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1. 发明申请

WO2006015306A3 METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES 审中-公开
标题翻译：方法，组合物和装置，包括微流体装置，包装涂覆的疏水性表面
公开(公告)号：WO2006015306A3
公开(公告)日：2008-10-16
申请号：PCT/US2005027225
申请日：2005-07-29
申请人： PREDICANT BIOSCIENCES INC , CHAPMAN ROBERT G , ZHAO MINGQI , NI JING , BOOSSE LUC J , STULTS JOHN T , YANG SAY , RUDOLF ROGER
发明人： CHAPMAN ROBERT G , ZHAO MINGQI , NI JING , BOOSSE LUC J , STULTS JOHN T , YANG SAY , RUDOLF ROGER
IPC分类号： B32B9/04 , B05D1/36 , B05D7/00
CPC分类号： G01N33/6848 , B01L3/5027 , H01J49/0018 , H01J49/165
摘要： Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
摘要翻译：公开了用于涂覆至少一部分疏水表面的方法，包括塑料或其它聚合物的表面。这种方法包括使用与疏水表面相互作用的第一涂层和/或区域，尽管不需要在第一涂层和疏水表面之间形成化学键。然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。微流体装置向质谱仪提供物质。微流体装置包括具有至少一个微通道的衬底，布置在微通道表面上的盖和至少一个电势源。一些实施例包括在出口处加宽的微通道。其他实施例将电势源沿着盖的表面定位。其他实施例包括其中设置电极和膜的阱。各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。

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