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1. 发明申请

WO2012012377A3 DETECTOR ARRANGEMENT FOR BLOOD CULTURE BOTTLES WITH COLORIMETRIC SENSORS 审中-公开
标题翻译：用于彩色传感器的血液培养瓶的检测器装置
公开(公告)号：WO2012012377A3
公开(公告)日：2013-08-08
申请号：PCT/US2011044454
申请日：2011-07-19
申请人： BIO MERIEUX INC , CLAY BRADFORD G
发明人： CLAY BRADFORD G
IPC分类号： G01N33/543
CPC分类号： G01N33/84 , C12M41/26 , C12M41/34 , C12M41/36 , G01N21/3151 , G01N21/78 , G01N21/783 , G01N21/80 , G01N2021/3181 , G01N2201/127
摘要： A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or C02 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
摘要翻译：一种用于血液培养瓶的检测器装置，其包含由血培养瓶内的样品介质的pH或CO 2变化而使颜色变化的比色传感器。检测器装置包括照亮比色传感器的传感器LED，照亮比色传感器的参考LED，用于选择性地和交替地激活传感器LED和参考LED的控制电路和光电检测器。光电检测器在比色传感器与传感器LED和参考LED的选择性和交替照明期间测量来自比色传感器的反射率，并产生强度信号。参考LED被选择为具有照明的峰值波长，使得来自参考LED的照明的光电检测器的强度信号基本上不受比色传感器的颜色的变化的影响。

2. 发明申请

WO2010132823A2 SYSTEM AND METHODS FOR RAPID IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE 审中-公开
标题翻译：用于在样品中快速鉴定和/或表征微生物的系统和方法
公开(公告)号：WO2010132823A2
公开(公告)日：2010-11-18
申请号：PCT/US2010034987
申请日：2010-05-14
申请人： BIO MERIEUX INC , ROBINSON RONNIE J , WILSON MARK S , RONSICK CHRISTOPHER S , WALSH JOHN D , HYMAN JONES , CLAY BRADFORD
发明人： ROBINSON RONNIE J , WILSON MARK S , RONSICK CHRISTOPHER S , WALSH JOHN D , HYMAN JONES , CLAY BRADFORD
IPC分类号： C12M1/26
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically.
摘要翻译：一种测试包含在密封样品容器内的样品样品的方法。用一次性取样装置将样品从样品容器中取出。裂解试验样品的非微生物剂组分，从而产生裂解的样品。裂解的样品被输送到一次性分离装置。存在于试样中的微生物剂集中在一次性分离装置内。浓缩的微生物剂被询问，例如光谱法。

3. 发明申请

WO2010011798A2 METHOD AND SYSTEM FOR DETECTION AND/OR CHARACTERIZATION OF A BIOLOGICAL PARTICLE IN A SAMPLE 审中-公开
标题翻译：用于检测和/或表征样品中生物颗粒的方法和系统
公开(公告)号：WO2010011798A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051473
申请日：2009-07-23
申请人： BIOMERIEUX, INC , WALSH, John, D. , HYMAN, Jones, M. , THORPE, Thurman, C. , CLAY, Bradford, G.
发明人： WALSH, John, D. , HYMAN, Jones, M. , THORPE, Thurman, C. , CLAY, Bradford, G.
IPC分类号： C12M1/34
CPC分类号： C12Q1/04 , C12Q1/10 , G01N21/31 , G01N21/47 , G01N21/64 , G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle, that may be present in the sample.
摘要翻译：本发明提供了用于监测，检测和/或表征可能存在于样品中的生物颗粒的方法和系统，由此该方法可以通过利用时间依赖性地非侵入性地实现光谱技术以获得包含样品的生长组合物的至少两个测量结果，并将所述测量结果关联用于可能存在于样品中的生物颗粒的检测和/或表征。

4. 发明申请

WO2010062351A1 METHODS FOR SEPARATION, CHARACTERIZATION, AND/OR IDENTIFICATION OF MICROORGANISMS USING RAMAN SPECTROSCOPY 审中-公开
标题翻译：使用拉曼光谱分离，表征和/或鉴定微生物的方法
公开(公告)号：WO2010062351A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/005886
申请日：2009-10-30
申请人： BIOMERIEUX, INC. , CLAY, Bradford , HYMAN, Jones , WALSH, John , THORPE, Thurman , RONSICK, Christopher
发明人： CLAY, Bradford , HYMAN, Jones , WALSH, John , THORPE, Thurman , RONSICK, Christopher
IPC分类号： G01N21/65 , C12M1/12 , C12M1/34
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for Raman spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said Raman spectroscopic measurements.
摘要翻译：本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的随机裂解步骤，随后是随后的分离步骤。该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。本发明进一步提供分离的微生物样品的拉曼光谱询问以产生微生物的测量，并使用所述拉曼光谱测量来表征和/或鉴定样品中的微生物。

5. 发明申请

WO2010132829A2 COMBINED DETECTION INSTRUMENT FOR CULTURE SPECIMEN CONTAINERS AND INSTRUMENT FOR IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE 审中-公开
标题翻译：用于文化样本容器的组合检测仪器和用于在样品中鉴定和/或表征微生物剂的仪器
公开(公告)号：WO2010132829A2
公开(公告)日：2010-11-18
申请号：PCT/US2010034995
申请日：2010-05-14
申请人： BIO MERIEUX INC , ROBINSON RONNIE J , WILSON MARK S , RONSICK CHRISTOPHER S , WALSH JOHN D , HYMAN JONES , THORPE THURMAN , CLAY BRADFORD
发明人： ROBINSON RONNIE J , WILSON MARK S , RONSICK CHRISTOPHER S , WALSH JOHN D , HYMAN JONES , THORPE THURMAN , CLAY BRADFORD
IPC分类号： C12M1/26
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

6. 发明申请

WO2010132823A3 SYSTEM AND METHODS FOR RAPID IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE 审中-公开
公开(公告)号：WO2010132823A3
公开(公告)日：2010-11-18
申请号：PCT/US2010/034987
申请日：2010-05-14
申请人： BIOMERIEUX, INC. , ROBINSON, Ronnie, J. , WILSON, Mark, S. , RONSICK, Christopher, S. , WALSH, John, D. , HYMAN, Jones , CLAY, Bradford
发明人： ROBINSON, Ronnie, J. , WILSON, Mark, S. , RONSICK, Christopher, S. , WALSH, John, D. , HYMAN, Jones , CLAY, Bradford
IPC分类号： G01N33/50
摘要： A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically.

7. 发明申请

WO2010062354A1 METHODS FOR SEPARATION, CHARACTERIZATION, AND/OR IDENTIFICATION OF MICROORGANISMS USING MASS SPECTROMETRY 审中-公开
标题翻译：使用质谱分离，鉴定和/或识别微生物的方法
公开(公告)号：WO2010062354A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/005889
申请日：2009-10-30
申请人： BIOMERIEUX, INC. , HYMAN, Jones , CLAY, Bradford , WALSH, John , THORPE, Thurman
发明人： HYMAN, Jones , CLAY, Bradford , WALSH, John , THORPE, Thurman
IPC分类号： G01N33/68 , C12M1/34 , C12Q1/04
CPC分类号： C12Q1/04 , G01N33/6848 , H01J49/00
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for interrogation of the separated microorganism sample by mass spectrometry to produce a mass spectrum of the microorganism and characterizing and/or identifying the microorganism in the sample using the mass spectrum obtained.
摘要翻译：本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的随机裂解步骤，随后是随后的分离步骤。该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。本发明还提供了通过质谱法对分离的微生物样品进行询问以产生微生物的质谱，并使用所获得的质谱来表征和/或鉴定样品中的微生物。

8. 发明申请

WO2010062352A1 METHODS FOR THE ISOLATION AND IDENTIFICATION OF MICROORGANISMS 审中-公开
标题翻译： MICROORGANISMS的分离和鉴定方法
公开(公告)号：WO2010062352A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/005887
申请日：2009-10-30
申请人： BIOMERIEUX, INC. , WALSH, John , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
发明人： WALSH, John , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
IPC分类号： G01N33/68 , C12M1/34 , C12Q1/04
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides methods for separating, characterizing and/or identifying microorganisms in situ within a single system.
摘要翻译：本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的随机裂解步骤，随后是随后的分离步骤。该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。本发明还提供了在单个系统内原位分离，表征和/或鉴定微生物的方法。

9. 发明申请

WO2010062350A1 METHODS FOR DETECTION, CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS IN A SEALED CONTAINER 审中-公开
标题翻译：密封容器中微生物检测，表征和/或鉴定方法
公开(公告)号：WO2010062350A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/005885
申请日：2009-10-30
申请人： BIOMERIEUX, INC. , WALSH, John , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
发明人： WALSH, John , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
IPC分类号： C12M1/34 , C12Q1/04
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample. The method may be accomplished in a sealed container by utilizing a first step time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle that may be present in the sample. The method further provides for a subsequent step for the separation, characterizion and/or identification of the microorganisms in the sealed container.
摘要翻译：本发明提供了用于监测，检测和/或表征可能存在于样品中的生物颗粒的方法和系统。该方法可以在密封容器中通过利用第一步骤时间依赖性光谱技术来实现，以获得包含样品的生长组合物的至少两个测量值，并将所述测量结果与生物学颗粒的检测和/或表征相关联，生物颗粒可以是存在于样品中。该方法还提供了在密封容器中分离，表征和/或鉴定微生物的后续步骤。

10. 发明申请

WO2012012377A2 DETECTOR ARRANGEMENT FOR BLOOD CULTURE BOTTLES WITH COLORIMETRIC SENSORS 审中-公开
标题翻译：用于彩色传感器的血液培养瓶的检测器装置
公开(公告)号：WO2012012377A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044454
申请日：2011-07-19
申请人： BIOMERIEUX, INC. , CLAY, Bradford, G.
发明人： CLAY, Bradford, G.
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： G01N33/84 , C12M41/26 , C12M41/34 , C12M41/36 , G01N21/3151 , G01N21/78 , G01N21/783 , G01N21/80 , G01N2021/3181 , G01N2201/127
摘要： A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or C0 2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
摘要翻译：一种用于血液培养瓶的检测器装置，其包含由血培养瓶内的样品介质的pH或CO 2变化而使颜色变化的比色传感器。检测器装置包括照亮比色传感器的传感器LED，照亮比色传感器的参考LED，用于选择性地和交替地激活传感器LED和参考LED的控制电路和光电检测器。光电检测器在比色传感器与传感器LED和参考LED的选择性和交替照明期间测量来自比色传感器的反射率，并产生强度信号。参考LED被选择为具有照明的峰值波长，使得来自参考LED的照明的光电检测器的强度信号基本上不受比色传感器的颜色的变化的影响。

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