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1. 发明申请

WO0172201A3 DEVICE FOR CREATING A NEURAL INTERFACE AND METHOD FOR MAKING SAME 审中-公开
标题翻译：用于创建神经界面的装置及其制造方法
公开(公告)号：WO0172201A3
公开(公告)日：2008-02-21
申请号：PCT/US0110032
申请日：2001-03-29
申请人： UNIV ARIZONA , KIPKE DARYL , WILLIAMS JUSTIN , ROUSCHE PATRICK , PELLINEN DAVID S , PIVIN DAVID
发明人： KIPKE DARYL , WILLIAMS JUSTIN , ROUSCHE PATRICK , PELLINEN DAVID S , PIVIN DAVID
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61N1/0531 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/685 , A61B2562/187 , Y10S977/936 , Y10T29/49117
摘要： An implant device (500) for creating a neural interface with the central nervous system having a polyimide-based electrode arra (520) is presented along with a method for making the device. The device may be configured as a three dimensional structure (600) and is capable of sensing multi-unit neural activity from the cerebral cortex. Mechanical, electrical and biological characteristics of the device support it use as a reliable, long term implant.
摘要翻译：与用于制造该装置的方法一起呈现用于与具有基于聚酰亚胺的电极（520）的中枢神经系统产生神经界面的植入装置（500）。该装置可以被配置为三维结构（600）并且能够感测来自大脑皮质的多单位神经活动。该设备的机械，电气和生物特性支持其用作可靠的长期植入物。

2. 发明申请

WO2007042999A2 MODULAR MULTICHANNEL MICROELECTRODE ARRAY AND METHODS OF MAKING SAME 审中-公开
标题翻译：模块化多通道微电极阵列及其制备方法
公开(公告)号：WO2007042999A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053700
申请日：2006-10-09
申请人： NEURONEXUS TECHNOLOGIES , HETKE, Jamille , KIPKE, Daryl , PELLINEN, David , ANDERSON, David
发明人： HETKE, Jamille , KIPKE, Daryl , PELLINEN, David , ANDERSON, David
IPC分类号： A61N1/18
CPC分类号： A61B5/04001 , A61B2562/0209 , A61B2562/043 , A61N1/0534 , Y10T29/49117 , Y10T29/49147 , Y10T29/49149 , Y10T29/49155 , Y10T29/49211
摘要： Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed.
摘要翻译：本发明的一些实施例包括可定制的多通道微电极阵列，其具有连接到载体的模块化平面微加工电极阵列和设置在其上的高密度记录和/或刺激电极位置。还公开了制备和使用它们的新方法。

3. 发明申请

WO2006138358A2 FLEXIBLE POLYMER MICROELECTRODE WITH FLUID DELIVERY CAPABILITY AND METHODS FOR MAKING SAME 审中-公开
标题翻译：具有流体输送能力的柔性聚合物微电极及其制造方法
公开(公告)号：WO2006138358A2
公开(公告)日：2006-12-28
申请号：PCT/US2006023139
申请日：2006-06-14
申请人： UNIV MICHIGAN TECHNOLOGY MAN O , PELLINEN DAVID S , KIPKE DARYL R
发明人： PELLINEN DAVID S , KIPKE DARYL R
IPC分类号： A61B5/00
CPC分类号： A61B5/04001 , A61B5/4041 , A61B2562/125
摘要： A flexible multi-modal microelectrode is provided that combines multi-channel fluidic and electrical interfaces for biological and other systems. Methods of making and using same are also disclosed.
摘要翻译：提供了灵活的多模态微电极，其结合用于生物系统和其他系统的多通道流体和电接口。还公开了制造和使用方法。

4. 发明申请

WO2007042999A3 MODULAR MULTICHANNEL MICROELECTRODE ARRAY AND METHODS OF MAKING SAME 审中-公开
标题翻译：模块化多通道微电极阵列及其制备方法
公开(公告)号：WO2007042999A3
公开(公告)日：2009-04-16
申请号：PCT/IB2006053700
申请日：2006-10-09
申请人： NEURONEXUS TECHNOLOGIES , HETKE JAMILLE , KIPKE DARYL , PELLINEN DAVID , ANDERSON DAVID
发明人： HETKE JAMILLE , KIPKE DARYL , PELLINEN DAVID , ANDERSON DAVID
IPC分类号： A61B5/0478
CPC分类号： A61B5/04001 , A61B2562/0209 , A61B2562/043 , A61N1/0534 , Y10T29/49117 , Y10T29/49147 , Y10T29/49149 , Y10T29/49155 , Y10T29/49211
摘要： Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed.
摘要翻译：本发明的一些实施例包括可定制的多通道微电极阵列，其具有连接到载体的模块化平面微加工电极阵列和设置在其上的高密度记录和/或刺激电极位置。还公开了制备和使用它们的新方法。

5. 发明申请

WO2008109298A2 NEURAL INTERFACE SYSTEM 审中-公开
标题翻译：神经接口系统
公开(公告)号：WO2008109298A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/055025
申请日：2008-02-26
申请人： NEURONEXUS TECHNOLOGIES, INC. , VETTER, Rio , KIPKE, Daryl , PELLINEN, David , ANDERSON, David , HETKE, Jamille, Farraye
发明人： VETTER, Rio , KIPKE, Daryl , PELLINEN, David , ANDERSON, David , HETKE, Jamille, Farraye
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61B5/04001 , A61N1/0539 , A61N1/36082
摘要： The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
摘要翻译：本优选实施例的神经界面系统包括具有多个电极部位的电极阵列和支撑电极阵列的载体。电极阵列耦合到载体，使得电极位置围绕载体周向布置并且沿着载体轴向布置。一组电极位点可以被同时激活以创建激活模式。优选实施例的系统优选设计用于深度脑刺激，并且更具体地用于具有精细电极位置定位，选择性，可调谐性和精确激活图案化的深度脑刺激。然而，优选实施例的系统可以可选地用于任何合适的环境（诸如脊髓，周围神经，肌肉或任何其它合适的解剖位置）并且用于任何合适的原因。

6. 发明申请

WO2006138358A3 FLEXIBLE POLYMER MICROELECTRODE WITH FLUID DELIVERY CAPABILITY AND METHODS FOR MAKING SAME 审中-公开
公开(公告)号：WO2006138358A3
公开(公告)日：2006-12-28
申请号：PCT/US2006/023139
申请日：2006-06-14
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN TECHNOLOGY MANAGEMENT OFFICE , PELLINEN, David, S. , KIPKE, Daryl, R.
发明人： PELLINEN, David, S. , KIPKE, Daryl, R.
IPC分类号： A61N1/00
摘要： A flexible multi-modal microelectrode is provided that combines multi-channel fluidic and electrical interfaces for biological and other systems. Methods of making and using same are also disclosed.

7. 发明申请

WO2008109298A3 NEURAL INTERFACE SYSTEM 审中-公开
标题翻译：神经接口系统
公开(公告)号：WO2008109298A3
公开(公告)日：2008-12-24
申请号：PCT/US2008055025
申请日：2008-02-26
申请人： NEURONEXUS TECHNOLOGIES INC , VETTER RIO , KIPKE DARYL , PELLINEN DAVID , ANDERSON DAVID , HETKE JAMILLE FARRAYE
发明人： VETTER RIO , KIPKE DARYL , PELLINEN DAVID , ANDERSON DAVID , HETKE JAMILLE FARRAYE
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61B5/04001 , A61N1/0539 , A61N1/36082
摘要： The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
摘要翻译：优选实施例的神经接口系统包括具有多个电极位置的电极阵列和支撑电极阵列的载体。电极阵列耦合到载体，使得电极位置沿着载体周向布置并且沿着载体轴向布置。可以同时激活一组电极部位以产生激活模式。优选实施例的系统优选地设计用于深部脑刺激，更具体地，针对具有精细电极位置定位，选择性，可调性和精确激活图案化的深部脑刺激。然而，优选实施例的系统可以替代地在任何合适的环境（例如脊髓，周围神经，肌肉或任何其他合适的解剖学位置）中使用，并且由于任何合适的原因。

8. 发明申请

WO2012122502A1 NEURAL INTERFACE SYSTEM WITH AN EDGE ARRAY 审中-公开
标题翻译：具有边缘阵列的神经接口系统
公开(公告)号：WO2012122502A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028552
申请日：2012-03-09
申请人： NEURONEXUS TECHNOLOGIES , SEYMOUR, John , HETKE, Jamille , VETTER, Rio , KIPKE, Daryl , PELLINEN, David , KONG, K.C.
发明人： SEYMOUR, John , HETKE, Jamille , VETTER, Rio , KIPKE, Daryl , PELLINEN, David , KONG, K.C.
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61B1/07 , A61M25/0009 , A61M25/0023 , A61N1/0553 , A61N5/0601 , A61N2005/0632 , H05K1/028 , H05K1/118 , H05K3/10 , H05K2201/051 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155
摘要： The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.
摘要翻译：一个实施例的神经接口系统包括圆柱形轴，纵向耦合到轴的至少一部分并且具有小于轴的直径的厚度的横向延伸部和布置在横向延伸部上的径向偏移的电极阵列轴，包括与其周围环境电接触的电极位置。用于制造神经接口系统的一个实施例的方法包括：形成具有至少一个金属化层的平面聚合物衬底，在至少一个金属化层上图案化在衬底的第一端上的电极阵列，在至少一个金属化层将基板的一部分朝向基板的第一端滚动，并且将轧制的基板固定到轴中，该轴具有从轴横向延伸的基板的第一端并且电极阵列从轴径向偏移。

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