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1. 发明申请

WO2006034432A3 ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE 审中-公开
标题翻译：具有集成电极的电绝缘装置
公开(公告)号：WO2006034432A3
公开(公告)日：2006-08-17
申请号：PCT/US2005034093
申请日：2005-09-21
申请人： PREDICANT BIOSCIENCES INC , BOUSSE LUC J , ZHAO MINGQI
发明人： BOUSSE LUC J , ZHAO MINGQI
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/167 , B05B5/025 , B05B5/0533 , H01J49/0018 , Y10T29/494
摘要： The invention provides related apparatus and methods of making an integrated electrospray tip (102) by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate (104) to the surface of a second planar substrate (105), wherein a surface on at least one of the substrates includes one or more microfluidic channels (109, 112) and/or reservoirs ((108, 113, 114) which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels (109, 112) within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices (101) with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel (109, 112) containing a conductive material selected from a variety of solutions and gels.
摘要翻译：本发明提供了通过将离子和/或电子导体材料沉积到平面基底上来制造集成电喷雾尖端（102）的相关装置和方法。本发明还具有形成电喷射装置的方法，包括将第一平面基底（104）耦合到第二平面基底（105）的表面，其中至少一个基底上的表面包括一个或多个微流体通道（109， 112）和/或至少部分或完全封闭在其间的储存器（（108,113,114））。设备的导电区域优选地不与装置的其它部分内的微流体通道（109,112）相交。本发明还提供了用于制造和使用具有用于电喷雾离子化的集成电极的微流体装置（101）的相关装置和方法。一些实施例中的电喷射装置可以包括由微流体通道（109,112）形成的电子导体电极或离子导体电极），其含有选自多种溶液和凝胶的导电材料。

2. 发明申请

WO2006015306A2 METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES 审中-公开
标题翻译：方法，组合物和装置，包括微流体装置，包装涂覆的疏水性表面
公开(公告)号：WO2006015306A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027225
申请日：2005-07-29
申请人： PREDICANT BIOSCIENCES, INC. , CHAPMAN, Robert, G. , ZHAO, Mingqi , NI, Jing , BOOSSE, Luc, J. , STULTS, John, T. , YANG, Say , RUDOLF, Roger
发明人： CHAPMAN, Robert, G. , ZHAO, Mingqi , NI, Jing , BOOSSE, Luc, J. , STULTS, John, T. , YANG, Say , RUDOLF, Roger
IPC分类号： H01J49/00
CPC分类号： G01N33/6848 , B01L3/5027 , H01J49/0018 , H01J49/165
摘要： Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
摘要翻译：公开了用于涂覆至少一部分疏水表面的方法，包括塑料或其它聚合物的表面。这种方法包括使用与疏水表面相互作用的第一涂层和/或区域，尽管不需要在第一涂层和疏水表面之间形成化学键。然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。微流体装置向质谱仪提供物质。微流体装置包括具有至少一个微通道的衬底，布置在微通道表面上的盖和至少一个电势源。一些实施例包括在出口处加宽的微通道。其他实施例将电势源沿着盖的表面定位。其他实施例包括其中设置电极和膜的阱。各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。

3. 发明申请

WO2004111609A3 METHODS FOR ACCURATE COMPONENT INTENSITY EXTRACTION FROM SEPARATIONS-MASS SPECTROMETRY DATA 审中-公开
标题翻译：分离精确分量强度提取方法 - 质谱分析数据
公开(公告)号：WO2004111609A3
公开(公告)日：2005-07-14
申请号：PCT/US2004017908
申请日：2004-06-04
申请人： PREDICANT BIOSCIENCES INC , AHMED ZULFIKAR , BITTER HANS , BROWN MICHAEL , HELLER JONATHAN C , DONOHO DAVID , BALASINGHAM ARJUNA , QUARATO JAMES , DE VALPINE PERRY
发明人： AHMED ZULFIKAR , BITTER HANS , BROWN MICHAEL , HELLER JONATHAN C , DONOHO DAVID , BALASINGHAM ARJUNA , QUARATO JAMES , DE VALPINE PERRY
IPC分类号： G01N20060101 , G01N31/00
CPC分类号： G01N1/00 , G01N31/00 , H01J49/0036
摘要： Methods and apparatuses are disclosed that model the lineshapes of mass spectrometry data. Ions can be modeled with an initial distribution that models molecules as having multiple positions and/or energies prior to traveling in the mass spectrometer. These initial distributions can be pushed forward by time of flight functions. Fitting can be performed between the modeled lineshapes and empirical data. Filtering can greatly reduce dimensions of the empirical data, remove noise, compress the data, recover lost and/or damaged data.
摘要翻译：公开了对质谱数据的线形进行建模的方法和装置。离子可以用初始分布建模，在分子在质谱仪中行进之前将分子模拟成具有多个位置和/或能量。这些初始分配可以通过飞行时间功能推动。可以在建模的线条和经验数据之间进行拟合。过滤可以大大减少经验数据的尺寸，消除噪音，压缩数据，恢复丢失和/或损坏的数据。

4. 发明申请

WO2004111609A2 METHODS FOR ACCURATE COMPONENT INTENSITY EXTRACTION FROM SEPARATIONS-MASS SPECTROMETRY DATA 审中-公开
标题翻译：分离精确分量强度提取方法 - 质谱分析数据
公开(公告)号：WO2004111609A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/017908
申请日：2004-06-04
申请人： PREDICANT BIOSCIENCES, INC. , AHMED, Zulfikar , BITTER, Hans , BROWN, Michael , HELLER, Jonathan, C. , DONOHO, David , BALASINGHAM, Arjuna , QUARATO, James , DE VALPINE, Perry
发明人： AHMED, Zulfikar , BITTER, Hans , BROWN, Michael , HELLER, Jonathan, C. , DONOHO, David , BALASINGHAM, Arjuna , QUARATO, James , DE VALPINE, Perry
IPC分类号： G01N
CPC分类号： G01N1/00 , G01N31/00 , H01J49/0036
摘要： Methods and apparatuses are disclosed that model the lineshapes of mass spectrometry data. Ions can be modeled with an initial distribution that models molecules as having multiple positions and/or energies prior to traveling in the mass spectrometer. These initial distributions can be pushed forward by time of flight functions. Fitting can be performed between the modeled lineshapes and empirical data. Filtering can greatly reduce dimensions of the empirical data, remove noise, compress the data, recover lost and/or damaged data.
摘要翻译：公开了对质谱数据的线形进行建模的方法和装置。离子可以用初始分布建模，在分子在质谱仪中行进之前将分子模拟成具有多个位置和/或能量。这些初始分配可以通过飞行时间功能推动。可以在建模的线条和经验数据之间进行拟合。过滤可以大大减少经验数据的尺寸，消除噪音，压缩数据，恢复丢失和/或损坏的数据。

5. 发明申请

WO2006015306A3 METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES 审中-公开
标题翻译：方法，组合物和装置，包括微流体装置，包装涂覆的疏水性表面
公开(公告)号：WO2006015306A3
公开(公告)日：2008-10-16
申请号：PCT/US2005027225
申请日：2005-07-29
申请人： PREDICANT BIOSCIENCES INC , CHAPMAN ROBERT G , ZHAO MINGQI , NI JING , BOOSSE LUC J , STULTS JOHN T , YANG SAY , RUDOLF ROGER
发明人： CHAPMAN ROBERT G , ZHAO MINGQI , NI JING , BOOSSE LUC J , STULTS JOHN T , YANG SAY , RUDOLF ROGER
IPC分类号： B32B9/04 , B05D1/36 , B05D7/00
CPC分类号： G01N33/6848 , B01L3/5027 , H01J49/0018 , H01J49/165
摘要： Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
摘要翻译：公开了用于涂覆至少一部分疏水表面的方法，包括塑料或其它聚合物的表面。这种方法包括使用与疏水表面相互作用的第一涂层和/或区域，尽管不需要在第一涂层和疏水表面之间形成化学键。然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。微流体装置向质谱仪提供物质。微流体装置包括具有至少一个微通道的衬底，布置在微通道表面上的盖和至少一个电势源。一些实施例包括在出口处加宽的微通道。其他实施例将电势源沿着盖的表面定位。其他实施例包括其中设置电极和膜的阱。各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。

6. 发明申请

WO2004094994A3 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO2004094994A3
公开(公告)日：2005-06-23
申请号：PCT/US2004006918
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES INC , HELLER JONATHAN , STULTS JOHN , SRINIVASAN UTHARA , BOUSSE LUC , ZHAO MINGQI , NI JING
发明人： HELLER JONATHAN , STULTS JOHN , SRINIVASAN UTHARA , BOUSSE LUC , ZHAO MINGQI , NI JING
IPC分类号： F15C1/04 , F16L58/04 , G01N20060101 , H01J49/04 , H01J49/16
CPC分类号： H01J49/0018 , H01J49/165 , Y10T137/0402 , Y10T137/2082 , Y10T137/2191 , Y10T137/2224 , Y10T137/7036 , Y10T436/2575
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.
摘要翻译：微流体装置向质谱仪提供物质。微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

7. 发明申请

WO2004094994A2 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO2004094994A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/006918
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES, INC. , HELLER, Jonathan , STULTS, John , SRINIVASAN, Uthara , BOUSSE, Luc , ZHAO, Mingqi , NI, Jing
发明人： HELLER, Jonathan , STULTS, John , SRINIVASAN, Uthara , BOUSSE, Luc , ZHAO, Mingqi , NI, Jing
IPC分类号： G01N
CPC分类号： H01J49/0018 , H01J49/165 , Y10T137/0402 , Y10T137/2082 , Y10T137/2191 , Y10T137/2224 , Y10T137/7036 , Y10T436/2575
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.
摘要翻译：微流体装置向质谱仪提供物质。微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

8. 发明申请

WO2006034432A2 ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE 审中-公开
标题翻译：具有集成电极的电绝缘装置
公开(公告)号：WO2006034432A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/034093
申请日：2005-09-21
申请人： PREDICANT BIOSCIENCES, INC. , BOUSSE, Luc, J. , ZHAO, Mingqi
发明人： BOUSSE, Luc, J. , ZHAO, Mingqi
IPC分类号： B01D59/44
CPC分类号： H01J49/167 , B05B5/025 , B05B5/0533 , H01J49/0018 , Y10T29/494
摘要： The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.
摘要翻译：本发明提供了通过将离子和/或电子导体材料沉积到平面衬底上来制造集成电喷雾尖端的相关装置和方法。本发明还具有形成电喷射装置的方法，其包括将第一平面基底耦合到第二平面基底的表面，其中至少一个基底上的表面包括一个或多个微流体通道和/或至少部分地或完全封闭在其间。设备的导电区域优选地不与装置的其它部分内的微流体通道相交。本发明还提供了用于制造和使用具有用于电喷雾电离的集成电极的微流体装置的相关装置和方法。在一些实施例中，电喷雾装置可以包括由包含选自多种溶液和凝胶的导电材料的微流体通道形成的电子导体电极或离子导体电极。

9. 发明申请

WO2005019804A3 MICROFLUIDIC CHIP WITH ENHANCED TIP FOR STABLE ELECTROSPRAY IONIZATION 审中-公开
标题翻译：微波芯片，增强了稳定的电泳放电
公开(公告)号：WO2005019804A3
公开(公告)日：2006-01-26
申请号：PCT/US2004027774
申请日：2004-08-25
申请人： PREDICANT BIOSCIENCES INC , ZHAO MINGQI , BLAGA LULIU , BOUSSE LUC , STULTS JOHN
发明人： ZHAO MINGQI , BLAGA LULIU , BOUSSE LUC , STULTS JOHN
IPC分类号： H01J49/04 , H03H19/00 , B01D59/44 , B01L3/00 , B01L3/02 , B81B1/00 , G01D5/20 , G01N20060101 , G01N27/447
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/027 , B81B1/008 , B81B2201/058 , G01N27/44717 , H01J49/0018
摘要： A microfluidic chip (10) formed with multiple fluid channels (12) terminating at a tapered electrospray ionization tip (14) for mass spectrometric analysis. The fluid channels (12) may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip (15) can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels (12) may terminate at an open-tip region (18) of the electrospray tip (15). A covering plate (5) may substantially enclose most portions of the fluid channels (12) formed on the channel plate except for the open-tip region (18). Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels (12) in a single microfluidic chip (10) that is formed with a tapered electrospray tip (14) having an open-tip region (18).
摘要翻译：形成有多个流体通道（12）的微流体芯片（10），其终止于锥形电喷雾离子化尖端（14），用于质谱分析。流体通道（12）可以形成在与相应的储存器流体连通的通道板上。电喷雾头（15）可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。流体通道（12）可以终止于电喷雾头（15）的开口尖端区域（18）。覆盖板（5）可以基本上封闭除了开口尖端区域（18）之外形成在通道板上的流体通道（12）的大部分。本发明的另一方面提供了用于对流过单个微流体芯片（10）中的各个流体通道（12）的多个样品进行质谱分析的方法，所述单个微流体芯片（10）由具有开口尖端区域（18）的锥形电喷枪尖端）。

10. 发明申请

WO2005019804A2 MICROFLUIDIC CHIP WITH ENHANCED TIP FOR STABLE ELECTROSPRAY IONIZATION 审中-公开
标题翻译：微波芯片，增强了稳定的电泳放电
公开(公告)号：WO2005019804A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/027774
申请日：2004-08-25
申请人： PREDICANT BIOSCIENCES, INC. , ZHAO, Mingqi , BLAGA, Luliu , BOUSSE, Luc , STULTS, John
发明人： ZHAO, Mingqi , BLAGA, Luliu , BOUSSE, Luc , STULTS, John
IPC分类号： G01N
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/027 , B81B1/008 , B81B2201/058 , G01N27/44717 , H01J49/0018
摘要： A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.
摘要翻译：微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。流体通道可以形成在与相应的储存器流体连通的通道板上。电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。流体通道可以终止于电喷雾尖端的开口尖端区域。覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。

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