAN, Jun , SANBERG, Paul, R.
发明人： SHYTLE, Douglas , TAN, Jun , SANBERG, Paul, R.
IPC分类号： A61K
CPC分类号： A61K31/44 , A61K31/13 , A61K31/24 , A61K38/1703 , A61K45/06 , A61K2300/00
摘要： Novel therapeutic targets in the treatment of neuroimmunological and neurodegenerative disorders. Accordingly, methods of treating a neurodegenerative disorder in a patient, as well as inhibiting the release of a proinflammatory cytokine, comprising the step of contacting a target cell with a therapeutically effective amount of a cholinergic agonist, such as those chosen from the group consisting of acetycholine, nicotine, choline, galantamine, cytisine, GTS-21, or derivatives thereof, wherein the target cell is a microglia is provided.
摘要翻译：治疗神经免疫和神经退行性疾病的新型治疗靶点。因此，治疗患者神经退行性病症以及抑制促炎细胞因子释放的方法包括使靶细胞与治疗有效量的胆碱能激动剂（例如选自以下的那些）乙酰胆碱，尼古丁，胆碱，加兰他敏，金雀花碱，GTS-21或其衍生物，其中靶细胞是小神经胶质细胞。

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