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1. 发明申请

WO2006138358A3 FLEXIBLE POLYMER MICROELECTRODE WITH FLUID DELIVERY CAPABILITY AND METHODS FOR MAKING SAME 审中-公开
公开(公告)号：WO2006138358A3
公开(公告)日：2006-12-28
申请号：PCT/US2006/023139
申请日：2006-06-14
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN TECHNOLOGY MANAGEMENT OFFICE , PELLINEN, David, S. , KIPKE, Daryl, R.
发明人： PELLINEN, David, S. , KIPKE, Daryl, R.
IPC分类号： A61N1/00
摘要： A flexible multi-modal microelectrode is provided that combines multi-channel fluidic and electrical interfaces for biological and other systems. Methods of making and using same are also disclosed.

2. 发明申请

WO2013016347A2 NEURAL DEVICE WITH MODULAR ELECTRODE ARRAY 审中-公开
标题翻译：神经元模块电极阵列
公开(公告)号：WO2013016347A2
公开(公告)日：2013-01-31
申请号：PCT/US2012/047994
申请日：2012-07-24
申请人： KIPKE, Daryl, R. , VETTER, Rio, J. , KONG, Kc , HETKE, Jamille , ANDERSON, David
发明人： KIPKE, Daryl, R. , VETTER, Rio, J. , KONG, Kc , HETKE, Jamille , ANDERSON, David
IPC分类号： A61N1/05 , A61B5/0478 , A61B5/00 , A61N5/06
CPC分类号： A61N1/0476 , A61B5/0059 , A61B5/04001 , A61B5/0478 , A61B5/4064 , A61B5/4094 , A61B2562/0209 , A61B2562/046 , A61N1/0502 , A61N1/0531 , A61N1/36064 , A61N5/06 , A61N5/0622 , Y10T29/49117
摘要： An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.
摘要翻译：一种装置包括柔性基板，柔性基板包括设置在柔性基板上的模块化电极阵列。模块化电极阵列包括多个电极模块，其中电极模块包括多个电极。柔性衬底还包括模块化电极阵列的电极模块和耦合到多个电极的电极的导电互连之间的空间分隔。

3. 发明申请

WO2011057137A1 WAVEGUIDE NEURAL INTERFACE DEVICE 审中-公开
标题翻译：波形神经界面装置
公开(公告)号：WO2011057137A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055720
申请日：2010-11-05
申请人： NEURONEXUS TECHNOLOGIES , SEYMOUR, John, P. , GULARI, Mayurachat , KIPKE, Daryl, R. , KONG, K., C.
发明人： SEYMOUR, John, P. , GULARI, Mayurachat , KIPKE, Daryl, R. , KONG, K., C.
IPC分类号： A61B5/00
CPC分类号： A61N5/0622 , A61B5/0084 , A61B5/04001 , A61B5/4076 , A61B2562/0233 , A61B2562/046 , A61N2005/0626 , A61N2005/0643 , Y10T29/49016
摘要： A waveguide neural interface device including: a neural device implantable in tissue and including an array of electrode sites that electrically communicate with their surroundings, in which the array of electrode sites includes at least one recording electrode site; and a waveguide, coupled to the neural device, that carries light along a longitudinal axis and includes a light directing element that redirects the carried light from the waveguide to illuminate selectively targeted tissue, in which at least a portion of the redirected light is directed laterally away from the longitudinal axis and the recording electrode site is configured to sample illuminated tissue. A method for assembling a waveguide neural interface device is also described.
摘要翻译：一种波导神经接口装置，包括：可植入组织中并包括与其周围环境电连通的电极位置阵列的神经装置，其中所述电极位置阵列包括至少一个记录电极位置; 以及耦合到所述神经装置的波导，其沿着纵向轴线承载光，并且包括导光元件，所述光导向元件重新导向所述被传输的光从所述波导照射选择性地靶向的组织，其中所述重定向的光的至少一部分被侧向远离纵向轴线并且记录电极部位被配置为对照射的组织进行采样。还描述了一种用于组装波导神经接口装置的方法。

4. 发明申请

WO2013016351A1 NEURAL DRUG DELIVERY SYSTEM WITH MICROVALVES 审中-公开
标题翻译：神经药物递送系统与微卫星
公开(公告)号：WO2013016351A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047998
申请日：2012-07-24
申请人： HEWITT, Nicholas, D. , HETKE, Jamille , KIPKE, Daryl, R. , VETTER, Rio, J. , SEYMOUR, John
发明人： HEWITT, Nicholas, D. , HETKE, Jamille , KIPKE, Daryl, R. , VETTER, Rio, J. , SEYMOUR, John
IPC分类号： A61M5/168 , A61M5/142 , A61M25/00 , A61N1/05
CPC分类号： A61M25/0021 , A61M5/14276 , A61M5/16881 , A61M25/0009 , A61M25/0012 , A61M25/0015 , A61M25/007 , A61M25/0075 , A61M25/0102 , A61M2025/0042 , A61M2210/0693 , A61N1/05 , Y10T29/49416
摘要： An apparatus comprises a tubular body (110) having a lumen and a distal region (115), a plurality of ports at the distal region of the tubular body, and a plurality of independently gatable microvalves (120) disposed at the plurality of ports. A port extends from internal to the lumen to outside the tubular body, and a gatable microvalve is controllable by a stimulus to provide and prevent fluidic transfer through the ports.
摘要翻译：一种装置包括具有内腔和远侧区域（115）的管状主体（110），在管状体的远端区域处的多个端口以及设置在多个端口处的多个可独立测量的微型阀（120）。端口从内部延伸到内腔到管状体外部，并且可控的微型阀可以通过刺激来控制，以提供和防止通过端口的流体传递。

5. 发明申请

WO2013016343A1 DISTRIBUTED NEURAL STIMULATION ARRAY SYSTEM 审中-公开
标题翻译：分布式神经刺激阵列系统
公开(公告)号：WO2013016343A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047988
申请日：2012-07-24
申请人： KIPKE, Daryl, R. , ANDERSON, David , VETTER, Rio, J. , HETKE, Jamille
发明人： KIPKE, Daryl, R. , ANDERSON, David , VETTER, Rio, J. , HETKE, Jamille
IPC分类号： A61N1/05 , A61B5/04 , A61M5/142
CPC分类号： A61N1/0551 , A61B5/04001 , A61B2562/125 , A61M5/14276 , A61N1/0534 , A61N1/0553 , H05K13/0023 , Y10T29/49002 , Y10T29/49117
摘要： A device comprises a device carrier having a substantially cylindrical shape and including an array of neural probes. The array of neural probes extend substantially longitudinally from a distal end of the device carrier and include a plurality of central neural probes, wherein a central probe includes at least one stimulating electrode site, and a plurality of peripheral neural probes arranged at a periphery of the plurality of central neural probes, wherein a peripheral neural probe is electrically conducting.
摘要翻译：一种装置包括具有基本上圆柱形形状并且包括神经探针阵列的装置载体。神经探针阵列从装置载体的远端基本纵向地延伸并且包括多个中心神经探针，其中中心探针包括至少一个刺激电极部位，以及多个周边神经探针，其布置在多个中心神经探针，其中周围神经探针是导电的。

6. 发明申请

WO2009052425A1 IMPLANTABLE DEVICE INCLUDING A RESORBABLE CARRIER 审中-公开
标题翻译：可移植的设备，包括一个可移动的载体
公开(公告)号：WO2009052425A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080366
申请日：2008-10-17
申请人： NEURONEXUS TECHNOLOGIES , HETKE, Jamille, F. , KIPKE, Daryl, R. , VETTER, Rio, J.
发明人： HETKE, Jamille, F. , KIPKE, Daryl, R. , VETTER, Rio, J.
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/4041 , A61B2562/0209 , A61B2562/028 , A61B2562/046 , A61N1/05 , A61N1/0551
摘要： An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译：一种用于身体组织的可植入装置，包括在身体组织内部弯曲并与身体组织接触的电子系统，以及以下述两种模式操作的载体：在将装置植入身体组织期间为电子系统提供结构支撑，并允许电子子系统在植入人体组织后的装置。可植入装置优选被设计成植入脑，脊髓，周围神经，肌肉或任何其它合适的解剖学位置。然而，可植入装置可以替代地在任何合适的环境中使用，并且出于任何合适的原因。

7. 发明申请

WO2004080343A2 COMPOSITIONS AND METHODS FOR USE OF ALGINATE DURAL SEALANTS 审中-公开
标题翻译：用于治疗ALGINATE DURAL SEALANTS的组合物和方法
公开(公告)号：WO2004080343A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/007357
申请日：2004-03-10
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KIPKE, Daryl, R. , BECKER, Timothy, A. , WILLIAMS, Justin, C. , VETTER, Rio, J.
发明人： KIPKE, Daryl, R. , BECKER, Timothy, A. , WILLIAMS, Justin, C. , VETTER, Rio, J.
IPC分类号： A61F
CPC分类号： A61L24/0015 , A61L24/08 , A61L2300/41 , C08L5/04
摘要： The present invention comprises compositions and methods for use of an alginate dural sealant in conjunction with mammalian neurosurgical procedures, including but not limited to, the implantation of neuroprosthetic devices.
摘要翻译：本发明包括与哺乳动物神经外科手术结合使用藻酸盐硬脑膜封闭剂的组合物和方法，包括但不限于神经假体装置的植入。

8. 发明申请

WO2011046665A1 NEURAL INTERFACE SYSTEM 审中-公开
标题翻译：神经接口系统
公开(公告)号：WO2011046665A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/044167
申请日：2010-08-02
申请人： NEURONEXUS TECHNOLOGIES , ANDERSON, David , VETTER, Rio, J. , HETKE, Jamille, F. , KIPKE, Daryl, R.
发明人： ANDERSON, David , VETTER, Rio, J. , HETKE, Jamille, F. , KIPKE, Daryl, R.
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61N1/0534 , A61N1/0539 , Y10T29/49204
摘要： A neural interface system including an electrode array and a carrier that supports the electrode array, in which the electrode array includes a substrate rolled into a three- dimensional shape, a plurality of conductive traces patterned on the substrate and adapted to transmit electrical signals, and a plurality of elliptically shaped, externally facing electrode sites coupled to the plurality of conductive traces that electrically communicate with their surroundings. The plurality of electrodes are arranged in a triangular lattice circumferentially around and axially along the carrier, and the substrate includes an edge that extends axially along the carrier and is constrained between a first axial row portion of the plurality of electrode sites and a second axial row portion of the plurality of electrode sites adjacent to the first axial row portion.
摘要翻译：一种包括支撑电极阵列的电极阵列和载体的神经接口系统，其中电极阵列包括滚动成三维形状的基底，在基底上图案化并适于传输电信号的多个导电迹线，以及耦合到与其周围环境电连通的多个导电迹线的多个椭圆形的外部对置的电极位置。多个电极沿着载体围绕并且沿轴向布置成三角形格栅，并且基板包括沿着载体轴向延伸并且限制在多个电极位置的第一轴向行部分和第二轴向行所述多个电极位置的与所述第一轴向行部分相邻的部分。

9. 发明申请

WO2009052423A1 THREE-DIMENSIONAL SYSTEM OF ELECTRODE LEADS 审中-公开
标题翻译：电极引线三维系统
公开(公告)号：WO2009052423A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080364
申请日：2008-10-17
申请人： NEURONEXUS TECHNOLOGIES , VETTER, Rio, J. , KIPKE, Daryl, R. , HETKE, Jamille, F.
发明人： VETTER, Rio, J. , KIPKE, Daryl, R. , HETKE, Jamille, F.
IPC分类号： A61B5/04
CPC分类号： A61B5/0478 , A61B5/04001 , A61N1/0534 , A61N1/0551
摘要： The electrode lead system of a preferred embodiment includes a series of first electrical subsystems; a guiding element that positions the series of first electrical subsystems in a three dimensional arrangement within body tissue; a second electrical subsystem; and at least one connector that couples the first electrical subsystems to the second electrical subsystem. The electrode lead system of another preferred embodiment includes a series of electrode arrays; a guide tube that facilitates implantation of electrode arrays within body tissue and temporarily contains the series of electrode arrays; and a guiding element that provides a bias on the series of electrode arrays such that (a) when contained by the guide tube, the first electrical subsystems maintain a substantially singular path within body tissue, and (b) when not contained by the guide tube, the first electrical subsystems diverge along more than one path into a three dimensional arrangement within body tissue.
摘要翻译：优选实施例的电极引线系统包括一系列第一电子子系统; 引导元件，其将所述一系列第一电子系统定位在身体组织内的三维排列中; 第二电子系统; 以及将第一电子系统耦合到第二电子系统的至少一个连接器。另一个优选实施例的电极引线系统包括一系列电极阵列; 引导管，其有助于将电极阵列植入体内组织并暂时包含一系列电极阵列; 以及引导元件，其在所述一系列电极阵列上提供偏置，使得（a）当由所述引导管容纳时，所述第一电子系统在所述主体组织内保持基本上奇异的路径，以及（b）当所述引导管未被所述导管，第一电子子系统沿着多于一条的路径发散成体内组织内的三维排列。

10. 发明申请

WO2007089738A2 MICROELECTRODE WITH LATERALLY EXTENDING PLATFORM FOR REDUCTION OF TISSUE ENCAPSULATION 审中-公开
标题翻译：具有用于减少组织封装的具有横向扩展平台的微电子
公开(公告)号：WO2007089738A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002465
申请日：2007-01-26
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , SEYMOUR, John, P. , KIPKE, Daryl, R.
发明人： SEYMOUR, John, P. , KIPKE, Daryl, R.
IPC分类号： B61D45/00
CPC分类号： A61B5/04001 , A61B5/685 , A61B2562/125 , A61N1/0551 , A61N1/0558
摘要： In some embodiments, an implantable microelectrode is provided with a shank comprised of a laterally extending platform whose thickness and/or configuration contributes to reduced tissue encapsulation, with at least one electrode site disposed at least partially on or in the laterally extending platform. Novel methods of designing, making, and using an implantable microelectrode or biosensor resulting in reduced tissue encapsulation are also disclosed.
摘要翻译：在一些实施例中，可植入微电极设置有由横向延伸的平台构成的柄，其厚度和/或构型有助于减少组织封装，其中至少一个电极位置至少部分地设置在横向延伸的平台上或横向延伸的平台中。还公开了设计，制造和使用导致减少的组织包封的可植入微电极或生物传感器的新方法。

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