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1. 发明申请

WO02056935A9 CARDIAC ELECTRODE CATHETER AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译： CARDIAC电极导管及其制造方法
公开(公告)号：WO02056935A9
公开(公告)日：2004-04-08
申请号：PCT/US0201089
申请日：2002-01-16
申请人： QUETZAL BIOMEDICAL INC
发明人： SCHMIDT JOHN A
IPC分类号： A61B5/042 , A61B18/14 , A61N1/05 , A61B17/39
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2562/125 , A61N1/056
摘要： An electrode catheter used in an endocardial procedure to map cardiac electrical activity, heart wall position, heart wall motion and tissue viability. The electrode catheter has a flexible geometric shape for mapping any cardiac chamber and can be rotated within the chamber without being re-deployed. The electrode catheter is made from joining a tube with 4 to 256 wire leads having terminal ends (2) and coiled electrodes (10). The tube either has holes or a longitudinal slit so that the coiled electrodes can protrude from the central cavity of the tube. The electrode catheter ends with a tip member that is attached to the tube by a swivel connector. The tip member has tines to allow for temporary stability when in contact with a cardiac wall. The electrode catheter is conformed to a flexible shape using a jig and heating process.
摘要翻译：在心内膜手术中使用的电极导管来描绘心脏电活动，心脏壁位置，心脏壁运动和组织活力。电极导管具有灵活的几何形状，用于映射任何心室，并且可以在腔内旋转而不重新部署。电极导管由具有端子（2）和线圈电极（10）的4〜256根导线的管接合而成。管具有孔或纵向狭缝，使得线圈电极可以从管的中心腔突出。电极导管末端具有通过旋转连接器附接到管的尖端构件。尖端构件具有齿以允许当与心脏壁接触时的临时稳定性。使用夹具和加热工艺使电极导管符合柔性形状。

2. 发明申请

WO2003026737A2 MULTI-ELECTRODE STIMULATION PARALLEL TO CARDIAC MYOFIBERS 审中-公开
标题翻译：多电极刺激并发与心脏肌钙蛋白
公开(公告)号：WO2003026737A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/030116
申请日：2002-09-23
申请人： QUETZAL BIOMEDICAL, INC.
发明人： SCHMIDT, John, A.
IPC分类号： A61N1/18
CPC分类号： A61N1/056
摘要： A cardiac stimulation system 10 includes multiple electrodes E1... En and a cardiac stimulator (12) for generating stimulation pulses. The electrodes are mounted on a tube (22) and stimulation electrodes are designated (106, 108) which are characterized by a optimal stimulation level. Preferably the optimal stimulation level is selected such that the electrical field associated with a stimulation pulse is directed substantially in parallel with the cardiac fibers being stimulated.
摘要翻译：心脏刺激系统10包括多个电极E1 ... En和用于产生刺激脉冲的心脏刺激器（12）。电极安装在管（22）上，指示刺激电极（106,108），其特征在于最佳刺激水平。优选地，选择最佳刺激水平使得与刺激脉冲相关联的电场基本上与被刺激的心脏纤维平行地指向。

3. 发明申请

WO02056935A3 CARDIAC ELECTRODE CATHETER AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译： CARDIAC电极导管及其制造方法
公开(公告)号：WO02056935A3
公开(公告)日：2003-04-03
申请号：PCT/US0201089
申请日：2002-01-16
申请人： QUETZAL BIOMEDICAL INC
发明人： SCHMIDT JOHN A
IPC分类号： A61B5/042 , A61B18/14 , A61N1/05 , A61B17/39
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2562/125 , A61N1/056
摘要： An electrode catheter used in an endocardial procedure to map cardiac electrical activity, heart wall position, heart wall motion and tissue viability. The electrode catheter has a flexible geometric shape for mapping any cardiac chamber and can be rotated within the chamber without being re-deployed. The electrode catheter is made from joining a tube with 4 to 256 wire leads having terminal ends (2) and coiled electrodes (10). The tube either has holes or a longitudinal slit so that the coiled electrodes can protrude from the central cavity of the tube. The electrode catheter ends with a tip member that is attached to the tube by a swivel connector. The tip member has tines to allow for temporary stability when in contact with a cardiac wall. The electrode catheter is conformed to a flexible shape using a jig and heating process.
摘要翻译：在心内膜手术中使用的电极导管来描绘心脏电活动，心脏壁位置，心脏壁运动和组织活力。电极导管具有灵活的几何形状，用于映射任何心室，并且可以在腔内旋转而不重新部署。电极导管由具有端子（2）和线圈电极（10）的4〜256根导线的管接合而成。管具有孔或纵向狭缝，使得线圈电极可以从管的中心腔突出。电极导管末端具有通过旋转连接器附接到管的尖端构件。尖端构件具有齿以允许当与心壁接触时的临时稳定性。使用夹具和加热工艺使电极导管符合柔性形状。

4. 发明申请

WO2002087684A2 CARDIAC STIMULATION APPARATUS AND METHOD FOR TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译：心脏刺激装置及其治疗方法
公开(公告)号：WO2002087684A2
公开(公告)日：2002-11-07
申请号：PCT/US2002/013237
申请日：2002-04-26
申请人： QUETZAL BIOMEDICAL, INC.
发明人： FUKA, Mary, Z. , MATHIS, Scott, C. , PRENTICE, John, K. , SCHMIDT, John, A. , ROTTENBERG, William, E.
IPC分类号： A61N
CPC分类号： A61N1/3956 , A61N1/056 , A61N1/3684 , A61N1/395
摘要： A cardiac stimulation apparatus and multi-electrode pacing lead for prevention or treatment of atrial fibrillation. The multi-electrode lead will distribute electrodes throughout the right atrium to provide a choice of pacing sites at locations best suited to multi-focal control of the rapid atrial heartbeats that may precede atrial fibrillation. Cardiac electrical activity is sensed in four dimensions (three spatial dimensions, X, Y, and Z, and in time). The system triangulates the location of a given event in three spatial dimensions, and then paces the heart in areas that will disrupt the propagation of the arrhythmia. Termination involves delivering low voltage pulses to large areas of the heart, either simultaneously or in rapid sequence.
摘要翻译：心脏刺激装置（100）和用于预防或治疗心房颤动的多电极起搏引线（14）。多电极引线将电极（16）分布在整个右心房中，以便在最适合多焦点控制心房颤动之前的快速心房心跳的位置提供起搏位置的选择。心脏电活动在四个维度（三个空间维度，X，Y和Z，及时）中被感测。该系统在三个空间维度上对给定事件的位置进行三角测量，然后在将破坏心律失常传播的区域中心脏起搏。终止包括同时或以快速顺序将低电压脉冲输送到心脏的大部分区域。

5. 发明申请

WO2003066160A1 A MULTI-ELECTRODE CARDIAC LEAD ADAPTER WITH MULTIPLEXER 审中-公开
标题翻译：带多路复用器的多电极心脏引线适配器
公开(公告)号：WO2003066160A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/002967
申请日：2003-01-31
申请人： QUETZAL BIOMEDICAL, INC.
发明人： ROTTENBERG, William, E. , PRENTICE, John, K. , SCHMIDT, John, A.
IPC分类号： A61N1/05
CPC分类号： A61N1/3686 , A61N1/3752
摘要： An adapter, which allows the use of a complex multi-electrode pacing and sensing cardiac lead with a conventional one-channel cardiac pacing pulse generator (20), has a connector (40) that attaches to the multi-electrode cardiac lead, a multiplexer (35) to select which of the electrodes of the multi-electrode lead are to be connected to the one channel cardiac pacing pulse generator (20), and a connector to connect the adapter to a connector such as the industry standard IS-1 connector (30).
摘要翻译：允许使用复杂的多电极起搏并用传统的单通道心脏起搏脉冲发生器（20）感测心脏引线的适配器具有连接到多电极心脏引线的连接器（40），多路复用器（35），选择所述多电极引线的哪一个电极要连接到所述单通道心脏起搏脉冲发生器（20）;以及连接器，用于将所述适配器连接到诸如工业标准IS-1连接器（30）。

6. 发明申请

WO03026737A3 MULTI-ELECTRODE STIMULATION PARALLEL TO CARDIAC MYOFIBERS 审中-公开
标题翻译：多电极刺激并联至心脏肌纤维
公开(公告)号：WO03026737A3
公开(公告)日：2003-07-10
申请号：PCT/US0230116
申请日：2002-09-23
申请人： QUETZAL BIOMEDICAL INC
发明人： SCHMIDT JOHN A
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/056
摘要： A cardiac stimulation system 10 includes multiple electrodes E1... En and a cardiac stimulator (12) for generating stimulation pulses. The electrodes are mounted on a tube (22) and stimulation electrodes are designated (106, 108) which are characterized by a optimal stimulation level. Preferably the optimal stimulation level is selected such that the electrical field associated with a stimulation pulse is directed substantially in parallel with the cardiac fibers being stimulated.
摘要翻译：心脏刺激系统10包括多个电极E1 ... En和用于生成刺激脉冲的心脏刺激器（12）。电极安装在管（22）上并且刺激电极被指定为（106,108），其特征在于最佳刺激水平。优选地，选择最佳刺激水平，使得与刺激脉冲相关联的电场基本平行于被刺激的心脏纤维。

7. 发明申请

WO02087501A3 IMPROVED LEADS FOR THE TREATMENT OF PATIENTS WITH CHF 审中-公开
标题翻译：改善治疗患有CHF患者的领导者
公开(公告)号：WO02087501A3
公开(公告)日：2003-03-13
申请号：PCT/US0213238
申请日：2002-04-26
申请人： QUETZAL BIOMEDICAL INC
发明人： SCHMIDT JOHN A
IPC分类号： A61N1/05 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/056 , A61N1/3684
摘要： A multi-electrode lead is provided for a cardiac device, the lead having anywhere from three to 258 electrodes (l0A) placed on a nonconductive polymer tube (18A). The lead is preformed to a particular shape selected so that when implanted, its electrodes are in contact with a particular cardiac tissue to sense cardiac activity and to provide CHF pacing. The lead can have a V-shape to stimulate the septal wall of the right ventricle, it could be spiral to simulate the conduction of a polarization wave of a sinus Purkinje cell system.
摘要翻译：为心脏装置提供多电极引线，引线具有置于非导电聚合物管（18A）上的三个至258个电极（10A）的任何一个。引线被制成选定的特定形状，使得当植入时，其电极与特定心脏组织接触以感测心脏活动并提供CHF起搏。铅可以具有V形刺激右心室的隔壁，可以是螺旋形的，以模拟窦浦肯野细胞系统的极化波的传导。

8. 发明申请

WO02089901A2 METHOD AND APPARATUS FOR DETERMINING SPATIAL RELATION OF MULTIPLE IMPLANTABLE ELECTRODES 审中-公开
标题翻译：用于确定多个可植入电极的空间关系的方法和装置
公开(公告)号：WO02089901A2
公开(公告)日：2002-11-14
申请号：PCT/US0213152
申请日：2002-04-25
申请人： QUETZAL BIOMEDICAL INC
发明人： PRENTICE JOHN K , COSTELLO JIM , FUKA MARY Z
IPC分类号： A61N1/05 , A61N1/368 , A61N1/39 , A61N
CPC分类号： A61N1/3686 , A61N1/056 , A61N1/36185 , A61N1/3684 , A61N1/3956
摘要： An apparatus (100) and method to determine the relative locations of a set of implantable electrodes (E1-Ed), preferably five or more, which can be positioned in a chamber of the heart (18) or within another organ or chamber. At least two electrodes are configured to be a known distance from each other. A signal generation apparatus provides a signal having a frequency through a set of pairs of electrodes. This signal is detected on all other electrodes. Additional pairs of signal-emitting electrodes are selected and measurements are made on all other electrodes until sufficient sets of data have been acquired specify a set of equations. Solution of the sets of equations by numerical methods provides the relative locations of the electrodes in a dielectric medium. Where the electrodes are implanted in an environment comprising dielectric media of differing characteristics, such as blood and myocardial tissue, the signal generation apparatus is capable of producing signals at multiple frequencies. Sets of equations are acquired for multiple frequencies. Solutions of the equations derived from each of the sets of equations are combined to eliminate the effect of a non-uniform dielectric medium. Alternatively, the effect of differing media can be eliminated by calculating position vectors for image charges or virtual electrodes. Location of a dielectric boundary, such as the myocardial wall, may be determined.
摘要翻译：一种用于确定一组可植入电极（E1-Ed）的相对位置的装置（100）和方法，优选为五个或更多个，其可以位于心脏（18）的腔室中或在另一个器官或腔室内。至少两个电极被配置为彼此已知的距离。信号发生装置通过一组电极提供具有频率的信号。在所有其他电极上检测到该信号。选择附加的信号发射电极对，并且在所有其它电极上进行测量，直到获得足够的数据集来指定一组方程式。通过数值方法求解方程组提供电极在电介质中的相对位置。在电极被植入包括诸如血液和心肌组织等不同特征的电介质的环境中的情况下，信号发生装置能够产生多个频率的信号。针对多个频率采集一组方程式。将来自各组方程的方程的解组合起来以消除非均匀介电介质的影响。或者，可以通过计算图像电荷或虚拟电极的位置矢量来消除不同介质的影响。可以确定电介质边界的位置，例如心肌壁。

9. 发明申请

WO02087684A3 CARDIAC STIMULATION APPARATUS AND METHOD FOR TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译：心脏刺激装置及其治疗方法
公开(公告)号：WO02087684A3
公开(公告)日：2003-05-22
申请号：PCT/US0213237
申请日：2002-04-26
申请人： QUETZAL BIOMEDICAL INC
发明人： FUKA MARY Z , MATHIS SCOTT C , PRENTICE JOHN K , SCHMIDT JOHN A , ROTTENBERG WILLIAM E
IPC分类号： A61N1/05 , A61N1/368 , A61N1/39 , A61N1/18
CPC分类号： A61N1/3956 , A61N1/056 , A61N1/3684 , A61N1/395
摘要： A cardiac stimulation apparatus (100) and multi-electrode pacing lead (14) for prevention or treatment of atrial fibrillation. The multi-electrode lead will distribute electrodes (16) throughout the right atrium to provide a choice of pacing sites at locations best suited to multi-focal control of the rapid atrial heartbeats that may precede atrial fibrillation. Cardiac electrical activity is sensed in four dimensions (three spatial dimensions, X, Y, and Z, and in time). The system triangulates the location of a given event in three spatial dimensions, and then paces the heart in areas that will disrupt the propagation of the arrhythmia. Termination involves delivering low voltage pulses to large areas of the heart, either simultaneously or in rapid sequence.
摘要翻译：心脏刺激装置（100）和用于预防或治疗心房颤动的多电极起搏引线（14）。多电极引线将电极（16）分布在整个右心房中，以便在最适合多焦点控制心房颤动之前的快速心房心跳的位置提供起搏位置的选择。心脏电活动在四个维度（三个空间维度，X，Y和Z，及时）中被感测。该系统在三个空间维度上对给定事件的位置进行三角测量，然后在将破坏心律失常传播的区域中心脏起搏。终止包括同时或以快速顺序将低电压脉冲输送到心脏的大部分区域。

10. 发明申请

WO02064205A3 MULTI-ELECTRODE APPARATUS AND METHOD FOR TREATMENT OF CONGESTIVE HEART FAILURE 审中-公开
标题翻译：多电极装置和治疗心脏失效的方法
公开(公告)号：WO02064205A3
公开(公告)日：2003-03-20
申请号：PCT/US0204330
申请日：2002-02-13
申请人： QUETZAL BIOMEDICAL INC
发明人： MATHIS SCOTT , PRENTICE JOHN K , SCHMIDT JOHN A , ROTTENBERG WILLIAM B
IPC分类号： A61N1/362 , A61N1/368 , A61N1/18
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3686
摘要： An apparatus (100) and method for treatment of congestive heart failure from the right side of the heart. An implantable cardiac stimulation system (10) with a multi-electrode lead (14) having three or more selectable electrodes (E1, E2....En), together with apparatus for identifying an optimal subset of electrodes (114, 120, 124, 104), apparatus for shaping a propagating wave front, and apparatus for modifying the intrinsic ventricular cardiac activation sequence (104, 108, 118, 122, 126), or generating simultaneous or near simultaneous pacing pulses to the septum or right ventricular outflow tract during ventricular systole in order to improve left ventricular cardiac efficiency and reduce mitral regurgitation in patients with dilated cardiomyopathy. A three dimensional map of electrode placement may be calculated. A sub set of the available electrodes in the right side of the heart is selected for stimulation such that septal motion during systole is reduced or the mitral valve area is stiffened to reduce mitral regurgitation.
摘要翻译：一种用于从心脏右侧治疗充血性心力衰竭的装置（100）和方法。具有具有三个或更多个可选择电极（E1，E2 ... En）的多电极引线（14）的可植入心脏刺激系统（10），以及用于识别电极的最佳子集（114,120,124 ，104），用于整形传播波前的装置和用于修改内部心室心脏激活序列（104,108,118,122,126）的装置，或者产生同时或接近同时的起搏脉冲到隔膜或右心室流出道在心室收缩期间，为了改善左心室心脏功能并减少扩张型心肌病患者的二尖瓣反流。可以计算电极放置的三维图。选择心脏右侧的可用电极的一组子集用于刺激，使得收缩期间的间隔运动减少或二尖瓣区域被加强以减少二尖瓣反流。

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