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1. 发明申请

WO2010080765A2 HIGH-THROUGHPUT PRODUCTION OF INGESTIBLE EVENT MARKERS 审中-公开
标题翻译：高效率生产不可思议的事件标记
公开(公告)号：WO2010080765A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020142
申请日：2010-01-05
申请人： PROTEUS BIOMEDICAL, INC. , HAFEZI, Hooman , ZDEBLICK, Mark , AU-YEUNG, Kityee , MOON, Gregory , DUCK, Robert , HOLEN, Maria , ROBERTSON, Timothy , SNYDER, Eric , FOLENA, Mauro , COSTELLO, Benedict , RAO, Pratish
发明人： HAFEZI, Hooman , ZDEBLICK, Mark , AU-YEUNG, Kityee , MOON, Gregory , DUCK, Robert , HOLEN, Maria , ROBERTSON, Timothy , SNYDER, Eric , FOLENA, Mauro , COSTELLO, Benedict , RAO, Pratish
IPC分类号： A61K9/50 , A61K9/20 , G01N33/50 , A61B5/00
CPC分类号： A61B5/073 , A61B5/0031 , A61B5/4238 , A61B5/4255 , A61B2560/0406 , A61B2562/12 , A61B2562/162 , B01L3/545 , B30B11/34 , Y10T29/49885 , Y10T29/5191
摘要： High-throughput ingestible event marker manufacturing systems are provided. The systems include an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product. Also provided are manufacturing methods to produce such products which include assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier.
摘要翻译：提供高通量可摄入事件标记制造系统。系统包括组装单元，其被配置为稳定地将可摄入事件标记与载体相关联以产生产物。还提供了制造这样的产品的制造方法，其包括将可摄取事件标记与组装单元组合，其被配置为将可摄取事件标记与载体稳定相关联。

2. 发明申请

WO2010057063A3 PACING AND STIMULATION SYSTEM, DEVICE AND METHOD 审中-公开
公开(公告)号：WO2010057063A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/064487
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61N1/36 , A61N1/04 , A61N1/02
摘要： System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.

3. 发明申请

WO2010057046A3 MULTIPLEXED MULTI-ELECTRODE NEUROSTIMULATION DEVICES 审中-公开
公开(公告)号：WO2010057046A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/064468
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , THOMPSON, Todd , JENSEN, Marc , COLLIOU, Olivier , STRAND, Angela
发明人： ZDEBLICK, Mark , THOMPSON, Todd , JENSEN, Marc , COLLIOU, Olivier , STRAND, Angela
IPC分类号： A61N1/36 , A61N1/05 , A61N1/02
摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

4. 发明申请

WO2009131749A2 INTEGRATED CIRCUIT IMPLEMENTATION AND FAULT CONTROL SYSTEM, DEVICE, AND METHOD 审中-公开
标题翻译：集成电路实现和故障控制系统，设备和方法
公开(公告)号：WO2009131749A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/035586
申请日：2009-02-27
申请人： PROTEUS BIOMEDICAL, INC. , BI, Yafei , LI, Haifeng , ZDEBLICK, Mark , THOMPSON, Todd , LEICHNER, Robert
发明人： BI, Yafei , LI, Haifeng , ZDEBLICK, Mark , THOMPSON, Todd , LEICHNER, Robert
CPC分类号： A61N1/05 , A61N1/025 , A61N1/37 , A61N1/378
摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.
摘要翻译：装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动，以稳定的电压工作。引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力供应是本地控制电子产品。还提供了稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复的系统。

5. 发明申请

WO2008112577A1 IN-BODY DEVICE HAVING A MULTI-DIRECTIONAL TRANSMITTER 审中-公开
标题翻译：具有多方向发射器的身体设备
公开(公告)号：WO2008112577A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056296
申请日：2008-03-07
申请人： PROTEUS BIOMEDICAL, INC. , COLLIOU, Olivier , ROBERTSON, Timothy , ZDEBLICK, Mark
发明人： COLLIOU, Olivier , ROBERTSON, Timothy , ZDEBLICK, Mark
IPC分类号： A61B5/00
CPC分类号： H01Q9/30 , A61B5/0031 , A61B5/0205 , A61B5/073 , A61B5/1104 , A61B2562/08 , H01Q1/273 , H01Q21/29
摘要： Multi-directional transmitters for in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body multi-direction transmitters of the invention include signal transmitters configured to transmit an identifying signal in at least two different directions in an x-y plane. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
摘要翻译：提供用于体内装置的多向发射器，例如可植入和可摄取装置。本发明的体内多方向发射机的方面包括被配置为在x-y平面中以至少两个不同方向发射识别信号的信号发射机。身体内装置的实施例被配置为在与目标生理部位接触时发出可检测信号。还提供了制造和使用本发明的装置的方法。

6. 发明申请

WO2007028035A2 IMPLANTABLE ZERO-WIRE COMMUNICATIONS SYSTEM 审中-公开
标题翻译：可插拔的ZERO-WIRE通信系统
公开(公告)号：WO2007028035A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034258
申请日：2006-09-01
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , ROBERTSON, Timothy
发明人： ZDEBLICK, Mark , ROBERTSON, Timothy
IPC分类号： G08C17/00
CPC分类号： A61B5/0022 , A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/0215 , A61B5/026 , A61B5/0265 , A61B5/145 , A61B5/14535 , A61B5/415 , A61B5/418 , A61B5/6862 , A61B5/6876 , A61M5/172 , A61N1/37217 , A61N1/37223 , G06F19/00 , H02J50/20 , Y02A90/26
摘要： The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.
摘要翻译：本发明提供了使用能够使设备配置和应用迄今不可能的唯一格式彼此无线通信的可植入系统。本发明的实施例提供了与可植入医疗装置交换信息的通信装置和方法。在一些实施例中，两个可植入装置通过长波长/低频电磁波带中的准静电信号传输彼此进行通信，患者的身体用作导电介质。

7. 发明申请

WO2006042039A2 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续现场测量
公开(公告)号：WO2006042039A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036035
申请日：2005-10-06
申请人： PROTEUS BIOMEDICAL, INC. , SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Ben , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
发明人： SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Ben , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
IPC分类号： A61B8/02
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。使用感测元件检测所施加的连续场的特性，以评估组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

8. 发明申请

WO2006029090A3 METHODS AND APPARATUS FOR TISSUE ACTIVATION AND MONITORING 审中-公开
公开(公告)号：WO2006029090A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/031559
申请日：2005-09-01
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61B5/00
摘要： Techniques for controlling one or more modular circuits ("satellites") that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals ( e.g ., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned ( e.g ., heart muscles) or to sense analog signals ( e.g ., a propagating depolarization signal) within the tissue.

9. 发明申请

WO2013009786A2 POLYPHARMACY CO-PACKAGED MEDICATION DOSING UNIT INCLUDING COMMUNICATION SYSTEM THEREFOR 审中-公开
公开(公告)号：WO2013009786A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046124
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL, INC. , ROBERTSON, Timothy , MOON, Gregory , COSTELLO, Benedict , ZDEBLICK, Mark , HAFEZI, Hooman
发明人： ROBERTSON, Timothy , MOON, Gregory , COSTELLO, Benedict , ZDEBLICK, Mark , HAFEZI, Hooman
IPC分类号： A61J7/04 , G06Q50/22 , B65D51/24 , A61J1/00 , G08B21/02
CPC分类号： A61J3/007 , A61B5/0002 , A61B5/073 , A61B5/4839 , A61B2560/0412 , A61J7/0084 , A61J7/04 , A61J7/0418 , A61J7/0436 , A61J7/0481 , A61J2200/30 , A61J2205/60 , G06F19/00 , G06F19/3462 , H01Q1/273 , Y10T29/49826
摘要： A custom medication dosing unit is disclosed. The custom medication dosing unit includes a housing having a shell element provided with a bottom surface and a circumferential edge extending from the bottom surface and a portion defining an opening for accommodating a medication. A first closure element provided with a circumferential edge is placed on the circumferential edge of the shell element in an adhering and closing manner. A medication is disposed within the opening defined between the shell element and the first closure element. A circuit module is associated within the first closure element. A system includes the custom medication dosing unit operative to communicate with a local node. Also disclosed is a method of manufacturing the custom medication dosing unit.
摘要翻译：公开了一种定制药物剂量单元。定制药物剂量单元包括具有壳体元件的壳体，壳体元件设置有底表面和从底表面延伸的圆周边缘和限定用于容纳药物的开口的部分。设置有周向边缘的第一闭合元件以粘附和闭合的方式放置在壳体元件的周缘上。药物设置在壳体元件和第一封闭元件之间限定的开口内。电路模块关联在第一闭合元件内。系统包括用于与本地节点通信的定制药物给药单元。还公开了一种制造定制药物给药单元的方法。

10. 发明申请

WO2011130183A2 APPARATUS, SYSTEM AND METHOD FOR DETECTION AND DELIVERY OF A MEDICINAL DOSE 审中-公开
标题翻译：用于检测和递送药物剂量的装置，系统和方法
公开(公告)号：WO2011130183A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/031986
申请日：2011-04-11
申请人： PROTEUS BIOMEDICAL, INC. , ARNE, Lawrence , COSTELLO, Benedict , MESTMAN, Yuriy , ROBERTSON, Timothy , SAVAGE, George , STRAND, Angela , THOMPSON, Todd , ZDEBLICK, Mark
发明人： ARNE, Lawrence , COSTELLO, Benedict , MESTMAN, Yuriy , ROBERTSON, Timothy , SAVAGE, George , STRAND, Angela , THOMPSON, Todd , ZDEBLICK, Mark
IPC分类号： A61B5/00 , A61J1/00 , A61J7/02
CPC分类号： A61B5/4833 , A61B5/053 , A61B5/6846 , A61B2562/0214 , A61M15/0016 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/009 , A61M2016/0024 , A61M2016/0039 , A61M2205/13 , A61M2205/331 , A61M2205/3317 , A61M2205/332 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/6009 , A61M2205/6054 , A61M2230/63 , A61M2230/65
摘要： An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.
摘要翻译：公开了一种用于跟踪并确认向用户传送药用剂量的系统的一部分的装置。该装置包括检测器。检测器被固定并且通信地耦合到用户，并且能够检测通过用户身体的电流。当用户与设备接触时产生电流。该设备包括连接到电源的至少两个接触区域，其中当用户与设备接触时，电路和因此的电流路径通过用户的身体完成。电流由检测器检测到，该检测器耦合到用户。还公开了一种用于跟踪并确认药物剂量递送给用户的装置，其中该装置包括声学检测器。当将剂量加载到室中时，产生声振动。检测振动并与用户与设备接触时产生的电流相关联。振动检测和电流检测的组合事件证实了剂量被加载并且使用者与设备接触并准备接收剂量。

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