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1. 发明申请

WO2013009782A3 COMMUNICATION SYSTEM WITH ENHANCED PARTIAL POWER SOURCE AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：具有增强部分电源的通信系统及其制造方法
公开(公告)号：WO2013009782A3
公开(公告)日：2013-03-14
申请号：PCT/US2012046120
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL INC , FRANK JEREMY , BJELETICH PETER , HAFEZI HOOMAN , AZEVEDO ROBERT , DUCK ROBERT , PESIC ILIYA , COSTELLO BENEDICT , SNYDER ERIC
发明人： FRANK JEREMY , BJELETICH PETER , HAFEZI HOOMAN , AZEVEDO ROBERT , DUCK ROBERT , PESIC ILIYA , COSTELLO BENEDICT , SNYDER ERIC
IPC分类号： A61B1/273 , H04B7/24
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/14539 , A61B5/4839 , A61B5/6861 , A61B2560/0214 , A61B2562/12 , A61B2562/125 , A61B2562/162 , A61J3/007 , H01M4/0402 , H01M4/06 , H01M4/08 , H01M4/366 , H01M4/381 , H01M4/582 , H01M4/66 , H01M6/34 , H01M2220/30 , H01Q1/273 , Y10T29/49002 , Y10T29/49117 , Y10T156/1056
摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
摘要翻译：本发明的系统包括导电元件，电子元件和不相似材料形式的部分电源。一旦与导电流体接触，就会产生一个电压电势，并完成电源，从而激活系统。电子元件控制不同材料之间的电导以产生独特的电流特征。该系统还可以测量系统周围的环境条件。

2. 发明申请

WO2013009786A2 POLYPHARMACY CO-PACKAGED MEDICATION DOSING UNIT INCLUDING COMMUNICATION SYSTEM THEREFOR 审中-公开
公开(公告)号：WO2013009786A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046124
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL, INC. , ROBERTSON, Timothy , MOON, Gregory , COSTELLO, Benedict , ZDEBLICK, Mark , HAFEZI, Hooman
发明人： ROBERTSON, Timothy , MOON, Gregory , COSTELLO, Benedict , ZDEBLICK, Mark , HAFEZI, Hooman
IPC分类号： A61J7/04 , G06Q50/22 , B65D51/24 , A61J1/00 , G08B21/02
CPC分类号： A61J3/007 , A61B5/0002 , A61B5/073 , A61B5/4839 , A61B2560/0412 , A61J7/0084 , A61J7/04 , A61J7/0418 , A61J7/0436 , A61J7/0481 , A61J2200/30 , A61J2205/60 , G06F19/00 , G06F19/3462 , H01Q1/273 , Y10T29/49826
摘要： A custom medication dosing unit is disclosed. The custom medication dosing unit includes a housing having a shell element provided with a bottom surface and a circumferential edge extending from the bottom surface and a portion defining an opening for accommodating a medication. A first closure element provided with a circumferential edge is placed on the circumferential edge of the shell element in an adhering and closing manner. A medication is disposed within the opening defined between the shell element and the first closure element. A circuit module is associated within the first closure element. A system includes the custom medication dosing unit operative to communicate with a local node. Also disclosed is a method of manufacturing the custom medication dosing unit.
摘要翻译：公开了一种定制药物剂量单元。定制药物剂量单元包括具有壳体元件的壳体，壳体元件设置有底表面和从底表面延伸的圆周边缘和限定用于容纳药物的开口的部分。设置有周向边缘的第一闭合元件以粘附和闭合的方式放置在壳体元件的周缘上。药物设置在壳体元件和第一封闭元件之间限定的开口内。电路模块关联在第一闭合元件内。系统包括用于与本地节点通信的定制药物给药单元。还公开了一种制造定制药物给药单元的方法。

3. 发明申请

WO2013009777A2 COMMUNICATION SYSTEM WITH MULTIPLE SOURCES OF POWER 审中-公开
标题翻译：具有多个电源的通信系统
公开(公告)号：WO2013009777A2
公开(公告)日：2013-01-17
申请号：PCT/US2012046113
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL INC , WHITWORTH ADAM , ZDEBLICK MARK J
发明人： WHITWORTH ADAM , ZDEBLICK MARK J
IPC分类号： A61B5/00 , A61B1/273 , A61B5/05 , H04B7/24
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/4839 , A61B2560/0214 , A61J3/007 , H01M6/00 , H01Q1/273 , H04B1/0343 , H04B13/005
摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
摘要翻译：本发明的系统包括导电元件，电子元件和不相似材料形式的部分电源。一旦与导电流体接触，就会产生一个电压电势，并完成电源，从而激活系统。电子元件控制不同材料之间的电导以产生独特的电流特征。该系统还可以测量系统周围的环境条件。

4. 发明申请

WO2012125424A2 BIOLOGICAL SAMPLE COLLECTION DEVICE AND SYSTEM 审中-公开
标题翻译：生物样品采集装置和系统
公开(公告)号：WO2012125424A2
公开(公告)日：2012-09-20
申请号：PCT/US2012028342
申请日：2012-03-08
申请人： PROTEUS BIOMEDICAL INC , COSTELLO BENEDICT
发明人： COSTELLO BENEDICT
IPC分类号： C12M1/26 , A61M1/02 , G01N33/48
CPC分类号： A61B5/150091 , A61B5/0028 , A61B5/02055 , A61B5/024 , A61B5/026 , A61B5/0402 , A61B5/053 , A61B5/073 , A61B5/11 , A61B5/145 , A61B5/14514 , A61B5/150358 , A61B5/150984 , A61B5/157 , A61B5/6832 , A61B5/686 , A61B5/6861 , A61B10/0064 , A61B2560/0252 , A61B2560/0412
摘要： A biological sample collection device includes a top cover plate, a bottom portion attached to the top cover plate, the bottom portion comprising a remotely-analyzable biological sample collection portion to collect a biological sample from a body of a subject. The biological sample is to be analyzed at a remote processing facility at a later time. A fastening portion is provided on the bottom portion to affix the remotely-analyzable biological sample collection device to the body of the subject. A real time clock is coupled to the top cover plate and a memory is coupled to the top cover plate and electrically coupled to the real time clock. The remotely-analyzable biological sample collection device may further include a processing unit, at least two electrodes coupled to the processing unit, and a transbody conductive communication module. Additionally, a remotely-analyzable biological sample collection device communication system includes a wireless communication device configured to communicate with a communication device external to the patient.
摘要翻译：生物样本收集装置包括顶盖板，连接到顶盖板的底部，底部包括可远程分析的生物样本收集部分，以收集来自受试者身体的生物样本。生物样本将在稍后的远程处理设施处进行分析。紧固部分设置在底部上以将可远程分析的生物样本采集装置附着到对象的身体。实时时钟耦合到顶盖板并且存储器耦合到顶盖板并电耦合到实时时钟。可远程分析的生物样本收集装置可进一步包括处理单元，耦合到处理单元的至少两个电极，以及透明体导电通信模块。另外，可远程分析的生物样本收集装置通信系统包括被配置为与患者外部的通信装置通信的无线通信装置。

5. 发明申请

WO2012096852A2 SYSTEM, METHOD, AND ARTICLE TO PROMPT BEHAVIOR CHANGE 审中-公开
标题翻译：系统，方法和文章提供行为变化
公开(公告)号：WO2012096852A2
公开(公告)日：2012-07-19
申请号：PCT/US2012/020542
申请日：2012-01-06
申请人： PROTEUS BIOMEDICAL, INC. , O' REILLY, David , IONESCU, Arna Diana , DUFFY, Sean Patrick , SILVER, Jesse Amos , FETERSTONHAUGH, David Rae , RITHCER, Schirin Lucie
发明人： O' REILLY, David , IONESCU, Arna Diana , DUFFY, Sean Patrick , SILVER, Jesse Amos , FETERSTONHAUGH, David Rae , RITHCER, Schirin Lucie
IPC分类号： G06Q50/22 , G06K17/00
CPC分类号： G09B19/00 , G06F19/00 , G06F19/3456 , G06F19/3475 , G06F19/3481 , G09B19/003 , G09B19/0038
摘要： System, method, and article to prompt behavior change are provided. Various aspects of the system include health promotion data generated and / or communicated from / to a device; a methodology module associated with software / processor to identify at least one behavior change methodology associated with the health promotion data; and an instruction module associated with a software / processor to initiate the identified at least one behavior change methodology.
摘要翻译：提供系统，方法和文章来提示行为改变。系统的各个方面包括从设备产生和/或传送的健康促进数据; 与软件/处理器相关联的方法模块，用于识别与健康促进数据相关联的至少一种行为改变方法; 以及与软件/处理器相关联以发起所识别的至少一个行为改变方法的指令模块。

6. 发明申请

WO2012071280A2 INGESTIBLE DEVICE WITH PHARMACEUTICAL PRODUCT 审中-公开
标题翻译：不具有药用产品的装置
公开(公告)号：WO2012071280A2
公开(公告)日：2012-05-31
申请号：PCT/US2011061478
申请日：2011-11-18
申请人： PROTEUS BIOMEDICAL INC , HAFEZI HOOMAN
发明人： HAFEZI HOOMAN
IPC分类号： A61K9/48 , A61K9/20 , A61K9/44
CPC分类号： A61M31/002 , A61B5/14503 , A61B5/4833 , A61J3/071 , A61K9/0097 , A61K9/4808 , A61M2205/0238 , A61M2205/33 , A61M2205/50 , A61M2205/82 , A61M2207/00 , Y10T29/49826
摘要： A system and a manufacturing process are disclosed in accordance with the present invention that protect an electronic device and allows for placement or combination of the device within a pharmaceutical product or capsule. The system includes circuitry and components that can be placed within certain environments. The device includes an assembly including an electronic unit, a flexible membrane secured to the unit, and a protective coating.
摘要翻译：根据本发明公开了一种系统和制造方法，其保护电子设备并允许将该装置放置或组合在药物产品或胶囊内。该系统包括可放置在某些环境中的电路和组件。该装置包括一个组件，它包括一个电子单元，一个固定在该单元上的柔性膜和一个保护涂层。

7. 发明申请

WO2011130183A2 APPARATUS, SYSTEM AND METHOD FOR DETECTION AND DELIVERY OF A MEDICINAL DOSE 审中-公开
标题翻译：用于检测和递送药物剂量的装置，系统和方法
公开(公告)号：WO2011130183A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/031986
申请日：2011-04-11
申请人： PROTEUS BIOMEDICAL, INC. , ARNE, Lawrence , COSTELLO, Benedict , MESTMAN, Yuriy , ROBERTSON, Timothy , SAVAGE, George , STRAND, Angela , THOMPSON, Todd , ZDEBLICK, Mark
发明人： ARNE, Lawrence , COSTELLO, Benedict , MESTMAN, Yuriy , ROBERTSON, Timothy , SAVAGE, George , STRAND, Angela , THOMPSON, Todd , ZDEBLICK, Mark
IPC分类号： A61B5/00 , A61J1/00 , A61J7/02
CPC分类号： A61B5/4833 , A61B5/053 , A61B5/6846 , A61B2562/0214 , A61M15/0016 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/009 , A61M2016/0024 , A61M2016/0039 , A61M2205/13 , A61M2205/331 , A61M2205/3317 , A61M2205/332 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/6009 , A61M2205/6054 , A61M2230/63 , A61M2230/65
摘要： An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.
摘要翻译：公开了一种用于跟踪并确认向用户传送药用剂量的系统的一部分的装置。该装置包括检测器。检测器被固定并且通信地耦合到用户，并且能够检测通过用户身体的电流。当用户与设备接触时产生电流。该设备包括连接到电源的至少两个接触区域，其中当用户与设备接触时，电路和因此的电流路径通过用户的身体完成。电流由检测器检测到，该检测器耦合到用户。还公开了一种用于跟踪并确认药物剂量递送给用户的装置，其中该装置包括声学检测器。当将剂量加载到室中时，产生声振动。检测振动并与用户与设备接触时产生的电流相关联。振动检测和电流检测的组合事件证实了剂量被加载并且使用者与设备接触并准备接收剂量。

8. 发明申请

WO2011022732A3 APPARATUS AND METHOD FOR MEASURING BIOCHEMICAL PARAMETERS 审中-公开
标题翻译：用于测量生物化学参数的装置和方法
公开(公告)号：WO2011022732A3
公开(公告)日：2011-08-25
申请号：PCT/US2010046381
申请日：2010-08-23
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： G01N27/02 , A61B5/00 , G01N27/06 , G01N33/48
CPC分类号： A61B5/150229 , A61B5/0002 , A61B5/0537 , A61B5/14503 , A61B5/14517 , A61B5/14532 , A61B5/150305 , A61B5/150877 , A61B5/150969 , A61B5/157 , A61B5/6833 , A61B5/6846 , A61B10/0064 , A61B2560/0412
摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.
摘要翻译：在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。电阻之间以不同的频率测量阻抗。结果，在表面下方的不同区域处测量阻抗，一个区域比其他区域更深于表面下方。在第二实施例中，微流体装置执行分析。分析可以在粘附到表面的柔性贴片内，或者可以是植入在由组织包围的液体中的固体装置中。分析可以涉及泵送流体或者可以涉及通过微流体通道电泳分析分析物。

9. 发明申请

WO2011094608A3 TWO-WRIST DATA GATHERING SYSTEM 审中-公开
标题翻译：双手数据收集系统
公开(公告)号：WO2011094608A3
公开(公告)日：2011-08-04
申请号：PCT/US2011/023017
申请日：2011-01-28
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61B5/00 , A61B1/273 , H04B7/24 , A61K9/00
摘要： Sensing is carried out from locations at considerable remove from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated. And alternative power sources become available.
摘要翻译：
传感从胃中相当大的位置进行。配合传感器电子元件放置在病人的两个手腕上。减少或消除腹部贴片的潜在不适和不便。并且可以使用替代电源。

10. 发明申请

WO2011094606A3 DATA GATHERING SYSTEM 审中-公开
标题翻译：数据收集系统
公开(公告)号：WO2011094606A3
公开(公告)日：2011-08-04
申请号：PCT/US2011/023013
申请日：2011-01-28
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , HUTCHISON, James , ARNE, Lawrence
发明人： ZDEBLICK, Mark , HUTCHISON, James , ARNE, Lawrence
IPC分类号： A61B5/04 , A61B5/0408 , H04B13/00 , G06F19/00
摘要： A device for gathering data has first and second electrodes. The first electrode is coupled to a surface of interest, and the second electrode is coupled to "everything else" or "the air". The first electrode is shielded from the second, and from most sources of parasitic capacitance, by a shield that is driven by an active driver that drives the shield to track, and ideally to match, the instantaneous potential of the electrode. The second electrode is likewise shielded in a similar way from most sources of parasitic capacitance. These shields likewise help to limit the extent to which RFI from the device electronics couples with either of the electrodes. In this way the sensing device achieves a markedly better signal-to-noise ratio at frequency bands of interest.
摘要翻译：用于收集数据的设备具有第一和第二电极。第一电极耦合到感兴趣的表面，并且第二电极耦合到“其他所有物” 或“空气”。第一个电极与第二个电极以及大多数寄生电容源隔离，屏蔽由驱动屏蔽层跟踪的有源驱动器驱动，并理想地匹配电极的瞬时电位。第二个电极的屏蔽方式与绝大多数寄生电容相似。这些屏蔽同样有助于限制装置电子设备的RFI与任一电极耦合的程度。通过这种方式，传感设备在感兴趣的频段实现了明显更好的信噪比。

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